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Sleep and Quality of Life in Alzheimer’s Disease and the Dementias

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Sleep and Quality of Life in Clinical Medicine

Summary

Sleep changes are inherent to dementia but difficult to define or measure. As the sleep changes in dementia are probably related to neuronal changes in the brain, the location and severity of these changes, manifested as different clinical dementias, affects the presentation of sleep pathology. In the case of most dementias, including Alzheimer’s dementia, the sleep problems affect both the patient and the caregiver. Treatment involves a multifaceted approach, including identification of treatable medical problems, correction of sleep hygiene, and identification and treatment of the particular form of dementia. Cholinesterase inhibitors seem to be emerging as the drug of choice for sleep problems in dementia.

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References

  1. Vitiello MV, Borson S. Sleep disturbances in patients with Alzheimer’s disease: epidemiology, pathophysiology and treatment. CNS Drugs. 2001;15(10):777–96.

    Article  PubMed  CAS  Google Scholar 

  2. Prinz PN, Peskind ER, Vitaliano PP, Raskind MA, Eisdorfer C, Zemcuznikov N, et al. Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. J Am Geriatr Soc. 1982;30(2):86–93.

    PubMed  CAS  Google Scholar 

  3. van Someren EJ, Hagebeuk EE, Lijzenga C, Scheltens P, de Rooij SE, Jonker C, et al. Circadian rest-activity rhythm disturbances in Alzheimer’s disease. Biol Psychiatry. 1996;40(4): 259–70.

    Article  PubMed  Google Scholar 

  4. Wu YH, Fischer DF, Kalsbeek A, Garidou-Boof ML, van der Vliet J, van Heijningen C, et al. Pineal clock gene oscillation is disturbed in Alzheimer’s disease, due to functional disconnection from the “master clock”. Faseb J. 2006;20(11):1874–6.

    Article  PubMed  CAS  Google Scholar 

  5. Boeve BF, Saper CB. REM sleep behavior disorder: a possible early marker for synucleinopathies. Neurology. 2006;66(6):796–7.

    Article  PubMed  Google Scholar 

  6. Cameron D. Studies in senile nocturnal deliruim. Psychiatry Quarterly. 1941;15:47–53.

    Article  Google Scholar 

  7. Strejilevich SM. The nocturnal restlessness of the elderly psychotic. Encephale. 1962;51:238–62.

    PubMed  CAS  Google Scholar 

  8. Tractenberg RE, Singer CM, Kaye JA. Symptoms of sleep disturbance in persons with Alzheimer’s disease and normal elderly. J Sleep Res. 2005;14(2):177–85.

    Article  PubMed  Google Scholar 

  9. Moran M, Lynch CA, Walsh C, Coen R, Coakley D, Lawlor BA. Sleep disturbance in mild to moderate Alzheimer’s disease. Sleep Med. 2005;6(4):347–52.

    Article  PubMed  Google Scholar 

  10. Tractenberg RE, Singer CM, Kaye JA. Characterizing sleep problems in persons with Alzheimer’s disease and normal elderly. J Sleep Res. 2006;15(1):97–103.

    Article  PubMed  Google Scholar 

  11. Ancoli-Israel S, Klauber MR, Gillin JC, Campbell SS, Hofstetter CR. Sleep in non-institutionalized Alzheimer’s disease patients. Aging (Milano). 1994;6(6):451–8.

    CAS  Google Scholar 

  12. Bachman D, Rabins P. “Sundowning” and other temporally associated agitation states in dementia patients. Annu Rev Med. 2006;57:499–511.

    Article  PubMed  CAS  Google Scholar 

  13. Yesavage JA, Friedman L, Ancoli-Israel S, Bliwise D, Singer C, Vitiello MV, et al. Development of diagnostic criteria for defining sleep disturbance in Alzheimer’s disease. J Geriatr Psychiatry Neurol. 2003;16(3):131–9.

    Article  PubMed  Google Scholar 

  14. Hope T, Keene J, Gedling K, Fairburn CG, Jacoby R. Predictors of institutionalization for people with dementia living at home with a carer. Int J Geriatr Psychiatry. 1998;13(10):682–90.

    Article  PubMed  CAS  Google Scholar 

  15. McCurry SM, Logsdon RG, Teri L, Gibbons LE, Kukull WA, Bowen JD, et al. Characteristics of sleep disturbance in community-dwelling Alzheimer’s disease patients. J Geriatr Psychiatry Neurol. 1999 Summer;12(2):53–9.

    Article  PubMed  CAS  Google Scholar 

  16. Moe KE, Vitiello MV, Larsen LH, Prinz PN. Symposium: cognitive processes and sleep disturbances: sleep/wake patterns in Alzheimer’s disease: relationships with cognition and function. J Sleep Res. 1995;4(1):15–20.

    PubMed  Google Scholar 

  17. Mortimer JA, Ebbitt B, Jun SP, Finch MD. Predictors of cognitive and functional progression in patients with probable Alzheimer’s disease. Neurology. 1992;42(9):1689–96.

    PubMed  CAS  Google Scholar 

  18. Witting W, Kwa IH, Eikelenboom P, Mirmiran M, Swaab DF. Alterations in the circadian rest-activity rhythm in aging and Alzheimer’s disease. Biol Psychiatry. 1990 Mar 15;27(6): 563–72.

    Article  PubMed  CAS  Google Scholar 

  19. Schulz R, Beach SR. Caregiving as a risk factor for mortality: the Caregiver Health Effects Study. JAMA. 1999;282(23):2215–9.

    Article  PubMed  CAS  Google Scholar 

  20. von Kanel R, Dimsdale JE, Ancoli-Israel S, Mills PJ, Patterson TL, McKibbin CL, et al. Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer’s disease. J Am Geriatr Soc. 2006;54(3):431–7.

    Article  Google Scholar 

  21. Chong MS, Ayalon L, Marler M, Loredo JS, Corey-Bloom J, Palmer BW, et al. Continuous positive airway pressure reduces subjective daytime sleepiness in patients with mild to moderate Alzheimer’s disease with sleep disordered breathing. J Am Geriatr Soc. 2006;54(5):777–81.

    Article  PubMed  Google Scholar 

  22. Ayalon L, Ancoli-Israel S, Stepnowsky C, Marler M, Palmer BW, Liu L, et al. Adherence to continuous positive airway pressure treatment in patients with Alzheimer’s disease and obstructive sleep apnea. Am J Geriatr Psychiatry. 2006;14(2):176–80.

    Article  PubMed  Google Scholar 

  23. Van Someren EJ. Circadian rhythms and sleep in human aging. Chronobiol Int. 2000;17(3):233–43.

    Article  PubMed  Google Scholar 

  24. McCurry SM, Logsdon RG, Vitiello MV, Teri L. Treatment of sleep and nighttime disturbances in Alzheimer’s disease: a behavior management approach. Sleep Med. 2004;5(4):373–7.

    Article  PubMed  Google Scholar 

  25. Teri L, Logsdon RG, McCurry SM. Nonpharmacologic treatment of behavioral disturbance in dementia. Med Clin North Am. 2002;86(3):641–56, viii.

    Article  PubMed  Google Scholar 

  26. McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L. Nighttime insomnia treatment and education for Alzheimer’s disease: a randomized, controlled trial. J Am Geriatr Soc. 2005;53(5):793–802.

    Article  PubMed  Google Scholar 

  27. Dowling GA, Mastick J, Hubbard EM, Luxenberg JS, Burr RL. Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. Int J Geriatr Psychiatry. 2005;20(8):738–43.

    Article  PubMed  Google Scholar 

  28. Moraes Wdos S, Poyares DR, Guilleminault C, Ramos LR, Bertolucci PH, Tufik S. The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study. Sleep. 2006;29(2):199–205.

    PubMed  Google Scholar 

  29. Ancoli-Israel S, Amatniek J, Ascher S, Sadik K, Ramaswamy K. Effects of galantamine versus donepezil on sleep in patients with mild to moderate Alzheimer disease and their caregivers: a double-blind, head-to-head, randomized pilot study. Alzheimer Dis Assoc Disord. 2005;19(4):240–5.

    Article  PubMed  CAS  Google Scholar 

  30. Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. N Engl J Med. 2006;355(15):1525–38.

    Article  PubMed  CAS  Google Scholar 

  31. Ballard C, Howard R. Neuroleptic drugs in dementia: benefits and harm. Nat Rev Neurosci. 2006;7(6):492–500.

    Article  PubMed  CAS  Google Scholar 

  32. Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294(15):1934–43.

    Article  PubMed  CAS  Google Scholar 

  33. Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer’s disease. Sleep. 2003;26(7):893–901.

    PubMed  Google Scholar 

  34. Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch. 2003;70(4):334–41.

    Article  PubMed  Google Scholar 

  35. Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP. Melatonin and sleep in aging population. Exp Gerontol. 2005;40(12):911–25.

    Article  PubMed  CAS  Google Scholar 

  36. McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863–72.

    Google Scholar 

  37. Boddy F, Rowan EN, Lett D, O’Brien JT, McKeith IG, Burn DJ. Subjectively reported sleep quality and excessive daytime somnolence in Parkinson’s disease with and without dementia, dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2007;22(6):529–35.

    Article  PubMed  Google Scholar 

  38. Grace JB, Walker MP, McKeith IG. A comparison of sleep profiles in patients with dementia with lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2000;15(11): 1028–33.

    Article  PubMed  CAS  Google Scholar 

  39. Ferman TJ, Smith GE, Boeve BF, Ivnik RJ, Petersen RC, Knopman D, et al. DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology. 2004;62(2):181–7.

    PubMed  CAS  Google Scholar 

  40. McKeith I, Fairbairn A, Perry R, Thompson P, Perry E. Neuroleptic sensitivity in patients with senile dementia of Lewy body type. BMJ 1992;305(6855):673–8.

    Article  PubMed  CAS  Google Scholar 

  41. Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R, et al. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry. 2001;58(4):353–60.

    Article  PubMed  CAS  Google Scholar 

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© 2008 Humana Press, Totowa, NJ

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Neef, D., Larson, D. (2008). Sleep and Quality of Life in Alzheimer’s Disease and the Dementias. In: Verster, J.C., Pandi-Perumal, S.R., Streiner, D.L. (eds) Sleep and Quality of Life in Clinical Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-343-5_18

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  • DOI: https://doi.org/10.1007/978-1-60327-343-5_18

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-340-4

  • Online ISBN: 978-1-60327-343-5

  • eBook Packages: MedicineMedicine (R0)

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