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The Anatomy of Neglect

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Attention Disorders After Right Brain Damage

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Abstract

This chapter provides an overview of the debate concerning the lesional correlates of neglect signs, with emphasis on methodological problems in anatomo-clinical correlations. It aims at linking neglect-related deficits to the anatomy of the attention systems in the normal human brain.

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References

  • Bartolomeo P. The novelty effect in recovered hemineglect. Cortex. 1997;33:323–32.

    Article  CAS  PubMed  Google Scholar 

  • Bartolomeo P. A parieto-frontal network for spatial awareness in the right hemisphere of the human brain. Arch Neurol. 2006;63:1238–41.

    Article  PubMed  Google Scholar 

  • Bartolomeo P. Visual neglect. Curr Opin Neurol. 2007;20:381–6.

    Article  PubMed  Google Scholar 

  • Bartolomeo P. The quest for the ‘critical lesion site’ in cognitive deficits: problems and perspectives. Cortex. 2011;47:1010–2.

    Article  PubMed  Google Scholar 

  • Bartolomeo P. The elusive nature of white matter damage in anatomo-clinical correlations. Front Hum Neurosci. 2012;6:229.

    PubMed Central  PubMed  Google Scholar 

  • Bartolomeo P, D’Erme P, Gainotti G. The relationship between visuospatial and representational neglect. Neurology. 1994;44:1710–4.

    Article  CAS  PubMed  Google Scholar 

  • Bartolomeo P, Thiebaut de Schotten M, Doricchi F. Left unilateral neglect as a disconnection syndrome. Cereb Cortex. 2007;45:3127–48.

    Google Scholar 

  • Bartolomeo P, Zieren N, Vohn R, Dubois B, Sturm W. Neural correlates of primary and reflective consciousness of spatial orienting. Neuropsychologia. 2008;46:348–61.

    Article  PubMed  Google Scholar 

  • Bartolomeo P, Thiebaut Schotten M, Chica AB. Brain networks of visuospatial attention and their disruption in visual neglect. Human. Neuroscience. 2012;6:110.

    Google Scholar 

  • Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys J. 1994;66:259–67.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bates E, Wilson SM, Saygin AP, Dick F, Sereno MI, Knight RT, Dronkers NF. Voxel-based lesion-symptom mapping. Nat Neurosci. 2003;6:448–50.

    CAS  PubMed  Google Scholar 

  • Berlucchi G, Aglioti S, Tassinari G. Rightward attentional bias and left hemisphere dominance in a cue-target light detection task in a callosotomy patient. Neuropsychologia. 1997;35:941–52.

    Article  CAS  PubMed  Google Scholar 

  • Binder J, Marshall R, Lazar R, Benjamin J, Mohr JP. Distinct syndromes of hemineglect. Arch Neurol. 1992;49:1187–94.

    Article  CAS  PubMed  Google Scholar 

  • Bird C, Malhotra P, Parton A, Coulthard EJ, Rushworth MF, Husain M. Visual neglect after right posterior cerebral artery infarction. J Neurol Neurosurg Psychiatry. 2006;77:1008–12.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bisiach E, Capitani E, Luzzatti C, Perani D. Brain and conscious representation of outside reality. Neuropsychologia. 1981;19:543–51.

    Article  CAS  PubMed  Google Scholar 

  • Bozzali M, Mastropasqua C, Cercignani M, Giulietti G, Bonni S, Caltagirone C, Koch G. Microstructural damage of the posterior corpus callosum contributes to the clinical severity of neglect. PLoS One. 2012;7:e48079.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Brain RW. Visual disorientation with special reference to lesion of the right brain hemisphere. Brain. 1941;64:244–72.

    Article  Google Scholar 

  • Broca PP. Perte de la parole, ramollissement chronique et destruction partielle du lobe antérieur gauche. Bulletin de la Société Anthropologique. 1861;2:235–8.

    Google Scholar 

  • Catani M, ffytche DH. The rises and falls of disconnection syndromes. Brain. 2005;128:2224–39.

    Article  PubMed  Google Scholar 

  • Catani M, Mesulam M-M. The arcuate fasciculus and the disconnection theme in language and aphasia: history and current state. Cortex. 2008;44:953–61.

    Article  PubMed Central  PubMed  Google Scholar 

  • Catani M, Jones DK, Donato R, Ffytche DH. Occipito-temporal connections in the human brain. Brain. 2003;126:2093–107.

    Article  PubMed  Google Scholar 

  • Chechlacz M, Rotshtein P, Bickerton WL, Hansen PC, Deb S, Humphreys GW. Separating neural correlates of allocentric and egocentric neglect: distinct cortical sites and common white matter disconnections. Cogn Neuropsychol. 2010;27:277–303.

    Article  PubMed  Google Scholar 

  • Ciaraffa F, Castelli G, Parati EA, Bartolomeo P, Bizzi A. Visual neglect as a disconnection syndrome? A confirmatory case report. Neurocase. 2013;19(4):351–9.

    Article  PubMed  Google Scholar 

  • Committeri G, Pitzalis S, Galati G, Patria F, Pelle G, Sabatini U, Castriota-Scanderbeg A, Piccardi L, Guariglia C, Pizzamiglio L. Neural bases of personal and extrapersonal neglect in humans. Brain. 2007;130:431–41.

    Article  PubMed  Google Scholar 

  • Corballis MC, Corballis PM, Fabri M, Paggi A, Manzoni T. Now you see it, now you don’t: variable hemineglect in a commissurotomized man. Cogn Brain Res. 2005;25:521–30.

    Article  Google Scholar 

  • Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 2002;3:201–15.

    CAS  PubMed  Google Scholar 

  • Corbetta M, Kincade MJ, Lewis C, Snyder AZ, Sapir A. Neural basis and recovery of spatial attention deficits in spatial neglect. Nat Neurosci. 2005;8:1603–10.

    Article  CAS  PubMed  Google Scholar 

  • Doricchi F, Tomaiuolo F. The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? NeuroReport. 2003;14:2239–43.

    Article  PubMed  Google Scholar 

  • Doricchi F, Thiebaut de Schotten M, Tomaiuolo F, Bartolomeo P. White matter (dis)connections and gray matter (dys)functions in visual neglect: gaining insights into the brain networks of spatial awareness. Cortex. 2008;44:983–95.

    Article  PubMed  Google Scholar 

  • Duffau H, Capelle L, Sichez J, Faillot T, Abdennour L, Law Koune JD, Dadoun S, Bitar A, Arthuis F, Van Effenterre R, Fohanno D. Intra-operative direct electrical stimulations of the central nervous system: the Salpêtrière experience with 60 patients. Acta Neurochir. 1999;141:1157–67.

    Article  CAS  PubMed  Google Scholar 

  • Feeney DM, Baron JC. Diaschisis. Stroke. 1986;17:817–30.

    Article  CAS  PubMed  Google Scholar 

  • Gaffan D, Hornak J. Visual neglect in the monkey. Representation and disconnection. Brain. 1997;120:1647–57.

    Article  PubMed  Google Scholar 

  • Geschwind N. Disconnexion syndromes in animals and man – part I. Brain. 1965;88:237–94.

    Article  CAS  PubMed  Google Scholar 

  • Godefroy O, Duhamel A, Leclerc X, Saint Michel T, Henon H, Leys D. Brain-behaviour relationships. Some models and related statistical procedures for the study of brain-damaged patients. Brain. 1998;121(Pt 8):1545–56.

    Article  PubMed  Google Scholar 

  • Guariglia C, Padovani A, Pantano P, Pizzamiglio L. Unilateral neglect restricted to visual imagery. Nature. 1993;364:235–7.

    Article  CAS  PubMed  Google Scholar 

  • Halligan PW, Fink GR, Marshall JC, Vallar G. Spatial cognition: evidence from visual neglect. Trends Cogn Sci. 2003;7:125–33.

    Article  PubMed  Google Scholar 

  • Heilman KM, Adams DJ. Callosal neglect. Arch Neurol. 2003;60:276–9.

    Article  PubMed  Google Scholar 

  • Hillis AE, Newhart M, Heidler J, Barker PB, Herskovits EH, Degaonkar M. Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. J Neurosci. 2005;25:3161–7.

    Article  CAS  PubMed  Google Scholar 

  • Karnath H-O, Ferber S, Himmelbach M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature. 2001;411:950–63.

    Article  CAS  PubMed  Google Scholar 

  • Karnath H-O, Himmelbach M, Rorden C. The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain. 2002;125:350–60.

    Article  PubMed  Google Scholar 

  • Karnath H-O, Fruhmann Berger M, Kuker W, Rorden C. The anatomy of spatial neglect based on voxelwise statistical analysis: a study of 140 patients. Cerebral Cortex. 2004;14:1164–72.

    Article  PubMed  Google Scholar 

  • Kashiwagi A, Kashiwagi T, Nishikawa T, Tanabe H, Okuda J. Hemispatial neglect in a patient with callosal infarction. Brain. 1990;113:1005–23.

    Article  PubMed  Google Scholar 

  • Leibovitch FS, Black SE, Caldwell CB, Ebert PL, Ehrlich LE, Szalai JP. Brain-behavior correlations in hemispatial neglect using CT and SPECT: the Sunnybrook Stroke Study. Neurology. 1998;50:901–8.

    Article  CAS  PubMed  Google Scholar 

  • Molenberghs P, Sale MV, Mattingley JB. Is there a critical lesion site for unilateral spatial neglect? A meta-analysis using activation likelihood estimation. Front Hum Neurosci. 2012;6:78.

    PubMed Central  PubMed  Google Scholar 

  • Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, Husain M. The anatomy of visual neglect. Brain. 2003;126:1986–97.

    Article  PubMed  Google Scholar 

  • Nobre AC. The attentive homunculus: now you see it, now you don’t. Neurosci Biobehav Rev. 2001;25:477–96.

    Article  CAS  PubMed  Google Scholar 

  • Ortigue S, Viaud-Delmon I, Annoni JM, Landis T, Michel C, Blanke O, Vuilleumier P, Mayer E. Pure representational neglect after right thalamic lesion. Ann Neurol. 2001;50:401–4.

    Article  CAS  PubMed  Google Scholar 

  • Ota H, Fujii T, Suzuki K, Fukatsu R, Yamadori A. Dissociation of body-centered and stimulus-centered representations in unilateral neglect. Neurology. 2001;57:2064–9.

    Article  CAS  PubMed  Google Scholar 

  • Park KC, Lee BH, Kim EJ, Shin MH, Choi KM, Yoon SS, Kwon SU, Chung CS, Lee KH, Heilman KM, Na DL. Deafferentation-disconnection neglect induced by posterior cerebral artery infarction. Neurology. 2006;66:56–61.

    Article  CAS  PubMed  Google Scholar 

  • Pouget P, Pradat-Diehl P, Rivaud-Pechoux S, Wattiez N, Gaymard B. An oculomotor and computational study of a patient with diagonistic dyspraxia. Cortex. 2011;47:473–83.

    Article  PubMed  Google Scholar 

  • Rode G, Cotton F, Revol P, Jacquin-Courtois S, Rossetti Y, Bartolomeo P. Representation and disconnection in imaginal neglect. Neuropsychologia. 2010;48:2903–11.

    Article  CAS  PubMed  Google Scholar 

  • Sack AT, Camprodon JA, Pascual-Leone A, Goebel R. The dynamics of interhemispheric compensatory processes in mental imagery. Science. 2005;308:702–4.

    Article  CAS  PubMed  Google Scholar 

  • Schmahmann JD, Pandya DN. Fiber pathways of the brain. New York: Oxford University Press; 2006.

    Book  Google Scholar 

  • Thiebaut de Schotten M, Tomaiuolo F, Aiello M, Merola S, Silvetti M, Lecce F, Bartolomeo P, Doricchi F. Damage to white matter pathways in sub-acute and chronic spatial neglect: a group study and two single-case studies with complete virtual “in-vivo” tractography dissection. Cereb Cortex. 2012.

    Google Scholar 

  • Thiebaut de Schotten M, Urbanski M, Duffau H, Volle E, Levy R, Dubois B, Bartolomeo P. Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans. Science. 2005;309:2226–8.

    Article  CAS  PubMed  Google Scholar 

  • Thiebaut de Schotten M, Kinkingnéhun SR, Delmaire C, Lehéricy S, Duffau H, Thivard L, Volle E, Lévy R, Dubois B, Bartolomeo P. Visualization of disconnection syndromes in humans. Cortex. 2008;44:1097–103.

    Article  PubMed  Google Scholar 

  • Thiebaut de Schotten M, Dell’Acqua F, Forkel SJ, Simmons A, Vergani F, Murphy DGM, Catani M. A lateralized brain network for visuospatial attention. Nat Neurosci. 2011;14:1245–6.

    Article  CAS  PubMed  Google Scholar 

  • Tomaiuolo F, Voci L, Bresci M, Cozza S, Posteraro F, Oliva M, Doricchi F. Selective visual neglect in right brain damaged patients with splenial interhemispheric disconnection. Exp Brain Res. 2010;206:209–17.

    Article  PubMed  Google Scholar 

  • Urbanski M, Thiebaut de Schotten M, Rodrigo S, Catani M, Oppenheim C, Touzé E, Chokron S, Méder J-F, Lévy R, Dubois B, Bartolomeo P. Brain networks of spatial awareness: evidence from diffusion tensor imaging tractography. J Neurol Neurosurg Psychiatry. 2008;79:598–601.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Urbanski M, Thiebaut de Schotten M, Rodrigo S, Oppenheim C, Touzé E, Méder JF, Moreau K, Loeper-Jeny C, Dubois B, Bartolomeo P. DTI-MR tractography of white matter damage in stroke patients with neglect. Exp Brain Res. 2011;208:491–505.

    Article  CAS  PubMed  Google Scholar 

  • Vallar G. Extrapersonal visual unilateral spatial neglect and its neuroanatomy. Neuroimage. 2001;14:S52–8.

    Article  CAS  PubMed  Google Scholar 

  • Vallar G, Perani D. The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia. 1986;24:609–22.

    Article  CAS  PubMed  Google Scholar 

  • Vallar G, Bello L, Bricolo E, Castellano A, Casarotti A, Falini A, Riva M, Fava E, Papagno C. Cerebral correlates of visuospatial neglect: a direct cerebral stimulation study. Hum Brain Mapp. 2013.

    Google Scholar 

  • Verdon V, Lovblad K-O, Hauert C-A, Vuilleumier P. Neuroanatomical basis of hemispatial neglect components using voxel-based lesion symptom mapping. In: 2nd meeting of the European Societies of Neuropsychology. Toulouse; 2006. p. 277.

    Google Scholar 

  • Verdon V, Schwartz S, Lovblad KO, Hauert CA, Vuilleumier P. Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mapping. Brain. 2010;133:880–94.

    Article  PubMed  Google Scholar 

Further Reading

  • Corbetta M, Shulman GL. Spatial neglect and attention networks. Annu Rev Neurosci. 2011;34:569–99.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Doricchi F, Thiebaut de Schotten M, Tomaiuolo F, Bartolomeo P. White matter (dis)connections and gray matter (dys)functions in visual neglect: Gaining insights into the brain networks of spatial awareness. Cortex. 2008;44(8):983–95.

    Article  PubMed  Google Scholar 

  • Molenberghs P, Sale MV, Mattingley JB. Is there a critical lesion site for unilateral spatial neglect? A meta-analysis using activation likelihood estimation. Front Hum Neurosci. 2012;6:78.

    PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Brain and Spine Institute Hôpital de la Salpêtrière, Institut national de la santé et de la recherche médicale (INSERM), Paris, France

    Paolo Bartolomeo MD, PhD

  2. Department of Psychology, Catholic University, Milan, Italy

    Paolo Bartolomeo MD, PhD

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  1. Paolo Bartolomeo MD, PhD
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Bartolomeo, P. (2014). The Anatomy of Neglect. In: Attention Disorders After Right Brain Damage. Springer, London. https://doi.org/10.1007/978-1-4471-5649-9_7

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  • DOI: https://doi.org/10.1007/978-1-4471-5649-9_7

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