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Etiology and Pathophysiology

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Atlas of Psoriatic Arthritis

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Abstract

Initially considered to be relatively benign and uncommon, one-third of patients with psoriasis have arthritis, and a majority of those affected experience a chronic, progressive course [1],[2]. Psoriatic arthritis (PsA) is distinguished from rheumatoid arthritis (RA) by its unique clinical manifestations, characteristic radiographic findings, and the absence of rheumatoid factor. Patients often present with focal inflammation at multiple sites that include skin, joints, and tendon insertion sites or entheses. Clues to the pathogenesis of the disease have arisen out of observations that reveal a strong family history of psoriasis in PsA patients, an association of skin and joint disease with class I major histocompatibility complex (MHC) alleles, and paternal transmission. Environmental factors such as trauma or infection have also been shown to trigger skin and joint inflammation. The uncovering of the pathogenesis of PsA has been limited by small numbers of studies, the paucity of appropriate animal models, and the confounding presence of a disease within a disease, whereby factors associated with psoriasis can obscure those related to arthritis.

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Author information

Authors and Affiliations

  1. School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

    Christopher Ritchlin

  2. San Francisco Medical Center, University of California, San Francisco, CA, USA

    Jennifer Barton

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  1. Christopher Ritchlin
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  2. Jennifer Barton
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Editor information

Editors and Affiliations

  1. School of Medicine, University of Washington, Seattle, WA, USA

    P. J. Mease MED (RHUUH)

  2. Academic Unit of Musculoskeletal and Rehabilitation Medicine, University of Leeds, Leeds, UK

    P. S. Helliwell DM, PhD, FRCP

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© 2008 Springer-Verlag London Limited

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Ritchlin, C., Barton, J. (2008). Etiology and Pathophysiology. In: Mease, P.J., Helliwell, P.S. (eds) Atlas of Psoriatic Arthritis. Springer, London. https://doi.org/10.1007/978-1-84628-897-5_2

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  • DOI: https://doi.org/10.1007/978-1-84628-897-5_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-896-8

  • Online ISBN: 978-1-84628-897-5

  • eBook Packages: MedicineMedicine (R0)

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