Abstract
Of all the acid-basic disorders, metabolic acidosis is the one most likely to be associated with serious morbidity or even death. Examples are the lactic acidosis of shock states and servere acidosis associated with methanol or ethylene glycol poisoning; these require urgent therapy to prevent a fatal outcome. On the other hand, metabolic acidosis may be mild, chronic, and of little immediate clinical consequence. Examples include certain types of renal tubular acidosis (RTA) or chronic diarrhea.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Emmet ME, Narins RG: Clinical use of the anion gap. Medicine 56:38, 1977.
Oh MS, Carroll HJ: The anion gap. N Engl J Med 297:814–817, 1977.
Gabow PA: Disorders associated with an altered anion gap. Kidney Int 27:472–483, 1984.
Halperin ML, Goldstein MB, Richardson RMA, Stinebaugh BJ: Distal renal tubular acidosis syndromes: A pathophysiological approach. Am J Nephrol 5:1–8, 1985.
Goldstein MB, Bear RA, Richardson RMA, Marsden PA, Halperin ML: The urine anion gap: A clinically useful index of ammonium excretion. Am J Med Sci 29:198–202, 1986.
Halperin ML, Margolis BL, Robinsion LA, Halperin RM, West ML, Bear RA: The urine osmolar gap: Clue to estimate urine ammonium in “hybrid” types of metabolic acidosis. Clin Invest Med 11:198–202, 1988.
Glasser L, Sternglanz PD, Combie J, Robinson A: Serum osmolality and its applicability to drug overdose. Am J Clin Pathol 60:695–699, 1973.
Cohen RD, Woods HF: Lactic acidosis revisited. Diabetes 32:181–191, 1983.
Park R, Arieff AI: Lactic acidosis: Current concepts. Clin Endocr Metab 12:339–359, 1983.
Madias NE: Lactic acidosis. Kidney Int 29:752–774, 1986.
Halperin ML, Fields ALA: Lactic acidosis — emphasis on the carbon precursors and buffering of the acid load. Am J Med Sri 289:154–159, 1985.
Halperin ML, Connors HP, Relman AS, Karnovsky ML: Factors that control the effect of pH on glycolysis in leukocytes. J Biol Chem 244:384–390, 1969.
Narins RG, Cohen JJ: Bicarbonate therapy for organic acidosis: The case for its continued use. Ann Int Med 106:615–618, 1987.
Stacpoole PW, Harman EM, Curry SH, Baumgartner TG, Misbin RI: Treatment of lactic acidosis with dichloroacetate. N Engl J Med 309:390–396, 1983.
Fields ALA, Wolman SL, Halperin M L: Chronic lactic acidosis in a patient with cancer: Therapy and metabolic consequences. Cancer 47:2026–2029, 1981.
Fraley DS, Adler S, Bruns FJ, Zett B: Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasma and lactic acidosis. N Engl J Med 303:1100–1102, 1980.
Prescott LF, Balali-Mood M, Critchley JAJH, Johnstone AF, Proudfoot AT: Diuresis or urinary alkalinization for salicylate poisoning? Br Med J 285:1383–1386, 1982.
Gonda A, Gault H, Churchill D, Hollomby D: Hemodialysis for methanol intoxication. Am J Med 64:749–757, 1978.
McCoy HG, Cipolle RJ, Ehlers SM, Sawchuk RJ, Zaske DE: Severe methanol poisoning. Am J Med 67:804–807, 1979.
Parry ME, Wallach R: Ethylene glycol poisoning. Am J Med 67:804–807, 1979.
Peterson CD, Collins AJ, Bullock ML, Keane WF: Ethylene glycol poisoning. N Engl J Med 304:21–23, 1981.
Oh MS, Phelps KR, Traube M, Barbosa-Saldivar JL, Boxhill C, Carroll HJ: D-lactic acidosis in man with short-bowel syndrome. TV Engl J Med 301:249–252, 1979.
Oh MS, Uribarri J, Alveranga D, Lazar I, Bazilinski N, Carroll HJ: Metabolic utilization and renal handling of D-lactate in men. Metabolism 34:621–625, 1985.
Arieff AI, Leach W, Park R, Lazarowitz VC: Systemic effects of NaHCO3 in experimental lactic acidosis in dogs. Am J Physiol 242:F586–F591, 1982.
Graf H, Leach W, Arieff A I: Metabolic effects of sodium bicarbonate in hypoxic lactic acidosis in dogs. Am J Physiol 249:F630–F635, 1985.
Stacpoole PW: Lactic acidosis: The case against bicarbonate therapy. Ann Int Med 105:276–279, 1986.
Halperin ML, Goldstein MB, Haig A, Johnson MD, Stinebaugh BJ: Studies on the pathogenesis of type I (distal) renal tubular acidosis as revealed by the urinary PCO2 tensions. J Clin Invest 53:669–677, 1974.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Kluwer Academic Publishers
About this chapter
Cite this chapter
Richardson, R.M.A., Halperin, M.L. (1991). Metabolic Acidosis. In: Suki, W.N., Massry, S.G. (eds) Therapy of Renal Diseases and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0689-4_10
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0689-4_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8027-9
Online ISBN: 978-1-4613-0689-4
eBook Packages: Springer Book Archive