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Menopausal Insomnia

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Clinical Handbook of Insomnia

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Four major categories of sleep disorders associated with menopause may present with insomnia: “pure” menopausal insomnia, psychophysiologic insomnia, sleep-disordered breathing, and fibromyalgia. The subset of women with vasomotor symptoms has lower sleep efficiency, more sleep complaints, and higher risk of insomnia and depression. Subjective sleep quality may be poor even when the objective sleep quality is normal. Menopausal sleep disruption can aggravate other pre-existing sleep disorders including the restless legs syndrome (RLS) or circadian disorders. Co-morbidities without direct link with menopause as well as stressful changes in social environment coinciding with menopause should not be overlooked when exploring the etiology of insomnia in middle-aged women.

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References

  1. Polo O (2003) Sleep in postmenopausal women: better sleep for less satisfaction. Sleep 26:652–653

    PubMed  Google Scholar 

  2. McKinlay SM, Brambilla BJ, Posner JG (1992) The normal menopausal transition. Maturitas 14:103–115

    Article  CAS  PubMed  Google Scholar 

  3. World Health Organization (WHO) Scientific Group (1996) In: Research on the menopause in the 1990s. Geneva, pp 12–21

    Google Scholar 

  4. Freedman RR (2001) Physiology of hot flashes. Am J Hum Biol 13:453–464

    Article  CAS  PubMed  Google Scholar 

  5. Freedman RR, Krell W (1999) Reduced thermoregulatory null zone in postmenopausal women with hot flashes. Am J Obstet Gynecol 181:66–70

    Article  CAS  PubMed  Google Scholar 

  6. Freedman RR, Woodward S (1995) Altered shivering threshold in postmenopausal women with hot flashes. Menopause 2:163–168

    Google Scholar 

  7. Oldenhave A, Jaszmann LJ, Haspels AA, Everaerd WT (1993) Impact of climacteric on well-being. A survey based on 5213 women 39 to 60 years old. Am J Obstet Gynecol 168:772–780

    Article  CAS  PubMed  Google Scholar 

  8. Guttuso T, Kurlan R, McDermott M, McDermott MP, Kieburtz K (2003) Gabapentin’s effects on hot flashes in postmenopausal women: a randomized controlled trial. Am J Obstet Gynecol 101:337–345

    CAS  Google Scholar 

  9. Belchetz PE (1994) Drug therapy: hormonal treatment of postmenopausal women. N Engl J Med 330:1062–1071

    Article  CAS  PubMed  Google Scholar 

  10. Rodstrom K, Bengtsson C, Lissner L, Milsom I, Sundh V, Bjorkelund C (2002) A longitudinal study of the treatment of hot flushes: the population study of women in Gothenburg during a quarter of the century. Menopause 9:156–161

    Article  PubMed  Google Scholar 

  11. Milsom I (2006) Menopause-related symptoms and their treatment. In: Erkkola R (ed) The menopause. Elsevier, Amsterdam, pp 9–16

    Google Scholar 

  12. Moe KE (2004) Hot flashes and sleep in women. Sleep Med Rev 8:487–497

    Article  PubMed  Google Scholar 

  13. Erkkola R, Holma P, Järvi T, Nummi S, Punnonen R, Raudaskoski T, Rehn K, Ryynänen M, Sipilä P, Tunkelo E et al (1991) Transdermal oestrogen replacement therapy in a Finnish population. Maturitas 13:275–281

    Article  CAS  PubMed  Google Scholar 

  14. Moss RL, Gu Q, Wong M (1997) Estrogen: nontranscriptional signalling pathway. Recent Prog Horm Res 52:33–68

    CAS  PubMed  Google Scholar 

  15. McEwen BS, Alves SE (1999) Estrogen actions in the central nervous system. Endocr Rev 20:279–307

    CAS  PubMed  Google Scholar 

  16. Koehler KF, Helguero LA, Haldosen L-A, Warner M, Gustafsson J-A (2005) Reflections on the discovery and significance of estrogen receptor β. Endocr Rev 26:465–478

    Article  CAS  PubMed  Google Scholar 

  17. Shneerson JM (2005) Sleep medicine. A guide to sleep and its disorders, 2nd ed. Blackwell, Oxford, UK, 336 pp

    Google Scholar 

  18. Barrett-Connor E (1998) Rethinking estrogen and the brain. J Am Geriatr Soc 46:90–92

    Article  Google Scholar 

  19. Freedman RR (2005) Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med 23:117–125

    Article  PubMed  Google Scholar 

  20. Rapkin AJ (2007) Vasomotor symptoms in menopause: physiologic condition and central nervous system approaches to treatment. Am J Obstet Gynecol 196:97–106

    Article  PubMed  Google Scholar 

  21. Dzaja A, Arber S, Hislop J, Kerkhofs M, Kopp C, Pollmächer T, Polo-Kantola P, Skene DJ, Stenuit P, Tobler I, Porkka-Heiskanen T (2005) Women’s sleep in health and disease. J Psychiatr Res 39:55–76

    Article  PubMed  Google Scholar 

  22. Fernandez B, Malde JL, Montero A, Acuna D (1990) Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. J Steroid Biochem 35:257–262

    Article  CAS  PubMed  Google Scholar 

  23. Fonseca E, Ochoa R, Galván R, Hernández M, Mercado M, Zárate A (1999) Increased serum levels of growth hormone and insulin-like growth factor-I associated with simultaneous decrease of circulating insulin in postmenopausal women receiving hormone replacement therapy. Menopause 6:56–60

    Article  CAS  PubMed  Google Scholar 

  24. Woods NF, Carr MC, Tao EY, Taylor HJ, Mitchell ES (2006) Increased urinary cortisol levels during the menopausal transition. Menopause 13:212–221

    Article  PubMed  Google Scholar 

  25. Bellantoni MF, Vittone J, Campfield AT, Bass KM, Harman SM, Blackman MR (1996) Effects of oral versus transdermal estrogen on the growth hormone/insulin-like growth factor I axis in younger and older postmenopausal women: a clinical research center study. J Clin Endocrinol Metab 81:2848–2853

    CAS  PubMed  Google Scholar 

  26. Moe KE, Prinz PN, Larsen LH, Vitiello MV, Reed SO, Merriam GR (1998) Growth hormone in postmenopausal women after long-term oral estrogen replacement therapy. J Gerontol Biol Sci 53A:B117–B124

    Article  CAS  Google Scholar 

  27. Weissberger AJ, Ho KKY, Lazarus L (1991) Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab 72:374–381

    Article  CAS  PubMed  Google Scholar 

  28. Cano A, Castelo-Branco C, Tarin JJ (1999) Effect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releasing hormone-stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels. Fertil Steril 71:261–267

    Article  CAS  PubMed  Google Scholar 

  29. Katznelson L, Riskind PN, Saxe VC, Klibanski A (1998) Prolactin pulsatile characteristics in postmenopausal women. J Clin Endocrinol Metab 83:761–764

    CAS  PubMed  Google Scholar 

  30. Chang RJ, Davidson BJ, Carlson HE, Judd HL (1982) Circadian pattern of prolactin secretion in postmenopausal women receiving estrogen with or without progestin. Am J Obstet Gynecol 144:402–407

    Article  CAS  PubMed  Google Scholar 

  31. Gudmundsson A, Goodman B, Lent S, Barczi S, Grace A, Boyle L, Ershler WB, Carnes M (1999) Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women. Exp Gerontol 34:809–818

    Article  CAS  PubMed  Google Scholar 

  32. Pluchino N, Genazzani AD, Bernardi F, Casarosa E, Pieri M, Palumbo M, Picciarelli G, Gabbanini M, Luisi M, Genazzani AR (2005) Tibolone, transdermal estradiol or oral estrogen-progestin therapies: effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels. Gynecol Endocrinol 20:144–149

    Article  CAS  PubMed  Google Scholar 

  33. Ohayon M (1996) Epidemiological study on insomnia in the general population. Sleep 19:7–15

    Google Scholar 

  34. Leger D, Guilleminault C, Dreyfus JP, Delahaye C, Paillard M (2000) Prevalence of insomnia in a survey of 12, 778 adults in France. J Sleep Res 9:35–42

    Article  CAS  PubMed  Google Scholar 

  35. Zhang B, Wing YK (2006) Sex differences in insomnia: a meta-analysis. Sleep 29:85–93

    PubMed  Google Scholar 

  36. Vaari T, Engblom J, Helenius H, Erkkola R, Polo-Kantola P (2008) Survey of sleep problems in 3421 women aged 41-55. Menopause Int 14:78–82.

    PubMed  Google Scholar 

  37. Kuh DL, Wadsworth M, Hardy R (1997) Women’s health in midlife: the influence of the menopause, social factors and health in earlier life. Br J Obstet Gynaecol 104:923–933

    Article  CAS  PubMed  Google Scholar 

  38. Kravitz HM, Ganz PA, Bromberger J, Powell LH, Sutton-Tyrrell K, Meyer PM (2003) Sleep difficulty in women at midlife. Menopause 10:19–28

    PubMed  Google Scholar 

  39. Ledesert B, Ringa V, Breart G (1994) Menopause and perceived health status among the women of the French GAZEL cohort. Maturitas 20:113–120

    Article  CAS  PubMed  Google Scholar 

  40. Anderson E, Hamburger S, Liu JH, Rebar RW (1987) Characteristics of menopausal women seeking assistance. Am J Obstet Gynecol 156:428–433

    Article  CAS  PubMed  Google Scholar 

  41. Polo-Kantola P, Erkkola R, Irjala K, Helenius H, Pullinen S, Polo O (1999) Climacteric symptoms and sleep quality. Obstet Gynecol 94:219–224

    CAS  PubMed  Google Scholar 

  42. Baker A, Simpson S, Dawson D (1997) Sleep disruption and mood changes associated with menopause. J Psychosom Res 43:359–369

    Article  CAS  PubMed  Google Scholar 

  43. Thurston RC, Blumenthal JA, Babyak MA, Sherwood A (2006) Association between hot flashes, sleep complaints, and psychological functioning among healthy menopausal women. Int J Behav Med 13:163–172

    Article  PubMed  Google Scholar 

  44. Shaver J, Giblin E, Lentz M, Lee K (1988) Sleep patterns and stability in perimenopausal woman. Sleep 11:556–561

    CAS  PubMed  Google Scholar 

  45. Young T, Rabago D, Zgierska A, Austin D, Finn L (2003) Objective and subjective sleep quality in pre-, peri- and postmenopausal women in the Wisconsin sleep cohort study. Sleep 26:667–672

    PubMed  Google Scholar 

  46. Sharkey KM, Bearpark HM, Acebo C, Millman RP, Cavallo A, Carskadon MA (2003) Effects of menopausal status on sleep in midlife women. Behav Sleep Med 1:69–80

    Article  PubMed  Google Scholar 

  47. Woodward S, Freedman RR (1994) The thermoregulatory effects of menopausal hot flashes on sleep. Sleep 17:497–501

    CAS  PubMed  Google Scholar 

  48. Freedman RR, Roehrs TA (2004) Lack of sleep disturbance from menopausal hot flashes. Fertil Steril 82:138–144

    Article  PubMed  Google Scholar 

  49. Freedman RR, Roehrs TA (2006) Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance. Menopause 13:576–583

    Article  PubMed  Google Scholar 

  50. International Menopause Society (2007) IMS updated recommendations on postmenopausal hormone therapy. Climacteric 10:181–194

    Article  CAS  Google Scholar 

  51. Rosen CJ (2005) Postmenopausal osteoporosis. N Engl J Med 353:595–603

    Article  CAS  PubMed  Google Scholar 

  52. Samsioe G (2006) Current views on hormone replacement therapy and cardiovascular disease. In: Erkkola R (ed) The menopause. Elsevier, Amsterdam, pp 63–80

    Google Scholar 

  53. Weiner MG, Barnhart K, Xie D, Tannen RL (2008) Hormone therapy and coronary heart disease in young women. Menopause 15:86–93

    PubMed  Google Scholar 

  54. Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in health postmenopausal women. Principal results from the Women’s health Initiative randomized controlled trial. JAMA 288:321–333

    Article  Google Scholar 

  55. Hays J, Ockene JK, Brunner RL, Kotchen JM, Manson JE, Patterson RE, Aragaki AK, Shumaker SA, Brzyski RG, LaCroix AZ, Granek IA, Valanis BG, Women’s Health Initiative Investigators (2003) Effects of estrogen plus progestin on health-related quality of life. N Engl J Med 348:1839–1854

    Article  CAS  PubMed  Google Scholar 

  56. Wiklund I, Berg G, Hammar M, Karlberg J, Lindgren R, Sandin K (1992) Long-term effect of transdermal hormonal therapy on aspects of quality of life in postmenopausal women. Maturitas 14:225–236

    Article  CAS  PubMed  Google Scholar 

  57. Polo-Kantola P, Erkkola R, Helenius H, Irjala K, Polo O (1998) When does estrogen replacement therapy improve sleep quality? Am J Obstet Gynecol 178:1002–1009

    Article  CAS  PubMed  Google Scholar 

  58. Rebar RW, Trabal J, Mortola J (2000) Low-dose esterified estrogens (0.3 mg/day): long-term and short-term effects on menopausal symptoms and quality of life in postmenopausal women. Climacteric 3:176–182

    Article  CAS  PubMed  Google Scholar 

  59. Gambacciani M, Ciaponi M, Cappagli B, Monteleone P, Benussi C, Bevilacqua G, Genazzani AR (2003) Effects of low-dose, continuous combined estradiol and noretisterone acetate on menopausal quality of life in early postmenopausal women. Maturitas 44:157–163

    Article  CAS  PubMed  Google Scholar 

  60. Thomson J, Oswald I (1977) Effect of oestrogen on the sleep, mood, and anxiety of menopausal women. BMJ 2:1317–1319

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Schiff I, Regestein Q, Tulchinsky D, Ryan KJ (1979) Effects of estrogens on sleep and psychological state of hypogonadal women. JAMA 242:2405–2407

    Article  CAS  PubMed  Google Scholar 

  62. Antonijevic IA, Stalla GK, Steiger A (2000) Modulation of the sleep electroencephalogram by estrogen replacement in postmenopausal women. Am J Obstet Gynecol 182:277–282

    Article  CAS  PubMed  Google Scholar 

  63. Parry BL, Meliska CJ, Martinez LF, Basavaraj N, Zirpoli GG, Sorenson D, Maurer EL, Lopez A, Markova K, Gamst A, Wolfson T, Hauger R, Kripke DF (2004) Menopause: neuroendocrine changes and hormone replacement therapy. J Am Med Womens Assoc 59:135–145

    PubMed  Google Scholar 

  64. Erlik Y, Tataryn IV, Meldrum DR, Lomax P, Bajorek JG, Judd HL (1981) Association of waking episodes with menopausal hot flushes. JAMA 245:1741–1744

    Article  CAS  PubMed  Google Scholar 

  65. Scharf MB, McDannold MD, Stover R, Zaretsky N, Berkowitz DV (1997) Effects of estrogen replacement therapy on rates of cyclic alternating patterns and hot-flush events during sleep in postmenopausal women: a pilot study. Clin Ther 19:304–311

    Article  CAS  PubMed  Google Scholar 

  66. Polo-Kantola P, Erkkola R, Irjala K, Pullinen S, Virtanen I, Polo O (1999) Effect of short-term transdermal estrogen replacement therapy on sleep: a randomized, double-blind crossover trial in postmenopausal women. Fertil Steril 71:873–880

    Article  CAS  PubMed  Google Scholar 

  67. Montplaisir J, Lorrain J, Denesle R, Petit D (2001) Sleep in menopause: differential effects of two forms of hormone replacement therapy. Menopause 8:10–16

    Article  CAS  PubMed  Google Scholar 

  68. Moe KE, Larsen LH, Vitiello MV, Prinz PN (2001) Estrogen replacement therapy modulates the sleep disruption associated with nocturnal blood sampling. Sleep 24:886–894

    CAS  PubMed  Google Scholar 

  69. Pickett CK, Regensteiner JG, Woodard WD, Hagerman DD, Weil JV, Moore LG (1989) Progestin and estrogen reduce sleep-disordered breathing in postmenopausal women. J Appl Physiol 66:1656–1661

    CAS  PubMed  Google Scholar 

  70. Purdie DW, Empson JAC, Crichton C, MacDonald L (1995) Hormone replacement therapy, sleep quality and psychological wellbeing. Br J Obstet Gynaecol 2:735–739

    Article  Google Scholar 

  71. Saletu-Zyhlarz G, Anderer P, Gruber G, Mandl M, Gruber D, Metka M, Huber J, Oettel M, Gräser T, Abu-Bakr MH, Grätzhofer E, Saletu B (2003) Insomnia related to postmenopausal syndrome and hormone replacement therapy: sleep laboratory studies on baseline differences between patients and controls and double-blind, placebo-controlled investigations on the effects of a novel estrogen-progestogen combination versus estrogen alone. J Sleep Res 12:239–254

    Article  PubMed  Google Scholar 

  72. Kalleinen N, Polo O, Himanen S-L, Joutsen A, Polo-Kantola P (2008) The effect of estrogen plus progestin treatment on sleep: a randomized, placebo-controlled, double-blind trial in premenopausal and late postmenopausal women. Climacteric 11:233–243

    Article  CAS  PubMed  Google Scholar 

  73. Kronenberg F (1990) Hot flashes: epidemiology and physiology. Ann NY Acad Sci 592:52–86

    Article  CAS  PubMed  Google Scholar 

  74. Kalleinen N, Polo-Kantola P, Himanen S-L, Alhola P, Joutsen A, Urrila AS, Polo O (2008) Sleep and menopause – Do postmenopausal women sleep worse than premenopausal women? Menopause Int 14(3):97–104

    PubMed  Google Scholar 

  75. Miller RG, Ashar BH (2004) Managing menopause: current therapeutic options for vasomotor symptoms. Adv Stud Med 4:484–492

    Google Scholar 

  76. Speroff L (2005) Alternative therapies for postmenopausal women. Int J Fertil Womens Med 50:101–114

    PubMed  Google Scholar 

  77. Ancoli-Israel S (2000) Insomnia in the elderly: a review for the primary care practitioner. Sleep 23:S23–S30

    PubMed  Google Scholar 

  78. Kornstein SG (1997) Gender differences in depression: implications for treatment. J Clin Psychiatry 58:12–18

    Article  PubMed  Google Scholar 

  79. Pigott TA (1999) Gender differences in the epidemiology and treatment of anxiety disorders. J Clin Psychiatry 60:4–15

    Article  PubMed  Google Scholar 

  80. Avis NE, Stellato R, Crawford S, Bromberger J, Ganz P, Cain V, Kagawa-Singer M (2001) Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 52:345–356

    Article  CAS  PubMed  Google Scholar 

  81. Steiger A, Antonijevic IA, Bohlhalter S, Frieboes RM, Fiess E, Murck H (1998) Effects of hormones on sleep. Horm Res 49:125–130

    Article  CAS  PubMed  Google Scholar 

  82. Friess E, Tagaya H, Trachsel L, Holsboer F, Rupprecht R (1997) Progesterone-induced changes in sleep in male subjects. Am J Physiol 272:E885–E891

    CAS  PubMed  Google Scholar 

  83. Saaresranta T, Polo-Kantola P, Rauhala E, Polo O (2001) Medroxyprogesterone in postmenopausal females with partial upper airway obstruction during sleep. Eur Respir J 18:989–995

    Article  CAS  PubMed  Google Scholar 

  84. Saaresranta T, Aittokallio T, Utriainen K, Polo O (2005) Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease. Respir Res 6(1):28(12 s) http://respiratory-research.com/content/6/1/28

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235

    Article  CAS  PubMed  Google Scholar 

  86. Redline S, Kump K, Tishler PV, Browner I, Ferrette V (1994) Gender differences in sleep-disordered breathing in a community based sample. Am J Respir Crit Care Med 149:722–726

    Article  CAS  PubMed  Google Scholar 

  87. Kripke DF, Ancoli-Israel S, Klauber MR, Wingard DL, Mason WJ, Mullaney DJ (1997) Prevalence of sleep-disordered breathing in ages 40–64 years: a population-based survey. Sleep 20:65–76

    CAS  PubMed  PubMed Central  Google Scholar 

  88. Olson LG, King MT, Hensley MJ, Saunders NA (1995) A community study of snoring and sleep-disordered breathing. Prevalence. Am J Respir Crit Care Med 152:711–716

    Article  CAS  PubMed  Google Scholar 

  89. Block AJ, Boysen PG, Wynne JW, Hunt LA (1979) Sleep apnea, hypopnea and oxygen desaturation in normal subjects. A strong male predominance. N Engl J Med 300:513–517

    Article  CAS  PubMed  Google Scholar 

  90. Gislason T, Benediktsdóttir B, Björnsson JK, Kjartansson G, Kjeld M, Kristbjarnarson H (1993) Snoring, hypertension, and the sleep apnea syndrome. An epidemiologic survey of middle-aged women. Chest 103:1147–1151

    Article  CAS  PubMed  Google Scholar 

  91. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, Kales A (2001) Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med 163:608–613

    Article  CAS  PubMed  Google Scholar 

  92. Young T, Finn L, Austin D, Peterson A (2003) Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med 167:1181–1185

    Article  PubMed  Google Scholar 

  93. Anttalainen U, Saaresranta T, Aittokallio J, Kalleinen N, Vahlberg T, Virtanen I, Polo O (2006) Impact of menopause on the manifestation and severity of sleep-disordered breathing. Acta Obstet Gynecol Scand 85:1381–1388

    Article  PubMed  Google Scholar 

  94. Saaresranta T, Polo O (2005) Sleep-disordered breathing and hormones. In: Cardinali D, Pandi-Perumal SR (eds) Neuroendocrine correlates of sleep/wakefulness, 1st edn. Springer, New York, pp 437–470

    Google Scholar 

  95. Behan M, Zabka AG, Thomas CF, Mitchell GS (2003) Sex steroid hormones and the neural control of breathing. Respir Phys Neurobiol 136:249–263

    Article  CAS  Google Scholar 

  96. Popovic RM, White DP (1998) Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol 84:1055–1062

    CAS  PubMed  Google Scholar 

  97. Bonham AC (1995) Neurotransmitters in the CNS control of breathing. Respir Physiol 101:219–230

    Article  CAS  PubMed  Google Scholar 

  98. Biegon A, Reches A, Snyder L, McEwen BS (1983) Serotonergic and noradrenergic receptors in the rat brain: modulation by chronic exposure to ovarian hormones. Life Sci 32:2015–2021

    Article  CAS  PubMed  Google Scholar 

  99. Blum I, Vered Y, Lifshitz A, Harel D, Blum M, Nordenberg Y, Harsat A, Sulkes J, Gabbay U, Graff E (1996) The effect of estrogen replacement therapy on plasma serotonin and catecholamines of postmenopausal women. Isr J Med Sci 32:1158–1162

    CAS  PubMed  Google Scholar 

  100. Biver F, Lotsra F, Monclus M, Wikler D, Damhaut P, Mendlewicz J, Goldman S (1996) Sex difference in 5HT2 receptor in the living human brain. Neurosci Lett 204:25–28

    Article  CAS  PubMed  Google Scholar 

  101. Moses EL, Drevets WC, Smith G, Mathis CA, Kalro BN, Butters MA, Leondires MP, Greer PJ, Lopresti B, Loucks TL, Berga SL (2000) Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study. Biol Psychiatry 48:854–860

    Article  CAS  PubMed  Google Scholar 

  102. Lindsay AD, Feldman JL (1993) Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. J Physiol Lond 461:213–233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Di Pasquale E, Lindsay A, Feldman J, Monteau R, Hilaire G (1997) Serotonergic inhibition of phrenic motoneuron activity: an vitro study in neonatal rat. Neurosci Lett 230:29–32

    Article  PubMed  Google Scholar 

  104. Skatrud JB, Dempsey JA, Kaiser DG (1978) Ventilatory response to medroxyprogesterone acetate in normal subjects: time course and mechanism. J Appl Physiol 44:939–944

    CAS  PubMed  Google Scholar 

  105. Zwillich CW, Natalino MR, Sutton FD, Weil JV (1978) Effects of progesterone on chemosensitivity in normal men. J Lab Clin Med 92:262–269

    CAS  PubMed  Google Scholar 

  106. Driver HS, McLean H, Kumar DV, Farr N, Day AG, Fitzpatrick MF (2005) The influence of the menstrual cycle on upper airway resistance and breathing during sleep. Sleep 28:449–456

    PubMed  Google Scholar 

  107. Regensteiner JG, Hiatt WR, Byyny RL, Pickett CK, Woodard WD, Moore LG (1989) Combined effects of female hormones and metabolic rate on ventilatory drives in women. J Appl Physiol 66:808–813

    CAS  PubMed  Google Scholar 

  108. Brodeur P, Mockus M, McCullough M, Moore LG (1986) Progesterone receptors and ventilatory stimulation by progestin. J Appl Physiol 60:590–595

    CAS  PubMed  Google Scholar 

  109. Manber R, Kuo TF, Cataldo N, Colrain IM (2003) The effects of hormone replacement therapy on sleep-disordered breathing in postmenopausal women: a pilot study. Sleep 26:163–168

    PubMed  Google Scholar 

  110. Leavitt WW, Blaha GC (1972) An estrogen-stimulated, progesterone-binding system in the hamster uterus and vagina. Steroids 19:263–274

    Article  CAS  PubMed  Google Scholar 

  111. Netzer NC, Eliasson AH, Strohl KP (2003) Women with sleep apnea have lower levels of sex hormones. Sleep Breath 7:25–29

    Article  PubMed  Google Scholar 

  112. Polo-Kantola P, Rauhala E, Helenius H, Erkkola R, Irjala K, Polo O (2003) Breathing during sleep in menopause: a randomized, controlled, crossover trial with estrogen therapy. Obstet Gynecol 102:68–75

    CAS  PubMed  Google Scholar 

  113. Anttalainen U, Saaresranta T, Kalleinen N, Aittokallio J, Vahlberg T, Polo O (2007) CPAP adherence and partial upper airway obstruction during sleep. Sleep Breath 11:171–176

    Article  PubMed  Google Scholar 

  114. American Academy of Sleep Medicine Task Force (1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 22:667–689

    Google Scholar 

  115. Engleman HM, Kingshott RN, Wraith PK, Mackay TW, Deary IJ, Douglas NJ (1999) Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med 159:461–467

    Article  CAS  PubMed  Google Scholar 

  116. Rosenthal L, Gerhardstein R, Lumley A, Guido P, Day R, Syron ML, Roth T (2000) CPAP therapy in patients with mild OSA: implementation and treatment outcome. Sleep Med 1:215–220

    Article  PubMed  Google Scholar 

  117. Kapsimalis F, Kryger MH (2002) Gender and obstructive sleep apnea syndrome, part 1: clinical features. Sleep 25:412–419

    PubMed  Google Scholar 

  118. Jordan AS, McEvoy RD (2003) Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms. Sleep Med Rev 7:377–389

    Article  PubMed  Google Scholar 

  119. Young T, Hutton R, Finn L, Badr S, Palta M (1996) The gender bias in sleep apnea diagnosis – are women missed because they have different symptoms? Arch Intern Med 156:2445–2451

    Article  CAS  PubMed  Google Scholar 

  120. Valipour A, Lothaller H, Rauscher H, Zwick H, Burghuber OC, Lavie P (2007) Gender-related differences in symptoms of patients with suspected breathing disorders in sleep: a clinical population study using the sleep disorders questionnaire. Sleep 30:312–319

    PubMed  Google Scholar 

  121. Larsson LG, Lindberg A, Franklin KA, Lundbäck B (2003) Gender differences in symptoms related to sleep apnea in a general population and in relation to referral to sleep clinic. Chest 124:204–211

    Article  PubMed  Google Scholar 

  122. Ambrogetti A, Olson LG, Saunders NA (1991) Differences in the symptoms of men and women with obstructive sleep apnea. Aust NZ J Med 21:863–866

    Article  CAS  Google Scholar 

  123. Chervin RD (2000) Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea. Chest 118:372–379

    Article  CAS  PubMed  Google Scholar 

  124. Shepertycky MR, Banno K, Kryger MH (2005) Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome. Sleep 28:309–314

    PubMed  Google Scholar 

  125. Guilleminault C, Palombini L, Poyares D, Chowdhuri S (2002) Chronic insomnia, postmenopausal women, and sleep disordered breathing: part 1. Frequency of sleep disordered breathing in a cohort. J Psychosom Res 53:611–615

    Article  PubMed  Google Scholar 

  126. Hachul de Campos H, Brandão LC, D’Almeida V, Grego BH, Bittencourt LR, Tufik S, Baracat EC (2006) Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Climacteric 9:312–319

    Article  CAS  PubMed  Google Scholar 

  127. Pillar G, Lavie P (1998) Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. Chest 114:697–703

    Article  CAS  PubMed  Google Scholar 

  128. Collop NA (1994) Medroxyprogesterone acetate and ethanol-induced exacerbation of obstructive sleep apnea. Chest 106:792–799

    Article  CAS  PubMed  Google Scholar 

  129. Saaresranta T, Polo-Kantola P, Virtanen I, Vahlberg T, Irjala K, Polo O (2006) Menopausal estrogen therapy predicts better nocturnal oxyhemoglobin saturation. Maturitas 55:255–263

    Article  CAS  PubMed  Google Scholar 

  130. Cistulli PA, Barnes DJ, Grunstein RR, Sullivan CE (1994) Effect of short-term hormone replacement in the treatment of obstructive sleep apnoea in postmenopausal women. Thorax 49:699–702

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  131. Keefe DL, Watson R, Naftolin F (1999) Hormone replacement therapy may alleviate sleep apnea in menopausal women: a pilot study. Menopause 6:196–200

    Article  CAS  PubMed  Google Scholar 

  132. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L (1995) The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 33:160–172

    Article  Google Scholar 

  133. Waxman J, Zatzkis SM (1986) Fibromyalgia and menopause. Examination of the relationship. Postgrad Med 80:165–167, 170–171

    Article  CAS  PubMed  Google Scholar 

  134. Pamuk ÖN, Çakir N (2005) The variation in chronic widespread pain and other symptoms in fibromyalgia patients. The effects of menses and menopause. Clin Exp Rheumatol 23:778–782

    CAS  PubMed  Google Scholar 

  135. Neumann L, Buskila D (2003) Epidemiology of fibromyalgia. Curr Pain Headache Rep 7:362–368

    Article  PubMed  Google Scholar 

  136. Robinson RL, Birnbaum HG, Morley MA, Sisitsky T, Greenberg PE, Claxton AJ (2003) Economic cost and epidemiological characteristics of patients with fibromyalgia claims. J Rheumatol 30:1318–1325

    PubMed  Google Scholar 

  137. Moldofsky HK (2001) Disordered sleep in fibromyalgia and related myofascial facial pain conditions. Dent Clin North Am 45:701–713

    CAS  PubMed  Google Scholar 

  138. Nicassio PM, Moxham EG, Schuman CE, Gevirtz RN (2002) The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain 100:271–279

    Article  PubMed  Google Scholar 

  139. Press J, Phillip M, Neumann L, Barak R, Segev Y, Abu-Shakra M, Buskila D (1998) Normal melatonin levels in patients with fibromyalgia syndrome. J Rheumatol 25:551–555

    CAS  PubMed  Google Scholar 

  140. Wikner J, Hirsch U, Wetterberg L, Röjdmark S (1998) Fibromyalgia - a syndrome associated with decreased nocturnal melatonin secretion. Clin Endocrinol (Oxf) 49:179–183

    Article  CAS  Google Scholar 

  141. Korszun A, Sackett-Lundeen L, Papadopoulos E, Brucksch C, Masterson L, Engelberg NC, Haus E, Demitrack MA, Crofford L (1999) Melatonin levels in women with fibromyalgia and chronic fatigue syndrome. J Rheumatol 26:2675–2680

    CAS  PubMed  Google Scholar 

  142. Adler GK, Kinsley BT, Hurwitz S, Mossey CJ, Goldenberg DL (1999) Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. Am J Med 106:534–543

    Article  CAS  PubMed  Google Scholar 

  143. Torpy DJ, Papanicolaou DA, Lotsikas AJ, Wilder RL, Chrousos GP, Pillemer SR (2000) Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: a pilot study in fibromyalgia. Arthritis Rheum 43:872–880

    Article  CAS  PubMed  Google Scholar 

  144. Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL (1994) Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 37:1583–1592

    Article  CAS  PubMed  Google Scholar 

  145. McCain GA, Tilbe KS (1989) Diurnal hormone variation in fibromyalgia syndrome: a comparison with rheumatoid arthritis. J Rheumatol Suppl 19:154–157

    CAS  PubMed  Google Scholar 

  146. Klerman EB, Goldenberg DL, Brown EN, Maliszewski AM, Adler GK (2001) Circadian rhythms of women with fibromyalgia. J Clin Endocrinol Metab 86:1034–1039

    CAS  PubMed  Google Scholar 

  147. Roizenblatt S, Moldofsky H, Benedito-Silva AA, Tufik S (2001) Alpha sleep characteristics in fibromyalgia. Arthritis Rheum 44:222–230

    Article  CAS  PubMed  Google Scholar 

  148. Goldenberg DL, Felson DT, Dinerman H (1986) A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis Rheum 29:1371–1377

    Article  CAS  PubMed  Google Scholar 

  149. Moldofsky H, Lue FA, Mously C, Roth-Schechter B, Reynolds WJ (1996) The effect of zolpidem in patients with fibromyalgia: a dose ranging, double blind, placebo controlled, modified crossover study. J Rheumatol 23:529–533

    CAS  PubMed  Google Scholar 

  150. Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG (1991) Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis Rheum 34:552–560

    Article  CAS  PubMed  Google Scholar 

  151. Scharf MB, Baumann M, Berkowitz DV (2003) The effects of sodium oxybate on clinical symptoms and sleep patterns in patients with fibromyalgia. J Rheumatol 30:1070–1074

    CAS  PubMed  Google Scholar 

  152. Edinger JD, Wohlgemuth WK, Krystal AD, Rice JR (2005) Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial. Arch Intern Med 165:2527–2535

    Article  PubMed  Google Scholar 

  153. Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K (2000) Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology 54:1064–1068

    Article  CAS  PubMed  Google Scholar 

  154. Trenkwalder C, Paulus W, Walters AS (2005) The restless leg syndrome. Lancet Neurol 4:465–475

    Article  CAS  PubMed  Google Scholar 

  155. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C (2004) Sex and the risk of restless legs in the general population. Arch Intern Med 164:196–202

    Article  PubMed  Google Scholar 

  156. Ulfberg J, Bjorvatn B, Leissner L, Gyring J, Karlsborg M, Regeur L, Skeidsvoll H, Polo O, Partinen M (2007) Comorbidity in restless legs syndrome among a sample of Swedish adults. Sleep Med 8:768–772

    Article  PubMed  Google Scholar 

  157. Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O (2001) Estrogen replacement therapy and nocturnal periodic limb movements: a randomized trial. Obstet Gynecol 97:548–554

    CAS  PubMed  Google Scholar 

  158. Chesson AL Jr, Wise M, Davila D, Johnson S, Littner M, Anderson WM, Hartse K, Rafecas J (1999) Practise parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Report. Standards of Practise Committee of the American Academy of Sleep Medicine. Sleep 22:961–968

    PubMed  Google Scholar 

  159. Saaresranta T, Irjala K, Aittokallio T, Polo O (2005) Sleep quality, daytime sleepiness and fasting insulin levels in women with chronic obstructive pulmonary disease. Respir Med 99:856–863

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pulmonary Diseases, Sleep Research Unit, Turku University Central Hospital, University of Turku, Turku, Finland

    Tarja Saaresranta MD, PhD

  2. Department of Obstetrics and Gynecology, Sleep Research Unit, Turku University Central Hospital, University of Turku, Turku, Finland

    Päivi Polo-Kantola MD, PhD

  3. Department of Pulmonary Diseases, Tampere University Hospital, Tampere, Finland

    Olli Polo MD, PhD

  4. Sleep Research Unit, University of Turku, Turku, Finland

    Olli Polo MD, PhD

Authors
  1. Tarja Saaresranta MD, PhD
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  2. Päivi Polo-Kantola MD, PhD
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  3. Olli Polo MD, PhD
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Editors and Affiliations

  1. Department of Neurology and Medicine, Loyola University of Chicago, South First Ave. 2160, Maywood, 60153, USA

    Hrayr P. Attarian

  2. Pondview Rd. 20, Arlington, 02474, USA

    Catherine Schuman

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Saaresranta, T., Polo-Kantola, P., Polo, O. (2010). Menopausal Insomnia. In: Attarian, H., Schuman, C. (eds) Clinical Handbook of Insomnia. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-042-7_9

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