Skip to main content

Role of Duplex Ultrasound in Carotid Screening

  • Chapter
  • First Online:
Noninvasive Vascular Diagnosis

Abstract

Screening programs designed to identify disease in the general public have proliferated in recent years, and increased stroke awareness has resulted in both free and for-profit screening programs for carotid disease being offered to the public. This chapter evaluates the effectiveness of screening for carotid artery disease, which by definition means identifying patients with asymptomatic internal carotid disease. A literature review of the history of carotid screening for both general and high-risk populations was undertaken, and the cost-effectiveness of screening programs analyzed. Despite the increased interest related to patients with asymptomatic carotid artery stenosis, screening for carotid artery disease is difficult to justify as the prevalence of asymptomatic carotid artery stenosis and risk of subsequent ipsilateral stroke are low in the general public. Moreover, the number of patients needed to screen in order to prevent one stroke is excessive. At present, there are no data supporting screening for asymptomatic carotid disease in individuals appropriately treated for cardiovascular risk reduction. It is unlikely that screening for carotid artery disease will improve patient care or be cost-effective.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 249.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis. JAMA. 1995;273(18):1421–8.

    Article  Google Scholar 

  2. Barnett HJ, Gunton RW, Eliasziw M, Fleming L, Sharpe B, Gates P, et al. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis. JAMA. 2000;283(11):1429–36.

    Article  PubMed  CAS  Google Scholar 

  3. Jahromi AS, Cina CS, Liu Y, Clase CM. Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis. J Vasc Surg. 2005;41(6):962–72.

    Article  PubMed  Google Scholar 

  4. American Heart Association. Heart disease and stroke statistics. 2011. Available at: http://www.heart.org/HEARTORG/General/Heart-and-Stroke-Association-Statistics_UCM_319064_SubHomePage.jsp. Accessed 13 June 2011.

  5. Kelly-Hayes M, Beiser A, Kase CS, Scaramucci A, D’Agostino RB, Wolf PA. The influence of gender and age on disability following ischemic stroke: the Framingham study. J Stroke Cerebrovasc Dis. 2003;12(3):119–26.

    Article  PubMed  Google Scholar 

  6. Colgan MP, Strode GR, Sommer JD, Gibbs JL, Sumner DS. Prevalence of asymptomatic carotid disease: results of duplex scanning in 348 unselected volunteers. J Vasc Surg. 1988;8(6):674–8.

    PubMed  CAS  Google Scholar 

  7. Ricci S, Flamini FO, Marini M, Antonini D, Bartolini S, Celani MG, et al. The prevalence of stenosis of the internal carotid in subjects over 49: a population study. Epidemiol Prev. 1991;13(48–49):173–6.

    PubMed  CAS  Google Scholar 

  8. Warlow C. Endarterectomy for asymptomatic carotid stenosis? Lancet. 1995;345(8960):1254–5.

    Article  PubMed  CAS  Google Scholar 

  9. Bots ML, Breslau PJ, Briet E, de Bruyn AM, van Vliet HH, van den Ouweland FA, et al. Cardiovascular determinants of carotid artery disease. The Rotterdam Elderly study. Hypertension. 1992;19(6 Pt 2):717–20.

    Article  PubMed  CAS  Google Scholar 

  10. Fine-Edelstein JS, Wolf PA, O’Leary DH, Poehlman H, Belanger AJ, Kase CS, et al. Precursors of extracranial carotid atherosclerosis in the Framingham study. Neurology. 1994;44(6):1046–50.

    Article  PubMed  CAS  Google Scholar 

  11. Vecchio TJ. Predictive value of a single diagnostic test in unselected populations. N Engl J Med. 1966;274(21):1171–3.

    Article  PubMed  CAS  Google Scholar 

  12. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical epidemiology: a basic science for clinical medicine. 2nd ed. Boston: Little, Brown and Co; 1991.

    Google Scholar 

  13. Faught WE, Mattos MA, Van Bemmelen PS, Hodgson KJ, Barkmeier LD, Ramsey DE, et al. Color-flow duplex scanning of carotid arteries: new velocity criteria based on receiver operator characteristic analysis for threshold stenoses used in the symptomatic and asymptomatic carotid trials. J Vasc Surg. 1994;19(5):818–27.

    Article  PubMed  CAS  Google Scholar 

  14. Norris JW, Zhu CZ, Bornstein NM, Chambers BR. Vascular risks of asymptomatic carotid stenosis. Stroke. 1991;22(12):1485–90.

    Article  PubMed  CAS  Google Scholar 

  15. European Carotid Surgery Trialists’ Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet. 1998;351(9113):1379–87.

    Google Scholar 

  16. Hobson RW, Weiss DG, Fields WS, Goldstone J, Moore WS, Towne JB, et al. Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. The Veterans Affairs Cooperative Study Group. N Engl J Med. 1993;328(4):221–7.

    Article  PubMed  Google Scholar 

  17. Hill AB. Should patients be screened for asymptomatic carotid artery stenosis? Can J Surg. 1998;41(3):208–13.

    PubMed  CAS  Google Scholar 

  18. Sleight SP, Poloniecki J, Halliday AW. Asymptomatic carotid stenosis in patients on medical treatment alone. Eur J Vasc Endovasc Surg. 2002;23(6):519–23.

    Article  PubMed  CAS  Google Scholar 

  19. Nehler MR, Moneta GL, Lee RW, Edwards JM, Taylor Jr LM, Porter JM. Improving selection of patients with less than 60% asymptomatic internal carotid artery stenosis for follow-up carotid artery duplex scanning. J Vasc Surg. 1996;24(4):580–5.

    Article  PubMed  CAS  Google Scholar 

  20. Rockman CB, Riles TS, Lamparello PJ, Giangola G, Adelman MA, Stone D, et al. Natural history and management of the asymptomatic, moderately stenotic internal carotid artery. J Vasc Surg. 1997;25(3):423–31.

    Article  PubMed  CAS  Google Scholar 

  21. Mansour MA, Littooy FN, Watson WC, Blumofe KA, Heilizer TJ, Steffen GF, et al. Outcome of moderate carotid artery stenosis in patients who are asymptomatic. J Vasc Surg. 1999;29(2):217–25.

    Article  PubMed  CAS  Google Scholar 

  22. Muluk SC, Muluk VS, Sugimoto H, Rhee RY, Trachtenberg J, Steed DL, et al. Progression of asymptomatic carotid stenosis: a natural history study in 1004 patients. J Vasc Surg. 1999;29(2):208–14.

    Article  PubMed  CAS  Google Scholar 

  23. Garvey L, Makaroun MS, Muluk VS, Webster MW, Muluk SC. Etiologic factors in progression of carotid stenosis: a 10-year study in 905 patients. J Vasc Surg. 2000;31(1 Pt 1):31–8.

    Article  PubMed  CAS  Google Scholar 

  24. Shanik DG, Moore DJ, Leahy A, Grouden MC, Colgan M-P. Asymptomatic carotid stenosis: a benign lesion? Eur J Vasc Surg. 1992;6(1):10–5.

    Article  PubMed  CAS  Google Scholar 

  25. Ellis MR, Franks PJ, Cuming R, Powell JT, Greenhalgh RM. Prevalence, progression and natural history of asymptomatic carotid stenosis: is there a place for carotid endarterectomy? Eur J Vasc Surg. 1992;6(2):172–7.

    Article  PubMed  CAS  Google Scholar 

  26. Naylor AR. Delay may reduce procedural risk, but at what price to the patient? Eur J Vasc Endovasc Surg. 2008;35(4):383–91.

    Article  PubMed  CAS  Google Scholar 

  27. McPhee JT, Schanzer A, Messina LM, Eslami MH. Carotid artery stenting has increased rates of postprocedure stroke, death, and resource utilization than does carotid endarterectomy in the United States, 2005. J Vasc Surg. 2008;48(6):1442–50.

    Article  PubMed  Google Scholar 

  28. Bunch CT, Kresowik TF. Can randomized trial outcomes for carotid endarterectomy be achieved in community-wide practice? Semin Vasc Surg. 2004;17(3):209–13.

    PubMed  Google Scholar 

  29. Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685–96.

    Article  PubMed  CAS  Google Scholar 

  30. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360(9326):7–22.

    Article  Google Scholar 

  31. Amarenco P, Bogousslavsky J, Callahan III A, Goldstein LB, Hennerici M, Rudolph AE, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006;355(6):549–59.

    Article  PubMed  CAS  Google Scholar 

  32. Marquardt L, Geraghty OC, Mehta Z, Rothwell PM. Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: a prospective, population-based study. Stroke. 2010;41(1):e11–7.

    Article  PubMed  Google Scholar 

  33. Goessens BM, Visseren FL, Kappelle LJ, Algra A, van Der GY. Asymptomatic carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease: the SMART study. Stroke. 2007;38(5):1470–5.

    Article  PubMed  Google Scholar 

  34. Lavenson GS. Stroke prevention screening: rationale, method, and implementation. Vasc Ultrasound Today. 2003;8(1):1–24.

    Google Scholar 

  35. Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284(22):2901–6.

    Article  PubMed  CAS  Google Scholar 

  36. Wolf PA, D’Agostino RB, Kannel WB, Bonita R, Belanger AJ. Cigarette smoking as a risk factor for stroke. The Framingham study. JAMA. 1988;259(7):1025–9.

    Article  PubMed  CAS  Google Scholar 

  37. Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, et al. The lifetime risk of stroke: estimates from the Framingham study. Stroke. 2006;37(2):345–50.

    Article  PubMed  Google Scholar 

  38. Lee IM, Hennekens CH, Berger K, Buring JE, Manson JE. Exercise and risk of stroke in male physicians. Stroke. 1999;30(1):1–6.

    Article  PubMed  CAS  Google Scholar 

  39. Lee IM, Paffenbarger Jr RS. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke. 1998;29(10):2049–54.

    Article  PubMed  CAS  Google Scholar 

  40. Hu FB, Stampfer MJ, Colditz GA, Ascherio A, Rexrode KM, Willett WC, et al. Physical activity and risk of stroke in women. JAMA. 2000;283(22):2961–7.

    Article  PubMed  CAS  Google Scholar 

  41. Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, et al. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women’s Health Initiative: a randomized trial. JAMA. 2003;289(20):2673–84.

    Article  PubMed  CAS  Google Scholar 

  42. D’Agostino RS, Svensson LG, Neumann DJ, Balkhy HH, Williamson WA, Shahian DM. Screening carotid ultrasonography and risk factors for stroke in coronary artery surgery patients. Ann Thorac Surg. 1996;62(6):1714–23.

    Article  PubMed  Google Scholar 

  43. Reed III GL, Singer DE, Picard EH, DeSanctis RW. Stroke following coronary-artery bypass surgery. A case-control estimate of the risk from carotid bruits. N Engl J Med. 1988;319(19):1246–50.

    Article  PubMed  Google Scholar 

  44. Li Y, Walicki D, Mathiesen C, Jenny D, Li Q, Isayev Y, et al. Strokes after cardiac surgery and relationship to carotid stenosis. Arch Neurol. 2009;66(9):1091–6.

    Article  PubMed  Google Scholar 

  45. Marek J, Mills JL, Harvich J, Cui H, Fujitani RM. Utility of routine carotid duplex screening in patients who have claudication. J Vasc Surg. 1996;24(4):572–7.

    Article  PubMed  CAS  Google Scholar 

  46. Turnipseed WD, Berkoff HA, Belzer FO. Postoperative stroke in cardiac and peripheral vascular disease. Ann Surg. 1980;192(3):365–8.

    Article  PubMed  CAS  Google Scholar 

  47. Barnes RW, Liebman PR, Marszalek PB, Kirk CL, Goldman MH. The natural history of asymptomatic carotid disease in patients undergoing cardiovascular surgery. Surgery. 1981;90(6):1075–83.

    PubMed  CAS  Google Scholar 

  48. Ahn SS, Baker JD, Walden K, Moore WS. Which asymptomatic patients should undergo routine screening carotid duplex scan? Am J Surg. 1991;162(2):180–3.

    Article  PubMed  CAS  Google Scholar 

  49. Fowl RJ, Marsch JG, Love M, Patterson RB, Shukla R, Kempczinski RF. Prevalence of hemodynamically significant stenosis of the carotid artery in an asymptomatic veteran population. Surg Gynecol Obstet. 1991;172(1):13–6.

    PubMed  CAS  Google Scholar 

  50. Gentile AT, Taylor Jr LM, Moneta GL, Porter JM. Prevalence of asymptomatic carotid stenosis in patients undergoing infrainguinal bypass surgery. Arch Surg. 1995;130(8):900–4.

    Article  PubMed  CAS  Google Scholar 

  51. de Virgiolio C, Toosie K, Arnell T, Lewis RJ, Donayre CE, Baker JD, et al. Asymptomatic carotid artery stenosis screening in patients with lower extremity atherosclerosis: a prospective study. Ann Vasc Surg. 1997;11(4):374–7.

    Article  Google Scholar 

  52. Hennerici M, Aulich A, Sandmann W, Freund HJ. Incidence of asymptomatic extracranial arterial disease. Stroke. 1981;12(6):750–8.

    Article  PubMed  CAS  Google Scholar 

  53. Naylor AR, John T, Howlett J, Gillespie I, Allan P, Ruckley CV. Fate of the non-operated carotid artery after contralateral endarterectomy. Br J Surg. 1995;82(1):44–8.

    Article  PubMed  CAS  Google Scholar 

  54. AbuRahma AF, Cook CC, Metz MJ, Wulu Jr JT, Bartolucci A. Natural history of carotid artery stenosis contralateral to endarterectomy: results from two randomized prospective trials. J Vasc Surg. 2003;38(6):1154–61.

    Article  PubMed  Google Scholar 

  55. Ballotta E, Da GG, Meneghetti G, Barbon B, Militello C, Baracchini C. Progression of atherosclerosis in asymptomatic carotid arteries after contralateral endarterectomy: a 10-year prospective study. J Vasc Surg. 2007;45(3):516–22.

    Article  PubMed  Google Scholar 

  56. Lee TT, Solomon NA, Heidenreich PA, Oehlert J, Garber AM. Cost-effectiveness of screening for carotid stenosis in asymptomatic persons. Ann Intern Med. 1997;126(5):337–46.

    PubMed  CAS  Google Scholar 

  57. Derdeyn CP, Powers WJ. Cost-effectiveness of screening for asymptomatic carotid atherosclerotic disease. Stroke. 1996;27(11):1944–50.

    Article  PubMed  CAS  Google Scholar 

  58. Obuchowski NA, Modic MT, Magdinec M, Masaryk TJ. Assessment of the efficacy of noninvasive screening for patients with asymptomatic neck bruits. Stroke. 1997;28(7):1330–9.

    Article  PubMed  CAS  Google Scholar 

  59. Yin D, Carpenter JP. Cost-effectiveness of screening for asymptomatic carotid stenosis. J Vasc Surg. 1998;27(2):245–55.

    Article  PubMed  CAS  Google Scholar 

  60. Qureshi AI, Janardhan V, Bennett SE, Luft AR, Hopkins LN, Guterman LR. Who should be screened for asymptomatic carotid artery stenosis? Experience from the Western New York Stroke Screening Program. J Neuroimaging. 2001;11(2):105–11.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anthony J. Comerota M.D., RVT, FACS, FACC .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag London

About this chapter

Cite this chapter

Aziz, F., Scissons, R.P., Comerota, A.J. (2013). Role of Duplex Ultrasound in Carotid Screening. In: AbuRahma, A., Bandyk, D. (eds) Noninvasive Vascular Diagnosis. Springer, London. https://doi.org/10.1007/978-1-4471-4005-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-4005-4_12

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4004-7

  • Online ISBN: 978-1-4471-4005-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics