Abstract
Urine formation starts with ultrafiltration at the glomerulus. The ultrafiltrate is then subjected to osmotic effects and the influence of electropotential gradients as it passes through to the collecting ducts. Sodium is reabsorbed from at least three sites, the proximal convoluted tubule, the ascending limb of the loop of Henle, and the distal convoluted tubule. The purpose of diuretic therapy is to obtain sodium and water loss, and the various drugs in clinical use interfere with sodium reabsorption and conservation at one or more of these sites in the nephron.
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© 1976 Plenum Press, New York
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Dall, J.L.C. (1976). Diuretics. In: Caird, F.I., Dall, J.L.C., Kennedy, R.D. (eds) Cardiology in Old Age. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8777-4_14
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DOI: https://doi.org/10.1007/978-1-4615-8777-4_14
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