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Psychopharmacology of the Response to Noise, with Special Reference to Audiogenic Seizure in Mice

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Physiological Effects of Noise

Abstract

Troubles induced by intense noise can affect various physiological functions: cardiovascular or circulatory systems, sleep, endocrines, reproduction, susceptibility to infection. One of the most obvious harmful effects of noise is its influence on the nervous system. The first nervous system damages induced by noise are located at its most peripheral level: the ear. Very loud and long lasting noises can give auditory troubles going as far as total deafness. The only protection against these injuries is to obstruct the ears, as done in airfields, for example. But noises loud enough to induce injuries at the auditory level can, however, be very harmful for the nervous system and can give troubles going from an abnormal excitability to loss of sleep and to a real nervous breakdown. The degree of nuisance of this overstimulation is felt differently according to different individuals and is closely related to the state of their nervous system; a defect in it can sensitize to noise and lead to more or less important disorders.

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References

  1. Lehmann, A. and R.G. Busnel, 1963. A study of the audiogenic seizure. In: R.G. Busnel (Ed.), Acoustic behaviour of animals, Elsevier, Amsterdam, pp. 244–274.

    Google Scholar 

  2. Forster, F.M., P. Hansotia, C.S. Cleeland and A. Ludwig, 1969. A case of voice-induced epilepsy treated by conditioning. Neurology 19:32 5–331.

    Google Scholar 

  3. Lehmann, A. et D.A. Fless, 1962. Etude de l’action de drogues psychotropes sur les processus d’excitation et d’inhibition du S.N.C. par le test de la crise audiogène du rat. Psychopharma-cologia 3:331–343.

    Article  CAS  Google Scholar 

  4. Cosnier, J., A.M. Brandon et A. Duveau, 1962. Quelques particularités du comportement des souris sensibles à la crise audiogène. Compte Rendu Societe des Biologie (Paris) 156:2071–2074.

    CAS  Google Scholar 

  5. Cosnier, J., A. Duveau et E. Vernet-Maury, 1963. Caractères différentiels du comportement des rats et des souris sensibles et réfractaires a la crise audiogène. Journal de Physiologie (Paris) 55:130–131.

    CAS  Google Scholar 

  6. Ginsburg, B.E., 1954. Genetics and the physiology of the nervous system. Genetics and the inheritance of integrated neurological and psychiatric patterns. Proceedings Association Research Nervous and Mental Disease 33:39–56.

    CAS  Google Scholar 

  7. Lehmann, A. et E. Boesiger, 1964. Sur le déterminisme génétique de l’épilepsie acoustique de Mus muscuius (Swiss Rb). Compte Rendu Academie des Sciences (Paris). 258:4858–4861.

    CAS  Google Scholar 

  8. Mouse News Letter, 1959. 21:42.

    Google Scholar 

  9. Suter, C., W.O. Klingmann, D. Boggs, O.W. Lacey, R. Marks and C.B. Coplinger, 1958. Sound-induced seizures in animals. The efficiency of certain anticonvulsivants in controlling sound-induced seizures in DBA/2 mice. Neurology 8, Suppl. 1:121–124.

    PubMed  CAS  Google Scholar 

  10. Swinyard, E.A., 1963. Some physiological properties of audiogenic seizures in mice and their alteration by drugs. In: R.G. Busnel (Ed.), Psychophysiologie, Neuropharmacologie et Biochimie de la crise audiogene, Editions du C.N.R.S., Paris. pp. 405–421.

    Google Scholar 

  11. Fink, G.B. and E.A. Swinyard, 1959. Modification of maximal audiogenic and electroshock seizures in mice by psychopharma-cologic drugs. Journal Pharmacology and Experimental Therapeutics 127:318–324.

    CAS  Google Scholar 

  12. Halpern, B.N. et Lehmann, A., 1957. Bases expérimentales de l’action thérapeutique d’une nouvelle médication sédative et anti-anxieuse, le carbamate de méthyl 3 pentyne 1 ol 3. Presse Médicale 27:622–625.

    Google Scholar 

  13. Wilson, C.W.M., 1959. Drug antagonism and audiogenic seizures in mice. British Journal of Pharmacology 14:415–419.

    CAS  Google Scholar 

  14. Plotnikoff, N.P., 1961. Drug resistance due to inbreeding. Science 134:1881–1882.

    Article  PubMed  CAS  Google Scholar 

  15. Plotnikoff, N.P., 1958. Bioassay of potential tranquilizers and sedatives against audiogenic seizures in mice. Archives Internationales de Pharmacodynamie et de Therapie 116:130–135.

    PubMed  CAS  Google Scholar 

  16. Langer, S.Z., J.M. Trifaro and V.G. Foglia, 1962. Accion protectora de la hidroxidiona sobre las convulsiones audiogenas. Revista de la Sociedad Argentina de Biologia (Buenos Aires) 38: 50–54.

    CAS  Google Scholar 

  17. Busnel, R.G., A. Lehmann et M.C. Busnel, 1958. Etude de la drise audiogène de la souris comme test psychopharmacologique: son application aux substances du type “tranquilliseurs”. Pathologie et Biologie (Paris) 1–10:749–762.

    Google Scholar 

  18. Foglia, V.G., R.P. Montanelli, S.Z. Langer et R. Epstein, 1963. Action des drogues psychotropes sur les convulsions audiogènes chez la souris. Compte Rendu Société Biologie (Paris) 157: 1813–1814.

    CAS  Google Scholar 

  19. Plotnikoff, N.P., 1963. A neuropharmacological study of escape from audiogenic seizures. In: R.G. Busnel (Ed.), Psychophysiologie, Neuropharmacologie et Biochimie de la crise audiogene, Editions du C.N.R.S., Paris, pp. 429–443.

    Google Scholar 

  20. Halpern, B.N. et A. Lehmann, 1956. Action protectrice du carbamate de methyl 3 pentyne 1 ol 3 (CMP) contre la crise convulsive audiogene. Compte Rendu Societe Biologie (Paris) 150:1863–1866.

    CAS  Google Scholar 

  21. Raynaud, G. et G. Valette, 1963. Action des dérivés de la phénothiazine et de l’halopéridol sur la crise audiogène de la souris. Archives Internationales de Pharmacodynamie et de Therapie 142:425–439.

    PubMed  CAS  Google Scholar 

  22. Valette, G. et G. Raynaud, 1963. Action des dérivés de la phénothiazine sur la crise audiogène de la souris. In: R.G. Busnel (Ed.), Psychophysiologie, Neuropharmacologie et Biochimie de la crise audiogene, Editions du C.N.R.S., Paris, pp. 311–324.

    Google Scholar 

  23. Roberts, E., C.F. Baxter and E. Eidelberg, 1960. Some aspects of cerebral metabolism and physiology of gamma-amino-butyric acid. In : D.B. Tower and J.P. Schade (Eds), Structure and function of the cerebral cortex, Elsevier, Amsterdam, pp. 392–404.

    Google Scholar 

  24. Kravitz, E.A., S.W. Kuffler and D.D. Potter, 1963. Gamma-amino-butyric acid and other blocking compound in Crustacea. III — Their relative concentrations in separated motor and inhibitory axons. Journal Neurophysiology 26:739–751.

    CAS  Google Scholar 

  25. Balzer, A., P. Holtz und D. Palm, 1960. Untersuchen über die biochemischen Grundlagen der Konvulsiven Wirkung von Hydraziden. Naunyn-Schmiedberg’s Archive für Experimentelle Pathologie und Pharmakologie (Berlin) 239:550–552.

    Google Scholar 

  26. Buchel, L., A. Debay, J. Levy et O. Tanguy, 1961. Conditions de la sensibilisation des Rongeurs, par des hydrazides, a la crise convulsive audiogene. Etude des substances protectrices. Therapie 16:729–742.

    PubMed  CAS  Google Scholar 

  27. Lehmann, A., 1963. Action des hydrazides convulsivants sur l’épilepsie acoustique dite crise audiogène de la souris. Journal de Physiologie (Paris) 55:282–283.

    CAS  Google Scholar 

  28. Ballantine, E., 1963. The effect of gamma-amino-butyric acid on audiogenic seizures. In : R.G. Bushnel (Ed.), Psychophysiologie, Neuropharmacologie et Biochimie de la crise audiogene, Editions du Ç.N.R.S., Paris, pp. 447–450.

    Google Scholar 

  29. Ginsburg, B.E., 1963. Causal mechanisms in audiogenic seizures. In : R.G. Busnel (Ed.), Psychophysiologie, Neuropharmacologie et Biochimie de la crise audiogene, Editions du C.N.R.S., Paris, pp. 228–237.

    Google Scholar 

  30. Lehmann, A., 1963. L’acide gamma-amino-butyrique est-il un inhibiteur du système nerveux central. Convulsions et acide gamma-amino-butyrique. Therapie 18:1509–1523.

    PubMed  CAS  Google Scholar 

  31. Trifaro, J.M., E. Mikulio, H. Armendariz and V.G. Foglia, 1964. Accion del Acido gamma Aminobutirico (GABA) y de la Hidroxilamina sobre las convulsiones audiogenas del Raton. Acta Physiologica Latino-Americana 14:315–323.

    PubMed  CAS  Google Scholar 

  32. Schlesinger, K., W. Boggan and D.X. Freedman, 1968. Genetic of audiogenic seizures. II-Effects of pharmacological manipulation of brain serotonin, norepinephrine and gamma amino butyric acid. Life Sciences 7, Part I :437–447.

    Article  PubMed  CAS  Google Scholar 

  33. Simler, S., H. Randrianarisoa et A. Lehmann, 1968. Effets du di-n-propyl-acetate sur les crises audiogenes de la souris. Journal de Physiologie (Paris) 60, Suppl. 2:547.

    Google Scholar 

  34. Lehmann, A., S. Simler et P. Mandel, 1967. Protection contre les crises audiogenes de la souris par la nicotinamide. Journal de Physiologie (Paris) 59:446–447.

    CAS  Google Scholar 

  35. Mitchell, J.F. and V. Srinivasan, 1969. Release of 3H-gamma aminobutyric acid from the brain during synaptic inhibition. Nature 224:663–666.

    Article  CAS  Google Scholar 

  36. Ginsburg, B.E., S. Ross, M.J. Zamis and A. Perkins, 1950. An assay method for the behavioral effect of L-glutamic acid. Science 112:12–13.

    Article  PubMed  CAS  Google Scholar 

  37. Ginsburg, B.E., S. Ross, M.J. Zamis and A. Perkins, 1951. Some effect of 1(+) glutamic acid on sound induced seizures in mice. Journal of Comparative and Physiological Psychology 44:134–141.

    Article  PubMed  CAS  Google Scholar 

  38. Ginsburg, B.E. and E. Roberts, 1951. Glutamic acid and central nervous system activity. Anatomical Record 111:492–493.

    Google Scholar 

  39. Ginsburg, B.E. and J.L. Fuller, 1954. A comparison of chemical and mechanical alterations of seizure patterns in mice. Journal of Comparative and Physiological Psychology 47:344–348.

    Article  PubMed  CAS  Google Scholar 

  40. Miller, D.S., B.E. Ginsburg and M.Z. Potas, 1955. The effect of glutamine and glutamic acid on audiogenic seizures in mice. Anatomical Record 122:438.

    Google Scholar 

  41. Iversen, L.L., 1967. The uptake and storage of noradrenaline in sympathetic nerves, University Press, Cambridge.

    Google Scholar 

  42. Page, I.H., 1958. Serotonin. Year Book Medical Publisher, Inc., Chicago.

    Google Scholar 

  43. Lehmann, A. et R.G. Busnel, 1963. Le métabolisme de la Sérotonine cérébrale dans ses rapports avec la crise audio-gène de la souris et ses variations sous 1Tinfluence de divers composés psychotropes. In : R.G. Busnel (Ed.), Psychophysiologie, Neuropharmacologie et Biochimie de la crise audiogène, Editions du C.N.R.S., Paris, pp. 453–468.

    Google Scholar 

  44. Langer, S.Z., 1962. Convulsiones audiogenas. Thesis, Buenos-Aires.

    Google Scholar 

  45. Langer, S.Z., R. Epstein and V.G. Foglia, 1962. Comparacion de las acciones de la reserpina y la guanetidina sobre las convulsiones audiogenas. Revista de la Sociedad Argentina de Biologie (Buenos Aires) 38:45–49.

    CAS  Google Scholar 

  46. Trifaro, J.M., S.Z. Langer, A. Gallo and V.G. Foglia, 1962. Estudio Farmacodinamico de las Respuestas Audiogenas mortales en el Raton. Actas de las II sesiones de Biologia, Univ. Nac. Cordoba, Argentina, p. 97.

    Google Scholar 

  47. Bielec, S. 1959. Influence of reserpine on the behavior of mice susceptible to audiogenic seizures. Archives Internationales de Pharmacodynamie et de Therapie 119:352–357.

    PubMed  CAS  Google Scholar 

  48. Lehmann, A., 1964. Contribution à l’étude psychophysiologique et neuropharmacologique de l’épilepsie acoustique de la Souris et du Rat. Ph.D. Thesis, Agressologie 5:211–221 et 311–347.

    CAS  Google Scholar 

  49. Busnel, R.G. et A. Lehmann, 1960. Nouvelles données pharma-codynamiques relatives a la crise audiogène de la Souris. Journal de Physiologie (Paris) 52:37–38.

    CAS  Google Scholar 

  50. Lehmann, A., 1968. Modification de l’intensité de la crise audiogene par des substances actives sur le métabolisme des amines biogènes du cerveau de souris. Compte Rendu Société Biologie (Paris) 162:24–27.

    CAS  Google Scholar 

  51. Lehmann, A., 1965. Rapports entre le taux cérébral de noradrénaline et la léthalité au cours de la crise d’épilepsie acoustique de la Souris. Journal de Physiologie (Paris) 57: 646–647.

    Google Scholar 

  52. Lehmann, A., 1969. Relationship between sympathetic ganglion activity and audiogenic seizure in mice. Life Sciences (in press).

    Google Scholar 

  53. Golberg, L.I., 1964. Monoamine Oxidase Inhibitors — Adverse reactions and possible mechanisms. Journal American Medical Association 190:456–462.

    Article  Google Scholar 

  54. Lehmann, A. and R.G. Busnel, 1962. A new test for detecting MAO-inhibitor effects. International Journal of Neuropharmacology 1:61–70.

    Article  CAS  Google Scholar 

  55. Plotnikoff, N.P., J. Huang and P. Havens, 1963. Effect of monoamine-oxidase inhibitors on audiogenic seizures. Journal of Pharmaceutical Science 52:172–173.

    Article  CAS  Google Scholar 

  56. Langer, S.Z., J.M. Trifaro, A. Gallo and V.G. Foglia, 1962. Estudio comparativo de las acciones de la feniprazine y el imipramine sobre las convulsiones audiogenas. Revista de la Sociedad Argentina de Biologia (Buenos Aires) 38:84–89.

    CAS  Google Scholar 

  57. Lehmann, A., 1967. Audiogenic seizures data in mice, supporting new theories of biogenic amines mechanisms in the central nervous system. Life Sciences 6, pt. I : 1423–1431.

    Article  PubMed  CAS  Google Scholar 

  58. Le Douarec, J.C., H. Schmitt et M. Laubie, 1966. Etude pharmacologique de la fenfluramine et de ses isomeres optiques. Archives Internationales de Pharmacodynamie et de Therapie 161:206–232.

    PubMed  Google Scholar 

  59. Frings, H. and A. Kivert, 1953. Nicotine facilitation of audiogenic seizures in laboratory mice. Journal of Mammalogy 34:391–393.

    Google Scholar 

  60. Burn, J.H. and M.J. Rand, 1965. Acetylcholine in adrenergic transmission. Annual Review of Pharmacology 5:163–182.

    Article  CAS  Google Scholar 

  61. Lehmann, A., 1965. Action de crises répétées d’épilepsie acoustique sur le taux de noradrenaline des zones corticales et sous-corticales du cerveau de Souris. Compte Rendu Société Biologie (Paris) 159:62–64.

    Google Scholar 

  62. Welch, A. and B.L. Welch, 1968. Reduction of norepinephrine in the lower brainstem by psychological stimulus. Proceedings of the National Academy of Sciences, U.S.A., 60:478–481.

    Article  CAS  Google Scholar 

  63. Thierry, A.M., F. Javoy, J. Glowinski and S.S. Kety, 1968. Effects of stress on the metabolism of norepinephrine, dopamine and serotonin in the central nervous system of the rat. I-Modifications of norepinephrine turnover. Journal of Pharmacology and Experimental Therapeutics 163:163–171.

    PubMed  CAS  Google Scholar 

  64. Bliss, E.L. and J. Zwanziger, 1966. Brain amines and emotional stress. Journal of Psychiatric Research 4:189–198.

    Article  PubMed  CAS  Google Scholar 

  65. Leduc, J., 1961. Catecholamine production and release in exposure and acclimatation to cold. Acta Physiologie Scandinavia 53: Suppl. 183.

    Google Scholar 

  66. Oliviero, A. and L. Stjarne, 1965. Acceleration of noradrenaline turnover in the mouse heart by cold exposure. Life Sciences 4:2339–2343.

    Article  Google Scholar 

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Lehmann, A.G. (1970). Psychopharmacology of the Response to Noise, with Special Reference to Audiogenic Seizure in Mice. In: Welch, B.L., Welch, A.S. (eds) Physiological Effects of Noise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8807-4_19

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  • DOI: https://doi.org/10.1007/978-1-4684-8807-4_19

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