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Pituitary Desensitization with a Long-Acting Luteinizing-Hormone-Releasing Hormone Analog

A Potential New Treatment for Idiopathic Precocious Puberty

  • Chapter
Girls at Puberty

Abstract

Normal puberty appears to be initiated by the pulsatile secretion of luteinizing-hormone-releasing hormone (LHRH) from the hypothalamus at a frequency of about 1 pulse/hr (see Figure 1) (Boyar, Finkelstein, Roffwarg, Kapen, Weitzman, and Hellman, 1972; Knobil, 1980). The pulsatile secretion of LHRH stimulates secretion of the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate gonadal sex steroid secretion. The rise in the gonadal sex steroids estradiol and testosterone induces the secondary sexual changes at puberty.

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Author information

Authors and Affiliations

  1. Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Gordon B. Cutler Jr., Florence Comite & D. Lynn Loriaux

  2. Peptide Biology Laboratory, Salk Institute, San Diego, California, 92138, USA

    Jean Rivier & Wylie W. Vale

  3. Vincent Research Laboratories, Departments of Internal Medicine and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA

    William F. Crowley Jr.

Authors
  1. Gordon B. Cutler Jr.
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  2. Florence Comite
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  3. Jean Rivier
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  4. Wylie W. Vale
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  5. D. Lynn Loriaux
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  6. William F. Crowley Jr.
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Editor information

Editors and Affiliations

  1. Institute for the Study of Exceptional Children, Educational Testing Service, 08541, Princeton, New Jersey, USA

    Jeanne Brooks-Gunn

  2. Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 10019, New York, New York, USA

    Jeanne Brooks-Gunn

  3. Department of Individual and Family Studies, College of Human Development, The Pennsylvania State University, 16802, University Park, Pennsylvania, USA

    Anne C. Petersen

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© 1983 Springer Science+Business Media New York

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Cutler, G.B., Comite, F., Rivier, J., Vale, W.W., Loriaux, D.L., Crowley, W.F. (1983). Pituitary Desensitization with a Long-Acting Luteinizing-Hormone-Releasing Hormone Analog. In: Brooks-Gunn, J., Petersen, A.C. (eds) Girls at Puberty. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0354-9_5

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  • DOI: https://doi.org/10.1007/978-1-4899-0354-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0356-3

  • Online ISBN: 978-1-4899-0354-9

  • eBook Packages: Springer Book Archive

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