Abstract
Developmental disorders affecting intelligence and behavior are among the most mystifying diseases of humankind. This is because they are primarily caused by abnormalities in the development of the most complex human organ, the brain. Perhaps the reason so little is understood about mental retardation, autism, childhood schizophrenia, attention deficit disorder, specific learning disorders, and Tourette disorder is that very little is still understood about how a normal brain develops. The premise of this chapter is that the key to understand these illnesses is an understanding of the processes involved in neurodevelopment.
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References
Altman, J., & Bayer, S. A. (1985). Embryonic development of the rat cerebellum: 3. Regional differences in the time of origin, migration, and settling of purkinje cells. Journal of Comparative Neurology, 231, 42–65
Armstrong-James, M., & Fox, K. (1988). The physiology of developing cortical neurons. In A. Peters & E. Jones (Eds.), Cerebral cortex (pp. 237–272). New York: Plenum Press.
August, G. J., Steware, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children.British Journal of Psychiatry, 138, 416–422.
Barde, Y. A. (1989). Trophic factors and neuronal survival.Neuron, 2, 1525–1534.
Barth, P. G. (1987). Disorders of neuronal migration. Canadian Journal of Neurological Sciences, 14, 1–16.
Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism. Neurology, 35, 866–874.
Bayer, S. A., & Altman, J. (1987). Directions in neurogenetic gradients and patterns of anatomical connections in the telencephalon. Progress in Neurobiology, 29, 57–106.
Bemtson, G., & Torello, M. W. (1982). The paleocerebellum and the integration of behavioral function. Phys. Psych., 10, 2–12.
Blomquist, H. K., Gustavson, G. H., Nordendon, I., & Palsson-Strae, U. (1983). Fragile X syndrome in mildly mentally retarded children in a northern Swedish county: A prevalence study. Clinical Genetics, 24, 393–399.
Blomquist, H., Bohman, M., Edvinsson, S. O., Gillberg, C., Gustavson, H. K., Holmgren, G., & Wahlstrom, J. (1985). Frequency of the fragile X syndrome in infantile autism: A multicenter study. Clinical Genetics, 27, 113–117.
Bregman, B. S., Kunkel-Bagden, E., McAtee, M., & O’Neill, A. (1989). Extension of the critical period for developmental plasticity of the corticospinal pathway. Journal of Comparative Neurology, 282, 355–370.
Brummendorf, T, Wolff, J. M., Frank, R., & Rathjen, F. G. (1989). Neural recognition molecule Fll: Homology with fibronectin Type III and immunoglobulin Type C domains. Neuron, 2, 1351–1361.
Buck, C. A., & Horwitz, A. F. (1987). Integrin, a transmembrane glycoprotein complex mediating cell-substratum adhesion. Journal of Cell Science (Suppl.), 8, 231–250.
Campbell, M., Rosenbloom, S., Perry, R., George, A. E., Kricheff, I. I., Anderson, L., Small, A. M., & Jennings, S. J. (1982). Computerized axial tomography in young autistic children. American Journal of Psychiatry, 139(4), 510–512.
Carpenter, M. B. (1978). Core text of neuroanatomy (2nd ed.). Baltimore: Williams & Wilkins.
Caviness, V. S. J., & Rakic, P. (1978). Mechanisms of cortical development: A view from mutations in mice. Annual Review of Neuroscience, 1, 49–89.
Caviness, V. S. J., Crandall, J. E., & Edwards, M. A. (1988). The reeler malformation: Implications for neocortical histogenesis. In A. Peters, & E. G. Jones (Eds.), Cerebral cortex (pp. 59–90). New York: Plenum Press.
Chess, S. (1977). Report on autism in congenital rubella. Journal of Autism and Childhood Schizophrenia, 7, 68–81.
Chow, C. W., Halliday, J. L., Anderson, R. M., Danks, D. M., & Fortune, D. W. (1985). Congenital absence of pyramids and its significance in genetic diseases. Acta Neuropathologica, 65, 313–317.
Ciaranello, R. D., VandenBerg, S. R., & Anders, T. F. (1982). Intrinsic and extrinsic determinants of neuronal development: Relations to infantile autism. Journal of Autism and Developmental Disorders, 12 (2), 115–146.
Code, R. A., & Winer, J. A. (1986). Columnar organization and reciprocity of commissural connections in cat primary auditory cortex (Al). Hearing Research, 23, 205–222.
Cohen, D. J., Caparulo, B. K., Shaywitz, B. J., & Bowers, M. B. (1977). Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. Archives of General Psychiatry, 34, 545–550.
Cohen, M., Campbell, R., & Yaghmai, F. (1989). Neuropathological abnormalities in developmental dysphasia. Annals of Neurology, 25, 567–570.
Coleman, P. D., Romano, J., Laphan, L., & Simon, W. (1985). Cell counts in cerebral cortex of an autistic patient. Journal of Autism and Developmental Disorders, 15, 245–255.
Comings, D. E. (1986). The genetics of Rett syndrome: The consequences of a disorder where every case is a new mutation. American Journal of Medical Genetics, 24, 383–388.
Courchesne, E. (1987). A neurophysiological view of autism. In E. Schopler & G. B. Mexibov (Eds.), Neurobiological issues in autism (pp.285–324). New York: Plenum Press.
Courchesne, E. Kilman, B. A., Galambos, R., & Lincoln, A. J. (1984). Autism: Processing of novel auditory information assessed by event-related brain potentials. Electroencephalography and Clinical Neurophysiology, 59, 238–248.
Courchesne, D., Lincoln, A. J., Kilman, B. A., & Galambos, R. (1985). Event-related brain potential correlates of the processing of novel visual and auditory information in autism. Journal of Autism and Developmental Disorders, 15, 55–76.
Courchesne, E., Yeung-Courchesne, R., Press, R. A., Hesselink, J. R., & Jernigan, T. L. (1988). Hypoplasia of cerebellar vermal lobules VI and VII in autism. New England Journal of Medicine, 318, 1349–1353.
Creasey, H., Rumsey, J. M., Schwartz, M., Dura, R., Rapport, J. L., & Rapport, S. I. (1986). Brain morphometry in autistic men as measurd by volumetric computed tomography. Archives of Neurology, 43, 669–672.
Damasio, J., Maurer, R. F., Damasio, A. R., & Chui, H. C. (1980). Computerized tomographic scan findings in patients with autistic behavior. Archives of Neurology, 37, 504–510.
Dawson, G., Warrenburg, S., & Fuller, P. (1982). Cerebral lateralization in individuals diagnosed as autistic in early childhood. Brain and Language, 15, 353–368.
Dawson, G., Warrenburg, S., & Fuller, P. (1983). Hemisphere functioning and motor imitation in autistic persons. Brain and Cognition, 2, 346–354.
Dawson, G., Finley, C., Phillips, S., & Galpert, L. (1986). Hemispheric specialization and the language abilities of autistic children.Child Development, 57, 1440–1453.
Desmond, M. M., Wüson, G. S., Melnick, J. L., Singer, D. B., Zion, T. E., Rudolph, A. J., Pineda, R. F., Ziai, M., & Blattner, R. J. (1967). Congenital rubella encephalitis: Course and early sequelae. Journal of Pediatrics, 71(3), 311–331.
Dodd, J., & Jessell, T. M. (1988). Axon guidance and the patterning of neuronal projections in vertebrates. Science, 242, 692–699.
Doe, C. Q., & Scott, M. P. (1988). Segmentation and homeotic gene function in the developing nervous system of Drosophila. Trends in Neuroscience, 11, 101–106.
Doe, C. Q., Kuwada, J. Y., & Goodman, C. S. (1985). From epithelium to neuroblasts: The role of cell interactions and cell lineage during insect neurogenesis. Philosophical Transactions of the Royal Society, 312, 67–81.
Doe, C. Q., Hiromi, Y., Gehring, W. J., & Goodman, C. S. (1988). Expression and function of the gene fushi tarazu during Drosophila neurogenesis. Science, 239, 170–175.
Duane, D. D. (1989). Neurobiologie correlates of learning disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 314–318.
Edelman, G. M. (1988). Morphoregulatory molecules. Biochemistry, 27, 3533–3543.
Ellenberger, C. J., Hanaway, J., & Netsky, M. G. (1969). Embryogenesis of the inferior olivary nucleus in the rat: A radiographic study and re-evaluation of the rhombic lip. Journal of Comparative Neurology, 137, 71–88.
Elliott, G. R., & Ciaranello, R. D. (1987). Neurochemical hypotheses of childhood psychoses. In E. Schopler & G. B. Mesibov (Eds.), Neurobiological issues in autism (pp. 245–261). New York: Plenum Press.
Folstein, S. E., & Rutter, M. L. (1988). Autism: familial aggregation and genetic implications. Journal of Autism and Developmental Disorders, 18(1), 3–30.
Freeman, B. J., Ritvo, E., Mason-Brothers, A., Pingree, C., Yokata, A., Jenson, W. R., McMahon, W. M., Petersen, P. B., Mo, A., & Schroth, P. (1989). Psychometric assessment of first-degree relatives of 62 autistic probands in Utah. American Journal of Psychiatry, 146(3), 361–364.
Friedman, E. (1969). The “autistic syndrome” and phenylketonuria.Schizophrenia, 1, 249–261.
Frost, D. O., & Metin, C. (1985). Induction of functional retinal projections to the somatosensory system. American Journal of Diseases in Children, 141, 1330–1332.
Gaffney, G. R., Tsai, L. Y, Kuperman, S., & Minchin, S. (1987). Cerebellar structure in autism. American Journal of Diseases in Children, 141, 1330–1332.
Gaffney, G. R., Kuperman, S., Tsai, L. Y, & Minchin, S. (1989). Forebrain structure in infantile autism. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 534–537.
Galaburda, A. M., & Kemper, T. L. (1979). Cytoarchitectonic abnormalities in developmental dyslexia: A case report. Annals of Neurology, 6, 94–100.
Geschwind, N., & Galaburda, A. M. (1985). Cerebral lateralization: Biological mechanism, associations and pathology. A hypothesis and a program for research. Archives of Neurology, 42, 428–459.
Gillberg, C., & Wahlstrom, J. (1985). Chromosome abnormalities in infantile autism and other childhood psychoses: A population study of 66 cases. Developmental Medicine and Child Neurology, 27, 293–304.
Gillberg, C., Persson, E., & Wahlstrom, J. (1986). The autism-fragüe X syndrome (AFRAX): A population-based study of ten boys. Journal of Mental Deficiency Research, 30, 27–39.
Gillberg, C., Ohlson, V., Wahlstrom, J., Steffenburg, S., & Blix, K. (1988). Monozygotic female twins with autism and the fragile-X syndrome (AFRAX). Journal of Child Psychology and Psychiatry, 29(4), 447–451.
Goffinet, A. M. (1983). The embryonic development of the cerebellum in normal and reeler mutant mice. Anatomical Embryology, 168, 73–86.
Goldfine, P. E., McPherson, P. J., Heath, G. A., Hardesty, V. A., Beauregard, L. J., & Gordon, B. (1985). Association of fragile X syndrome with autism. American Journal of Psychiatry, 142(1), 108–110.
Goldman, P. S., & Nauta, W. J. H. (1977). Columnar distribution of cortico-cortical fibers in the fronal association, limbic, and motor cortex of the developing rhesus monkey. Brain Research, 122, 369–413.
Guillery, R. (1974). Visual pathways in albinos. Scientific American, 230 (5), 44–54.
Guillery, R., Ombrellaro, M., & LaMantia, A. (1985). The organization of the lateral geniculate nucleus and of the geniculocortical pathway that develops without retinal af-ferents. Developmental Brain Research, 20, 221–233.
Hagberg, G., Aicardi, J., Dias, K., & Ramos, O. (1983). A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett’s syndrome: Report of 35 cases. Annals of Neurology, 14, 471–470.
Hahn, W. E., Chaudari, N., Sikela, J., & Owens, G. (1986). Messenger RNA and the brain. In A. Guiditta, B. B. Kaplan, & C. Zomzely-Neurath (Eds.), Role of RNA and DNA in brain function (pp. 10–22). Boston: Nijhoff.
Harlow, H. F., & Harlow, M. K. (1973). Social deprivation in monkeys. In Readings from Scientific American (pp. 108–116). San Francisco: W. H. Freeman.
Harrelson, A. L., & Goodman, C. S. (1988). Growth cone guidance in insects: Fasciclin II is a member of the immunoglobulin superfamily. Science, 242, 700–708.
Harris, W. A. (1989). Local positional cues in the neuroepithelium guide retinal axons in embryonic Xenopus brain. Nature, 339, 218–221.
He, X., Treacy, M. N., Simmons, D. M., Ingraham, H. A., Swanson, L. W., & Rosenfeld, M. G. (1989). Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature, 340, 35–42.
Heath, R., Franklin, D., & Shraberg, D. (1979). Gross pathology of the cerebellum in patients diagnosed and treated as functional psychiatric disorders. Journal of Nervous and Mental Diseases, 167, 585–592.
Heh, C. W., Smith, R., Wu, J., Hazlett, E., Russel, A., Asamow, R., Tanguay, P., & Buchsbaum, M. S. (1989). Positron emission tomography of the cerebellum in autism. American Journal of Psychiatry, 146(2), 242–245.
Henry, E. W., & Sidman, R. L. (1988). Long lives for homozygous trembler mutant mice despite virtual absence of peripheral nerve myelin. Science, 241, 344–346.
Herbst, D. S., & Miller, J. J. (1980). Nonspecific X-linked mental retardation: 2. The frequency in British Columbia.American Journal of Medical Genetics, 7, 461–469.
Hoffman, W. L., & Prior, M. R. (1982). Neuropsychological dimensions of autism in children: A test of the hemispheric dysfunction hypothesis. Journal of Clinical Neuropsychology, 4, 27–41.
Hori, A. (1988). Abnormal course of spinal posterior roots and tracts associated with brain malformations. Acta Neuropathologica, 75, 637–639.
Hubel, D. H. (1988). Eye, brain and vision. New York: W. H. Freeman.
Huether, G., Neuhoff, V., & Kaus, R. (1983). Brain development in experimental hyperphenylalaninaemia: Disturbed proliferation and reduced cell numbers in the cerebellum. Neuropediatrics, 14, 12–19.
Hütt, C., Forrest, S. J., & Richer, J. (1975). Cardiac arrythmia and behavior in autistic children. Acta Psychiatrica Scandinavica, 51, 361–372.
Issac, M., & Best, P. (1987). Two cases of agenesis of the vermis of the cerebellum, with fusion of the dentate nuclei and cerebellar hemispheres. Acta Neuropathologica, 74, 278–280.
James, A. L., & Barry, R. J. (1980). Respiratory and vascular responses to simple visual stimuli in autistics, retardates and normals. Psychophysiology, 17, 541–547.
James, A. L., & Barry, R. J. (1983). Developmental effects in the cerebral lateralization of autistic, retarded and normal children. Journal of Autism and Developmental Disorders, 13, 43–54.
Jellinger, K., Armstrong, D., Zoghbi, H. Y., & Percy, A. K. (1988). Neuropathology of Rett syndrome. Acta Neuropathologica, 76, 142–158.
Jensen, K. F., & Killackey, H. P. (1984). Subcortical projections from ectopic neocortical neurons. Proceedings of the National Academy of Sciences, 81, 964–968.
Jeret, J. S., Serur, M. S., Wisniewski, K. E., & Lubin, R. A. (1987). Clinicopathological findings associated with agenesis of the corpus callosum.Brain and Development, 9, 255–261.
Jiminez, F. (1988). Genetic control of neuronal differentiation in insects. Trends in Neurological Sciences, 11, 378–380.
Jones, D. G. (1988). Influence of ethanol on neuronal and synaptic maturation in the central nervous system: Morphological investigations. Progress in Neurobiology, 31, 171–197.
Jones, E. G., Burton, H., & Porter, R. (1975). Commissural and corticocortical columns in the somatic sensory cortex of primates. Science, 190, 572–574.
Joubert, M., Eisenring, J. J., Robb, J. P., & Andermann, F. (1969). Familial agenesis of the cerebellar vermis: A syndrome of episodic hyperpnea, abnormal eye movements, ataxia and mental retardation. Neurology, 19, 813–825.
Kanner, L. (1943). Autistic disturbances of affective contact. Nerv. Child, 2, 217–250.
Kinney, H. C., Brody, B. A., Kloman, A. S., & Güles, F. H. (1988). Sequence of central nervous system myelination in human infancy: 2. Patterns of myelination in autopsied infants. Journal of Neuropathology and Experimental Neurology, 47, 217–234.
Kuffler, S. W., Nicholls, J. G., & Martin, A. R. (1984). From neuron to brain. Sunderland, MA: Sinauer.
Lake, C. R., Ziegler, M. G., & Murphy, D. L. (1977). Increased norepinephrine levels and decreased dopamine ß-hydroxylase activity in primary autism. Archives of General Psychiatry, 34, 553–566.
Lamouroux, A., Vigny, A., Faucon-Biquet, N., Darmon, M. C., Franck, R., Henry, J. P., & Mallet, J. (1988). The primary structure of human dopamine ß-hydroxylase: Insights into the relationship between the soluble and the membrane-bound forms of the enzyme. European Molecular Biology Journal, 6, 3921–3937.
Lemire, R. K., Loeser, J. D., Leech, R. W., & Alvord, E. C. (1975). Normal and abnormal development of the human nervous system. Hagerstown, MD: Harper & Row.
Livingstone, M., & Hubel, D. (1988). Segregation of form, color, movement and depth: Anatomy, physiology and perception. Science, 240, 740–749.
Lowe, T. L., Tanaka, K., Seashore, M. R., Young, J. G., & Cohen, D. J. (1980). Detection of phenylketonuria in autistic and psychotic children. Journal of the American Medical Association, 243(2), 126–128.
Lubs, H. A. (1968). A marker X chromosome. American Journal of Human Genetics, 21, 231–244.
Lumsden, A., & Keynes, R. (1989). Segmental patterns of neuronal development in the chick hindbrain. Nature, 337, 424–428.
Luskin, M. B., Pearlman, A. L., & Sanes, J. R. (1988). Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a recombinant retrovirus. Neuron, 1, 635–647.
Mabry, C. C., Denniston, J. C., Nelson, T. L., & Son, C. D. (1963). Maternal phenylketonuria. The New England Journal of Medicine, 269, 1404–1408.
MacCulloch, M. J., & Williams, C. (1971). On the nature of infantile autism. Acta Psychi-atrica Scandinavica, 47, 295–314.
Machado-Salas, J. P. (1984). Abnormal dendritic patterns and aberrant spine development in Boumeville’s disease: A Golgi study. Clinical Neuropathology, 3, 52–58.
Maeda, N., Niiobe, M., Inoue, Y., & Mikoshiba, K. (1989). Developmental expression and intracellular localization of P400 protein characteristic of Purkinje cells in the mouse cerebellum. Developmental Biology, 133, 67–76.
Marin-Padilla, M. (1988). Early ontogenesis of the human cerebral cortex. In A. Peters & E. G. Jones (Eds.), Cerebral cortex (pp. 1–34). New York: Plenum Press.
Martin, J. P., & Bell, J. A. (1943). A pedigree of mental defect showing sex-linkage. Journal of Neurology and Psychiatry, 6, 154–157.
McConnell, S. K. (1988). Development and decision-making in the mammalian cerebral cortex. Brain Research Reviews, 13, 1–23.
McGillvray, B. C., Herbst, D. S., Dill, F. J., Sandercock, H. J., & Tischler, B. (1986). Infantile autism: An occasional manifestation of fragile X mental retardation. American Journal of Medical Genetics, 23, 353–358.
Mesulam, M. M. (1986). Patterns in behavioral neuroanatomy: Association areas, the limbic system, and hemispheric specialization. In M. M. Mesulam (Ed.), Principles of behavioral neurology. Philadelphia: F. A. Davis.
Michel, A. E., & Carey, L. J. (1984). The development of dendritic spines in the human visual cortex. Human Neurobiology, 3, 223–227.
Minton, J., Campbell, M., Creen, W. H., Jennings, S., & Samit, C. (1982). Cognitive assessment of siblings of autistic children. Journal of the American Academy of Child Psychiatry, 21(3), 256–261.
Moore, K. L. (1977). The developing human (2nd ed.). Philadelphia: W. B. Saunders.
Morriss-Kay, G., & Tuckett, F. (1987). Fluidity of the neural epithelium during forebrain formation in rat embryos.Journal of Cell Science (Suppl), 8, 433–449.
Mountcastie, V. B. (1957). Modality and topographic properties of single neurons of cat’s somatic sensory cortex. Journal of Neurophysiology, 20, 408–434.
Murakami, J. W., Courchesne, E., Press, G. A., Yeung-Courchesne, R., & Hesselink, R. (1989). Reduced cerebellar hemisphere size and its relationship to vermal hypolasia in autism.Archives of Neurology, 46, 689–694.
Naidu, S., Kitt, C. A., Wong, D. F., Price, D. L., Troncoso, J. C., & Moser, H. W. (1988). Research on Rett syndrome: Strategy and preliminary results. Journal of Child Neurology, 3(Suppl.), S78-S86.
Nikolic, I., & Kostovis, K. (1986). Development of the lateral amygdaloid nucleus in the human fetus: Transient presence of discrete cytoarchitectonic units. Anatomical Embryology, 174, 355–360.
Noguchi, T. (1988). Brain development in dwarf mice. Progress in Neurobiology, 31, 149–170.
Novick, B., Kurtsberg, D., & Vaughan, H. G. (1979). An electrophysiologic indication of defective information storage in childhood autism. Psychiatry Research, 1, 101–108.
Novick, B., Vaughan, H. G., Kurtsberg, D., & Simon, R. (1980). An electrophysiologic indication of auditory processing defects in autism.Psychiatry Research, 3, 107–114.
Ogawa, T, Baba, C., Nadashita, Y, & Hiramatsu, K. (1979). The ontogeny of functional asymmetry of EEC in preterm infants (in Japanese).No To Shindwi, 31, 1105–1110.
Ornitz, E. M. (1985). Neurophysiology of infantile autism. Journal of the American Academy of Child Psychiatry, 24(3), 251–262.
Ornitz, E. M. (1989). Autism: At the interface between sensory and information processing. In G. Dawson (Ed.), Autism: Nature, diagnosis and treatment (pp. 174–207). New York: Guilford Press.
Papadimitriou, J. M., Hockey, A., Tan, N., & Masters, C. L. (1988). Abnormal membranebound lamellated inclusions in neurons and Oligodendroglia. American Journal of Medical Genetics, 29, 365–368.
Parnavelas, J. G., Papadopoulos, G. C., & Cavanagh, M. E. (1988). Changes in neurotransmitters during development. In A. Peters & E. G. Jones (Eds.), Cerebral cortex. New York: Plenum Press.
Popko, B., Puckett, C., Lai, E., Shine, H. D., Readhead, C., Takahashi, N., Hunt, S. W III., Sidman, R. L., & Hood, L. (1987). Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin. Cell, 48, 713–721.
Prior, M. R., Tress, B., Hoffman, W. L., & Boldt, D. (1984). Computed tomographic study of children with classic autism. Archives of Neurology, 41, 482–484.
Purpura, D. P. (1975). Dendritic differentiation in human cerebral cortex: Normal and aberrant developmental patterns. In G. W. Kretuzberg (Ed.), Physiology and pathology of dendrites (pp. 91–116). New York: Raven Press.
Purves, D., & Lichtman, J. W. (1985). Principles of neural development. Sunderland, MA: Sinauer.
Rakic, P. (1972). Mode of cell migration to the superficial layers of fetal monkey neocortex. Journal of Comparative Neurology, 145, 61–84.
Rakic, P. (1977). Prenatal development of the visual system of the rhesus monkey. Philosophical Transactions of the Royal Society, 278, 245–260.
Rakic, P. (1988). Specification of cerebral cortical areas. Science, 241, 170–176.
Reiss, A. L., Patel, S., Kumar, A. J., & Freund, L. (1988). Preliminary communication: Neuroanatomical variations of the posterior fossa in men with frame X (Martin-Bell) syndrome.American Journal of Medical Genetics, 31, 407–414.
Rimland, B. (1964). Infantile autism. New York: Appleton-Century-Crofts.
Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 46 pairs of afflicted twins. American Journal of Psychiatry, 142, 74–77.
Ritvo, E. R., Freeman, B. J., Schiebel, A. B., Duong, T., Robinson, H., Guthrie, D., & Ritvo, A. (1986). Lower Purkinje cell counts in the cerebellum of four autistic subjects: Initial findings of the UCLA-NSAC autopsy research report. American Journal of Psychiatry, 143(7), 862–866.
Roessmann, U., & Hori, A. (1985). Agyria (lissencephaly) with anomalous pyramidal crossing. Journal of Neurological Science, 69, 357–364.
Rudelli, R. D., Brown, W. T., Wisniewski, K., Jenkins, E. C., Laure-Kamionowska, M., Connell, R., & Wisniewski, H. M. (1985). Adult fragile X syndrome: Clinico-neuropathologic findings. Acta Neuropathologica, 67, 289–295.
Rumsey, J. M., Duara, R., Grady, C., Rapoport, J. L., Margolin, R. A., Rapoport, S. I., & Cutler, N. R. (1985). Brain metabolism in autism: Resting cerebral glucose utilization rates as measured with positron emission tomography. Archives of General Psychiatry, 42, 448–455.
Samat, H. B., & Alcala, H. (1980). Human cerebellar hypoplasia: A syndrome of diverse causes. Archives of Neurology, 37, 300–305.
Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. Journal of Pediatrics, 58, 315–329.
Schwartz, M. L., & Goldman-Rakic, P. S. (1986). Some callosal neurons of the fetal monkey frontal cortex have axons in the contralateral hemisphere prior to the completion of migration. Society for Neuroscience Abstracts, 12, 1211.
Scott, M. P., & Caroll, S. B. (1987). The segmentation and homeotic gene network in early Dropsophila development. Cell, 51, 689–698.
Shackelford, G. M., & Varmus, H. E. (1987). Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Cell, 50, 89–95.
Shatz, C. J. (1983). Prenatal development of the cat’s retinogeniculate pathway. Journal of Neuroscience, 3, 482–499.
Shatz, C. J., Chun, J. J. M., & Luskin, M. B. (1988). The role of the subplate in the development of the mammalian telencephalon. In A. Peters & E. G. Jones (Eds.), Cerebral cortex (pp. 35–58). New York: Plenum Press.
Smalley, S. L., Asarnow, R. R, & Spence, M. A. (1988). Autism and genetics. Archives of General Psychiatry, 45, 953–961.
Smeyne, R. J., & Goldowitz, D. (1989). Development and death of external granular layer cells in the Weaver mouse cerebellum: A quantitative study. Journal of Neuroscience, 9(5), 1608–1620.
Snider, S. R. (1982). Cerebellar pathology in schizophrenia: Cause or consequence? Neuroscience and Biobehavior Review, 6, 47–53.
Spence, M. A., Ritvo, E. R., Marazita, M. L., Funderburk, S. L., Sparkes, R. S., & Freeman, B. J. (1985). Gene mapping studies with the syndrome of autism. Behavior Genetics, 15, 1–13.
Sretevan, D. W., Shatz, C. J., & Stryker, M. P. (1988). Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin. Nature, 336, 468–471.
Stanfield, B. B., & O’ Leary, D. D. M. (1985). Fetal occipital cortical neurons transplanted to the rostral cortex can extend and maintain a pyramidal tract axon. Nature, 313, 135–137.
Stryker, M. P., & Harris, W. A. (1986). Binocular impulse blockade prevents the formation of ocular dominance columns in the cat visual cortex. Journal of Neuroscience, 6, 2117–2133.
Supple, W. F., Leaton, R. N., & Fanselow, M. S. (1987). Effects of cerebellar vermal lesions on species-specific fear responses, neophobia, and taste-aversion learning in rats. Physiology & Behavior, 39, 579–586.
Sur, M., Garraghty, P. E., & Roe, A. W. (1988). Experimentally induced visual projections into auditory thalamus and cortex.Science, 242, 1437–1441.
Sutherland, G. R. (1977). Fragile sites on human chromosomes: Demonstration of their dependence on the type of tissue culture medium. Science, 197, 265–266.
Takashima, S., Leshima, A., Nakamura, H., & Becker, L. E. (1989). Dendrites, dementia and the Down syndrome. Brain and Development, 11, 131–133.
Takeichi, M. (1988). The Cadherins: Cell-cell adhesion molecules controlling animal morphogenesis. Development, 102, 639–655.
Turner, G., & Jacobs, P. (1983). Marker (X)-linked mental retardation. Advances in Human Genetics, 13, 83–112.
Turner, G., Brookwell, R., Daniel, A., Selikowitz, M., & Zilibowitz, M. (1980). Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27). The New England Journal of Medicine, 303, 662–664.
van der Kooy, D., & Fishell, G. (1987). Neuronal birthdate underlies the development of striatal compartments. Brain Research, 401, 155–161.
Veenema, H., Geraedts, J. P. M., Beverstock, G. C., & Pearson, P. L. (1987). The fragüe X syndrome in a large family: 1. Cytogenetic and clinical investigations. Journal of Medical Genetics, 24, 23–31.
Vielmetter, J., & Stuermer, C. A. O. (1989). Goldfish retinal axons respond to position-specific properties of tectal cell membranes in vitro. Neuron, 2, 1331–1339.
Walter, J., Henke-Fahle, S., & Bonhoeffer, F. (1987). Avoidance of posterial tectal membranes by temporal retinal axons. Development, 101, 909–913.
Watson, M. S., Leckman, J. F., Annex, B., Breg, W. R., Boles, D., Volkmar, F. R., & Cohen, D. J. (1984). Fragile X in a survey of 75 autistic males. The New England Journal of Medicine, 310, 1462.
Weinberger, D., Kleinman, J., Luchins, D., Bigelow, L., & Wyatt, R. J. (1980). Cerebellar pathology in schizophrenia: A controlled portmortum study. American Journal of Psychiatry, 137, 359–361.
Wetherby, A. M., Koegel, R. L., & Mendel, M. (1981). Central auditory nervous system dysfunction in echolalic autistic individuals.Journal of Speech and Hearing, 24, 420–429.
Wiggins, R. C. (1986). A critical state in development. Neurotoxicology, 7, 103–120.
Wilkinson, D. G., Bailes, J. A., & McMahon, A. P. (1987). Expression of the proto-on-cogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell, 50, 79–88.
Williams, R. S., Hauser, S. L., Purpura, D. P., DeLong, F. R., & Swisher, C. N. (1980). Autism and mental retardation: Neuropathologic studies performed in four retarded persons with autistic behavior. Archives of Neurology, 37, 749–753.
Wilson, D. B., & Wyatt, D. P. (1986). Pathogenesis of neural dysraphism in the mouse mutant vacuolated lens (vl). Journal of Neuropathology and Experimental Neurology, 45, 43–55.
Zametkin, A. J., & Rapoport, J. L. (1987). Neurobiology of attention deficit disorder with hyperactivity: Where have we come in 50 years? Journal of the American Academy of Child and Adolescent Psychiatry, 26, 676–686.
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© 1990 Plenum Press, New York
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Rubenstein, J.L.R., Lotspeich, L., Ciaranello, R.D. (1990). The Neurobiology of Developmental Disorders. In: Lahey, B.B., Kazdin, A.E. (eds) Advances in Clinical Child Psychology. Advances in Clinical Child Psychology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9835-6_1
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