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Analgesia Produced by Stimulation of the Periaqueductal Gray Matter: True Antinoceptive Effects Versus Stress Effects

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The Midbrain Periaqueductal Gray Matter

Part of the book series: NATO ASI Series ((NSSA,volume 213))

Abstract

Since Reynold’s initial report years ago (1969) revealed that during and after periaqueductal gray matter (PAG) stimulation rats could support severe, painful interventions such as laparotomies, the “stimulation produced analgesia phenomenon” (SPA) has been extensively studied in the rat, cat and monkey (see reviews in Liebeskind et al., 1976; Mayer and Price, 1976; Basbaum and Fields, 1978; Mayer, 1979; Besson et al., 1981; Basbaum and Fields, 1984; Olivéras and Besson, 1988). Furthermore, SPA from central gray (anatomically including the caudal periventricular hypothalamic region and the PAG) has been used to relieve severe intractable pain in human patients (Adams, 1976; Gybels et al., 1976; Hosobuchi et al., 1977; 1979; Richardson and Akil, 1977a,b). However, after an initial rush of enthusiasm by neurosurgical teams involved in this pain treatment, the use of central gray deep brain stimulation became controversial (Gybels et al., 1976; Meyerson, 1988). These controversies are justifiable in light of certain behavioral observations: the PAG and the central gray are complex regions involved in diverse functions and states including not only analgesia but also “intense emotion” (very unpleasant to intolerable sensations) when electrically stimulated in both human beings and animals.

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Authors and Affiliations

  1. Unité de Recherches de Physiopharmacologie du Système Nerveux de I’INSERM (U.161), Paris, France

    Jean-Marie Besson & Jean-Louis Olivéras

  2. Département de Biologie, Rhône-Poulenc-Santé Centre de Recherches de Vitry, Vitry-sur-Seine, France

    Véronique Fardin

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  1. Jean-Marie Besson
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  2. Véronique Fardin
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  3. Jean-Louis Olivéras
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  1. L.N.B.C, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67084, Strasbourg Cedex, France

    Antoine Depaulis

  2. Dept. of Anatomy, University of Sydney, 2006, Sydney, NSW, Australia

    Richard Bandler

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Besson, JM., Fardin, V., Olivéras, JL. (1991). Analgesia Produced by Stimulation of the Periaqueductal Gray Matter: True Antinoceptive Effects Versus Stress Effects. In: Depaulis, A., Bandler, R. (eds) The Midbrain Periaqueductal Gray Matter. NATO ASI Series, vol 213. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3302-3_8

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