Skip to main content

Treatment of Attention Disorders

  • Chapter
  • First Online:
Attention Disorders After Right Brain Damage
  • 1685 Accesses

Abstract

This chapter outlines several forms of intervention devised to treat attention disorders consequent to right hemisphere damage, and particularly visual neglect, which is the most severe and common of these conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Angeli V, Meneghello F, Mattioli F, Ladavas E. Mechanisms underlying visuo-spatial amelioration of neglect after prism adaptation. Cortex. 2004;40:155–6.

    Article  PubMed  Google Scholar 

  • Antonucci G, Guariglia C, Judica A, Magnotti L, Paolucci S, Pizzamiglio L, Zoccolotti P. Effectiveness of neglect rehabilitation in a randomized group study. J Clin Exp Neuropsychol. 1995;17:383–9.

    Article  CAS  PubMed  Google Scholar 

  • Barrett AM, Crucian GP, Schwartz RL, Heilman KM. Adverse effect of dopamine agonist therapy in a patient with motor-intentional neglect. Arch Phys Med Rehabil. 1999;80:600–3.

    Article  CAS  PubMed  Google Scholar 

  • Berberovic N, Mattingley JB. Effects of prismatic adaptation on judgments of spatial extent in peripersonal and extrapersonal space. Neuropsychologia. 2003;41:493–503.

    Article  PubMed  Google Scholar 

  • Berthier ML, Green C, Higueras C, Fernandez I, Hinojosa J, Martin MC. A randomized, placebo-controlled study of donepezil in poststroke aphasia. Neurology. 2006;67:1687–9.

    Article  CAS  PubMed  Google Scholar 

  • Bisiach E, Rusconi ML, Vallar G. Remission of somatoparaphrenic delusion through vestibular stimulation. Neuropsychologia. 1991;29:1029–31.

    Article  CAS  PubMed  Google Scholar 

  • Bisiach E, Pizzamiglio L, Nico D, Antonucci G. Beyond unilateral neglect. Brain. 1996;119:851–7.

    Article  PubMed  Google Scholar 

  • Brem A-K, Fried PJ, Horvath JC, Robertson EM, Pascual-Leone A. Is neuroenhancement by noninvasive brain stimulation a net zero-sum proposition? Neuroimage. 2013.

    Google Scholar 

  • Brighina F, Bisiach E, Oliveri M, Piazza A, La Bua V, Daniele O, Fierro B. 1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans. Neurosci Lett. 2003;336:131–3.

    Article  CAS  PubMed  Google Scholar 

  • Bromberg-Martin ES, Matsumoto M, Hikosaka O. Dopamine in motivational control: rewarding, aversive, and alerting. Neuron. 2010;68:815–34.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Buxbaum LJ, Ferraro M, Whyte J, Gershkoff A, Coslett HB. Amantadine treatment of hemispatial neglect: a double-blind, placebo-controlled study. Am J Phys Med Rehabil. 2007;86:527–37.

    Article  PubMed  Google Scholar 

  • Cappa SF, Sterzi R, Vallar G, Bisiach E. Remission of hemineglect and anosognosia during vestibular stimulation. Neuropsychologia. 1987;25:775–82.

    Article  CAS  PubMed  Google Scholar 

  • Chica AB, Thiebaut de Schotten M, Toba MN, Malhotra P, Lupiáñez J, Bartolomeo P. Attention networks and their interactions after right-hemisphere damage. Cortex. 2012;48:654–63.

    Article  PubMed  Google Scholar 

  • Chokron S, Dupierrix E, Tabert M, Bartolomeo P. Experimental remission of unilateral spatial neglect. Neuropsychologia. 2007;45:3127–48.

    Article  PubMed  Google Scholar 

  • Coulthard E, Singh-Curry V, Husain M. Treatment of attention deficits in neurological disorders. Curr Opin Neurol. 2006;19:613–8.

    Google Scholar 

  • DeGutis JM, Van Vleet TM. Tonic and phasic alertness training: a novel behavioral therapy to improve spatial and non-spatial attention in patients with hemispatial neglect. Front Hum Neurosci. 2010;4:60.

    PubMed Central  PubMed  Google Scholar 

  • Farnè A, Rossetti Y, Toniolo S, Ladavas E. Ameliorating neglect with prism adaptation: visuo-manual and visuo-verbal measures. Neuropsychologia. 2002;40:718–29.

    Article  PubMed  Google Scholar 

  • Fimm B, Willmes K, Spijkers W. The effect of low arousal on visuo-spatial attention. Neuropsychologia. 2006;44:1261–8.

    Article  CAS  PubMed  Google Scholar 

  • Fink GR, Marshall JC, Weiss PH, Stephan T, Grefkes C, Shah NJ, Zilles K, Dieterich M. Performing allocentric visuospatial judgments with induced distortion of the egocentric reference frame: an fMRI study with clinical implications. Neuroimage. 2003;20:1505–17.

    Article  PubMed  Google Scholar 

  • Fleet WS, Valenstein E, Watson RT, Heilman KM. Dopamine agonist therapy for neglect in humans. Neurology. 1987;37:1765–70.

    Article  CAS  PubMed  Google Scholar 

  • Frassinetti F, Rossi M, Làdavas E. Passive limb movements improve visual neglect. Neuropsychologia. 2001;39:725–33.

    Article  CAS  PubMed  Google Scholar 

  • Frassinetti F, Angeli V, Meneghello F, Avanzi S, Ladavas E. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain. 2002;125:608–23.

    Article  PubMed  Google Scholar 

  • Gainotti G. The role of spontaneous eye movements in orienting attention and in unilateral neglect. In: Robertson IH, Marshall JC, editors. Unilateral neglect: clinical and experimental studies. Hove: Lawrence Erlbaum Associates; 1993. p. 107–22.

    Google Scholar 

  • Geminiani G, Bottini G, Sterzi R. Dopaminergic stimulation in unilateral neglect. J Neurol Neurosurg Psychiatry. 1998;65:344–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gorgoraptis N, Mah YH, Machner B, Singh-Curry V, Malhotra P, Hadji-Michael M, Cohen D, Simister R, Nair A, Kulinskaya E, Ward N, Greenwood R, Husain M. The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke. Brain. 2012;135:2478–91.

    Article  PubMed Central  PubMed  Google Scholar 

  • Gouvier W, Bua B, Blanton P, Urey J. Behavioural changes following visual scanning training: observations of five cases. Int J Clin Neuropsychol. 1987;9:74–80.

    Google Scholar 

  • Grujic Z, Mapstone M, Gitelman DR, Johnson N, Weintraub S, Hays A, Kwasnica C, Harvey R, Mesulam MM. Dopamine agonists reorient visual exploration away from the neglected hemispace. Neurology. 1998;51:1395–8.

    Article  CAS  PubMed  Google Scholar 

  • Guariglia C, Lippolis G, Pizzamiglio L. Somatosensory stimulation improves imagery disorders in neglect. Cortex. 1998;34:233–41.

    Article  CAS  PubMed  Google Scholar 

  • Halligan PW, Bartolomeo P. Visual neglect. In: Ramachandran VS, editor. Encyclopedia of human behavior. 2nd ed. vol. 3. San Diego: Academic Press; 2012. p. 652–64.

    Google Scholar 

  • Halligan PW, Manning L, Marshall JC. Hemispheric activation vs spatio-motor cuing in visual neglect: a case study. Neuropsychologia. 1991;29:165–76.

    Article  CAS  PubMed  Google Scholar 

  • Karnath H-O, Christ K, Hartje W. Decrease of contralateral neglect by neck muscle vibration and spatial orientation of trunk midline. Brain. 1993;116:383–96.

    Article  PubMed  Google Scholar 

  • Koch G, Bonni S, Giacobbe V, Bucchi G, Basile B, Lupo F, Versace V, Bozzali M, Caltagirone C. Theta-burst stimulation of the left hemisphere accelerates recovery of hemispatial neglect. Neurology. 2012;78:24–30.

    Article  CAS  PubMed  Google Scholar 

  • Làdavas E, Berti A, Ruozzi E, Barboni F. Neglect as a deficit determined by an imbalance between multiple spatial representations. Exp Brain Res. 1997;116:493–500.

    Article  PubMed  Google Scholar 

  • Lazar RM, Fitzsimmons B-F, Marshall RS, Berman MF, Bustillo MA, Young WL, Mohr JP, Shah J, Robinson JV. Reemergence of stroke deficits with midazolam challenge. Stroke. 2002;33:283–5.

    Article  CAS  PubMed  Google Scholar 

  • Lopez C, Blanke O, Mast FW. The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis. Neuroscience. 2012;212:159–79.

    Article  CAS  PubMed  Google Scholar 

  • Luaute J, Halligan P, Rode G, Rossetti Y, Boisson D. Visuo-spatial neglect: a systematic review of current interventions and their effectiveness. Neurosci Biobehav Rev. 2006a;30:961–82.

    Google Scholar 

  • Luaute J, Michel C, Rode G, Pisella L, Jacquin-Courtois S, Costes N, Cotton F, le Bars D, Boisson D, Halligan P, Rossetti Y. Functional anatomy of the therapeutic effects of prism adaptation on left neglect. Neurology. 2006b;66:1859–67.

    Article  CAS  PubMed  Google Scholar 

  • Lucas N, Saj A, Schwartz S, Ptak R, Thomas C, Conne P, Leroy R, Pavin S, Diserens K, Vuilleumier P. Effects of pro-cholinergic treatment in patients suffering from spatial neglect. Front Hum Neurosci. 2013;7:574.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Malhotra PA, Parton AD, Greenwood R, Husain M. Noradrenergic modulation of space exploration in visual neglect. Ann Neurol. 2006;59:186–90.

    Article  CAS  PubMed  Google Scholar 

  • Manly T, Dobler VB, Dodds CM, George MA. Rightward shift in spatial awareness with declining alertness. Neuropsychologia. 2005;43:1721–8.

    Article  PubMed  Google Scholar 

  • Mattingley JB. Visuomotor adaptation to optical prisms: a new cure for spatial neglect? Cortex. 2002;38:277–83.

    Article  PubMed  Google Scholar 

  • Mukand JA, Guilmette TJ, Allen DG, Brown LK, Brown SL, Tober KL, Vandyck WR. Dopaminergic therapy with carbidopa L-dopa for left neglect after stroke: a case series. Arch Phys Med Rehabil. 2001;82:1279–82.

    Article  CAS  PubMed  Google Scholar 

  • Müri RM, Cazzoli D, Nef T, Mosimann UP, Hopfner S, Nyffeler T. Non-invasive brain stimulation in neglect rehabilitation: an update. Front Hum Neurosci. 2013;7:248.

    Google Scholar 

  • Nyffeler T, Cazzoli D, Hess CW, Müri RM. One session of repeated parietal theta burst stimulation trains induces long-lasting improvement of visual neglect. Stroke. 2009;40:2791–6.

    Article  PubMed  Google Scholar 

  • Oliveri M, Bisiach E, Brighina F, Piazza A, La Bua V, Buffa D, Fierro B. RTMS of the unaffected hemisphere transiently reduces contralesional visuospatial hemineglect. Neurology. 2001;57:1338–40.

    Article  CAS  PubMed  Google Scholar 

  • Paolucci S, Bureca I, Multari M, Nocentini U, Matano A. An open-label pilot study of the use of rivastigmine to promote functional recovery in patients with unilateral spatial neglect due to first ischemic stroke. Funct Neurol. 2010;25:195–200.

    PubMed  Google Scholar 

  • Pizzamiglio L, Frasca R, Guariglia C, Incoccia C, Antonucci G. Effect of optokinetic stimulation in patients with visual neglect. Cortex. 1990;26:535–40.

    Article  CAS  PubMed  Google Scholar 

  • Robertson IH, Gray JM, Pentland B, Waite LJ. Microcomputer-based rehabilitation for unilateral left visual neglect: a randomized controlled trial. Arch Phys Med Rehabil. 1990;71:663–8.

    CAS  PubMed  Google Scholar 

  • Robertson IH, North NT, Geggie C. Spatio-motor cueing in unilateral left neglect: three case studies of its therapeutic effects. J Neurol Neurosurg Psychiatry. 1992;55:799–805.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Robertson IH, Tegner R, Goodrich SJ, Wilson C. Walking trajectory and hand movements in unilateral left neglect: a vestibular hypothesis. Neuropsychologia. 1994;32:1495–502.

    Article  CAS  PubMed  Google Scholar 

  • Robertson IH, Tegner R, Tham K, Lo A, Nimmo-Smith I. Sustained attention training for unilateral neglect: theoretical and rehabilitation implications. J Clin Exp Neuropsychol. 1995;17:416–30.

    Article  CAS  PubMed  Google Scholar 

  • Robertson IH, Mattingley JB, Rorden C, Driver J. Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature. 1998;395:169–72.

    Article  CAS  PubMed  Google Scholar 

  • Rode G, Perenin MT. Temporary remission of representational hemineglect through vestibular stimulation. NeuroReport. 1994;5:869–72.

    Article  CAS  PubMed  Google Scholar 

  • Rode G, Rossetti Y, Li L, Boisson D. The effect of prism adaptation on neglect for visual imagery. Behav Neurol. 1998;11:251–8.

    PubMed  Google Scholar 

  • Rode G, Rossetti Y, Boisson D. Prism adaptation improves representational neglect. Neuropsychologia. 2001;39:1250–4.

    Article  CAS  PubMed  Google Scholar 

  • Rode G, Pisella L, Rossetti Y, Farnè A, Boisson D. Bottom-up transfer of sensory-motor plasticity to recovery of spatial cognition: visuomotor adaptation and spatial neglect. Prog Brain Res. 2003;142:273–87.

    Article  PubMed  Google Scholar 

  • Rorsman I, Magnusson M, Johansson BB. Reduction of visuo-spatial neglect with vestibular galvanic stimulation. Scand J Rehabil Med. 1999;31:117–24.

    Article  CAS  PubMed  Google Scholar 

  • Rossetti Y, Rode G, Pisella L, Farnè A, Li L, Boisson D, Perenin MT. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature. 1998;395:166–9.

    Article  CAS  PubMed  Google Scholar 

  • Rossetti Y, Rode G, Boisson D. Sensori-motor plasticity and the rehabilitation of hemispatial neglect (plasticité sensori-motrice et récupération fonctionnelle: les effets thérapeutiques de l’adaptation prismatique sur la négligence spatiale unilatérale). Medecine/Sciences. 1999;15:239–45.

    Article  Google Scholar 

  • Rubens AB. Caloric stimulation and unilateral visual neglect. Neurology. 1985;35:1019–24.

    Article  CAS  PubMed  Google Scholar 

  • Sarter M, Bruno JP. Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents. Neuroscience. 1999;95:933–52.

    Article  Google Scholar 

  • Seron X, Deloche G, Coyette F. A retrospective analysis of a single case neglect therapy: a point of theory. In: Seron X, Deloche G, editors. Cognitive approaches in neuropsychological rehabilitation. Hillsdale: Lawrence Erlbaum Associates; 1989. p. 289–316.

    Google Scholar 

  • Sturm W, Thimm M, Kust J, Karbe H, Fink GR. Alertness-training in neglect: behavioral and imaging results. Restor Neurol Neurosci. 2006;24:371–84.

    CAS  PubMed  Google Scholar 

  • Thiel CM, Fink GR. Effects of the cholinergic agonist nicotine on reorienting of visual spatial attention and top-down attentional control. Neuroscience. 2008;152:381–90.

    Article  CAS  PubMed  Google Scholar 

  • Thimm M, Fink GR, Kust J, Karbe H, Sturm W. Impact of alertness training on spatial neglect: a behavioural and fMRI study. Neuropsychologia. 2006;44:1230–46.

    Article  CAS  PubMed  Google Scholar 

  • Tilikete C, Rode G, Rossetti Y, Li L, Pichon J, Boisson D. Prism adaptation to rightward optical deviation improves postural imbalance in left hemiparetic patients. Curr Biol. 2001;11:524–8.

    Article  CAS  PubMed  Google Scholar 

  • Vallar G, Rusconi ML, Barozzi S, Bernardini B, Ovadia D, Papagno C, Cesarini A. Improvement of left visuo-spatial hemineglect by left-sided transcutaneous electrical stimulation. Neuropsychologia. 1995;33:73–82.

    Article  CAS  PubMed  Google Scholar 

  • Weinberg J, Diller J, Gordon WA, Gerstman LJ, Lieberman A, Lakin P, Hodges G, Ezrachi O. Visual scanning training effect on reading-related tasks in acquired right-brain damage. Arch Phys Med Rehabil. 1977;58:479–86.

    CAS  PubMed  Google Scholar 

  • Wiart L, Bon Saint Come A, Debelleix X, Petit H, Joseph PA, Mazaux JM, Barat M. Unilateral neglect syndrome rehabilitation by trunk rotation and scanning training. Arch Phys Med Rehabil. 1997;78:424–9.

    Article  CAS  PubMed  Google Scholar 

  • Williams GV, Goldman-Rakic PS. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature. 1995;376:572–5.

    Article  CAS  PubMed  Google Scholar 

Further Reading

  • Coulthard E, Singh-Curry V, Husain M. Treatment of attention deficits in neurological disorders. Curr Opin Neurol. 2006;19:613–8.

    Google Scholar 

  • Halligan PW, Bartolomeo P. Visual neglect. In: Ramachandran VS, editor. Encyclopedia of human behavior. 2nd ed. vol. 3. San Diego: Academic; 2012. p. 652–64.

    Google Scholar 

  • Luaute J, Halligan P, Rode G, Rossetti Y, Boisson D. Visuo-spatial neglect: a systematic review of current interventions and their effectiveness. Neurosci Biobehav Rev. 2006;30:961–82.

    Google Scholar 

  • Müri RM, Cazzoli D, Nef T, Mosimann UP, Hopfner S, Nyffeler T. Non-invasive brain stimulation in neglect rehabilitation: an update. Front Hum Neurosci. 2013;7:248.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag London

About this chapter

Cite this chapter

Bartolomeo, P. (2014). Treatment of Attention Disorders. In: Attention Disorders After Right Brain Damage. Springer, London. https://doi.org/10.1007/978-1-4471-5649-9_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-5649-9_9

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-5648-2

  • Online ISBN: 978-1-4471-5649-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics