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Puberty and Pediatric-Onset Inflammatory Bowel Disease

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Pediatric Inflammatory Bowel Disease

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Abstract

Delayed growth and sexual maturation is a frequently described potential consequence of inflammatory bowel disease (IBD) with onset during childhood and adolescence. Evidence suggests that many of the nutritional, inflammatory/immunological, and endocrine factors which result from IBD affect both growth and the onset and progression of puberty. This chapter will address how puberty can be affected in children with IBD, and how disorders in puberty can influence other aspects of health in the pediatric age population with IBD.

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References

  1. Bordini B, Rosenfield RL. Normal pubertal development: part I: the endocrine basis of puberty. Pediatr Rev. 2011;32(6):223–9.

    PubMed  Google Scholar 

  2. Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L. Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N Engl J Med. 1972;287(12):582–6.

    CAS  PubMed  Google Scholar 

  3. Reiter EO, Fuldauer VG, Root AW. Secretion of the adrenal androgen, dehydroepiandrosterone sulfate, during normal infancy, childhood, and adolescence, in sick infants, and in children with endocrinologic abnormalities. J Pediatr. 1977;90(5):766–70.

    CAS  PubMed  Google Scholar 

  4. Guercio G, Rivarola MA, Chaler E, Maceiras M, Belgorosky A. Relationship between the growth hormone/insulin-like growth factor-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls. J Clin Endocrinol Metab. 2003;88(3):1389–93.

    CAS  PubMed  Google Scholar 

  5. Friedman JM. The function of leptin in nutrition, weight, and physiology. Nutr Rev. 2002;60(10 Pt 2):S1–14. discussion S68–84, 85–7

    PubMed  Google Scholar 

  6. Farooqi IS. Leptin and the onset of puberty: insights from rodent and human genetics. Semin Reprod Med. 2002;20(2):139–44.

    CAS  PubMed  Google Scholar 

  7. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614–27.

    CAS  PubMed  Google Scholar 

  8. Pralong FP, Voirol M, Giacomini M, et al. Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors. Regul Pept. 2000;95(1–3):47–52.

    CAS  PubMed  Google Scholar 

  9. Blogowska A, Rzepka-Gorska I, Krzyzanowska-Swiniarska B. Is neuropeptide Y responsible for constitutional delay of puberty in girls? A preliminary report. Gynecol Endocrinol. 2004;19(1):22–5.

    CAS  PubMed  Google Scholar 

  10. Bordini B, Rosenfield RL. Normal pubertal development: part II: clinical aspects of puberty. Pediatr Rev. 2011;32(7):281–92.

    PubMed  Google Scholar 

  11. Brain CE, Savage MO. Growth and puberty in chronic inflammatory bowel disease. Baillieres Clin Gastroenterol. 1994;8(1):83–100.

    CAS  PubMed  Google Scholar 

  12. Rosenfield RL, Lipton RB, Drum ML. Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics. 2009;123(1):84–8.

    PubMed  Google Scholar 

  13. Irwin CE Jr, Shafer M. Adolescent health problems. Harrison’s principals of internal medicine. 14th ed. New York: McGraw Hill; 1998. p. 30–3.

    Google Scholar 

  14. Lifshitz F. Puberty and its disorders. Pediatric endocrinology, vol. 2. 5th ed. New York, NY: Informa Healthcare USA, Inc; 2007. p. 275.

    Google Scholar 

  15. Radovick S, Madhusmita M. Precocious puberty. Pediatric endocrinology: a practical clinical guide. 3rd ed. New York, NY: Springer; 2018. p. 593.

    Google Scholar 

  16. MacMahon B. Age at Menarche: United States, 1960-1970. Vital Health Stat. 1973;11(133):1–36.

    Google Scholar 

  17. Tanner JM, Davies PS. Clinical longitudinal standards for height and height velocity for North American children. J Pediatr. 1985;107(3):317–29.

    CAS  PubMed  Google Scholar 

  18. Sedlmeyer IL, Palmert MR. Delayed puberty: analysis of a large case series from an academic center. J Clin Endocrinol Metab. 2002;87(4):1613–20.

    CAS  PubMed  Google Scholar 

  19. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44(235):291–303.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970;45(239):13–23.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976;51(3):170–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Nakamoto JM, Franklin SL, Geffner ME, Kappy MD, Allen DB. Pediatric practice endocrinology. The McGraw-Hill Companies, Inc; 2010. p. 261–4.

    Google Scholar 

  23. Tanner JM. Growth at adolescence. 2nd ed. Oxford: Blackwell Scientific Publications; 1962.

    Google Scholar 

  24. Schall JI, Semeao EJ, Stallings VA, et al. Self-assessment of sexual maturity status in children with Crohn’s disease. J Pediatr. 2002;141(2):223–9.

    PubMed  Google Scholar 

  25. Rapkin AJ, Tsao JC, Turk N, et al. Relationships among self-rated tanner staging, hormones, and psychosocial factors in healthy female adolescents. J Pediatr Adolesc Gynecol. 2006;19(3):181–7.

    PubMed  Google Scholar 

  26. Ezri J, Marques-Vidal P, Nydeggar A. Impact of disease and treatments on growth and puberty of pediatric patients with inflammatory bowel disease. Digestion. 2012;85:308–19.

    CAS  PubMed  Google Scholar 

  27. Hildebrand H, Karlberg J, Kristiansson B. Longitudinal growth in children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1994;18(2):165–73.

    CAS  PubMed  Google Scholar 

  28. Mason A, Malik S, Russell R, Bishop J, McGrogan P, Ahmed S. Impact of inflammatory bowel disease on pubertal growth. Horm Res Paediatr. 2011;76:293–9.

    CAS  PubMed  Google Scholar 

  29. Kirschner BS, Uebler N, Sutton MM. Growth after menarche in pediatric patients with chronic inflammatory bowel disease. Gastroenterology. 1993;104:A629.

    Google Scholar 

  30. Homer DR, Grand RJ, Colodny AH. Growth, course, and prognosis after surgery for Crohn’s disease in children and adolescents. Pediatrics. 1977;59(5):717–25.

    CAS  PubMed  Google Scholar 

  31. Gupta N, Lustig RH, Kohn MA, Vittinghoff E. Menarche in pediatric patients with Crohn’s disease. Dig Dis Sci. 2012;57(11):2975–81.

    PubMed  Google Scholar 

  32. Pfefferkorn M, Burke G, Griffiths A, Markowitz J, Rosh J, Mack D, et al. Growth abnormalities persist in newly diagnosed children with Crohn disease despite current treatment paradigms. J Pediatr Gastroenterol Nutr. 2009;48(2):168–74.

    CAS  PubMed  Google Scholar 

  33. Malik S, Wong SC, Bishop J, Hassan K, McGrogan P, Ahmed SF, et al. Improvement in growth of children with Crohn disease following anti-TNF-alpha therapy can be independent of pubertal progress and glucocorticoid reduction. J Pediatr Gastroenterol Nutr. 2011;52(1):31–7.

    CAS  PubMed  Google Scholar 

  34. Cameron F, Altowati M, Rogers P, et al. Disease status and pubertal stage predict improved growth in antitumor necrosis factor therapy for pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2017;64:47–55.

    CAS  PubMed  Google Scholar 

  35. Beumont PJ, George GC, Pimstone BL, Vinik AI. Body weight and the pituitary response to hypothalamic releasing hormones in patients with anorexia nervosa. J Clin Endocrinol Metab. 1976;43(3):487–96.

    CAS  PubMed  Google Scholar 

  36. Ballinger AB, Camacho-Hubner C, Croft NM. Growth failure and intestinal inflammation. QJM. 2001;94(3):121–5.

    CAS  PubMed  Google Scholar 

  37. Frisch RE. Fatness, menarche, and female fertility. Perspect Biol Med. 1985;28(4):611–33.

    CAS  PubMed  Google Scholar 

  38. Frisch RE, Gotz-Welbergen AV, McArthur JW, Albright T, Witschi J, Bullen B, et al. Delayed menarche and amenorrhea of college athletes in relation to age of onset of training. JAMA. 1981;246(14):1559–63.

    CAS  PubMed  Google Scholar 

  39. Frisch RE, Wyshak G, Vincent L. Delayed menarche and amenorrhea in ballet dancers. N Engl J Med. 1980;303(1):17–9.

    CAS  PubMed  Google Scholar 

  40. Dreizen S, Spirakis CN, Stone RE. A comparison of skeletal growth and maturation in undernourished and well-nourished girls before and after menarche. J Pediatr. 1967;70(2):256–63.

    CAS  PubMed  Google Scholar 

  41. Dreizen S, Stone R. Human nutritive and growth failure. Postgrad Med. 1962;32(4):381–6.

    Google Scholar 

  42. Kelts DG, Grand RJ, Shen G, et al. Nutritional basis of growth failure in children and adolescents with Crohn’s disease. Gastroenterology. 1979;76(4):720–7.

    CAS  PubMed  Google Scholar 

  43. Kirschner BS, Voinchet O, Rosenberg IH. Growth retardation in inflammatory bowel disease. Gastroenterology. 1978;75(3):504–11.

    CAS  PubMed  Google Scholar 

  44. Thomas AG, Taylor F, Miller V. Dietary intake and nutritional treatment in childhood Crohn’s disease. J Pediatr Gastroenterol Nutr. 1993;17(1):75–81.

    CAS  PubMed  Google Scholar 

  45. Kirschner BS, Sutton MM. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology. 1986;91(4):830–6.

    CAS  PubMed  Google Scholar 

  46. Sentongo TA, Semeao EJ, Piccoli DA, et al. Growth, body composition, and nutritional status in children and adolescents with Crohn’s disease. J Pediatr Gastroenterol Nutr. 2000;31(1):33–40.

    CAS  PubMed  Google Scholar 

  47. Burnham JM, Shults J, Semeao E, Foster B, Zemel BS, Stallings VA, et al. Whole body BMC in pediatric Crohn disease: independent effects of altered growth, maturation, and body composition. J Bone Miner Res. 2004;19(12):1961–8.

    PubMed  Google Scholar 

  48. Kaplowitz P. Clinical characteristics of 104 children referred for evaluation of precocious puberty. J Clin Endocrinol Metab. 2004;89(8):3644–50.

    CAS  PubMed  Google Scholar 

  49. Chong SK, Grossman A, Walker-Smith JA, et al. Endocrine dysfunction in children with Crohn’s disease. J Pediatr Gastroenterol Nutr. 1984;3(4):529–34.

    CAS  PubMed  Google Scholar 

  50. Farthing MJ, Campbell CA, Walker-Smith J, et al. Nocturnal growth hormone and gonadotrophin secretion in growth retarded children with Crohn’s disease. Gut. 1981;22(11):933–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Gotlin RW, Dubois RS. Nyctohemeral growth hormone levels in children with growth retardation and inflammatory bowel disease. Gut. 1973;14(3):191–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Tenore A, Berman WF, Parks JS, et al. Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease. J Clin Endocrinol Metab. 1977;44(4):622–8.

    CAS  PubMed  Google Scholar 

  53. Corkins MR, Gohil AD, Fitzgerald JF. The insulin-like growth factor axis in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2003;36(2):228–34.

    CAS  PubMed  Google Scholar 

  54. Thomas AG, Holly JM, Taylor F, et al. Insulin like growth factor-I, insulin like growth factor binding protein-1, and insulin in childhood Crohn’s disease. Gut. 1993;34(7):944–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001;131(11 Suppl):3109S–20S.

    CAS  PubMed  Google Scholar 

  56. Azooz OG, Farthing MJ, Savage MO, et al. Delayed puberty and response to testosterone in a rat model of colitis. Am J Physiol Regul Integr Comp Physiol. 2001;281(5):R1483–91.

    CAS  PubMed  Google Scholar 

  57. DeBoer MD, Li Y. Puberty is delayed in male mice with dextran sodium sulfate colitis out of proportion to changes in food intake, body weight, and serum levels of leptin. Pediatr Res. 2011;69(1):34–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. DeBoer MD, Li Y, Cohn S. Colitis causes delay in puberty in female mice out of proportion to changes in leptin and corticosterone. J Gastroenterol. 2010;45(3):277–84.

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Wong SC, Macrae VE, McGrogan P, Ahmed SF. The role of pro-inflammatory cytokines in inflammatory bowel disease growth retardation. J Pediatr Gastroenterol Nutr. 2006;43(2):144–55.

    CAS  PubMed  Google Scholar 

  60. Wang P, Li N, Li JS, Li WQ. The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity. World J Gastroenterol. 2002;8(3):531–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  61. Denson LA, Menon RK, Shaufl A, et al. TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding. J Clin Invest. 2001;107(11):1451–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  62. Theiss AL, Fruchtman S, Lund PK. Growth factors in inflammatory bowel disease: the actions and interactions of growth hormone and insulin-like growth factor-I. Inflamm Bowel Dis. 2004;10(6):871–80.

    PubMed  Google Scholar 

  63. DeBoer MD, Steinman J, Li Y. Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-alpha antibody. J Gastroenterol. 2012;47(6):647–54.

    CAS  PubMed  PubMed Central  Google Scholar 

  64. Nottelmann ED, Susman EJ, Inoff-Germain G, et al. Developmental processes in early adolescence: relationships between adolescent adjustment problems and chronologic age, pubertal stage, and puberty-related serum hormone levels. J Pediatr. 1987;110(3):473–80.

    CAS  PubMed  Google Scholar 

  65. Mamula P, Markowitz JE, Baldassano RN. Inflammatory bowel disease in early childhood and adolescence: special considerations. Gastroenterol Clin N Am. 2003;32(3):967–95.

    Google Scholar 

  66. Consten D, Bogerd J, Komen J, et al. Long-term cortisol treatment inhibits pubertal development in male common carp. Cyprinus carpio L. Biol Reprod. 2001;64(4):1063–71.

    CAS  PubMed  Google Scholar 

  67. Alperstein G, Daum F, Fisher SE, Aiges H, Markowitz J, Becker J, et al. Linear growth following surgery in children and adolescents with Crohn’s disease: relationship to pubertal status. J Pediatr Surg. 1985;20(2):129–33.

    CAS  PubMed  Google Scholar 

  68. Benabbad I, Rosilio M, Tauber M, et al. Growth hormone in combination with leuprorelin in pubertal children with idiopathic short stature. Endocr Connect. 2018;7(5):708–18.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Carel JC. Management of short stature with GnRH agonist co-treatment with growth hormone: a controversial issue. Mol Cell Endocrinol. 2006;25(254-255):226–33.

    Google Scholar 

  70. Allen DB, Julius JR, Breen TJ, Attie KM. Treatment of glucocorticoid-induced growth suppression with growth hormone. National Cooperative Growth Study. J Clin Endocrinol Metab. 1998;83(8):2824–9.

    CAS  PubMed  Google Scholar 

  71. Heyman MB, Garnett EA, Wojcicki J, Gupta N, Davis C, Cohen SA, et al. Growth hormone treatment for growth failure in pediatric patients with Crohn’s disease. J Pediatr. 2008;153(5):651–8. 658.e1–3

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, et al. A randomized controlled trial of growth hormone in active pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2010;51(2):130–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Mauras N, Ross JL, Gagliardi P, et al. Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature. J Clin Endocrinol Metab. 2016;101(12):4984–93.

    CAS  PubMed  PubMed Central  Google Scholar 

  74. Mason A, Wong SC, McGrogan P, Ahmed SF. Effect of testosterone therapy for delayed growth and puberty in boys with inflammatory bowel disease. Horm Res Paediatr. 2011;75(1):8–13.

    CAS  PubMed  Google Scholar 

  75. Ballinger AB, Savage MO, Sanderson IR. Delayed puberty associated with inflammatory bowel disease. Pediatr Res. 2003;53(2):205–10.

    PubMed  Google Scholar 

  76. Deplewski D, Gupta N, Kirschner BS. Puberty and pediatric-onset inflammatory bowel disease. In: Mamula P, Grossman AB, Baldassano RN, Kelsen JR, Markowitz JE, editors. Pediatric inflammatory bowel disease. 3rd ed. Cham, Switzerland: Springer International Publishing; 2017. p. 171–80.

    Google Scholar 

  77. Finkelstein JS, Klibanski A, Neer RM. A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty. J Clin Endocrinol Metab. 1996;81(3):1152–5.

    CAS  PubMed  Google Scholar 

  78. Pappa H, Thayu M, Sylvester F, Leonard M, Zemel B, Gordon C. Skeletal health of children and adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011;53(1):11–25.

    PubMed  PubMed Central  Google Scholar 

  79. Bernstein CN, Leslie WD, Taback SP. Bone density in a population-based cohort of premenopausal adult women with early onset inflammatory bowel disease. Am J Gastroenterol. 2003;98(5):1094–100.

    PubMed  Google Scholar 

  80. Nakamoto JM, Mason PW, editors. Endocrinology: quest diagnostics manual. 5th ed. San Juan Capistrano: Quest Diagnostics Inc.; 2012.

    Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Jacquelyn Hatch-Stein

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  1. Jacquelyn Hatch-Stein
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Correspondence to Jacquelyn Hatch-Stein .

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Editors and Affiliations

  1. Division of GI, Hepatology & Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Petar Mamula

  2. Division of GI, Hepatology & Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Judith R. Kelsen

  3. Division of GI, Hepatology & Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Andrew B. Grossman

  4. Division of GI, Hepatology & Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Robert N. Baldassano

  5. Division of Pediatric Gastroenterology, Prisma Health Children’s Hospital—Upstate, Greenville, SC, USA

    Jonathan E. Markowitz

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Hatch-Stein, J. (2023). Puberty and Pediatric-Onset Inflammatory Bowel Disease. In: Mamula, P., Kelsen, J.R., Grossman, A.B., Baldassano, R.N., Markowitz, J.E. (eds) Pediatric Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-14744-9_14

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  • DOI: https://doi.org/10.1007/978-3-031-14744-9_14

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