Abstract
Rapid progress has been made during the past decade in our understanding of neural circuits and neuromodulatory systems that mediate economic behavior. This research has produced a set of experimental tools that have been successfully applied to a variety of neuropsychiatric and focal lesion cohorts. Despite these advances, however, major gaps still exist between this scientific understanding and future clinical applications. In particular, little systematic work has been done to map these behavioral and neural measures to clinically relevant characteristics, in ways that can (1) organize clinical descriptions of decision-making deficits or (2) refine and quantify these descriptions. Medical charts constitute a rich source of primary data on behavioral symptoms, and have been largely untapped in translational research. Here we discuss and provide an example of how to connect scientific insights of neural basis of decision-making to clinical data. We conclude by discussing the scientific and ethical challenges to a more full integration of these sources of experimental and clinical data.
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Hsu, M., Chiong, W. (2016). From Laboratory to Clinic and Back: Connecting Neuroeconomic and Clinical Measures of Decision-Making Dysfunctions. In: Diefenbach, M., Miller-Halegoua, S., Bowen, D. (eds) Handbook of Health Decision Science. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3486-7_4
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