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Mindfulness for the Treatment of Stress Disorders

  • Chapter
Mindfulness and Buddhist-Derived Approaches in Mental Health and Addiction

Part of the book series: Advances in Mental Health and Addiction ((AMHA))

Abstract

Long-term stress can lead to mental and bodily dysfunctions and diseases. Stress also appears as a companion that worsens the course of existing diseases. Although the evolutionary perspective on stress offers a compelling framework for the increasing occurrence of stress-related disorders in modern societies, the underlying biological mechanisms are not completely understood. In this chapter, we describe the physiological response to stressors (allostasis) and how stress may cause harm to the body (allostatic load). We follow the explanatory track from epigenetic influences via altered gene expression to pathological changes. We finally discuss the effects of mindfulness-based interventions on these changes. Can the damage be reversed?

Stress-induced modulation of physiological processes may account for a group of poorly understood “functional” disorders, commonly labelled as “medically unexplained symptoms”, “functional somatic syndromes”, or “bodily distress syndrome”. In our research clinic, we use mindfulness-based stress reduction to treat patients with these disorders. The beneficial effects of the treatment have received increasing support from empirical studies, which indicate that mindfulness-based therapies mediate neuroplastic changes and changes in physiological stress mechanisms. We describe some of the experiences gained and results obtained using mindfulness-based stress reduction in clinical treatment.

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References

  • Afari, N., Ahumada, S. M., Wright, L. J., Mostoufi, S., Golnari, G., Reis, V., et al. (2014). Psychological trauma and functional somatic syndromes: A systematic review and meta-analysis. Psychosomatic Medicine, 76(1), 2–11.

    PubMed Central  PubMed  Google Scholar 

  • Agargun, M. Y., Tekeoglu, I., Gunes, A., Adak, B., Kara, H., & Ercan, M. (1999). Sleep quality and pain threshold in patients with fibromyalgia. Comprehensive Psychiatry, 40(3), 226–228. doi: S0010-440X(99)90008-1 [pii].

    PubMed  Google Scholar 

  • Akehurst, R. L., Brazier, J. E., Mathers, N., O’Keefe, C., Kaltenthaler, E., Morgan, A., et al. (2002). Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting. PharmacoEconomics, 20(7), 455–462. doi: 200703 [pii].

    PubMed  Google Scholar 

  • Amin, S. N., El-Aidi, A. A., Ali, M. M., Attia, Y. M., & Rashed, L. A. (2015). Modification of hippocampal markers of synaptic plasticity by memantine in animal models of acute and repeated restraint stress: implications for memory and behavior. Neuromolecular Med. doi:10.1007/s12017-015-8343-0.

    PubMed  Google Scholar 

  • Ancelin, M. L., Carriere, I., Helmer, C., Rouaud, O., Pasquier, F., Berr, C., et al. (2012). Steroid and nonsteroidal anti-inflammatory drugs, cognitive decline, and dementia. Neurobiology of Aging, 33(9), 2082–2090. doi:10.1016/j.neurobiolaging.2011.09.038. S0197-4580(11)00392-7 [pii].

    PubMed  Google Scholar 

  • Armanini, M. P., Hutchins, C., Stein, B. A., & Sapolsky, R. M. (1990). Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent. Brain Research, 532(1–2), 7–12. doi: 0006-8993(90)91734-X [pii].

    PubMed  Google Scholar 

  • Barrett, B., Hayney, M. S., Muller, D., Rakel, D., Ward, A., Obasi, C. N., et al. (2012). Meditation or exercise for preventing acute respiratory infection: a randomized. Annals of Family Medicine, 10, 337–346. doi:10.1370/afm.1376.INTRODUCTION.

    PubMed Central  PubMed  Google Scholar 

  • Barsky, A. J., Ettner, S. L., Horsky, J., & Bates, D. W. (2001). Resource utilization of patients with hypochondriacal health anxiety and somatization. Medical Care, 39(7), 705–715.

    PubMed  Google Scholar 

  • Bender, B. G., Lerner, J. A., & Kollasch, E. (1988). Mood and memory changes in asthmatic children receiving corticosteroids. Journal of the American Academy of Child and Adolescent Psychiatry, 27(6), 720–725. doi:10.1097/00004583-198811000-00010. S0890-8567(09)65853-6 [pii].

    PubMed  Google Scholar 

  • Berk, M., Williams, L., Jacka, F., O’Neil, A., Pasco, J., Moylan, S., et al. (2013). So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine, 11.

    Google Scholar 

  • Bhikkhu, A. (2010). The earliest recorded discourses of the Buddha (translated) (from Lalitavistara, Mahākhandhaka & Mahāvastu. Kuala Lumpur: Sukhi Hotu.

    Google Scholar 

  • Black, D. S., Cole, S. W., Irwin, M. R., Breen, E., Cyr, S., Nazarian, N. M., et al. (2013). Yogic meditation reverses NF-kappaB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology, 38(3), 348–355. doi:10.1016/j.psyneuen.2012.06.011. S0306-4530(12)00226-0 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Bohmelt, A. H., Nater, U. M., Franke, S., Hellhammer, D. H., & Ehlert, U. (2005). Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosomatic Medicine, 67(2), 288–294. doi:10.1097/01.psy.0000157064.72831.ba. 67/2/288 [pii].

    PubMed  Google Scholar 

  • Bremner, J. D., Randall, P., Scott, T. M., Bronen, R. A., Seibyl, J. P., Southwick, S. M., et al. (1995). MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. The American Journal of Psychiatry, 152(7), 973–981.

    PubMed Central  PubMed  Google Scholar 

  • Brown, E. S., Jeon-Slaughter, H., Lu, H., Jamadar, R., Issac, S., Shad, M., et al. (2014). Hippocampal volume in healthy controls given 3-day stress doses of hydrocortisone. Neuropsychopharmacology, 40, 1216–1221. doi:10.1038/npp.2014.307. npp2014307 [pii].

    Google Scholar 

  • Browning, M., Fletcher, P., & Sharpe, M. (2011). Can neuroimaging help us to understand and classify somatoform disorders? A systematic and critical review. Psychosomatic Medicine, 73(2), 173–184. doi:10.1097/PSY.0b013e31820824f6. PSY.0b013e31820824f6 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Cahill, L., & McGaugh, J. L. (1998). Mechanisms of emotional arousal and lasting declarative memory. Trends in Neurosciences, 21(7), 294–299. doi: S0166-2236(97)01214-9 [pii].

    PubMed  Google Scholar 

  • Carson, A. J., Stone, J., Warlow, C., & Sharpe, M. (2004). Patients whom neurologists find difficult to help. Journal of Neurology, Neurosurgery and Psychiatry, 75(12), 1776–1778. doi:10.1136/jnnp.2003.032169. 75/12/1776 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Carstensen, T. B., Frostholm, L., Oernboel, E., Kongsted, A., Kasch, H., Jensen, T. S., et al. (2008). Post-trauma ratings of pre-collision pain and psychological distress predict poor outcome following acute whiplash trauma: A 12-month follow-up study. Pain, 139(2), 248–259. doi:10.1016/j.pain.2008.04.008. S0304-3959(08)00196-6 [pii].

    PubMed  Google Scholar 

  • Chang, L., Sundaresh, S., Elliott, J., Anton, P. A., Baldi, P., Licudine, A., et al. (2009). Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterology and Motility, 21(2), 149–159. doi:10.1111/j.1365-2982.2008.01171.x. NMO1171 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Chaturvedi, R. K., & Beal, M. F. (2013). Molecular and cellular neuroscience mitochondria targeted therapeutic approaches in Parkinson’s and Huntington’s diseases. Molecular and Cellular Neurosciences, 55, 101–114.

    PubMed  Google Scholar 

  • Chew-Graham, C., & May, C. (1999). Chronic low back pain in general practice: The challenge of the consultation. Family Practice, 16(1), 46–49.

    PubMed  Google Scholar 

  • Choi, D. W. (1988). Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends in Neurosciences, 11(10), 465–469. doi: 0166-2236(88)90200-7 [pii].

    PubMed  Google Scholar 

  • Clauw, D. J. (2001). Potential mechanisms in chemical intolerance and related conditions. The Annals of the New York Academy of Sciences, 933, 235–253.

    PubMed  Google Scholar 

  • Cockshella, S. J., & Mathiasa, J. L. (2010). Cognitive functioning in chronic fatigue syndrome: A meta-analysis. Psychological Medicine, 40, 1253–1267.

    Google Scholar 

  • Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., et al. (2012). Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proceedings of the National Academy of Sciences of the United States of America, 109(16), 5995–5999. doi:10.1073/pnas.1118355109. 1118355109 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Cole, S. W. (2013). Social regulation of human gene expression: Mechanisms and implications for public health. American Journal of Public Health, 103, 84–93. doi:10.2105/AJPH.2012.301183.

    Google Scholar 

  • Cook, D. B., O’Connor, P. J., Lange, G., & Steffener, J. (2007). Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. NeuroImage, 36(1), 108–122. doi:10.1016/j.neuroimage.2007.02.033. S1053-8119(07)00127-9 [pii].

    PubMed  Google Scholar 

  • Coplan, J. D., Fulton, S. L., Reiner, W., Jackowski, A., Panthangi, V., Perera, T. D., et al. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: Preliminary implications for serotonin-related function in mood and anxiety disorders. Frontiers in Behavioral Neuroscience, 8, 440. doi:10.3389/fnbeh.2014.00440.

    PubMed Central  PubMed  Google Scholar 

  • Creed, F., Barsky, A. J., & Leiknes, K. A. (2011). Epidemiology: Prevalence, causes and consequences. In F. Creed, P. Henningsen, & P. Fink (Eds.), Medically unexplained symptoms, somatization and bodily distress. Developing better clinical services (pp. 1–42). New York: Cambridge University Press.

    Google Scholar 

  • Creswell, J. D., Irwin, M. R., Burklund, L. J., Lieberman, M. D., Arevalo, J. M. G., Ma, J., et al. (2012). Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial. Brain, Behavior, and Immunity, 26, 1095–1101. doi:10.1016/j.bbi.2012.07.006.

    PubMed Central  PubMed  Google Scholar 

  • Creswell, J. D., Myers, H. F., Cole, S. W., & Irwin, M. R. (2009). Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: A small randomized controlled trial. Brain, Behavior, and Immunity, 23, 184–188. doi:10.1016/j.bbi.2008.07.004.

    PubMed Central  PubMed  Google Scholar 

  • Dahlgaard, J., & Zachariae, R. (2014). Gene expression anti-stress effects following a mind-body intervention. Paper presented at the 72nd annual scientific meeting of the American Psychosomatic Society, San Francisco, CA.

    Google Scholar 

  • Davidson, R. J. (2000). Affective style, psychopathology, and resilience: Brain mechanisms and plasticity. The American Psychologist, 55(11), 1196–1214.

    PubMed  Google Scholar 

  • Davidson, R. J. (2004). Well-being and affective style: Neural substrates and biobehavioural correlates. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 359(1449), 1395–1411. doi:10.1098/rstb.2004.1510 MCADFWA2B7X1KJAW [pii].

    PubMed Central  PubMed  Google Scholar 

  • Davidson, R., Kabat-Zinn, J., Schumacher, J., Rosenkranz, M., Muller, D., Santorelli, S., et al. (2003). Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine, 65, 564–570. doi:10.1097/01.PSY.0000077505.67574.E3.

    PubMed  Google Scholar 

  • de Lange, F. P., Kalkman, J. S., Bleijenberg, G., Hagoort, P., van der Meer, J. W., & Toni, I. (2005). Gray matter volume reduction in the chronic fatigue syndrome. NeuroImage, 26(3), 777–781. doi:10.1016/j.neuroimage.2005.02.037. S1053-8119(05)00139-4 [pii].

    PubMed  Google Scholar 

  • de Quervain, D. J., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000). Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nature Neuroscience, 3(4), 313–314. doi:10.1038/73873.

    PubMed  Google Scholar 

  • de Quervain, D. J., Roozendaal, B., & McGaugh, J. L. (1998). Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature, 394(6695), 787–790. doi:10.1038/29542.

    PubMed  Google Scholar 

  • de Waal, M. W., Arnold, I. A., Eekhof, J. A., & van Hemert, A. M. (2004). Somatoform disorders in general practice: Prevalence, functional impairment and comorbidity with anxiety and depressive disorders. British Journal of Psychiatry, 184, 470–476.

    PubMed  Google Scholar 

  • Dinan, T. G., Quigley, E. M., Ahmed, S. M., Scully, P., O’Brien, S., O’Mahony, L., et al. (2006). Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: Plasma cytokines as a potential biomarker? Gastroenterology, 130(2), 304–311. doi:10.1053/j.gastro.2005.11.033. S0016-5085(05)02394-2 [pii].

    PubMed  Google Scholar 

  • Drevets, W. C., & Raichle, M. E. (1992). Neuroanatomical circuits in depression: Implications for treatment mechanisms. Psychopharmacology Bulletin, 28(3), 261–274.

    PubMed  Google Scholar 

  • Dunlop, S. P., Jenkins, D., & Spiller, R. C. (2003). Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. American Journal of Gastroenterology, 98(7), 1578–1583. doi:10.1111/j.1572-0241.2003.07542.x. S0002927003003757 [pii].

    PubMed  Google Scholar 

  • Engel, G. L. (1980). The clinical application of the biopsychosocial model. The American Journal of Psychiatry, 137(5), 535–544. doi:10.1176/ajp.137.5.535.

    PubMed  Google Scholar 

  • Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., et al. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17312–17315. doi:10.1073/pnas.0407162101. 0407162101 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Escolas, S. M., & Escolas, H. D. (2015). Temperament dimensions and posttraumatic stress symptoms in a previously deployed military sample. US Army Medical Department Journal, Jan-Mar, 79–85.

    Google Scholar 

  • Fardet, L., Petersen, I., & Nazareth, I. (2012). Suicidal behavior and severe neuropsychiatric disorders following glucocorticoid therapy in primary care. The American Journal of Psychiatry, 169(5), 491–497.

    PubMed  Google Scholar 

  • Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., et al. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245–258. doi: S0749379798000178 [pii].

    PubMed  Google Scholar 

  • Fink, P., Rosendal, M., & Toft, T. (2002). Assessment and treatment of functional disorders in general practice: The extended reattribution and management model--an advanced educational program for nonpsychiatric doctors. Psychosomatics, 43(2), 93–131. doi:10.1176/appi.psy.43.2.93. S0033-3182(02)70423-4 [pii].

    PubMed  Google Scholar 

  • Fink, P., & Schroder, A. (2010). One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders. Journal of Psychosomatic Research, 68(5), 415–426. doi:10.1016/j.jpsychores.2010.02.004. S0022-3999(10)00075-9 [pii].

    PubMed  Google Scholar 

  • Fink, P., Sorensen, L., Engberg, M., Holm, M., & Munk-Jorgensen, P. (1999). Somatization in primary care. Prevalence, health care utilization, and general practitioner recognition. Psychosomatics, 40(4), 330–338. doi:10.1016/S0033-3182(99)71228-4. S0033-3182(99)71228-4 [pii].

    PubMed  Google Scholar 

  • Fink, P., Toft, T., Hansen, M. S., Ornbol, E., & Olesen, F. (2007). Symptoms and syndromes of bodily distress: An exploratory study of 978 internal medical, neurological, and primary care patients. Psychosomatic Medicine, 69(1), 30–39. doi:10.1097/PSY.0b013e31802e46eb. 69/1/30 [pii].

    PubMed  Google Scholar 

  • Fjorback, L. O. (2012). Mindfulness and Bodily Distress. Ph.D. dissertation, Aarhus University, Aarhus.

    Google Scholar 

  • Fjorback, L. O., Arendt, M., Ornbol, E., Walach, H., Rehfeld, E., Schroder, A., et al. (2013). Mindfulness therapy for somatization disorder and functional somatic syndromes: Randomized trial with one-year follow-up. Journal of Psychosomatic Research, 74(1), 31–40. doi:10.1016/j.jpsychores.2012.09.006. S0022-3999(12)00244-9 [pii].

    PubMed  Google Scholar 

  • Ford, A. C., & Talley, N. J. (2011). Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: A systematic review. Journal of Gastroenterology, 46(4), 421–431. doi:10.1007/s00535-011-0379-9.

    PubMed  Google Scholar 

  • Frostholm, L., Petrie, K. J., Ornbol, E., & Fink, P. (2014). Are illness perceptions related to future healthcare expenditure in patients with somatoform disorders? Psychological Medicine, 44(13), 2903–2911. doi:10.1017/S003329171400035X. S003329171400035X [pii].

    PubMed  Google Scholar 

  • Gagliardi, L., Ho, J. T., & Torpy, D. J. (2010). Corticosteroid-binding globulin: The clinical significance of altered levels and heritable mutations. Molecular and Cellular Endocrinology, 316(1), 24–34. doi:10.1016/j.mce.2009.07.015. S0303-7207(09)00375-X [pii].

    PubMed  Google Scholar 

  • Geiss, A., Rohleder, N., & Anton, F. (2012). Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia. Psychoneuroendocrinology, 37(5), 671–684. doi:10.1016/j.psyneuen.2011.07.021. S0306-4530(11)00263-0 [pii].

    PubMed  Google Scholar 

  • Gold, S. M., Dziobek, I., Sweat, V., Tirsi, A., Rogers, K., Bruehl, H., et al. (2007). Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes. Diabetologia, 50(4), 711–719. doi:10.1007/s00125-007-0602-7.

    PubMed  Google Scholar 

  • Goleman, D. (2003). Destructive emotions: How can we overcome them? A scientific dialogue with the Dalai Lama. New York: Bantam Dell. A Division of the Random House, Inc.

    Google Scholar 

  • Hanson, J. L., Nacewicz, B. M., Sutterer, M. J., Cayo, A. A., Schaefer, S. M., Rudolph, K. D., et al. (2015). Behavioral problems after early life stress: Contributions of the hippocampus and amygdala. Biological Psychiatry, 77(4), 314–323. doi:10.1016/j.biopsych.2014.04.020. S0006-3223(14)00351-5 [pii].

    PubMed  Google Scholar 

  • Hatcher, S., & House, A. (2003). Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: A case–control study. Psychological Medicine, 33(7), 1185–1192.

    PubMed  Google Scholar 

  • Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49(12), 1023–1039. doi: S000632230101157X [pii].

    PubMed  Google Scholar 

  • Henningsen, P., Zipfel, S., & Herzog, W. (2007). Management of functional somatic syndromes. Lancet, 369(9565), 946–955. doi:10.1016/S0140-6736(07)60159-7. S0140-6736(07)60159-7 [pii].

    PubMed  Google Scholar 

  • Hölzel, B. K., Carmody, J., Evans, K. C., Hoge, E. A., Dusek, J. A., Morgan, L., et al. (2010). Stress reduction correlates with structural changes in the amygdala. Social Cognitive and Affective Neuroscience, 5, 11–17. doi:10.1093/scan/nsp034.

    PubMed Central  PubMed  Google Scholar 

  • Holzel, B. K., Carmody, J., Vangel, M., Congleton, C., Yerramsetti, S. M., Gard, T., et al. (2011). Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Research, 191(1), 36–43. doi:10.1016/j.pscychresns.2010.08.006. S0925-4927(10)00288-X [pii].

    PubMed Central  PubMed  Google Scholar 

  • Hunter, R. G., Gagnidze, K., McEwen, B. S., & Pfaff, D. W. (2014). Stress and the dynamic genome: Steroids, epigenetics, and the transposome. Proceedings of the National Academy of Sciences of the United States of America, 11(22), 6828–6833. doi:10.1073/pnas.1411260111. 1411260111 [pii].

    Google Scholar 

  • Iqbal, R., Mughal, M. S., Arshad, N., & Arshad, M. (2011). Pathophysiology and antioxidant status of patients with fibromyalgia. Rheumatology International, 31(2), 149–152. doi:10.1007/s00296-010-1470-x.

    PubMed  Google Scholar 

  • Irie, M., Asami, S., Nagata, S., Miyata, M., & Kasai, H. (2002). Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers. Psychotherapy and Psychosomatics, 71(2), 90–96. doi: 49351 [pii] 49351.

    PubMed  Google Scholar 

  • Irwin, M. R., & Cole, S. W. (2011). Reciprocal regulation of the neural and innate immune systems. Nature Reviews Immunology, 11, 625–632.

    PubMed Central  PubMed  Google Scholar 

  • Irwin, M. R., & Olmstead, R. (2012). Mitigating cellular inflammation in older adults: A randomized controlled trial of Tai Chi Chih. The American Journal of Geriatric Psychiatry, 20(9), 764–772. doi:10.1097/JGP.0b013e3182330fd3.

    PubMed Central  PubMed  Google Scholar 

  • Jaremka, M., Fagundes, C., Peng, J., Bennett, J., Glaser, R., Malarkey, W., et al. (2013). Loneliness promotes inflammation during acute stress. Psychological Science, 24. doi: 10.1177/0956797612464059

    Google Scholar 

  • Jensen, K. B., Kosek, E., Wicksell, R., Kemani, M., Olsson, G., Merle, J. V., et al. (2012). Cognitive behavioral therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia. Pain, 153(7), 1495–1503. doi:10.1016/j.pain.2012.04.010. S0304-3959(12)00238-2 [pii].

    PubMed  Google Scholar 

  • Kabat-Zinn, J. (1990). Full catastrophe living: Using the wisdom of your body and mind to face stress, pain, and illness. New York: Delacorte.

    Google Scholar 

  • Kabat-Zinn, J., Wheeler, E., Light, T., Skillings, A., Scharf, M. J., Cropley, T. G., et al. (1998). Influence of a mindfulness meditation-based stress reduction intervention on rates of skin clearing in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA). Psychosomatic Medicine, 60, 625–632.

    PubMed  Google Scholar 

  • Kelly, S. J., & Ismail, M. (2015). Stress and type 2 diabetes: A review of how stress contributes to the development of type 2 diabetes. Annual Review of Public Health. doi:10.1146/annurev-publhealth-031914-122921.

    PubMed  Google Scholar 

  • Kemeny, M. E., & Laudenslager, M. L. (1999). Introduction beyond stress: The role of individual difference factors in psychoneuroimmunology. Brain, Behavior, and Immunity, 13(2), 73–75. doi:10.1006/brbi.1999.0562. S0889-1591(99)90562-7 [pii].

    PubMed  Google Scholar 

  • Kennedy, P. J., Clarke, G., O’Neill, A., Groeger, J. A., Quigley, E. M., Shanahan, F., et al. (2014). Cognitive performance in irritable bowel syndrome: Evidence of a stress-related impairment in visuospatial memory. Psychological Medicine, 44(7), 1553–1566. doi:10.1017/S0033291713002171. S0033291713002171 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Kirmayer, L. J., & Robbins, J. M. (1991). Three forms of somatization in primary care: Prevalence, co-occurrence, and sociodemographic characteristics. Journal of Nervous and Mental Disease, 179(11), 647–655.

    PubMed  Google Scholar 

  • Kolk, A. M., Schagen, S., & Hanewald, G. J. (2004). Multiple medically unexplained physical symptoms and health care utilization: Outcome of psychological intervention and patient-related predictors of change. Journal of Psychosomatic Research, 57(4), 379–389. doi:10.1016/j.jpsychores.2004.02.012. S0022399904000364 [pii].

    PubMed  Google Scholar 

  • Korte, S., Koolhaas, J., & Wingfield, J. (2005). The Darwinian concept of stress: Benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neuroscience & Biobehavioral Reviews, 29, 3–38.

    Google Scholar 

  • Kringlen, E., Torgersen, S., & Cramer, V. (2006). Mental illness in a rural area: A Norwegian psychiatric epidemiological study. Social Psychiatry and Psychiatric Epidemiology, 41(9), 713–719. doi:10.1007/s00127-006-0080-0.

    PubMed  Google Scholar 

  • Kroenke, K., & Price, R. K. (1993). Symptoms in the community. Prevalence, classification, and psychiatric comorbidity. Archives of Internal Medicine, 153(21), 2474–2480.

    PubMed  Google Scholar 

  • Krusche, A., Cyhlarova, E., & Williams, J. M. G. (2013). Mindfulness online: An evaluation of the feasibility of a web-based mindfulness course for stress, anxiety and depression. BMJ Open, 3, e003498. doi:10.1136/bmjopen-2013-003498.

    PubMed Central  PubMed  Google Scholar 

  • Kuzminskyte, R., Kupers, R., Videbech, P., Gjedde, A., & Fink, P. (2010). Increased sensitivity to supra-threshold painful stimuli in patients with multiple functional somatic symptoms (MFS). Brain Research Bulletin, 82(1–2), 135–140. doi:10.1016/j.brainresbull.2010.03.002. S0361-9230(10)00062-6 [pii].

    PubMed  Google Scholar 

  • Lange, G., Steffener, J., Cook, D. B., Bly, B. M., Christodoulou, C., Liu, W. C., et al. (2005). Objective evidence of cognitive complaints in Chronic Fatigue Syndrome: A BOLD fMRI study of verbal working memory. NeuroImage, 26(2), 513–524. doi:10.1016/j.neuroimage.2005.02.011. S1053-8119(05)00104-7 [pii].

    PubMed  Google Scholar 

  • Lapate, R. C., Lee, H., Salomons, T. V., van Reekum, C. M., Greischar, L. L., & Davidson, R. J. (2012). Amygdalar function reflects common individual differences in emotion and pain regulation success. Journal of Cognitive Neuroscience, 24(1), 148–158. doi:10.1162/jocn_a_00125.

    PubMed Central  PubMed  Google Scholar 

  • Lavretsky, H., Altstein, L., Olmstead, R., Ercoli, L., Riparetti-Brown, M., Cyr, N., et al. (2011). Complementary use of tai chi chih augments escitalopram treatment of geriatric depression: A randomized controlled trial. The American Journal of Geriatric Psychiatry, 19, 839–850. doi:10.1097/JGP.0b013e31820ee9ef.Complementary.

    PubMed Central  PubMed  Google Scholar 

  • Lavretsky, H., Epel, E. S., Siddarth, P., Nazarian, N., Cyr, N. S., Khalsa, D. S., et al. (2013). A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: Effects on mental health, cognition, and telomerase activity. International Journal of Geriatric Psychiatry, 28(1), 57–65. doi:10.1002/gps.3790.

    PubMed Central  PubMed  Google Scholar 

  • Lazar, S. W., Kerr, C. E., Wasserman, R. H., Gray, J. R., Greve, D. N., Treadway, M. T., et al. (2005). Meditation experience is associated with increased cortical thickness. Neuroreport, 16(17), 1893–1897. doi: 00001756-200511280-00005 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Lin, H. Y., Muller, Y. A., & Hammond, G. L. (2010). Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Molecular and Cellular Endocrinology, 316(1), 3–12. doi:10.1016/j.mce.2009.06.015. S0303-7207(09)00374-8 [pii].

    PubMed  Google Scholar 

  • Lupien, S. J., Parent, S., Evans, A. C., Tremblay, R. E., Zelazo, P. D., Corbo, V., et al. (2011). Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14324–14329. doi:10.1073/pnas.1105371108. 1105371108 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Lutz, J., Herwig, U., Opialla, S., Hittmeyer, A., Jäncke, L., Rufer, M., et al. (2014). Mindfulness and emotion regulation–an fMRI study. Social Cognitive and Affective Neuroscience, 9, 776–785. doi:10.1093/scan/nst043.

    PubMed Central  PubMed  Google Scholar 

  • Macedo, J. A., Hesse, J., Turner, J. D., Meyer, J., Hellhammer, D. H., & Muller, C. P. (2008). Glucocorticoid sensitivity in fibromyalgia patients: Decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper. Psychoneuroendocrinology, 33(6), 799–809. doi:10.1016/j.psyneuen.2008.03.012. S0306-4530(08)00070-X [pii].

    PubMed  Google Scholar 

  • Maeda, T., Guan, J. Z., Koyanagi, M., Higuchi, Y., & Makino, N. (2012). Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson’s disease. Journal of Neurogenetics, 26, 245–251. doi:10.3109/01677063.2011.651665.

    PubMed  Google Scholar 

  • Maes, M. (2009). Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms. Current Opinion in Psychiatry, 22(1), 75–83.

    PubMed  Google Scholar 

  • Maes, M., & Twisk, F. N. (2010). Chronic fatigue syndrome: Harvey and Wessely’s (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Medicine, 8, 35. doi:10.1186/1741-7015-8-35. 1741-7015-8-35 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Magarinos, A. M., & McEwen, B. S. (1995). Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience, 69(1), 89–98. doi: 030645229500259L [pii].

    PubMed  Google Scholar 

  • Manji, H., Kato, T., Di Prospero, N. A., Ness, S., Beal, M. F., Krams, M., et al. (2012). Impaired mitochondrial function in psychiatric disorders. Nature Reviews Neuroscience, 13, 293–307. doi:10.1038/nrn3229.

    PubMed  Google Scholar 

  • McEwen, B. S., Gray, J., & Nasca, C. (2015). Recognizing resilience: Learning from the effects of stress on the brain. Neurobiology Stress, 1, 1–11. doi:10.1016/j.ynstr.2014.09.001.

    Google Scholar 

  • McEwen, B. S., & Stellar, E. (1993). Stress and the individual. Mechanisms leading to disease. Archives of Internal Medicine, 153(18), 2093–2101.

    PubMed  Google Scholar 

  • McEwen, B. S., & Wingfield, J. C. (2003). The concept of allostasis in biology and biomedicine. Hormones and Behavior, 43(1), 2–15. doi: S0018506X02000247 [pii].

    PubMed  Google Scholar 

  • McGowan, P. O., Sasaki, A., D’Alessio, A. C., Dymov, S., Labonte, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12(3), 342–348. doi:10.1038/nn.2270. nn.2270 [pii].

    PubMed Central  PubMed  Google Scholar 

  • McWhinney, I. R., Epstein, R. M., & Freeman, T. R. (2001). Rethinking somatization. Advances in Mind-Body Medicine, 17(4), 232–239.

    PubMed  Google Scholar 

  • Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161–1192. doi:10.1146/annurev.neuro.24.1.1161. 24/1/1161 [pii].

    PubMed  Google Scholar 

  • Meerding, W. J., Bonneux, L., Polder, J. J., Koopmanschap, M. A., & van der Maas, P. J. (1998). Demographic and epidemiological determinants of healthcare costs in Netherlands: Cost of illness study. BMJ, 317(7151), 111–115.

    PubMed Central  PubMed  Google Scholar 

  • Meeus, M., Nijs, J., Hermans, L., Goubert, D., & Calders, P. (2013). The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: Peripheral and central mechanisms as therapeutic targets? Expert Opinion on Therapeutic Targets, 17(9), 1081–1089. doi:10.1517/14728222.2013.818657.

    PubMed  Google Scholar 

  • Moldofsky, H. (1995). Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome. Advances in Neuroimmunology, 5(1), 39–56.

    PubMed  Google Scholar 

  • Nicassio, P. M., Moxham, E. G., Schuman, C. E., & Gevirtz, R. N. (2002). The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain, 100(3), 271–279. doi: S0304395902003007 [pii].

    PubMed  Google Scholar 

  • Nijhof, S. L., Rutten, J. M., Uiterwaal, C. S., Bleijenberg, G., Kimpen, J. L., & Putte, E. M. (2014). The role of hypocortisolism in chronic fatigue syndrome. Psychoneuroendocrinology, 42, 199–206. doi:10.1016/j.psyneuen.2014.01.017. S0306-4530(14)00042-0 [pii].

    PubMed  Google Scholar 

  • O’Carroll, R. E., Drysdale, E., Cahill, L., Shajahan, P., & Ebmeier, K. P. (1999). Stimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in man. Psychological Medicine, 29(5), 1083–1088.

    PubMed  Google Scholar 

  • O’Donovan, A., Sun, B., Cole, S., Rempel, H., Lenoci, M., Pulliam, L., et al. (2011). Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Disease Markers, 30(2–3), 123–132. doi:10.3233/DMA-2011-0768. W1L2343430776467 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Oran, M., Tulubas, F., Mete, R., Aydin, M., Sarikaya, H. G., & Gurel, A. (2014). Evaluation of paraoxonase and arylesterase activities in patients with irritable bowel syndrome. Journal of the Pakistan Medical Association, 64(7), 820–822.

    PubMed  Google Scholar 

  • Oswald, L. M., Zandi, P., Nestadt, G., Potash, J. B., Kalaydjian, A. E., & Wand, G. S. (2006). Relationship between cortisol responses to stress and personality. Neuropsychopharmacology, 31(7), 1583–1591. doi:10.1038/sj.npp.1301012. 1301012 [pii].

    PubMed  Google Scholar 

  • Pace, T. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., et al. (2009). Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology, 34(1), 87–98. doi:10.1016/j.psyneuen.2008.08.011. S0306-4530(08)00219-9 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Papadopoulos, A. S., & Cleare, A. J. (2012). Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nature Reviews Endocrinology, 8(1), 22–32. doi:10.1038/nrendo.2011.153. nrendo.2011.153 [pii].

    Google Scholar 

  • Paras, M. L., Murad, M. H., Chen, L. P., Goranson, E. N., Sattler, A. L., Colbenson, K. M., et al. (2009). Sexual abuse and lifetime diagnosis of somatic disorders: A systematic review and meta-analysis. JAMA, 302(5), 550–561. doi:10.1001/jama.2009.1091. 302/5/550 [pii].

    PubMed  Google Scholar 

  • Pedersen, A. F., Zachariae, R., & Bovbjerg, D. H. (2009). Psychological stress and antibody response to influenza vaccination: A meta-analysis. Brain, Behavior, and Immunity, 23, 427–433. doi:10.1016/j.bbi.2009.01.004.

    PubMed  Google Scholar 

  • Pedersen, A., Zachariae, R., & Bovbjerg, D. H. (2010). Influence of psychological stress on upper respiratory infection–a meta-analysis of prospective studies. Psychosomatic Medicine, 72, 823–832. doi:10.1097/PSY.0b013e3181f1d003.

    PubMed  Google Scholar 

  • Pham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003). Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. European Journal of Neuroscience, 17(4), 879–886. doi: 2513 [pii].

    PubMed  Google Scholar 

  • Picard, M., Juster, R. P., & McEwen, B. S. (2014). Mitochondrial allostatic load puts the ‘gluc’ back in glucocorticoids. Nature Reviews Endocrinology, 10(5), 303–310. doi:10.1038/nrendo.2014.22. nrendo.2014.22 [pii].

    PubMed  Google Scholar 

  • Price, D. D. (2000). Psychological and neural mechanisms of the affective dimension of pain. Science, 288(5472), 1769–1772. doi: 8580 [pii].

    PubMed  Google Scholar 

  • Ramos, B. P., & Arnsten, A. F. (2007). Adrenergic pharmacology and cognition: Focus on the prefrontal cortex. Pharmacology and Therapeutics, 113(3), 523–536. doi:10.1016/j.pharmthera.2006.11.006. S0163-7258(06)00202-6 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000). Destruction and creation of spatial tuning by disinhibition: GABA(A) blockade of prefrontal cortical neurons engaged by working memory. Journal of Neuroscience, 20(1), 485–494.

    PubMed  Google Scholar 

  • Rask, C. U., Ornbol, E., Olsen, E. M., Fink, P., & Skovgaard, A. M. (2013). Infant behaviors are predictive of functional somatic symptoms at ages 5–7 years: Results from the Copenhagen Child Cohort CCC2000. Journal of Pediatrics, 162(2), 335–342. doi:10.1016/j.jpeds.2012.08.001. S0022-3476(12)00905-5 [pii].

    PubMed  Google Scholar 

  • Reynolds, K. J., Vernon, S. D., Bouchery, E., & Reeves, W. C. (2004). The economic impact of chronic fatigue syndrome. Cost Effectiveness and Resource Allocation, 2(1), 4. doi:10.1186/1478-7547-2-4. 1478-7547-2-4 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Rief, W., & Broadbent, E. (2007). Explaining medically unexplained symptoms-models and mechanisms. Clinical Psychology Review, 27(7), 821–841. doi:10.1016/j.cpr.2007.07.005. S0272-7358(07)00126-2 [pii].

    PubMed  Google Scholar 

  • Robinson, R. L., Birnbaum, H. G., Morley, M. A., Sisitsky, T., Greenberg, P. E., & Claxton, A. J. (2003). Economic cost and epidemiological characteristics of patients with fibromyalgia claims. Journal of Rheumatology, 30(6), 1318–1325. doi: 0315162X-30-1318 [pii].

    PubMed  Google Scholar 

  • Robinson, O. J., Krimsky, M., Lieberman, L., Allen, P., Vytal, K., & Grillon, C. (2014). Towards a mechanistic understanding of pathological anxiety: The dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit in unmedicated generalized and social anxiety disorders. Lancet Psychiatry, 1(4), 294–302. doi:10.1016/S2215-0366(14)70305-0.

    PubMed Central  PubMed  Google Scholar 

  • Roozendaal, B., Portillo-Marquez, G., & McGaugh, J. L. (1996). Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning. Behavioral Neuroscience, 110(5), 1074–1083.

    PubMed  Google Scholar 

  • Rosenkranz, M. A. (2007). Substance P at the nexus of mind and body in chronic inflammation and affective disorders. Psychological Bulletin, 133(6), 1007–1037. doi:10.1037/0033-2909.133.6.1007. 2007-15350-008 [pii].

    PubMed  Google Scholar 

  • Russell, I. J., Orr, M. D., Littman, B., Vipraio, G. A., Alboukrek, D., Michalek, J. E., et al. (1994). Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis and Rheumatism, 37(11), 1593–1601.

    PubMed  Google Scholar 

  • Sauer, S., Walach, H., & Kohls, N. (2011). Gray’s behavioural inhibition system as a mediator of mindfulness towards well-being. Personality and Individual Differences, 50, 506–511.

    Google Scholar 

  • Schnall, P. L., Pieper, C., Schwartz, J. E., Karasek, R. A., Schlussel, Y., Devereux, R. B., et al. (1990). The relationship between ‘job strain’, workplace diastolic blood pressure, and left ventricular mass index. Results of a case–control study. JAMA, 263(14), 1929–1935.

    PubMed  Google Scholar 

  • Schroder, A., & Fink, P. (2010). The proposed diagnosis of somatic symptom disorders in DSM-V: Two steps forward and one step backward? Journal of Psychosomatic Research, 68(1), 95–96. doi:10.1016/j.jpsychores.2009.06.013. author reply 99–100. S0022-3999(09)00266-9 [pii].

    PubMed  Google Scholar 

  • Schroder, A., & Fink, P. (2011). Functional somatic syndromes and somatoform disorders in special psychosomatic units: Organizational aspects and evidence-based treatment. The Psychiatric Clinics of North America, 34(3), 673–687. doi:10.1016/j.psc.2011.05.008. S0193-953X(11)00053-0 [pii].

    PubMed  Google Scholar 

  • Schroder, A., Rehfeld, E., & Ornbol, E. (2012). Cognitive-behavioural group treatment for a range of functional somatic syndromes: Randomized trial. British Journal of Psychiatry, 26(4).

    Google Scholar 

  • Segerstrom, S., & Miller, G. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130, 601–630.

    PubMed Central  PubMed  Google Scholar 

  • Sharpe, M., Mayou, R., & Seagroatt, V. (1994). Why do doctors find some patients difficult to help? QJM, 87, 187–193.

    PubMed  Google Scholar 

  • Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996). Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences of the United States of America, 93(9), 3908–3913.

    PubMed Central  PubMed  Google Scholar 

  • Siegel, D. J. (2007). The mindful brain. Reflection and attunement in the cultivation of well-being. New York: W. W. Norton & Company.

    Google Scholar 

  • Sirois, F. M., Kitner, R., Hirsch, J. K., Behaviors, H.-P., Kitner, R., & Hirsch, J. K. (2014). Self-compassion, affect, and health-promoting behaviors. Health Psychology, 2015 June; 34(6):661–669.

    Google Scholar 

  • Starkman, M. N., Gebarski, S. S., Berent, S., & Schteingart, D. E. (1992). Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing’s syndrome. Biological Psychiatry, 32(9), 756–765. doi: 0006-3223(92)90079-F [pii].

    PubMed  Google Scholar 

  • Swartz, J. R., Knodt, A. R., Radtke, S. R., & Hariri, A. R. (2015). A neural biomarker of psychological vulnerability to future life stress. Neuron, 85(3), 505–511. doi:10.1016/j.neuron.2014.12.055. S0896-6273(14)01164-7 [pii].

    PubMed  Google Scholar 

  • Tak, L. M., Cleare, A. J., Ormel, J., Manoharan, A., Kok, I. C., Wessely, S., et al. (2011). Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biological Psychology, 87(2), 183–194. doi:10.1016/j.biopsycho.2011.02.002. S0301-0511(11)00032-9 [pii].

    PubMed  Google Scholar 

  • Theorell, T., Blomkvist, V., Lindh, G., & Evengard, B. (1999). Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): An examination of CFS patients and subjects with a nonspecific life crisis. Psychosomatic Medicine, 61(3), 304–310.

    PubMed  Google Scholar 

  • Tillisch, K., Mayer, E. A., & Labus, J. S. (2011). Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology, 140(1), 91–100. doi:10.1053/j.gastro.2010.07.053. S0016-5085(10)01151-0 [pii].

    PubMed Central  PubMed  Google Scholar 

  • Tomas, C., Newton, J., & Watson, S. (2013). A review of hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome. ISRN Neuroscience, 2013, 784520. doi:10.1155/2013/784520.

    PubMed Central  PubMed  Google Scholar 

  • Vaeroy, H., Helle, R., Forre, O., Kass, E., & Terenius, L. (1988). Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: New features for diagnosis. Pain, 32(1), 21–26. doi: 0304-3959(88)90019-X [pii].

    PubMed  Google Scholar 

  • Vago, D. R., & Silbersweig, D. A. (2012). Self-awareness, self-regulation, and self-transcendence (S-ART): A framework for understanding the neurobiological mechanisms of mindfulness. Frontiers in Human Neuroscience, 6, 296. doi:10.3389/fnhum.2012.00296.

    PubMed Central  PubMed  Google Scholar 

  • van der Doelen, R. H., Calabrese, F., Guidotti, G., Geenen, B., Riva, M. A., Kozicz, T., et al. (2014). Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain. Frontiers in Behavioral Neuroscience, 8, 355. doi:10.3389/fnbeh.2014.00355.

    PubMed Central  PubMed  Google Scholar 

  • Velden, A. M. V., Kuyken, D., Wattar, W., Crane, U., Pallesen, C., Dahlgaard, K. J., et al. (2015). A systematic review of mechanisms of change in mindfulness-based cognitive therapy in the treatment of recurrent major depressive disorder. Clinical Psychology Review, 37, 26–39. doi:10.1016/j.cpr.2015.02.001.

    PubMed  Google Scholar 

  • Weaver, I. C., Cervoni, N., Champagne, F. A., D’Alessio, A. C., Sharma, S., Seckl, J. R., et al. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847–854. doi:10.1038/nn1276 nn1276 [pii].

    PubMed  Google Scholar 

  • Wileman, L., May, C., & Chew-Graham, C. A. (2002). Medically unexplained symptoms and the problem of power in the primary care consultation: A qualitative study. Family Practice, 19(2), 178–182.

    PubMed  Google Scholar 

  • Wilson, R. G., Stevens, B. W., Guo, A. Y., Russell, C. N., Thornton, A., Cohen, M. A., et al. (2015). High C-reactive protein is associated with poor sleep quality independent of nocturnal symptoms in patients with inflammatory bowel disease. Digestive Diseases and Sciences. doi:10.1007/s10620-015-3580-5.

    Google Scholar 

  • Wingenfeld, K., Nutzinger, D., Kauth, J., Hellhammer, D. H., & Lautenbacher, S. (2010). Salivary cortisol release and hypothalamic pituitary adrenal axis feedback sensitivity in fibromyalgia is associated with depression but not with pain. The Journal of Pain, 11(11), 1195–1202. doi:10.1016/j.jpain.2010.02.011. S1526-5900(10)00350-0 [pii].

    PubMed  Google Scholar 

  • Wingenfeld, K., Whooley, M. A., Neylan, T. C., Otte, C., & Cohen, B. E. (2015). Effect of current and lifetime posttraumatic stress disorder on 24-h urinary catecholamines and cortisol: Results from the mind your heart study. Psychoneuroendocrinology, 52, 83–91. doi:10.1016/j.psyneuen.2014.10.023. S0306-4530(14)00407-7 [pii].

    PubMed  Google Scholar 

  • Xu, L., Anwyl, R., & Rowan, M. J. (1997). Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature, 387(6632), 497–500. doi:10.1038/387497a0.

    PubMed  Google Scholar 

  • Zachariae, R. (2009). Psychoneuroimmunology: A bio-psycho-social approach to health and disease. Scandinavian Journal of Psychology, 50, 645–651.

    PubMed  Google Scholar 

  • Zieker, J., Zieker, D., Jatzko, A., Dietzsch, J., Nieselt, K., Schmitt, A., et al. (2007). Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder. Molecular Psychiatry, 12(2), 116–118. doi:10.1038/sj.mp.4001905. 4001905 [pii].

    PubMed  Google Scholar 

  • Zolkipli, Z., Pedersen, C. B., Lamhonwah, A.-M., Gregersen, N., & Tein, I. (2011). Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: Response to antioxidants. PLoS ONE, 6, e17534. doi:10.1371/journal.pone.0017534.

    PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Nørrebrogade 44, Aarhus C, 8000, Denmark

    Karen Johanne Pallesen Ph.D. & Lone Fjorback Ph.D.

  2. Unit for Psychooncology and Health Psychology, Aarhus University, Bartholins Allé 9, Aarhus C, 8000, Denmark

    Jesper Dahlgaard Ph.D.

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  1. Karen Johanne Pallesen Ph.D.
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  2. Jesper Dahlgaard Ph.D.
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  3. Lone Fjorback Ph.D.
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Correspondence to Karen Johanne Pallesen Ph.D. .

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  1. Awake to Wisdom, Centre for Meditation and Mindfulness Research, and Psychology Division, Chaucer Building, Bodhayati School of Buddhism, Nottingham, UK, and Nottingham Trent University, Nottingham, United Kingdom

    Edo Shonin

  2. & Nottingham Trent Univ., Bodhayati School of Buddhism, Nottingham & Nottingham Trent Univ., Nottingham, United Kingdom

    William Van Gordon

  3. Nottingham Trent University , Nottingham, United Kingdom

    Mark D. Griffiths

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Pallesen, K.J., Dahlgaard, J., Fjorback, L. (2016). Mindfulness for the Treatment of Stress Disorders. In: Shonin, E., Gordon, W., Griffiths, M. (eds) Mindfulness and Buddhist-Derived Approaches in Mental Health and Addiction. Advances in Mental Health and Addiction. Springer, Cham. https://doi.org/10.1007/978-3-319-22255-4_8

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