Skip to main content
SpringerLink
Log in

Magnetic Resonance Spectroscopy: Basics

  • Chapter
  • First Online:
MR Spectroscopy of Pediatric Brain Disorders

Abstract

In this chapter, the basic principles and procedures of proton magnetic resonance spectroscopy (MRS), with emphasis on clinical and experimental work in humans, are illustrated. An in-depth understanding of the laws of physics and chemistry that make MRS (and MRI) possible is outside the scope.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ross BD, Bluml S. Neurospectroscopy. In: Greenberg JO, editor. Neuroimaging second edition; a companion to Adams and Victor’s principles of neurology. New York: McGraw Hill; 1999. p. 727–73.

    Google Scholar 

  2. Ryner LN, Sorenson JA, Thomas MA. Localized 2D J-resolved 1H MR spectroscopy: strong coupling effects in vitro and in vivo [published erratum appears in Magn Reson Imaging 1995;13(7):1043]. Magn Reson Imaging. 1995;13(6):853–69.

    Article  PubMed  CAS  Google Scholar 

  3. Hurd RE, Gurr D, Sailasuta N. Proton spectroscopy without water suppression: the oversampled J- resolved experiment. Magn Reson Med. 1998;40(3):343–7.

    Article  PubMed  CAS  Google Scholar 

  4. Rothman DL, Petroff OA, Behar KL, Mattson RH. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci USA. 1993;90(12):5662–6.

    Article  PubMed  CAS  Google Scholar 

  5. Hetherington HP, Newcomer BR, Pan JW. Measurements of human cerebral GABA at 4.1 T using numerically optimized editing pulses. Magn Reson Med. 1998;39(1):6–10.

    Article  PubMed  CAS  Google Scholar 

  6. Shen J, Novotny EJ, Rothman DL. In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train. Magn Reson Med. 1998;40(5):783–8.

    Article  PubMed  CAS  Google Scholar 

  7. Bottomley PA, Inventor. Selective volume method for performing localized NMR spectroscopy. US patent US patent 4 480 2281984.

    Google Scholar 

  8. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Ann N Y Acad Sci. 1987;508:333–48.

    Article  PubMed  CAS  Google Scholar 

  9. Frahm J, Merboldt K, Haenicke W. Localized proton spectroscopy using stimulated echos. J Magn Reson. 1987;72:502–8.

    CAS  Google Scholar 

  10. Ordidge RJ, Connelly A, B. Lohman JA. Image-selected in-vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J Magn Reson. 1986;66:283–94.

    CAS  Google Scholar 

  11. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30(6):672–9.

    Article  PubMed  CAS  Google Scholar 

  12. Naressi A, Couturier C, Devos JM, et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA. 2001;12(2–3):141–52.

    PubMed  CAS  Google Scholar 

  13. Kreis R. Quantitative localized 1H MR spectroscopy for clinical use. Prog NMR Spectroscopy. 1997;31:155–95.

    Article  CAS  Google Scholar 

  14. Danielsen ER, Henriksen O. Absolute quantitative proton NMR spectroscopy based on the amplitude of the local water suppression pulse. Quantification of brain water and metabolites. NMR Biomed. 1994;7(7):311–8.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Stefan Blüml Ph.D.

Authors
  1. Stefan Blüml Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefan Blüml Ph.D. .

Editor information

Editors and Affiliations

  1. Keck School of Medicine, Dept. Radiology, University of Southern California, Zonal Avenue 1975, Los Angeles, 90089-9034, California, USA

    Stefan Blüml

  2. , Dept. of Pediatric Radiology, Children's Hospital of Pittsburg of UPMC, Penn Avenue 4401, Pittsburgh, 15224, Pennsylvania, USA

    Ashok Panigrahy

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Blüml, S. (2013). Magnetic Resonance Spectroscopy: Basics. In: Blüml, S., Panigrahy, A. (eds) MR Spectroscopy of Pediatric Brain Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5864-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-5864-8_2

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-5863-1

  • Online ISBN: 978-1-4419-5864-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation