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Magnetic Resonance Spectroscopy of Pediatric Brain Tumors

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MR Spectroscopy of Pediatric Brain Disorders

Abstract

Magnetic resonance spectroscopy can provide noninvasive metabolite profiles of childhood brain tumors and these are highly characteristic for tumor type. This information is increasingly being used to provide a noninvasive diagnostic aid but since tumor pathologies differ in children to adults, child specific classifiers are required. Despite the strong dependence of the MRS metabolite profile on tumor type, some metabolites are also biomarkers of prognosis both within and across tumor groups. Some evidence is also emerging that MRS can also provide biomarkers of treatment response where prior to changes on conventional MRI.

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Acknowledgments

CRUK and EPSRC Cancer Imaging Programme at the Children’s Cancer and Leukaemia Group (CCLG) in association with the MRC and Department of Health (England) (C7809/A10342).

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Authors and Affiliations

  1. School of Cancer Sciences, University of Birmingham, Birmingham, UK

    Simrandip K. Gill

  2. Department of Pediatric Radiology, Children’s Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA, 15224, USA

    Ashok Panigrahy M.D.

  3. Department of Radiology, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Suite Floor 2, Pittsburgh, PA, 15224, USA

    Ashok Panigrahy M.D.

  4. School of Electronic, Electrical & Computer Engineering, The University of Birmingham, Birmingham, UK

    Theodoros N. Arvanitis Ph.D.

  5. Institute of Child Health, University of Birmingham, Whittall Street, Birmingham, B4 6NH, UK

    Andrew C. Peet Ph.D., F.R.C.P.C.H.

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Correspondence to Andrew C. Peet Ph.D., F.R.C.P.C.H. .

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  1. Keck School of Medicine, Dept. Radiology, University of Southern California, Zonal Avenue 1975, Los Angeles, 90089-9034, California, USA

    Stefan Blüml

  2. , Dept. of Pediatric Radiology, Children's Hospital of Pittsburg of UPMC, Penn Avenue 4401, Pittsburgh, 15224, Pennsylvania, USA

    Ashok Panigrahy

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Gill, S.K., Panigrahy, A., Arvanitis, T.N., Peet, A.C. (2013). Magnetic Resonance Spectroscopy of Pediatric Brain Tumors. In: Blüml, S., Panigrahy, A. (eds) MR Spectroscopy of Pediatric Brain Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5864-8_5

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