Abstract
Diffuse intrinsic pontine gliomas (DIPG) are unique in pediatric neuro-oncology as they are inoperable and rarely being biopsied. They are a relatively clean tumor group to be studied with MR spectroscopy because lesions are always in the same region, generally large and homogeneous, and MR studies are technically not compromised by biopsies or surgery. These tumors are well suited for longitudinal studies to evaluate metabolic changes over the disease course. The absence of tissue samples, unfortunately, also means that definitive correlation between physiological features and tissue biology and histology is not possible. In this chapter, an overview of the MR spectroscopic features of DIPG at baseline and at follow-up is given.
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Blüml, S. (2013). Diffuse Intrinsic Pontine Gliomas. In: Blüml, S., Panigrahy, A. (eds) MR Spectroscopy of Pediatric Brain Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5864-8_6
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