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Specific Immunotherapeutic Strategies: Lessons from Myelin Basic Protein-Induced Experimental Allergic Encephalomyelitis

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Treatment of Multiple Sclerosis

Part of the book series: Clinical Medicine and the Nervous System ((CLIN.MED.NERV.))

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Abstract

The progress of research on the pathogenesis and treatment of multiple sclerosis (MS), the principal human demyelinating disease of the central nervous system (CNS), has intensified in the past 3 years. In part, this is due to the application of advances in molecular biology, like polymerase chain reaction (PCR), and to developments in cellular immunology, like technology for the growth of T-cell clones. Many lessons that have been learned in an animal model of CNS demyelinating disease, experimental allergic encephalomyelitis (EAE), have been verified in the human disease MS. Indeed, certain successful approaches for treatment of EAE are being attempted in MS at the present time.

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Authors
  1. Robert B. Bell
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  2. Lawrence Steinman
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Editor information

Editors and Affiliations

  1. Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195-5244, Cleveland, OH, USA

    Richard A. Rudick MD  & Donald E. Goodkin MD  & 

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© 1992 Springer-Verlag London Limited

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Bell, R.B., Steinman, L. (1992). Specific Immunotherapeutic Strategies: Lessons from Myelin Basic Protein-Induced Experimental Allergic Encephalomyelitis. In: Rudick, R.A., Goodkin, D.E. (eds) Treatment of Multiple Sclerosis. Clinical Medicine and the Nervous System. Springer, London. https://doi.org/10.1007/978-1-4471-3184-7_14

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  • DOI: https://doi.org/10.1007/978-1-4471-3184-7_14

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3186-1

  • Online ISBN: 978-1-4471-3184-7

  • eBook Packages: Springer Book Archive

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