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The Role of Genetics in Substance Abuse

  • Chapter
Determinants of Substance Abuse

Part of the book series: Perspectives on Individual Differences ((PIDF))

Abstract

Many factors clearly influence substance abuse. Our goal in this chapter is to acquaint the reader with a literature devoted to the hypothesis that an individual’s unique genetic constitution is one important factor. We believe that the studies performed during the last 20 years strongly imply that some humans suffer from a genetic predisposition to develop alcoholism. Extensive animal experiments corroborate this hypothesis and have begun to offer clues as to what, exactly, may be inherited. There are virtually no experiments demonstrating familial patterns of abuse for substances other than ethanol. Nonetheless, a growing animal literature demonstrates that responsiveness to opiates and barbiturates is also influenced markedly by inheritance. A few studies suggest that responsiveness to all psychoactive substances tends to be inherited to some degree.

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Authors and Affiliations

  1. Research Service, VA Medical Center, and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    John C. Crabbe

  2. Research Service, VA Medical Center, and Department of Medical Psychology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    John D. McSwigan

  3. Department of Pharmacology, School of Medicine, University of North Dakota, Grand Forks, North Dakota, 58202, USA

    J. K. Belknap

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  1. John C. Crabbe
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  1. Department of Psychology, University of North Carolina, Wilmington, North Carolina, USA

    Mark Galizio

  2. Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA

    Stephen A. Maisto

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Crabbe, J.C., McSwigan, J.D., Belknap, J.K. (1985). The Role of Genetics in Substance Abuse. In: Galizio, M., Maisto, S.A. (eds) Determinants of Substance Abuse. Perspectives on Individual Differences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9990-3_2

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