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Polyuric Syndromes

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Therapy of Renal Diseases and Related Disorders

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Abstract

Urine volume normally is closely matched to the dietary intake of water and is largely independent of the intake of solute over the range encountered in normal diets. Water balance in the face of varying intake is achieved by renal regulation of urine volume through the operation of the concentrating and diluting mechanism: Extrarenal fluid losses via the skin and lungs, and in stool, occur, but they are relatively constant and do not contribute to the pathophysiology of polyuric states. Although urine volume is regulated independently of solute excretion in most circumstances, the two are related at the extremes: very low rates of solute excretion may impair the ability to maintain water balance and result in dilutional hyponatremia, while extremely high rates of solute excretion may obligate urinary water excretion and lead to negative water balance and hypernatremia. This circumstance of solute diuresis is one of the polyuric syndromes and will be discussed more fully below.

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Authors
  1. William P. Muldowney
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  2. Michael H. Humphreys
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, The Methodist Hospital, Houston, Texas, USA

    Wadi N. Suki

  2. Division of Nephrology, University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

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© 1991 Kluwer Academic Publishers

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Muldowney, W.P., Humphreys, M.H. (1991). Polyuric Syndromes. In: Suki, W.N., Massry, S.G. (eds) Therapy of Renal Diseases and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0689-4_2

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  • DOI: https://doi.org/10.1007/978-1-4613-0689-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8027-9

  • Online ISBN: 978-1-4613-0689-4

  • eBook Packages: Springer Book Archive

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