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Biochemical Substrates of Drug Abuse

  • Chapter
Determinants of Substance Abuse

Part of the book series: Perspectives on Individual Differences ((PIDF))

Abstract

A variety of psychosocial factors are thought to predispose an individual to initiate the abuse of illicit drugs (Gorsuch & Butler, 1976). Once initiated, a number of psychopharmacological factors also come to play a role in the continuance of self-administration behavior. One important factor is the ability of the drug to produce a positive affective state or reinforcement upon its initial administration. For example. Haertzen, Kocher, & Miyasato (1983) found that the degree of reinforcement derived from the first drug experience was related directly to the magnitude of the subsequent drug habit. The relationship was true for several drugs including alcohol, barbiturates, minor tranquilizers, cocaine, stimulants, marijuana, solvents, hallucinogens, and opiates but was not true for caffeine (coffee) or nicotine (cigarettes). Thus, an understanding of the abuse potential of many psychoactive drugs requires an appreciation of the reinforcing value of the initial drug experience.

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Authors and Affiliations

  1. Department of Psychology, University of Kentucky, Lexington, Kentucky, 40506, USA

    Michael T. Bardo

  2. Addiction Research Center, National Institute on Drug Abuse, P.O. Box 5180, Baltimore, Maryland, 21224, USA

    Marcus E. Risner

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  1. Michael T. Bardo
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  2. Marcus E. Risner
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Editors and Affiliations

  1. Department of Psychology, University of North Carolina, Wilmington, North Carolina, USA

    Mark Galizio

  2. Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA

    Stephen A. Maisto

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Bardo, M.T., Risner, M.E. (1985). Biochemical Substrates of Drug Abuse. In: Galizio, M., Maisto, S.A. (eds) Determinants of Substance Abuse. Perspectives on Individual Differences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9990-3_3

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  • DOI: https://doi.org/10.1007/978-1-4757-9990-3_3

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