Abstract
The two key features of developmental psychopathology (DP) concern the importance of continuities and discontinuities across the span of development and the span between normality and disorder (Rutter, 1988; Rutter & Sroufe, 2000; Sroufe & Rutter, 1984). Both, however, required a shift from what has been traditional in developmental psychology and in child psychiatry (Rutter, 2003). Thus, developmental psychology has tended to focus particularly on developmental universals and on trait continuities over time, whereas DP demands a focus on individual differences and on the growing psychological cohesion that may extend across traits and on the modifications and changes that derive from altered circumstances. Child psychiatry, on the other hand, has tended to concentrate on the causes and course of individual diagnostic conditions. Of course, these are important, but what is different about a DP perspective is that it is necessary to go on to pose questions such as those involving age-related variations in susceptibility to stress, the extent to which development of disorder is dependent on prior circumstances at an earlier age, the query as to whether there are points in development when psychological qualities become relatively stabilized, and the question as to why some psychopathological patterns become so much more common during adolescence than they had been in childhood. DP concepts emphasize that both continuities and discontinuities have to be considered and that a central concern has to involve determination of the mediating mechanisms involved in both change and stability.
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References
Academy of Medical Sciences. (2007). Identifying the environmental causes of disease: How should we decide what to believe and when to take action? London: Academy of Medical Sciences.
Amato, R., Pinelli, M., D’Andrea, D., Miele, G., Nicodemi, M., Raiconi, G., et al. (2010). A novel approach to simulate gene-environment interactions in complex diseases. BMC Bioinformatics, 11(8).
Arseneault, L., Cannon, M., Poulton, R., Murray, R., Caspi, A., & Moffitt, T. E. (2002). Cannabis use in adolescence and risk for adult psychosis: Longitudinal prospective study. British Journal of Psychiatry, 325, 1212–1213.
Ayhan, Y., Sawa, A., Ross, C. A., & Pletnikov, M. V. (2009). Animal models of gene-environment interactions in schizophrenia. Behavioural Brain Research, 204, 274–281.
Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers’ externalizing behavior in a randomized controlled trial. Developmental Psychology, 44, 293–300.
Barr, C. S., Newman, T. K., Shannon, C., Parker, C., Dvoskin, R. L., Becker, M. L., et al. (2004). Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biological Psychiatry, 55, 733–738.
Beach, S. R. H., Brody, G. H., Lei, M. K., & Philibert, R. A. (2010). Differential susceptibility to parenting among African American youths: Testing the DRD4 hypothesis. Journal of Family Psychology, 24, 513–521.
Belay, H., Burton, C. L., Lovic, V., Meaney, M. J., Sokolowski, M., & Fleming, A. S. (2011). Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats. Behavioral Neuroscience, 125, 150–160.
Belsky, J., & Beaver, K. M. (2011). Cumulative-genetic plasticity, parenting and adolescent self-regulation. Journal of Child Psychology and Psychiatry, 52, 619–626.
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885–908.
Ben-Efraim, Y. J., Wasserman, D., Wasserman, J., & Sokolowski, M. (2011). Gene–environment interactions between CRHR1 variants and physical assault in suicide attempts. Genes, Brain, and Behavior, 10, 663–672.
Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., et al. (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry, 7, 118–122.
Braungart, J. M., Plomin, R., DeFries, J. C., & Fulker, D. W. (1992). Genetic influence on tester-rated infant temperament as assessed by Bayley’s infant behavior record: Nonadoptive and adoptive siblings and twins. Developmental Psychology, 28, 40–47.
Brody, G. H., Beach, S. R. H., Philibert, R. A., Chen, Y., & Murry, V. M. B. (2009). Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: Gene × Environment hypotheses tested via a randomized prevention design. Child Development, 80, 645–661.
Buckholtz, J. W., & Meyer-Lindenberg, A. (2008). MAOA and the neurogenetic architecture of human aggression. Trends in Neurosciences, 31, 120–129.
Casadio, P., Fernandes, C., Murray, R. M., & Di Forti, M. (2011). Cannabis use in young people: The risk for schizophrenia. Neuroscience and Biobehavioral Reviews, 35, 1779–1787.
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509–527.
Caspi, A., Langley, K., Milne, B., Moffitt, T. E., O’Donovan, M., Owen, M. J., et al. (2008). A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 65, 203–210. doi:10.1001/archgenpsychiatry.2007.24.
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H. L., et al. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction. Biological Psychiatry, 57, 1117–1127.
Champoux, M., Bennett, A., Shannon, C., Higley, J. D., Lesch, K. P., & Suomi, S. J. (2002). Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Molecular Psychiatry, 7, 1058–1063.
Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2011). The effects of child maltreatment and polymorphisms of the serotonin transporter and dopamine D4 receptor genes on infant attachment and intervention efficacy. Development and Psychopathology, 23, 357–372.
D’Amato, F. R., Zanettini, C., Lampis, V., Coccurello, R., Pascucci, T., Ventura, R., et al. (2011). Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay. PLoS One, 6, e18637.
D’Onofrio, B. M., Hulle, C. A., Waldman, I. D., Rodgers, J. L., Harden, K. P., Rathouz, P. J., et al. (2008). Smoking during pregnancy and offspring externalizing problems: An exploration of genetic and environmental confounds. Development and Psychopathology, 20, 139–164.
Di Forti, M., Morgan, C., Dazzan, P., Pariante, C., Mondelli, V., Marques, T. R., et al. (2009). High-potency cannabis and the risk of psychosis. British Journal of Psychiatry, 195, 488–491.
Ding, B., Källberg, H., Klareskog, L., Padyukov, L., & Alfredsson, L. (2011). GEIRA: Gene-environment and gene–gene interaction research application. European Journal of Epidemiology, 26, 557–561.
Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168, 1041–1049.
Eaves, L. J., Prom, E. C., & Silberg, J. L. (2010). The mediating effect of parental neglect on adolescent and young adult anti-sociality: A longitudinal study of twins and their parents. Behavior Genetics, 40, 425–437.
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psychopathology, 23, 7–28.
Estrada, G., Fatjó-Vilas, M., Munoz, M. J., Pulido, G., Minano, M. J., Toledo, E., et al. (2011). Cannabis use and age at onset of psychosis: Further evidence of interaction with COMT Val158Met polymorphism. Acta Psychiatrica Scandinavica, 123, 485–492.
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A., & Kennedy, M. A. (2012). Moderating role of the MAOA genotype in antisocial behaviour. British Journal of Psychiatry, 200, 116–123.
Fergusson, D. M., Horwood, L. J., & Swain-Campbell, N. R. (2003). Cannabis dependence and psychotic symptoms in young people. Psychological Medicine, 33, 15–21.
Flint, J., Greenspan, R. J., & Kendler, K. S. (2010). How genes influence behavior. Oxford & New York: Oxford University Press.
Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., et al. (2004). Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738.
Foley, D. L., Neale, M. C., & Kendler, K. S. (1996). A longitudinal study of stressful life events assessed at interview with an epidemiological sample of adult twins: The basis of individual variation in event exposure. Psychological Medicine, 26, 1239–1252.
Ge, X., Conger, R. D., Cadoret, R. J., Neiderhiser, J. M., Yates, W., Troughton, E., et al. (1996). The developmental interface between nature and nurture: A mutual influence model of child antisocial behavior and parent behaviors. Developmental Psychology, 32, 574–589.
Gunnar, M. R., & Vazquez, D. M. (2001). Low cortisol and a flattening of expected daytime rhythm: Potential indices of risk in human development. Development and Psychopathology, 13, 515–538.
Gunnar, M. R., & Vazquez, D. M. (2006). Stress, neurobiology and developmental psychopathology. In D. Cicchetti & D. Cohen (Eds.), Developmental psychopathology (Vol. 2, pp. 533–577). New York: Wiley.
Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152.
Hariri, A. R., Drabant, E. M., & Weinberger, D. R. (2006). Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry, 59, 888–897.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400–403.
Harley, M., Kelleher, I., Clarke, M., Lynch, F., Arseneault, L., Connor, D., et al. (2010). Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. Psychological Medicine, 40, 1627–1634.
Harrison, P. J., & Weinberger, D. R. (2004). Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Molecular Psychiatry, 10, 40–68.
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., et al. (2004). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience, 8, 20–21.
Henquet, C., Krabbendam, L., Spauwen, J., Kaplan, C., Lieb, R., Wittchen, H. U., et al. (2005). Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. British Medical Journal, 330, 11.
Henquet, C., Rosa, A., Delespaul, P., Papiol, S., Faňanás, L., Van Os, J., et al. (2009). COMT Val158Met moderation of cannabis-induced psychosis: A momentary assessment study of ‘switching on’ hallucinations in the flow of daily life. Acta Psychiatrica Scandinavica, 119, 156–160.
Henquet, C., Rosa, A., Krabbendam, L., & Sergi Papiol, L. F. (2006). An experimental study of catechol-O-methyltransferase Val158Met moderation of Δ-9-tetrahydrocannabinol-induced effects on psychosis and cognition. Neuropsychopharmacology, 31, 2748–2757.
Huizinga, D., Haberstick, B. C., Smolen, A., Menard, S., Young, S. E., Corley, R. P., et al. (2006). Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype. Biological Psychiatry, 60, 677–683.
Hyde, L. W., Bogdan, R., & Hariri, A. R. (2011). Understanding risk for psychopathology through imaging gene-environment interactions. Trends in Cognitive Sciences, 15, 417–427.
Ioannidis, J. P. (2005). Differentiating biases from genuine heterogeneity: Distinguishing artefactual from substantive effects. In H. R. Rothstein, A. J. Sutton, & M. Borenstein (Eds.), Publication bias in meta-analysis: Prevention, assessment and adjustments (pp. 287–302). Sussex: Wiley.
Jedema, H. P., Gianaros, P. J., Greer, P. J., Kerr, D. D., Liu, S., Higley, J. D., et al. (2009). Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. Molecular Psychiatry, 15, 512–522.
Karere, G. M., Kinnally, E. L., Sanchez, J. N., Famula, T. R., Lyons, L. A., & Capitanio, J. P. (2009). What is an “adverse” environment? Interactions of rearing experiences and MAOA genotype in rhesus monkeys. Biological Psychiatry, 65, 770–777.
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444–454.
Kegel, C. A. T., Bus, A. G., & van IJzendoorn, M. H. (2011). Differential susceptibility in early literacy instruction through computer games: The role of the dopamine D4 receptor gene (DRD4). Mind, Brain, and Education, 5, 71–78.
Kendler, K. S. (1997). Social support: A genetic-epidemiologic analysis. American Journal of Psychiatry, 154, 1398–1404.
Kendler, K. S. (2005). “A gene for…”. The nature of gene action in psychiatric disorders. American Journal of Psychiatry, 162, 1243–1252.
Kendler, K. S., & Baker, J. H. (2007). Genetic influences on measures of the environment: A systematic review. Psychological Medicine, 37, 615–626.
Kendler, K. S., & Gardner, C. O. (2010). Dependent stressful life events and prior depressive episodes in the prediction of major depression: The problem of causal inference in psychiatric epidemiology. Archives of General Psychiatry, 67, 1120–1127.
Kendler, K. S., Jacobson, K., Myers, J. M., & Eaves, L. J. (2008). A genetically informative developmental study of the relationship between conduct disorder and peer deviance in males. Psychological Medicine, 38, 1001–1011.
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913.
Kinnally, E. L., Karere, G. M., Lyons, L. A., Mendoza, S. P., Mason, W. A., & Capitanio, J. P. (2010). Serotonin pathway gene–gene and gene–environment interactions influence behavioral stress response in infant rhesus macaques. Development and Psychopathology, 22, 35–44.
Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magnusson, G., et al. (2012). Rate of de novo mutations and the importance of father’s age to disease risk. Nature, 488, 471–475.
Kumsta, R., Rutter, M., Stevens, S., & Sonuga-Barke, E. J. (2010). IX. Risk, causation, mediation, and moderation. Monographs of the Society for Research in Child Development, 75(1), 187–211. doi:10.1111/j.1540-5834.2010.00556.x.
Lee, S. S. (2011). Deviant peer affiliation and antisocial behavior: Interaction with monoamine oxidase A (MAOA) genotype. Journal of Abnormal Child Psychology, 39, 321–332.
Lehr, T., Yuan, J., Zeumer, D., Jayadev, S., & Ritchie, M. D. (2011). Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies. BioData Mining, 4(4).
Loman, M. M., & Gunnar, M. R. (2010). Early experience and the development of stress reactivity and regulation in children. Neuroscience and Biobehavioral Reviews, 34, 867–876.
Meaney, M. J. (2010). Epigenetics and the biological definition of gene × environment interactions. Child Development, 81, 41–79.
Meier, M. H., Caspi, A., Ambler, A., Harrington, H. L., Houts, R., Keefe, R. S. E., et al. (2012). Persistent cannabis users show neuropsychological decline from childhood to midlife. Proceedings of the National Academy of Sciences, 109(40), E2657–E2664.
Mertins, V., Schote, A. B., Hoffeld, W., Griessmair, M., & Meyer, J. (2011). Genetic susceptibility for individual cooperation preferences: The role of monoamine oxidase A gene (MAOA) in the voluntary provision of public goods. PLoS One, 6(6), e20959.
Meyer-Lindenberg, A. (2011). Neurogenetic mechanisms of gene-environment interactions. In K. A. Dodge & M. Rutter (Eds.), Gene-environment interactions in developmental psychopathology (pp. 71–86). New York: Guilford Press.
Meyer-Lindenberg, A., & Weinberger, D. R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews. Neuroscience, 7, 818–827.
Mueller, B. R., & Bale, T. L. (2008). Sex-specific programming of offspring emotionality after stress early in pregnancy. The Journal of Neuroscience, 28, 9055–9065.
Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852–857.
Neiderhiser, J. M., Reiss, D., Pedersen, N. L., Lichtenstein, P., Spotts, E. L., Hansson, K., et al. (2004). Genetic and environmental influences on mothering of adolescents: A comparison of two samples. Developmental Psychology, 40, 335–351.
Nelson, E. E., Herman, K. N., Barrett, C. E., Noble, P. L., Wojteczko, K., Chisholm, K., et al. (2009). Adverse rearing experiences enhance responding to both aversive and rewarding stimuli in juvenile rhesus monkeys. Biological Psychiatry, 66, 702–704.
Newman, T. K., Syagailo, Y. V., Barr, C. S., Wendland, J. R., Champoux, M., Graessle, M., et al. (2005). Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biological Psychiatry, 57, 167–172.
Nikulina, V., Widom, C. S., & Brzustowicz, L. M. (2012). Child abuse and neglect, MAOA, and mental health outcomes: A prospective examination. Biological Psychiatry, 71, 350–357.
O’Connor, T. G., Deater-Deckard, K., Fulker, D., Rutter, M., & Plomin, R. (1998). Genotype–environment correlations in late childhood and early adolescence: Antisocial behavioral problems and coercive parenting. Developmental Psychology, 34, 970–981.
O’Tuathaigh, C. M. P., Hryniewiecka, M., Behan, A., Tighe, O., Coughlan, C., Desbonnet, L., et al. (2010). Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: Impact on psychosis-related and other phenotypes. Neuropsychopharmacology, 35, 2262–2273.
Obel, C., Olsen, J., Henriksen, T. B., Rodriguez, A., Järvelin, M. R., Moilanen, I., et al. (2011). Is maternal smoking during pregnancy a risk factor for hyperkinetic disorder? Findings from a sibling design. International Journal of Epidemiology, 40, 338–345.
Overbeek, G., Weeland, J., & Chhangur, R. (2012). Research on gene-environment interdependence: Honing the tools and examining the angles. European Journal of Developmental Psychology, 9, 413–418.
Pelayo-Terán, J. M., Pérez-Iglesias, R., Mata, I., Carrasco-Marín, E., Vázquez-Barquero, J. L., & Crespo-Facorro, B. (2010). Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: Clinical-onset implications. Psychiatry Research, 179, 291–296.
Peng, B. (2010). Simulating gene-environment interactions in complex human diseases. Genome Medicine, 2, 21.
Pistis, M., Perra, S., Pillolla, G., Melis, M., Muntoni, A. L., & Gessa, G. L. (2004). Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons. Biological Psychiatry, 56, 86–94.
Plomin, R., DeFries, J. C., & Fulker, D. W. (1988). Nature and nurture during infancy and early childhood. Cambridge: Cambridge University Press.
Plomin, R., DeFries, J. C., & Loehlin, J. C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309–322.
Prichard, Z., Mackinnon, A., Jorm, A. F., & Easteal, S. (2008). No evidence for interaction between MAOA and childhood adversity for antisocial behavior. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 147, 228–232.
Reichenberg, A., Gross, R., Kolevzon, A., & Susser, E. (2011). Parental and perinatal risk factors for autism. In E. Hollander, A. Kolevzon, & J. Coyle (Eds.), Textbook of autism spectrum disorders (pp. 239–246). Washington, DC: American Psychiatric Publishing Inc.
Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. Journal of the American Medical Association, 301, 2462–2471.
Robins, L. (1978). Sturdy childhood predictors of adult antisocial behaviour: Replications from longitudinal studies. Psychological Medicine, 8, 611–622.
Rutter, M. (1988). Epidemiological approaches to developmental psychopathology. Archives of General Psychiatry, 45, 486–495.
Rutter, M. (2003). Categories, dimensions, and the mental health of children and adolescents. Annals of New York Academy of Sciences, 1008, 11–21.
Rutter, M. (2006). Genes and behavior: Nature-nurture interplay explained. Oxford: Blackwell Scientific.
Rutter, M. (2007). Proceeding from observed correlation to causal inference: The use of natural experiments. Perspectives on Psychological Science, 2, 377–395.
Rutter, M. (2008). Developing concepts in developmental psychopathology. In J. J. Hudziak (Ed.), Developmental psychopathology and wellness: Genetic and environmental influences (pp. 3–22). Arlington: American Psychiatric Publishing Inc.
Rutter, M. (2012a). Gene-environment interdependence. European Journal of Developmental Psychology, 9, 391–412.
Rutter, M. (2012b). ‘Natural experiments’ as a means of testing causal inferences. In C. Barzini, P. Dawid, & L. Bernardinelli (Eds.), Causality: Statistical perspectives and applications (pp. 253–272). Chichester: Wiley.
Rutter, M. (2012c). Response to commentaries on discussion paper “gene-environment interdependence”. European Journal of Developmental Psychology, 9, 426–431.
Rutter, M. (2012d). Achievements and challenges in the biology of environmental effects. Proceedings of the National Academy of Sciences , 109, 17149–17153.
Rutter, M. (2013). Developmental psychopathology: A paradigm shift or just a relabeling? Development and Psychopathology (25th Edn.), 25, 1201–1213.
Rutter, M., Kumsta, R., Schlotz, W., & Sonuga-Barke, E. (2012). Longitudinal studies using a “natural experiment” design: The case of adoptees from Romanian institutions. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 762–770.
Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene-environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226–261.
Rutter, M., & Pickles, A. (1991). Person-environment interactions: Concepts, mechanisms, and implications for data analysis. In T. D. Wachs & R. Plomin (Eds.), Conceptualization and measurement of organism-environment interaction (pp. 105–141). Washington, DC: American Psychological Association.
Rutter, M., & Silberg, J. (2002). Gene-environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology, 53, 463–490.
Rutter, M., & Sonuga-Barke, E. J. (2010). Deprivation-specific psychological patterns: Effects of institutional deprivation. Monographs of the Society for Research in Child Development, 75(1).
Rutter, M., & Sroufe, L. A. (2000). Developmental psychopathology: Concepts and challenges. Development and Psychopathology, 12(3), 265–296.
Rutter, M., Thapar, A., & Pickles, A. (2009). Gene-environment interactions: Biologically valid pathway or artifact? Archives of General Psychiatry, 66, 1287–1289. doi:10.1001/archgenpsychiatry.2009.167.
Sandin, S., Hultman, C. M., Kolevzon, A., Gross, R., MacCabe, J. H., & Reichenberg, A. (2012). Advancing maternal age is associated with increasing risk for autism: A review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 477–486.
Schneider, M., & Koch, M. (2004). Deficient social and play behavior in juvenile and adult rats after neonatal cortical lesion: Effects of chronic pubertal cannabinoid treatment. Neuropsychopharmacology, 30, 944–957.
Sillaber, I., Holsboer, F., & Wotjak, C. T. (2009). Animal models of mood disorders. In D. S. Charney & E. J. Nestler (Eds.), Neurobiology of mental illness (3rd ed., pp. 378–391). New York: Oxford University Press.
Simons, R. L., Lei, M. K., Stewart, E. A., Beach, S. R. H., Brody, G. H., Philibert, R. A., et al. (2012). Social adversity, genetic variation, street code, and aggression. Youth Violence and Juvenile Justice, 10, 3–24.
Spinelli, S., Schwandt, M. L., Lindell, S. G., Newman, T. K., Heilig, M., Suomi, S. J., et al. (2007). Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. Development and Psychopathology, 19, 977–987.
Sroufe, L. A., & Rutter, M. (1984). The domain of developmental psychopathology. Child Development, 55, 17–29.
Sugden, K., Arseneault, L., Harrington, H. L., Moffitt, T. E., Williams, B., & Caspi, A. (2010). Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 830–840.
Taylor, A., & Kim-Cohen, J. (2007). Meta-analysis of gene-environment interactions in developmental psychopathology. Development and Psychopathology, 19, 1029–1037.
Thapar, A., Langley, K., Fowler, T., Rice, F., Turic, D., Whittinger, N., et al. (2005). Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 62, 1275–1278.
Thapar, A., Rice, F., Hay, D., Boivin, J., Langley, K., van den Bree, M., et al. (2009). Prenatal smoking might not cause attention-deficit/hyperactivity disorder: Evidence from a novel design. Biological Psychiatry, 66, 722–727. doi:10.1016/j.biopsych.2009.05.032.
Thapar, A., & Rutter, M. (2009). Do prenatal risk factors cause psychiatric disorder? Be wary of causal claims. British Journal of Psychiatry, 195, 100–101. doi:10.1192/bjp.bp.109.062828.
Uher, R. (2009). The role of genetic variation in the causation of mental illness: An evolution-informed framework. Molecular Psychiatry, 14, 1072–1082.
Uher, R., Caspi, A., Houts, R., Sugden, K., Williams, B., Poulton, R., et al. (2011). Serotonin transporter gene moderates childhood maltreatment’s effects on persistent but not single-episode depression: Replications and implications for resolving inconsistent results. Journal of Affective Disorders, 135, 56–65.
Uher, R., & McGuffin, P. (2009). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry, 15, 18–22.
van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Belsky, J., Beach, S., Brody, G., Dodge, K. A., et al. (2011). Gene-by-environment experiments: A new approach to finding the missing heritability. Nature Reviews Genetics, 12(12), 881.
van Os, J., Bak, M., Hanssen, M., Bijl, R. V., De Graaf, R., & Verdoux, H. (2002). Cannabis use and psychosis: A longitudinal population-based study. American Journal of Epidemiology, 156, 319–327.
van Os, J., & Poulton, R. (2008). Environmental vulnerability and genetic-environmental interactions. In H. J. Jackson & P. D. McGorry (Eds.), The recognition and management of early psychosis: A preventive approach (2nd ed., pp. 47–60). Cambridge: Cambridge University Press.
Wakefield, J., De Vocht, F., & Hung, R. J. (2010). Bayesian mixture modeling of gene-environment and gene-gene interactions. Genetic Epidemiology, 34, 16–25.
Zammit, S., Allebeck, P., Andreasson, S., Lundberg, I., & Lewis, G. (2002). Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: Historical cohort study. British Medical Journal, 325, 1199.
Zammit, S., Owen, M. J., Evans, J., Heron, J., & Lewis, G. (2011). Cannabis, COMT and psychotic experiences. British Journal of Psychiatry, 199, 380–385.
Zink, C. F., Tong, Y., Chen, Q., Bassett, D. S., Stein, J. L., & Meyer-Lindenberg, A. (2008). Know your place: Neural processing of social hierarchy in humans. Neuron, 58, 273–283.
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Rutter, M. (2014). Nature–Nurture Integration. In: Lewis, M., Rudolph, K. (eds) Handbook of Developmental Psychopathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9608-3_3
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