Abstract
Cirrhosis of the liver ranks as the third to fifth leading cause of death in the United States (Galambos, 1979; Lieber and Leo, 1982). At autopsy, based on Victor’s (1979) seminal study of 3,548 serial postmortem cases, approximately eight percent of individuals have demonstrable neuropathological evidence of hepatic encephalopathy.
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References
Acker, W., Majumdar, S., Shaw, G., and Thomson, A. (1982). The relationship between brain and liver damage in chronic alcoholic patients. Journal of Neurology, Neurosurgery and Psychiatry, 45, 984–987.
Arias, I., Popper, H., Schacter, D., and Shafritz, D. (Eds.) (1982). The liver: Biology and pathobiology. New York: Raven Press, 1–895.
Atkinson, M. and Goligher, J. (1960). Recurrent hepatic coma treated by colectomy and ileorectal anastomosis. Lancet, 1, 461–464.
Berglund, M., Leijonquist, H., and Horlen, M. (1977). Prognostic significance and reversibility of cerebral dysfunction in alcoholics. Journal of Studies on Alcohol, 38, 1761–1769.
Berry, J., Owen, E., Flanagan, J., and Tyor, M. (1960). The effect of acute hyperventilation on the blood ammonia concentration of patients with liver disease. Journal of Laboratory and Clinical Medicine, 55, 849–854.
Carlen, P., Wilkinson, A., Wortman, G., Holgate, R., Cordingley, J., Lee, M., Huszar, L., Moddel, G., Singh, R., Kiraly, L., and Rankin, J. (1981). Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. Neurology, 31, 377–385.
Conn, H., Leevy, C., Vahcevic, Z., Rodgers, J., Maddrey, W., Seeff, L., and Levy, L. (1977). Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial. Gastroenterology, 72, 573–583.
Conn, H. and Lieberthal, M. (1979). The hepatic coma syndrome and lactulose. Baltimore: Williams and Wilkins, 1–419.
Davidson, P.W., Willoughby, R.H., O’Tuama, L.A., and Swisher, C.N. (1978). Neurological and intellectual sequelae of Reye’s Syndrome. American Journal of Mental Deficiency, 82, 535–541.
Dudrick, S., Mackie, J., and Serlin, O. (1968). Surgical exclusion of the colon for chronic hepatic encephalopathy. American Journal of Surgery, 115, 57–62.
Elsass, P., Lund, Y., and Ranek, L. (1978). Encephalopathy in patients with cirrhosis of the liver. A neuropsychological study. Scandinavian Journal of Gastroenterology, 13, 241–247.
Galambos, J. (1979). Cirrhosis: Epidemiology. In Smith, L. (Ed.), Major problems in internal medicine. Philadelphia: W.B. Saunders, 97–121.
Gilberstadt, S., Gilberstadt, H., Zieve, L., Buegel, B., Collier, R., and McClain, C. (1980). Psychomotor performance deficits in cirrhotic patients without overt encephalopathy. Archives of Internal Medicine, 140, 519–521.
Gundersen, H. and Amdisen, A, (1969). The electrophoretic pattern of alkaline phosphatase in schizophrenic females under long-term treatment with neuroleptic drugs and in young and old healthy women. Scandinavian Journal of Clinical and Laboratory Investigation, 24, 173–177.
Havens, L. and Child, C. (1955). Recurrent psychosis associated with liver disease and elevated blood ammonia. New England Journal of Medicine, 252, 756–759.
Heaton, R. and Pendleton, M. (1981). Use of neuropsychological tests to predict adult patients1 everyday functioning. Journal of Consulting and Clinical Psychology, 49, 807–821.
Hegedus, A., Tarter, R., Gavaler, J., Schade, R., Van Thiel, D., and Starzl, T. (1983). Neuropsychiatric capacity of patients with primary biliary cirrhosis and post-necrotic cirrhosis. Hepatology, 3, 830.
Hegedus, A., Tarter, R., Van Thiel, D., Schade, R., Gavaler, J., and Starzl, T. (1984). Neuropsychiatric characteristics associated with primary biliary cirrhosis. The International Journal of Psychiatry in Medicine, 14, 303–313.
James, J., MacDonald, L., and Xanalatos, C. (1974). Effect of ammonium salts on brain metabolism. Journal of Neurology, Neurosurgery and Psychiatry, 37, 948–953.
Jervis, G. (1979). Encephalopathy in infantile hepatic cirrhosis. Acta Neuropathologica, 48, 73–75.
Johannesson, G., Berglund, M., and Ingvar, D.H. (1982). Reduction of blood flow in cerebral white matter in alcoholics related to hepatic function: A CBF and EEG study. Acta Neurologica Scandinavica, 65, 190–202.
Kardel, T. and Stigsby, B. (1975). Period-amplitude analysis of the electroencephalogram correlated with liver function in patients with cirrhosis of the liver. Electroencephalography and Clinical Neurophysiology, 38, 605–609.
Kardel, T., Zander, O.P., Stigsby, B. and Tonnesen, K. (1972). Hepatic encephalopathy evaluated by automatic period analysis of the electroencephalogram during lactulose treatment. Acta Medica Scandinavica, 192, 493–498.
Laidlaw, J., Read, A., and Sherlock, S. (1961). Morphine tolerance in hepatic cirrhosis. Gastroenterology, 40, 389–396.
Lee, K., Moller, L., Hardt, F., Haubek, A., and Jensen, E. (1979). Alcohol-induced brain damage and liver damage in young males. Lancet, 2, 759–761.
Lieber, C. and Leo, M. (1982). Alcohol and the liver. In C. Lieber (Ed.), Medical disorders of alcoholism. Pathogenesis and treatment. Philadelphia: W.B. Saunders, 259–312.
Leevy, C. (1974). Exploring the brain-liver relationship. Modern Medicine, 42, 17–22.
McClain, C., Potter, T., Krombout, J., and Zieve, L. (1984). The effect of lactulose on psychomotor performance tests in alcoholic cirrhotics without overt hepatic encephalopathy. Journal of Clinical Gastroenterology, 6, 325–329.
Morgan, M. and Read, A. (1972). Antidepressants and liver disease. Gut, 13, 697–701.
O’Leary, M., Donovan, D., Chaney, E., and Walker, R. (1979). Cognitive impairment and treatment outcome with alcoholics: Preliminary findings. Journal of Clinical Psychology, 40, 397–398.
Parsons-Smith, B., Summerskill, W., Dawson, A., and Sherlock, S. (1957). The electroencephalograph in liver disease. Lancet, 2, 867–871.
Read, A., Laidlaw, J., and McCarthy, C. (1969). Effects of chlorpromazine in patients with hepatic disease. British Medical Journal, 3, 497–499.
Rehnstrom, S., Simert, G., Hansson, J., Johnson, G., and Vang, J. (1977). Chronic hepatic encephalopathy. A psychometrical study. Scandinavian Journal of Gastroenterology, 12, 305–311.
Reynolds, T., Redeker, A., and Davis, P. (1958). A controlled study of the effects of L-arginine on hepatic encephalopathy. American Journal of Medicine, 25, 359–367.
Rikkers, L., Jenko, P., Rudman, D., and Freides, D. (1978). Subclinical hepatic encephalopathy: Detection, prevalence and relationship to nitrogen metabolism. Gastroenterology, 75, 462–469.
Riley, J. and Walker, D. (1978). Morphological alterations in hippocampus after long-term alcohol consumption in mice. Science, 201, 646–648.
Schomerus, H., Hamster, W., Blunck, H., Reinhard, U., Mayer, K., and Dalle, W. (1981). Latent portasystemic encephalopathy. 1. Nature of cerebral functional defects and their effect on fitness to drive. Digestive Diseases and Sciences, 26, 622–630.
Sherlock, S., Summerskill, W., White, L., and Pheur, E. (1954). Portal-systemic encephalopathy. Neurological complications of liver disease. Lancet, 2, 453–457.
Simmons, F., Goldstein, H., and Boyle, J. (1970). A controlled clinical trial of lactulose in hepatic encephalopathy. Gastroenterology, 59, 827–832.
Smith, J. and Smith, L. (1977). WAIS functioning of cirrhotic and noncirrhotic alcoholics. Journal of Clinical Psychology, 33, 309–313.
Summerskill, W., Davidson, E., Sherlock, S., and Steiner, R. (1956). The neuropsychiatrie syndrome associated with hepatic cirrhosis and an extensive portal collateral circulation. Quarterly Journal of Medicine, 25, 245–266.
Tarter, R. and Alterman, A. (1984). Neuropsychological deficits in alcoholics. Etiological considerations. Journal of Studies on Alcohol, 45, 1–9.
Tarter, R. and Edwards, K. (1985). Neuropsychology of alcoholism. In R. Tarter and D. Van Thiel (Eds.), Alcohol and the brain: Chronic effects. New York: Plenum Press.
Tarter, R., Hegedus, A., Van Thiel, D., Edwards, N., and Starzl, T. (submitted for publication). Differentiation of severity and manifestation of cerebral dysfunction in portal-systemic encephalopathy according to type of liver pathology, (a)
Tarter, R., Hegedus, A., Van Thiel, D., Gavaler, J., and Schade, R. (submitted for publication). Association between hepatic dysfunction and neuropsychological test performance in alcoholics with cirrhosis, (b)
Tarter, R., Hegedus, A., Van Thiel, D., Schade, R., Gavaler, J., and Starzl, T. (1984b). Nonalcoholic cirrhosis associated with neuropsychological dysfunction in the absence of overt evidence of hepatic encephalopathy. Gastroenterology, 86, 1421–1427.
Tarter, R., Van Thiel, D., Hegedus, A., Schade, R., Gavaler, J., and Starzl, T. (1984c). Liver transplantation: Long-term neuropsychiatric status. The Journal of Laboratory and Clinical Medicine, 103, 776–182.
Tarter, R., Hegedus, A., Van Thiel, D., Schade, R., Iwatsuki, S., and Starzl, T. (1983). Neuropsychological capacity of alcoholic and nonalcoholic cirrhotics. Alcoholism: Clinical and Experimental Research, 7, 124.
Tarter, R., Hegedus, A., Van Thiel, D., Schade, R., Pollit-Heyl, A., and Gavaler, J. (1984a). Association between hepatic dysfunction and neuropsychological capacity in cirrhotic alcoholics. Alcoholism: Clinical and Experimental Research, 8, 123.
Victor, M. (1979). Neurologic disorders due to alcoholism and malnutrition. In A. Baker and L. Baker (Eds.), Clinical neurology. Hagerstown, MD: Harper & Row.
Zeegan, R., Drinkwater, J., and Dawson, A. (1970). Method for measuring cerebral dysfunction in patients with liver disease. British Medical Journal, 2, 633–636.
Zieve, L. (1979). Hepatic encephalopathy: Summary of present knowledge with an elaboration on recent developments. In H. Popper and F. Schaffer (Eds.), Progress in liver disease. New York: Grune and Stratton.
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Tarter, R.E., Edwards, K.L., Van Thiel, D.H. (1986). Hepatic Encephalopathy. In: Goldstein, G., Tarter, R.E. (eds) Advances in Clinical Neuropsychology. Advances in Clinical Neuropsychology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2211-5_8
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DOI: https://doi.org/10.1007/978-1-4613-2211-5_8
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