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Tissue Response to Implants (Biocompatibility)

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Biomaterials Science and Engineering

Abstract

In order to implant a material, we first have to injure the tissue. The injured or diseased tissues will be removed to some extent in the process of implantation. The success of the entire operation depends on the kind and degree of tissue response (biocompatibility) toward the implants during the healing process. The tissue response toward the injury may vary widely according to the site, species, contamination, etc. However, the inflammatory reaction and cellular response toward the wound for both intentional and accidental injuries are the same regardless of the site.

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References

  1. T. Gillman, On some aspects of collagen formation in localized repair and in diffuse fibrotic reactions to injury, in:Treatise on Collagen, B. S. Gould (ed.), Volume 2B, Chapter 4, Academic Press, New York, 1968.

    Google Scholar 

  2. R. Ross, Wound healing,Sci. Am.220, 40–50, 1969.

    Article  Google Scholar 

  3. E. E. Peacock, Jr., and W. Van Winkle, Jr.,Surgery and Biology of Wound Repair, Chapters 1, 5, 6, 11, Saunders, Philadelphia, 1970.

    Google Scholar 

  4. L. L. Hench and E. C. Erthridge, Biomaterials—The interfacial problem,Adv. Biomed. Eng.5, 35–150, 1975.

    Google Scholar 

  5. A. H. Ham and W. R. Harris, Repair and transplantation of bone, in:The Biochemistry’ and Physiology of Bone, G. Bourne (ed.), 2nd ed., Volume 3, pp. 337–399, Academic Press, New York, 1971.

    Google Scholar 

  6. Z. B. Friedenberg and C. T. Brighton, Bioelectric potentials in bone,J. Bone Jt. Surg.48A, 915–923, 1966.

    Google Scholar 

  7. J. K. Newcombe, Wound healing, in:Scientific Basis of Surgery?, 2nd ed., W. T. Irvin (ed.), Churchill, London, 1972.

    Google Scholar 

  8. J. Black,Biological Performance of Materials, Dekker, New York, 1981.

    Google Scholar 

  9. L. L. Hench and H. A. Paschall, Histochemical responses at a biomaterials interface,J. Biomed. Mater. Res. Symp.5, 49–64, 1974.

    Article  Google Scholar 

  10. D. F. Williams and R. Roaf,Implants in Surgery, p. 233, Saunders, Philadelphia, 1973.

    Google Scholar 

  11. J. Charnley,Acrylic Cement in Orthopaedic Surgery, Churchill/Livingstone, Edinburgh, 1970.

    Google Scholar 

  12. A. B. Ferguson, Y. Akahoshi, P. G. Laing, and E. S. Hodge, Characteristics of trace ions released from embedded metal implants in the rabbit,J. Bone Jt. Surg.44A, 323–336, 1962.

    Google Scholar 

  13. S. D. Bruck,Blood Compatible Synthetic Polymers: An Introduction, Thomas, Springfield, III., 1974.

    Google Scholar 

  14. E. W. Salzman, Surface effects in homeostasis and thrombosis, in:The Chemistry of Biosurfaces, M. L. Hair (ed.), Dekker, New York, 1971.

    Google Scholar 

  15. E. W. Salzman, Nonthrombogenic surfaces: Critical review,Blood 38, 509–523, 1971.

    Google Scholar 

  16. P. N. Sawyer and S. Srinivasan, The role of electrochemical surface properties in thrombosis at vascular interfaces: Cumulative experience of studies in animals and man,Bull. N.Y. Acad. Med.48, 235–256, 1972.

    Google Scholar 

  17. B. C. Taylor, W. V. Sharp, J. I. Wright, K. L. Ewing, and C. L. Wilson, The importance of zeta potential, ultrastructure, and electrical conductivity to thein vivoperformance of polyurethane-carbon black vascular prostheses,Trans. Am. Soc. Artif. Intern. Organs 17, 22–28, 1971.

    Google Scholar 

  18. R. E. Baier, The role of surface energy in thrombosis,Bull. N.Y. Acad. Med.48, 257–272, 1972.

    Google Scholar 

  19. A. S. Hoffman, Applications of radiation processing in biomedical engineering—A review of the preparation and properties of novel biomaterials,Radiat. Phys. Chem.9, 207–219, 1977.

    Google Scholar 

  20. D. R. Clarke and J. B. Park, Prevention of erythrocyte adhesion onto porous surfaces by fluid perfusion,Biomaterials 2, 9–13, 1981.

    Article  Google Scholar 

Bibliography

  • C. O. Bechtol, A. B. Ferguson, and P. G. Laing,Metals and Engineering in Bone and Joint Surgery, Balliere, Tindall & Cox, London, 1959.

    Google Scholar 

  • G. H. Bourne (ed.),The Biochemistry and Physiology of Bone, 2nd ed., Volume 3, Chapter 10, Academic Press, New York, 1971.

    Google Scholar 

  • S. D. Bruck,Blood Compatible Synthetic Polymers, Thomas, Springfield, III., 1974.

    Google Scholar 

  • J. Charnley,Acrylic Cement in Orthopaedic Surgery, Churchill/Livingstone, Edinburgh, 1970.

    Google Scholar 

  • L. L. Hench and E. C. Erthridge, Biomaterials—The interfacial problem,Adv. Biomed. Eng.5, 35–150, 1975.

    Google Scholar 

  • S. F. Hulbert, S. N. Levine, and D. D. Moyle,Prosthesis and Tissue: The Interfacial Problems, Wiley, New York, 1974.

    Google Scholar 

  • S. N. Levine (ed.),Materials in Biomedical Engineering, Ann. N.Y. Acad. Sci.146, 1968.

    Google Scholar 

  • H. I. Maibach and D. T. Rovee (ed.),Epidermal Wound Healing, Year Book Medical Publishers, Chicago, 1972.

    Google Scholar 

  • M. R. Urist (ed.),Fundamental and Clinical Bone Physiology, Lippincott, Philadelphia, 1980.

    Google Scholar 

  • L. Vroman,Blood, American Museum Science Books, B26, Doubleday, New York, 1971.

    Google Scholar 

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© 1984 Plenum Press, New York

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Park, J.B. (1984). Tissue Response to Implants (Biocompatibility). In: Biomaterials Science and Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2769-1_7

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  • DOI: https://doi.org/10.1007/978-1-4613-2769-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9710-9

  • Online ISBN: 978-1-4613-2769-1

  • eBook Packages: Springer Book Archive

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