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Part of the book series: Research Notes in Neural Computing ((NEURALCOMPUTING,volume 1))

Abstract

Mathematical models of learning that describe the effects of training with no regard for motor output are incomplete and consequently difficult to represent within natural systems. This chapter summarizes our efforts to reconcile a model that describes real-time topographical features of the classically conditioned nictitating membrane response (NMR) of the rabbit with knowledge about the cerebellum, the brain region thought to be most crucial for NMR conditioning. The NMR is a protective response resulting from retraction of the eyeball and the passive sweeping of the NM over the eye. The conditioned NMR is a graded, adaptive response.

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References

  • Barto, A.G., & Sutton, R.S. (1982). Simulation of anticipatory responses in classical conditioning by a neuron-like adaptive element. Behavioural Brain Research, 4, 221–235.

    Article  Google Scholar 

  • Berger, T.W., Weikart, C.L., Bassett, J.L., & Orr, W.B. (1986). Lesions of the retrosplenial cortex produce deficits in reversal learning of the rabbit nictitating membrane response: Implications for potential interactions between hippocampal and cerebellar brain systems. Behavioral Neuroscience, 100, 802–809.

    Article  Google Scholar 

  • Berthier, N.E., Desmond, J.E., & Moore, J.W. (1987). Brain stem control of the nictitating membrane response. In I. Gormezano, W.F. Prokasy, & R. F. Thompson (Eds.), Classical Conditioning III. Hillsdale, NJ: Lawrence Erlbaum Associates.

    Google Scholar 

  • Berthier, N.E., & Moore, J.W. (1986). Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response. Experimental Brain Research, 68, 341–350.

    Google Scholar 

  • Blazis, D.E.J., Desmond, J.E., Moore, J.W., & Berthier, N.E. (1986). Simulation of the classically conditioned response by a neuron-like adaptive element: a real-time variant of the Sutton-Barto model. Proceedings of the eighth annual conference of the Cognitive Science Society,, 176–186.

    Google Scholar 

  • Blazis, D.E.J., & Moore, J.W. (1987). Simulation of a classically conditioned response: components of the input trace and a cerebellar neural network implementation of the Sutton-Barto-Desmond model. Technical Report 87-74, Department of Computer and Information Sciences, University of Massachusetts, Amherst, MA.

    Google Scholar 

  • Bloedel, J.R. (1987). Technical comment. Science, 288, 1728–1729.

    Article  Google Scholar 

  • Bloedel, J.R., & Ebner, T.J. (1985). Climbing fiber function: Regulation of Purkinje cell responsiveness. In J.R. Bloedel, J. Dichgans, & W. Precht (Eds.), Cerebellar Functions (pp.247–260). NewYork: Springer-Verlag.

    Google Scholar 

  • Brodal, P., Dietrichs, E., & Walberg, F. (1986). Do pontocerebellar mossy fibres give off collaterals to the cerebellar nuclei? An experimental study in the cat with implantation of crystalline HRP-WGA. Neuroscience Research, 4, 12–24.

    Article  Google Scholar 

  • Clark, G.A., McCormick, D.A., Lavond, D.G., & Thompson, R.F. (1984). Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal responses. Brain Research, 291, 125–136.

    Article  Google Scholar 

  • Desmond, J.E. (1985). The classically conditioned nictitating membrane response: Analysis of learning-related single neurons of the brain stem. Ph.D. Dissertation. University of Massachusetts, Amherst, MA.

    Google Scholar 

  • Desmond, J.E., & Moore, J.W. (1982). A brain stem region essential for the classically conditioned but not unconditioned nictitating membrane response. Physiology & Behavior, 28, 1029–1033.

    Article  Google Scholar 

  • Desmond, J.E., & Moore, J.W. (1986). Dorsolateral pontine tegmentum and the classically conditioned nictitating membrane response: Analysis of CR-related activity. Experimental Brain Research, 65, 59–74.

    Article  Google Scholar 

  • Eccles, J.C, Sasaki, K., & Strata, P. (1967). A comparison of the inhibitory action of Golgi and basket cells. Experimental Brain Research, 3, 81–94.

    Google Scholar 

  • Gamble, E., & Koch, C. (1987). The dynamics of free calcium in dendritic spines in response to repetitive synaptic input. Science, 236, 1311–1315.

    Article  Google Scholar 

  • Hoehler, F.K., & Thompson, R.F. (1980). Effect of the interstimulus (CS-US) interval on hippocampal unit activity during classical conditioning of the nictitating membrane response of the rabbit. Journal of Comparative and Physiological Psychology, 94, 201–215.

    Article  Google Scholar 

  • Ito, M. (1984). The Cerebellum and Neural Control. New York: Raven Press.

    Google Scholar 

  • Kelso, S.R., Ganong, A.H., & Brown, T.H. (1986). Hebbian synapses in hippocampus. Proceedings of the National Academy of Science (USA), 83, 5326–5330.

    Google Scholar 

  • Lisberger, S.G., Morris, E.J., & Tychsen, L. (1987). Visual motion processing and sensory-motor integration for smooth pursuit eye movements. Annual Review of Neuroscience, 10, 97–129.

    Article  Google Scholar 

  • Llinas, R. (1985). Functional significance of the basic cerebellar circuit in motor coordination. In J.D.J.R. Bloedel & W. Precht (Eds.), Cerebellar functions (pp.230–247). NewYork: Springer-Verlag.

    Google Scholar 

  • Miles, F.A., Fuller, J.H., Braitman, D.J., & Dow, B.M. (1980). Long-term adaptive changes in primate vestibuloocular reflex. III. Electrophysiological observations in flocculus of normal monkeys. Journal of Neurophysiology, 43, 1437–1476.

    Google Scholar 

  • Mis, F.W. (1977). A midbrain-brain stem circuit for conditioned inhibition of the nictitating membrane response in the rabbit (Oryctolagus cuniculus). Journal of Comparative and Physiological Psychology, 91, 975–988.

    Article  Google Scholar 

  • Moore, J.W., Desmond, J.E., Berthier, N.E., Blazis, D.E.J., Sutton, R.S., & Barto, A.G. (1986). Simulation of the classically conditioned nictitating membrane response by a neuron-like adpative element: Response topography, neuronal firing, and interstimulus intervals. Behavioural Brain Research, 21, 143–154.

    Article  Google Scholar 

  • Moore, J.W., & Stickney, K.J. (1985). Antiassociations: Conditioned inhibition in attentional-associative networks. In R.R. Miller & N.E. Spear (Eds.), Information processes in animals: conditioned inhibition (pp.209–222). Hillsdale, N.J: Lawrence Erlbaum Associates.

    Google Scholar 

  • Port, R.L., Mikhail, A.A., & Patterson, M.M. (1985). Differential effects of hippocampectomy on classically conditioned rabbit nictitating membrane response related to interstimulus interval. Behavioral Neuroscience, 99, 200–208.

    Article  Google Scholar 

  • Port, R.L., Romano, A.G., Steinmetz, J.E., Mikhail, A.A., & Patterson, M.M. (1986). Retention and acquisition of classical trace conditioned responses by hippocampal lesioned rabbits. Behavioral Neuroscience, 100, 745–752.

    Article  Google Scholar 

  • Schmajuk, N.A. (1986). Real-time attentional models for classical conditioning and the hippocampus. Ph.D. Dissertation, University of Massachusetts, Amherst, MA.

    Google Scholar 

  • Schulman, J.A., & Bloom, F.E. (1981). Golgi cells of the cerebellum are inhibited by inferior olive activity. Brain Research, 210, 350–355.

    Article  Google Scholar 

  • Solomon, P.R., Vander Schaaf, E.R., Norbe, A.C., Weisz, D.J., & Thompson, R.F. (1986). Hippocampus and trace conditioning of the rabbit’s nictitating membrane response. Behavioral Neuroscience, 100, 729–744.

    Article  Google Scholar 

  • Sutton, R.S., & Barto, A.G. (1981). Toward a modern theory of adaptive networks: Expectation and prediction. Psychological Review, 88, 135–170.

    Article  Google Scholar 

  • Thompson, R.F. (1986). The neurobiology of learning and memory. Science, 233, 941–947.

    Article  Google Scholar 

  • Thompson, R.F., Donegan, N.H., Clark, G.A., Lavond, D.G., Lincoln, J.S., Madden, J., Mamounas, L.A., Mauk, M.D., and McCormick, D.A. Neuronal substrates of discrete, defensive conditioned reflexes, conditioned fear states, and their interactions in the rabbit. In I. Gormezano, W.F. Prokasy, and R.F. Thompson (Eds.), Classical conditioning, 3rd edition. Hillsdale, N.J.: Lawrence Erlbaum Associates, 1987, 371–400.

    Google Scholar 

  • Yeo, C.H., Hardiman, M.J., & Glickstein, M. (1984). Discrete lesions of the cerebellar cortex abolish the classically conditioned nictitating membrane response of the rabbit. Behavioural Brain Research, 13, 261–266.

    Article  Google Scholar 

  • Yeo, C.H., Hardiman, M.J., & Glickstein, M. (1985a). Classical conditioning of the nictitating membrane response of the rabbit: I. Lesions of the cerebellar nuclei. Experimental Brain Research, 60, 87–98.

    Article  Google Scholar 

  • Yeo, C.H., Hardiman, M.J., & Glickstein, M. (1985b). Classical conditioning of the nictitating membrane response of the rabbit. II. Lesions of the cerebellar cortex. Experimental Brain Research, 60, 99–113.

    Article  Google Scholar 

  • Yeo, C.H., Hardiman, M.J., & Glickstein, M. (1985c). Classical conditioning of the nictitating membrane response of the rabbit: III. Connections of cerebellar lobule HVI. Experimental Brain Research, 60, 114–126.

    Article  Google Scholar 

  • Yeo, C.H., Hardiman, M.J., Moore, J.W., & Steele-Russell, I. (1983). Retention of conditioned inhibition of the nictitating membrane response in decorticate rabbits. Behavioural Brain Research, 10, 383.

    Article  Google Scholar 

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© 1989 Springer-Verlag New York Inc.

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Moore, J.W., Blazis, D.E.J. (1989). Conditioning and the Cerebellum. In: Arbib, M.A., Amari, Si. (eds) Dynamic Interactions in Neural Networks: Models and Data. Research Notes in Neural Computing, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4536-0_16

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  • DOI: https://doi.org/10.1007/978-1-4612-4536-0_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96893-3

  • Online ISBN: 978-1-4612-4536-0

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