Skip to main content

Psychological Co-morbidities of Dementia

  • Chapter
  • First Online:
Psychological Co-morbidities of Physical Illness

Abstract

Dementia is a clinical syndrome characterized by a gradually progressing cognitive impairment. This impairment is commonly manifested by memory deficits; but the presence of one or more additional cognitive disturbances, including aphasia, agnosia, apraxia or executive dysfunction, is required to make the diagnosis, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) criteria. Those disturbances should be a change from the previous baseline and should cause significant distress to the patient and caregivers. Medical problems that can cause memory impairment, substance abuse and a psychiatric axis I diagnosis need to be ruled out before making the diagnosis of dementia (The American Journal of Psychiatry 164:5–56, 2007).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aalten, P., van Valen, E., Clare, L., Kenny, G., & Verhey, F. (2005). Awareness in dementia: A review of clinical correlates. Aging & Mental Health, 9, 414–422.

    Google Scholar 

  • Aalten, P., Verhen, F. R., Boziki, M., Brugnolo, A., Bullock, R., Byrne, E. J., et al. (2008). Consistency of neuropsychiatric syndromes across dementias: Results from the European Alzheimer Disease Consortium. Dementia and Geriatric Cognitive Disorders, 25, 1–8.

    PubMed  Google Scholar 

  • Agronin, M. E. (2004). Practical guides in psychiatry: Dementia. Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • AGS Panel on Persistent Pain in Older Persons. (2002). The management of persistent pain in older persons. Journal of the American Geriatrics Society, 50(6 Suppl), S205–S224.

    Google Scholar 

  • Aguero-Torres, H., von Strauss, E., Viitanen, M., Winblad, B., & Fratiglioni, L. (2001). Institutionalization in the elderly: The role of chronic diseases and dementia. Cross-sectional and longitudinal data from a population-based study. Journal of Clinical Epidemiology, 54, 795–801.

    PubMed  CAS  Google Scholar 

  • Alexopoulos, G. S., Abrams, R. C., Young, R. C., & Shamoian, C. A. (1988). Cornell scale for depression in dementia. Biological Psychiatry, 23, 271–284.

    PubMed  CAS  Google Scholar 

  • Alexopoulos, G. S., Jeste, D. V., Chung, H., Carpenter, D., Ross, R., & Docherty, J. P. (2005). The expert consensus guideline series: Treatment of dementia and its behavioral disturbances. Postgraduate Medicine Special Report, 2005, 1–108.

    Google Scholar 

  • Alzheimer’s Society. (2007). Dementia UK: The full report. London: Alzheimer’s Society.

    Google Scholar 

  • American Association for Geriatric Psychiatry. (2005). Comment on the US Food and Drug Administration’s (FDA) advisory on off-label use of atypical antipsychotics in the elderly [online]. Available from URL: http://www.aagponline.org/prof/antipsychstat_0705.asp. Accessed October 31, 2005.

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington: American Psychiatric Association.

    Google Scholar 

  • American Psychiatric Association Work Group on Alzheimer’s Disease and Other Dementias. (2007). Practice guideline for the treatment of patients with Alzheimer’s disease and other dementias of late life. The American Journal of Psychiatry, 51(3), S121–S131.

    Google Scholar 

  • Ancoli-Israel, S. (2000). Insomnia in the elderly: A review for the primary care practitioner. Sleep, 23(Suppl 1), S23–S30.

    PubMed  Google Scholar 

  • Arkin, S. M. (1991). Memory training in early Alzheimer’s disease: An optimistic look at the field. American Journal of Alzheimer’s Disease and Other Dementias, 6, 17–25.

    Google Scholar 

  • Auer, S. R., Monteiro, I. M., & Reisberg, B. (1996). The Empirical Behavioral Pathology in Alzheimer’s Disease (E-BEHAVE-AD) rating scale. International Psychogeriatrics, 8, 247–266.

    PubMed  CAS  Google Scholar 

  • Baehr, E. K., Eastman, C. I., Revelle, W., Olson, S. H., Wolfe, L. F., & Zee, P. C. (2003). Circadian phaseshifting effects of nocturnal exercise in older compared with young adults. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 284, R1542–R1550.

    PubMed  CAS  Google Scholar 

  • Baker, R., Holloway, J., Holtkamp, C. C. M., Larson, A., Hartman, L. C., Pearce, R., et al. (2003). Effects of multi-sensory stimulation for people with dementia. Journal of advanced Nursing, 43, 465–477.

    Google Scholar 

  • Bakker, T. J. E. M., Duivenvoorden, H. J., van der Lee, J., & Trijsburg, R. W. (2005). Prevalence of psychiatric function disorders in psychogeriatric patients at referral to nursing home care – The relation to cognition, activities of daily living and general details. Dementia and Geriatric Cognitive Disorders, 20, 215–224.

    PubMed  CAS  Google Scholar 

  • Ballard, C. (2006). The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer’s disease. Cochrane Database of Systematic Reviews, 1, 1–108.

    Google Scholar 

  • Bass, D. M., McClendon, G., Deimling, G. T., & Mukherjee, S. (1994). The influence of diagnosed mental impairment on family caregiver strain. Journal of Gerontology, 49, S146–S155.

    PubMed  CAS  Google Scholar 

  • Bass, D. M., Noelker, L. S., & Rechlin, L. R. (1996). The moderating influence of service use on negative caregiving consequences. The Journals of Gerontology, Series B, Psychological Sciences and Social Sciences, 51, S121–S131.

    CAS  Google Scholar 

  • Bassuk, S. S., Berkman, L. F., & Wypij, D. (1998). Depressive symptomatology and incident cognitive decline in an elderly community sample. Archives of General Psychiatry, 55, 1073–1081.

    PubMed  CAS  Google Scholar 

  • Beaudreau, S. A., & O’Hara, R. (2008). Late-life anxiety and cognitive impairment: A review. The American Journal of Geriatric Psychiatry, 16, 790–803.

    PubMed  Google Scholar 

  • Beck, C. K., Vogelpohl, T. S., Rasin, H. J., Uriri, J. T., O’Sullivan, P., Walls, R., et al. (2002). Effects of behavioral interventions on disruptive behavior and affect in demented nursing home residents. Nursing Research, 51, 219–228.

    PubMed  Google Scholar 

  • Benson, H., & Klipper, M. (1975). The relaxation response. New York: Avon Books.

    Google Scholar 

  • Bharani, N., & Snowden, M. (2005). Evidence-based interventions for nursing home residents with dementia-related behavioral symptoms. The Psychiatric Clinics of North America, 28, 985–1005.

    PubMed  Google Scholar 

  • Bhatt, M. H., Podder, N., & Chokroverty, S. (2005). Sleep and neurodegenerative disorders. Seminars in Neurology, 25, 39–51.

    PubMed  Google Scholar 

  • Blay, S. L., Andreoli, S. B., & Gastal, F. L. (2007). Chronic painful physical conditions, disturbed sleep and psychiatric morbidity: Results from an elderly survey. Annals of Clinical Psychiatry, 19, 169–174.

    PubMed  Google Scholar 

  • Boeve, B. F., Silber, M. H., & Ferman, T. J. (2004). REM sleep behavior disorder in Parkinson’s disease and dementia with Lewy bodies. Journal of Geriatric Psychiatry and Neurology, 17, 146–157.

    PubMed  Google Scholar 

  • Bondareff, W. (1996). Neuropathology of psychotic symptoms in Alzheimer’s disease. International Psychogeriatrics, 8(Suppl 3), 233–237.

    PubMed  Google Scholar 

  • Borja, N. L., & Daniel, K. L. (2006). Ramelteon for the treatment of insomnia. Clinical Therapeutics, 28, 1540–1555.

    PubMed  CAS  Google Scholar 

  • Bourgeois, M. S., Camp, C., Rose, M., White, B., Malone, M., Carr, J., et al. (2003). A comparison of training strategies to enhance use of external aids by persons with dementia. Journal of Communication Disorders, 36, 361–378.

    PubMed  Google Scholar 

  • Boyle, P. A., & Malloy, P. F. (2004). Treating apathy in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 17, 91–99.

    PubMed  Google Scholar 

  • Brassington, G. S., King, A. C., & Bliwise, D. L. (2000). Sleep problems as a risk factor for falls in a sample of community-dwelling adults aged 64–99 years. Journal of the American Geriatrics Society, 48, 1234–1240.

    PubMed  CAS  Google Scholar 

  • Braun, U. K., & Kunik, M. E. (2004). Behavioral disturbances in dementia: Finding the cause(s). Geriatrics, 59, 32–33.

    PubMed  Google Scholar 

  • Brodaty, H., & Luscombe, G. (1996). Depression in persons with dementia. International Psychogeriatrics, 8, 609–622.

    PubMed  CAS  Google Scholar 

  • Buettner, L. L., & Fitzsimmons, S. (2002). AD-venture program: Therapeutic biking for the treatment of depression in long-term care residents with dementia. American Journal of Alzheimer’s Disease and Other Dementias, 17, 121–127.

    PubMed  Google Scholar 

  • Bungener, C., Jouvent, R., & Derouesne, C. (1996). Affective disturbances in Alzheimer’s disease. Journal of the American Geriatrics Society, 44, 1066–1071.

    PubMed  CAS  Google Scholar 

  • Burns, A., & Iliffe, S. (2009). Dementia. British Medical Journal, 338, b75.

    PubMed  Google Scholar 

  • Burton, L. C., German, P. S., Rovner, B. W., & Brant, L. J. (1992). Physical restraint use and cognitive decline among nursing home residents. Journal of the American Geriatrics Society, 40, 811–816.

    PubMed  CAS  Google Scholar 

  • Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193–213.

    PubMed  CAS  Google Scholar 

  • Callahan, C. M., Boustani, M. A., Unverzagt, F. W., Austrom, M. G., Damush, T. M., Perkins, A. J., et al. (2006). Effectiveness of collaborative care for older adults with Alzheimer disease in primary care. Journal of the American Medical Association, 295, 2148–2157.

    PubMed  CAS  Google Scholar 

  • Camberg, L., Woods, P., Ooi, W. L., Hurley, A., Volicer, L., Ashley, J., et al. (1999). Evaluation of simulated presence: A personalized approach to enhance well-being in persons with Alzheimer’s disease. Journal of the American Geriatrics Society, 47, 446–452.

    PubMed  CAS  Google Scholar 

  • Camp, C. J. (2006). Spaced retrieval: A case study in dissemination of a cognitive intervention for persons with dementia. In D. K. Attix & K. A. Welsh-Bohmer (Eds.), Geriatric neuropsychology: Assessment and intervention (pp. 275–292). New York: Guilford.

    Google Scholar 

  • Camp, C. U. (1989). Facilitation of new learning in Alzheimers disease. In G. Gilmer, P. Whitehouse, & M. Wykle (Eds.), Memory and aging in dementia: Theory, assessment and treatment (pp. 212–225). New York: Springer.

    Google Scholar 

  • Chapman, S. B., Weiner, M. F., Rackley, A., Hynan, L. S., & Zientz, J. (2004). Effects of cognitive-communication stimulation for Alzheimer’s disease patients treated with donepezil. Journal of Speech, Language, and Hearing Research, 47, 1149–1163.

    PubMed  Google Scholar 

  • Chatterjee, A., Anderson, K. E., Moskowitz, C. B., Hauser, W. A., & Marder, K. S. (2005). A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 17, 378–383.

    PubMed  Google Scholar 

  • Chemerinski, E., Petracca, G., Manes, R., Leiguarda, R., & Starkstein, S. E. (1998). Prevalence and correlates of anxiety in Alzheimer’s disease. Depression and Anxiety, 7, 166–170.

    PubMed  CAS  Google Scholar 

  • Chow, T. W., Binns, M. A., Cummings, J. L., Lam, I., Black, S. E., Miller, B. L., et al. (2009). Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type. Archives of Neurology, 66, 888–893.

    PubMed  Google Scholar 

  • Cohen-Mansfield, J. (2000). Theoretical frameworks for behavioral problems in dementia. Alzheimers Care Quarterly, 1, 8–21.

    Google Scholar 

  • Cohen-Mansfield, J., Marx, M. S., & Rosenthal, A. S. (1989). A description of agitation in a nursing home. Journal of Gerontology, 44, M77–M84.

    PubMed  CAS  Google Scholar 

  • Cole, M. G., & Dendukuri, N. (2003). Risk factors for depression among elderly community subjects: A systematic review and metaanalysis. The American Journal of Psychiatry, 160, 1147–1156.

    PubMed  Google Scholar 

  • Colenda, C. C., Cohen, W., McCall, W. V., & Rosenquist, P. B. (1997). Phototherapy for patients with Alzheimer disease with disturbed sleep patterns: Results of a community-based pilot study. Alzheimer Disease and Associated Disorders, 11, 175–178.

    PubMed  CAS  Google Scholar 

  • Coon, D. W., & Evans, B. (2009). Empirically based treatments for family caregiver distress: What works and where do we go from here? Geriatric Nursing, 30, 426–436.

    PubMed  Google Scholar 

  • Craig, A. H., Cummings, J. L., Fairbanks, L., Itti, L., Miller, B. L., Li, J., et al. (1996). Cerebral blood flow correlates of apathy in Alzheimer disease. Archives of Neurology, 53, 1116–1120.

    PubMed  CAS  Google Scholar 

  • Cricco, M., Simonsick, E. M., & Foley, D. J. (2001). The impact of insomnia on cognitive functioning in older adults. Journal of the American Geriatrics Society, 49, 1185–1189.

    PubMed  CAS  Google Scholar 

  • Cummings, J. L. (1997). The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology, 48(Suppl 6), S10–S16.

    PubMed  CAS  Google Scholar 

  • Cummings, J. L. (2000). Cholinesterase inhibitors: A new class of psychotropic compounds. The American Journal of Psychiatry, 157, 4–15.

    PubMed  CAS  Google Scholar 

  • Cummings, J. L. (2003). Use of cholinesterase inhibitors in clinical practice: Evidence-based ­recommendations. The American Journal of Geriatric Psychiatry, 11, 131–145.

    PubMed  Google Scholar 

  • Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994). The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology, 44, 2308–2314.

    PubMed  CAS  Google Scholar 

  • Dauvilliers, Y. (2007). Insomnia in patients with neurodegenerative conditions. Sleep Medicine, 4(Suppl 4), S27–S34.

    Google Scholar 

  • Derouesné, C., Thibault, S., Lagha-Pierucci, S., Baudouin-Madec, V., Ancri, D., & Lacomblez, L. (1999). Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type. International Journal of Geriatric Psychiatry, 14, 1019–1103.

    PubMed  Google Scholar 

  • Deschenes, C. L., & McCurry, S. M. (2009). Current treatments for sleep disturbances in individuals with dementia. Current Psychiatry Reports, 11, 20–26.

    PubMed  Google Scholar 

  • Devanand, D. P., Jacobs, D. M., Tang, M. X., Del Castillo-Castaneda, C., Sano, M., Marder, K., et al. (1997). The course of psychopathologic features in mild to moderate Alzheimer disease. Archives of General Psychiatry, 54, 257–263.

    PubMed  CAS  Google Scholar 

  • Dowling, G. A., Burr, R. L., Van Someren, E. J., Hubbard, E. M., Luxenberg, J. S., Mastick, J., et al. (2008). Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. Journal of the American Geriatrics Society, 56, 239–246.

    PubMed  Google Scholar 

  • Dulcan, M. K. (1994). Treatment of children and adolescents. In R. E. Hales, S. C. Yudofsky, & J. A. Talbott (Eds.), Textbook of psychiatry (2nd ed., p. 1241). Washington: American Psychiatric Press.

    Google Scholar 

  • Fahim, S., van Duijn, C. M., Baker, F. M., Launer, L., Breteler, M. M., Schudel, W. J., et al. (1998). A study of familial aggregation of depression, dementia and Parkinson’s disease. European Journal of Epidemiology, 14, 233–238.

    PubMed  CAS  Google Scholar 

  • Ferretti, L., McCurry, S. M., Logsdon, R., Gibbons, L., & Teri, L. (2001). Anxiety and Alzheimer’s disease. Journal of Geriatric Psychiatry and Neurology, 14, 52–58.

    PubMed  CAS  Google Scholar 

  • Ferri, C. P., Prince, M., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., et al. (2005). Global prevalence of dementia: A Delphi consensus study. The Lancet, 366, 2112–2117.

    Google Scholar 

  • Finkel, S. I., Burns, A., & Cohen, G. D. (2000). Overview, behavioral and psychological symptoms of dementia (BPSD): A clinical and research update. International Psychogeriatrics, 12(S1), 13–18.

    Google Scholar 

  • Focht, A. (2009). Differential diagnosis of dementia. Geriatrics, 64, 20–26.

    PubMed  Google Scholar 

  • Forsell, Y., Jorm, A. F., Fratiglioni, L., Grut, M., & Winblad, B. (1993). Application of DSM-III-R criteria for major depressive episode to elderly subjects with and without dementia. The American Journal of Psychiatry, 150, 1199–1202.

    PubMed  CAS  Google Scholar 

  • Förstl, H., Burns, A., Luthert, P., Cairns, N., Lantos, P., & Levy, R. (1992). Clinical and neuropathological correlates of depression in Alzheimer’s disease. Psychological Medicine, 22, 877–884.

    PubMed  Google Scholar 

  • Fuh, J. L., Liu, C. K., Meg, M. S., Wang, S. J., & Cummings, J. L. (2001). Behavioral disorders and caregivers’ reaction in Taiwanese patients with Alzheimer’s disease. International Psychogeriatrics, 13, 121–128.

    PubMed  CAS  Google Scholar 

  • Gibbons, L. E., Teri, L., & Logsdon, R. (2002). Anxiety symptoms as predictors of nursing home placement in patients with Alzheimer’s disease. Journal of Clinical Geropsychology, 8, 335–342.

    Google Scholar 

  • Gibbons, L. E., Teri, L., Logsdon, R. G., & McCurry, S. M. (2006). Assessment of anxiety in dementia: An investigation into the association of different methods of measurement. Journal of Geriatric Psychiatry and Neurology, 19, 202–208.

    PubMed  Google Scholar 

  • Gilley, D. W., Wilson, R. S., Bennett, D. A., & Fox, J. H. (1991). Predictors of behavioral disturbance in Alzheimer’s disease. Journal of Gerontology, 46, P362–P371.

    PubMed  CAS  Google Scholar 

  • González-Salvador, T., Lyketsos, C. G., Baker, A., Hovanec, L., Roques, C., Brandt, J., et al. (2000). Quality of life in dementia patients in long-term care. International Journal of Geriatric Psychiatry, 15, 181–189.

    PubMed  Google Scholar 

  • Graeff, F. G., Guimaraes, F. S., De Andrade, T. G., & Deakin, J. F. (1996). Role of 5-HT instress, anxiety, and depression. Pharmacology Biochemistry and Behavior, 54, 129–141.

    CAS  Google Scholar 

  • Greenspan, A., Eerdekens, M., & Mahmoud, R. (2004). Is there an increased rate of cerebrovascular events among dementia patients? Presented at the 24th congress of the collegium internationale neuropsychopharmacologicum (CINP), June 20–24, Paris.

    Google Scholar 

  • Hadjistavropoulos, T., & Hadjistavropoulos, H. D. (2008). Pain management for older adults: A self-help guide. Seattle: IASP Press.

    Google Scholar 

  • Harwood, D. G., Ownby, R. L., & Barker, W. W. (1998). The behavioral pathology in Alzheimer’s disease scale (BEHAVE-AD): Factor structure among community-dwelling Alzheimer’s disease patients. International Journal of Geriatric Psychiatry, 13, 793–800.

    PubMed  CAS  Google Scholar 

  • Haupt, M., Karger, A., & Janner, M. (2000). Improvement of agitation and anxiety in demented patients after psychoeducative group intervention with their caregivers. International Journal of Geriatric Psychiatry, 15, 1125–1129.

    PubMed  CAS  Google Scholar 

  • Haw, C., Harwood, D., & Hawton, K. (2009). Dementia and suicidal behavior: A review of the literature. International Psychogeriatrics, 21, 440–453.

    PubMed  Google Scholar 

  • Herrmann, N. (1998). Valproic acid treatment of agitation in dementia. Canadian Journal of Psychiatry, 43, 69–72.

    CAS  Google Scholar 

  • Heun, R., Papassotiropoulos, A., Jessen, F., Maier, W., & Breitner, J. C. (2001). A family study of Alzheimer disease and early and late-onset depression in elderly patients. Archives of General Psychiatry, 58, 190–196.

    PubMed  CAS  Google Scholar 

  • Hoe, J., Hancock, G., Livingston, G., & Orrell, M. (2006). Quality of life of people with dementia in residential care homes. The British Journal of Psychiatry, 188, 460–464.

    PubMed  CAS  Google Scholar 

  • Holmes, C., Arranz, M., Collier, D., Powell, J., & Lovestone, S. (2003). Depression in Alzheimer’s disease: The effect of serotonin receptor gene variation. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, 119B(1), 40–43.

    Google Scholar 

  • Hwang, T. J., Masterman, D. L., Ortiz, F., Fairbanks, L. A., & Cummings, J. L. (2004). Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Disease and Associated Disorders, 18, 17–21.

    PubMed  Google Scholar 

  • Jeste, D. V., Sanford, I., & Finkel, S. I. (2000). Psychosis of Alzheimer’s disease and related dementias: Diagnostic criteria for a distinct syndrome. The American Journal of Geriatric Psychiatry, 8, 1.

    Google Scholar 

  • Johns, M. W. (1991). A new method for measuring daytime sleepiness. The Epworth Sleepiness Scale. Sleep, 14, 540–545.

    PubMed  CAS  Google Scholar 

  • Kalapatapu, R. K., & Neugroschl, J. A. (2009). Update on neuropsychiatric symptoms of dementia: Evaluation and management. Geriatrics, 64, 20–26.

    PubMed  Google Scholar 

  • Kang, S. J., Choi, S. H., Lee, B. H., Jeong, Y., Hahm, D. S., Han, I. W., et al. (2004). Caregiver-administered Neuropsychiatric Inventory (CGA-NPI). Journal of Geriatric Psychiatry and Neurology, 17, 32–35.

    PubMed  Google Scholar 

  • Kaplan, H. I., & Sadock, B. J. (2007). Kaplan and Sadock’s synopsis of psychiatry (10th ed., pp. 1117–1124). Philadelphia: Lippincott, Williams & Wilkins.

    Google Scholar 

  • Kapp, M. B. (2000). Increasing liability risks among nursing homes: Therapeutic consequences, costs, and alternatives. Journal of the American Geriatrics Society, 48(1), 97–99.

    PubMed  CAS  Google Scholar 

  • Kaufer, D. I., Cummings, J. L., Ketchel, P., Smith, V., MacMillan, A., Shelley, T., et al. (2000). Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. The Journal of Neuropsychiatry and Clinical Neurosciences, 12, 233–239.

    PubMed  CAS  Google Scholar 

  • Keefe, F. J. (1996). Cognitive behavioral therapy for managing pain. Clinical Psychology, 49(3), 4–5.

    Google Scholar 

  • Kim, D. H., Payne, M. E., Levy, R. M., MacFall, J. R., & Steffens, D. C. (2002). APOE genotype and hippocampal volume change in geriatric depression. Biological Psychiatry, 51, 426–429.

    PubMed  CAS  Google Scholar 

  • King, A. C., Oman, R. F., Brassington, G. S., Bliwise, D. L., & Haskell, W. L. (1979). Moderate-intensity exercise and self-rated quality of sleep in older adults. A randomized controlled trial. Journal of the American Medical Association, 277, 32–37.

    Google Scholar 

  • Koder, D. A. (1998). Treatment of anxiety in the cognitively impaired elderly: Can cognitive-behavior therapy help? International Psychogeriatrics, 10, 173–182.

    PubMed  CAS  Google Scholar 

  • Kraus, C. A., Seignourel, P., Balasubramanyam, V., Snow, A. L., Wilson, N. L., Kunik, M. E., et al. (2008). Cognitive-behavioral treatment for anxiety in patients with dementia: Two case studies. Journal of Psychiatric Practice, 14, 186–192.

    PubMed  Google Scholar 

  • Krishnan, K. R., Tupler, L. A., Ritchie, J. C. J., McDonald, W. M., Knight, D. L., Nemeroff, C. B., et al. (1996). Apolipoprotein E-epsilon 4 frequency in geriatric depression. Biological Psychiatry, 40, 69–71.

    PubMed  CAS  Google Scholar 

  • Kunik, M. E., Huffman, J. C., Bharani, N., Hillman, S. L., Molinari, V. A., & Orengo, C. A. (2000). Behavioral disturbances in geropsychiatric inpatients across dementia types. Journal of Geriatric Psychiatry and Neurology, 13, 49–52.

    PubMed  CAS  Google Scholar 

  • Kunik, M. E., Martinez, M., Snow, A. L., Beck, C. K., Cody, M., Rapp, C. G., et al. (2003). Determinants of behavioral symptoms in dementia patients. Clinical Gerontologist, 26, 83–89.

    Google Scholar 

  • Kunik, M. E., Snow, A. L., Davila, J. A., Steele, A. B., Balasubramanyam, V., Doody, R. S., et al. (2010). Causes of aggressive behavior in patients with dementia. The Journal of Clinical Psychiatry, 71(9), 1145–1152.

    PubMed  Google Scholar 

  • Kunik, M. E., Snow, L., Davila, J. A., Steele, A. B., Balasubramanyam, V., Doody, R. S., et al. (2008). High incidence of aggression in persons with dementia. In Presented at the American association for geriatric psychiatry 2008 annual meeting, March 14–17, Orlando, FL.

    Google Scholar 

  • LaBarge, E. (1993). A preliminary scale to measure the degree of worry among mildly demented Alzheimer disease patients. Physical and Occupational Therapy in Geriatrics, 11, 43–57.

    Google Scholar 

  • Lanctot, K. I., Best, T. S., Mittman, N., Liu, B. A., Oh, P. I., Einarson, T. R., et al. (1998). Efficacy and safety of 33 neuroleptics in behavioral disorders associated with dementia. The Journal of Clinical Psychiatry, 59, 550–561.

    PubMed  CAS  Google Scholar 

  • Landes, A. M., Sperry, S. D., Milton, E., Strauss, M. E., & Geldmacher, D. S. (2001). Apathy in Alzheimer’s disease. Journal of the American Geriatrics Society, 49, 1700–1707.

    PubMed  CAS  Google Scholar 

  • Lawton, M. P., Van Haitsma, K., Klapper, J., Kleban, M. H., Katz, I. R., & Corn, J. (1998). A stimulation-retreat special care unit for elders with dementing illness. International Psychogeriatric 10, 379–95.

    Google Scholar 

  • Leentjens, A. F. G., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I. H., Starkstein, S. E., et al. (2008). Apathy and anhedonia rating scales in Parkinson’s disease: Critique and recommendations. Movement Disorders, 23, 2004–2014.

    PubMed  Google Scholar 

  • Lenze, E. J., Mulsant, B. H., Shear, M. K., Dew, M. A., Miller, M. D., Pollock, B. G., et al. (2005). Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: Results from an 8-week randomized, placebo-controlled trial. The American Journal of Psychiatry, 162(1), 146–150.

    PubMed  Google Scholar 

  • Lerner, A. J., Strauss, M., & Sami, S. A. (2007). Recognizing apathy in Alzheimer’s disease. Geriatrics, 62(11), 14–17.

    PubMed  Google Scholar 

  • Lesser, J. M., & Hughes, S. V. (2006). Psychosis-related disturbances. Psychosis, agitation, and disinhibition in Alzheimer’s disease: Definitions and treatment options. Geriatrics, 61, 14–20.

    PubMed  Google Scholar 

  • Luppa, M., Luck, T., Brähler, E., König, H. H., & Riedel-Heller, S. G. (2008). Prediction of institutionalisation in dementia. Dementia and Geriatric Cognitive Disorders, 26, 65–78.

    PubMed  Google Scholar 

  • Lyketsos, C. G., DelCampo, L., Steinberg, M., Miles, Q., Steele, C. D., Munro, C., et al. (2003). Treating depression in Alzheimer disease: Efficacy and safety of sertraline therapy, and the benefits of depression reduction: The DIADS. Archives of General Psychiatry, 60, 737–746.

    PubMed  CAS  Google Scholar 

  • Lyketsos, C. G., & Lee, H. B. (2004). Diagnosis and treatment of depression in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 17, 1–4.

    Google Scholar 

  • Lyketsos, C. G., Lindell Veiel, L., Baker, A., & Steele, C. (1999). A randomized, controlled trial of bright light therapy for agitated behaviors in dementia patients residing in long-term care. International Journal of Geriatric Psychiatry, 14, 520–525.

    PubMed  CAS  Google Scholar 

  • Lyketsos, C. G., Sheppard, J. M., Steinberg, M., Tschanz, J. A., Norton, M. C., Steffens, D. C., et al. (2001). Neuropsychiatric disturbance in Alzheimer’s disease clusters into three groups: The Cache County study. International Journal of Geriatric Psychiatry, 16, 1043–1053.

    PubMed  CAS  Google Scholar 

  • Lyketsos, C. G., Steele, C., Baker, L., Galik, E., Kopunek, S., Steinberg, M., et al. (1997). Major and minor depression in Alzheimer’s disease: Prevalence and impact. The Journal of Neuropsychiatry and Clinical Neurosciences, 1997(9), 556–561.

    Google Scholar 

  • Lyketsos, C. G., Steele, C., Galik, E., Rosenblatt, A., Steinberg, M., Warren, A., et al. (1999). Physical aggression in dementia patients and its relationship to depression. The American Journal of Psychiatry, 156, 66–71.

    PubMed  CAS  Google Scholar 

  • Lyketsos, C. G., Steinberg, M., Tschanz, J. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. (2000). Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging. The American Journal of Psychiatry, 157, 708–714.

    PubMed  CAS  Google Scholar 

  • Lyketsos, C. G., & Olin, J. T. (2002). Depression in Alzheimer’s disease: Overview and ­treatment. Biological Psychiatry, 52, 243–252.

    Google Scholar 

  • Macdonald, A. J. (1999). Can delirium be separated from dementia? Dementia and Geriatric Cognitive Disorders, 10, 386–388.

    PubMed  CAS  Google Scholar 

  • Mack, J. L., & Patterson, M. B. (1994). The evaluation of behavioral disturbances in Alzheimer’s disease: The utility of three rating scales. Journal of Geriatric Psychiatry Neurology, 7, 101–117.

    Google Scholar 

  • Madhusoodanan, S., Shah, P., Brenner, R., & Gupta, S. (2007). Pharmacological treatment of the psychosis of Alzheimer’s disease: What is the best approach? CNS Drugs, 21, 101–115.

    PubMed  CAS  Google Scholar 

  • Manabe, K., Matsui, T., Yamaya, M., Sato-Nakagawa, T., Okamura, N., Arai, H., et al. (2000). Sleep patterns and mortality among elderly patients in a geriatric hospital. Gerontology, 46, 318–322.

    PubMed  CAS  Google Scholar 

  • Mathew, S. J., Mao, X., Coplan, J. D., Smith, E. L., Sackeim, H. A., Gorman, J. M., et al. (2004). Dorsolateral prefrontalcortical pathology in generalized anxiety disorder: A proton magnetic resonance spectroscopic imaging study. The American Journal of Psychiatry, 161, 1119–1121.

    PubMed  Google Scholar 

  • Mayer, L. S., Bay, R. C., Politis, A., Steinberg, M., Steele, C., Baker, A. S., et al. (2006). Comparison of three rating scales as outcome measures for treatment trials of depression in Alzheimer disease: Findings from DIADS. International Journal of Geriatric Psychiatry, 21, 930–936.

    PubMed  Google Scholar 

  • McCurry, S. M., Gibbons, L. E., Logsden, R. E., Logsdon, R. G., Vitiello, M. V., & Teri, L. (2005). Nighttime insomnia treatment and education for Alzheimer’s disease: A randomized, controlled trial. Journal of the American Geriatrics Society, 53, 793–802.

    PubMed  Google Scholar 

  • McCurry, S. M., Gibbons, L. E., Logsdon, R. G., Vitiello, M., & Teri, L. (2003). Training caregivers to change the sleep hygiene practices of patients with dementia: The NITE-AD project. Journal of the American Geriatrics Society, 51, 1455–1460.

    PubMed  Google Scholar 

  • McCurry, S. M., Logsdon, R. G., Teri, L., Gibbons, L. E., Kukull, W. A., Bowen, J. D., et al. (1999). Characteristics of sleep disturbance in community-dwelling Alzheimer’s disease patients. Journal of Geriatric Psychiatry and Neurology, 12, 53–59.

    PubMed  CAS  Google Scholar 

  • McCurry, S. M., Logsdon, R. G., Vitiello, M. V., & Teri, L. (2004). Treatment of sleep and nighttime disturbances in Alzheimer’s disease: A behavioral management approach. Sleep Medicine, 5, 373–377.

    PubMed  Google Scholar 

  • McCurry, S. M., Reynolds, C. F., Ancoli-Israel, S., Teri, L., & Vitiello, M. C. (2000). Treatment of sleep disturbance in Alzheimer’s disease. Sleep Medicine Reviews, 4, 603–608.

    PubMed  Google Scholar 

  • McKitrick, L. A., Camp, C. J., & Black, F. W. (1992). Prospective memory intervention in Alzheimer’s disease. Journal of Gerontology, 47, 337–343.

    Google Scholar 

  • Mega, M. S., Cummings, J. L., Fiorello, T., & Gornbein, J. (1996). The spectrum of behavioral changes in Alzheimer’s disease. Neurology, 46, 130–135.

    PubMed  CAS  Google Scholar 

  • Mendelson, W. B. (2005). A review of the evidence for the efficacy and safety of trazodone in insomnia. The Journal of Clinical Psychiatry, 66, 469–476.

    PubMed  CAS  Google Scholar 

  • Millan, M. J. (2003). The neurobiology and control of anxious states. Progress in Neurobiology, 70, 83–244.

    PubMed  CAS  Google Scholar 

  • Mintzer, J. E., & Brawman-Mintzer, O. (1996). Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: Toward a treatment approach. The Journal of Clinical Psychiatry, 57(Suppl 7), 55–63.

    PubMed  Google Scholar 

  • Mukaetova-Ladinska, E. B., Harrington, C. R., Xuereb, J., Roth, M., & Wischik, C. M. (1995). Treating Alzheimer’s and other dementias. In M. Bergene & S. I. Finkel (Eds.), Treating Alzheimer’s and other dementias (pp. 57–80). New York: Springer.

    Google Scholar 

  • Mulsant, B., Sweet, R., & Rifal, H. (1994). The use of Hamilton Depression Scale for depression in elderly patients with cognitive impairment and physical illness. The American Journal of Geriatric Psychiatry, 2, 220–229.

    Google Scholar 

  • National Institutes of Health. (2005). National Institutes of Health State of the science conference statement on manifestations and management of chronic insomnia in adults, June 13–15, 2005. Sleep, 28, 1049–1057.

    Google Scholar 

  • Nguyen, V. T., Love, A. R., & Kunik, M. E. (2008). Preventing aggression in persons with dementia. Geriatrics, 63, 21–26.

    PubMed  Google Scholar 

  • Olin, J. T., Katz, I. R., Meyers, B. S., Schneider, L. S., & Lebowitz, B. D. (2002). Provisional diagnostic criteria for depression of Alzheimer disease: Rationale and background. The American Journal of Psychiatry, 10, 129–141.

    Google Scholar 

  • Olin, J. T., Shneider, L. S., Katz, I. R., Meyers, B. S., Alexopoulos, G. S., Breitner, J. C., et al. (2002). Provisional diagnostic criteria for depression of Alzheimer disease. American Journal of Geriatric Psychiatry, 10, 125–128.

    PubMed  Google Scholar 

  • Onyike, C. U., Sheppard, J. M., Tschanz, J. T., Norton, M. C., Green, R. C., Steinberg, M., et al. (2007). Epidemiology of apathy in older adults: The Cache County study. The American Journal of Geriatric Psychiatry, 15, 365–375.

    PubMed  Google Scholar 

  • Patterson, M. B., Schnell, A. H., Martin, R. J., Mendez, M. F., Smyth, K. A., & Whitehouse, P. J. (1990). Assessment of behavioral and affective symptoms in Alzheimer’s disease. Journal of Geriatric Psychiatry and Neurology, 3, 21–30.

    PubMed  CAS  Google Scholar 

  • Paulsen, J. S., Salmon, D. P., Thal, L. J., Romero, R., Weisstein-Jenkins, C., Galasko, D., et al. (2000). Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology, 54, 1965–1971.

    PubMed  CAS  Google Scholar 

  • Payne, J. L., Lyketsos, C. G., Steele, C., Baker, L., Galik, E., Kopunek, S., et al. (1998). Relationship of cognitive and functional impairment to depressive features in Alzheimer’s disease and other dementias. The Journal of Neuropsychiatry and Clinical Neurosciences, 10(4), 440–447.

    PubMed  CAS  Google Scholar 

  • Petrella, R. J., Koval, J. J., Cunningham, D. A., & Paterson, D. H. (2003). Can primary care doctors prescribe exercise to improve fitness? The Step Test Exercise Prescription (STEP) project. American Journal of Preventive Medicine, 24, 316–322.

    PubMed  Google Scholar 

  • Plassman, B. L., Langa, K. M., Fisher, G. G., Heerringa, S. G., Weir, D. R., Ofstedal, M. B., et al. (2007). Prevalence of dementia in the United States: The aging, demographics, and memory study. Neuroepidemiology, 29, 125–132.

    PubMed  CAS  Google Scholar 

  • Politis, A. M., Vozzella, S., Mayer, L. S., Onyike, C. U., Baker, A. S., & Lyketsos, C. G. (2004). A randomized, controlled, clinical trial of activity therapy for apathy in patients with dementia residing in long-term care. International Journal of Geriatric Psychiatry, 19, 1087–1094.

    PubMed  Google Scholar 

  • Pollak, C. P., & Perlick, D. (1991). Sleep problems and institutionalization of the elderly. Journal of Geriatric Psychiatry and Neurology, 4, 204–210.

    PubMed  CAS  Google Scholar 

  • Pollock, B. G., Muisant, B. H., Rosen, J., Mazumdar, S., Blakesley, R. E., Houck, P. R., et al. (2007). A double-blind comparison of citaiopram and risperidonefor treatment of behavioral and psychotic symptoms associated with dementia. The American Journal of Geriatric Psychiatry, 15, 942–952.

    PubMed  Google Scholar 

  • Pollock, B. G., Mulsant, B. H., Rosen, J., Sweet, R. A., Mazumdar, S., Bharucha, A., et al. (2002). Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. The American Journal of Psychiatry, 159, 460–465.

    PubMed  Google Scholar 

  • Porter, V. R., Buxton, W. G., Fairbanks, L. A., Strickland, T., O’Connor, S. M., Rosenberg-Thompson, S., et al. (2003). Frequency and characteristics of anxiety among patients with Alzheimer’s disease and related dementias. The Journal of Neuropsychiatry and Clinical Neurosciences, 15, 180–186.

    PubMed  Google Scholar 

  • Qazi, A., Shankar, K., & Orrell, M. (2003). Managing anxiety in people with dementia. A case series. Journal of Affective Disorders, 76, 261–265.

    PubMed  Google Scholar 

  • Rabins, P. V., Blacker, D., Rovner, B. W., Rummans, T., Schneider, L. S., Tariot, P. N., et al. (2007). American Psychiatric Association practice guideline for the treatment of patients with Alzheimer’s disease and other dementias. The American Journal of Psychiatry, 164(Suppl 12), 5–56.

    PubMed  Google Scholar 

  • Rao, V., & Lyketsos, C. G. (2000). The benefits and risks of ECT for patients with primary dementia who also suffer from depression. International Journal of Geriatric Psychiatry, 15, 729–735.

    PubMed  CAS  Google Scholar 

  • Rayner, A., O’Brien, J., & Schoenbachier, B. (2006). Behavior disorders of dementia: Recognition and treatment. American Family Physician, 73, 647–652.

    PubMed  Google Scholar 

  • Reisberg, B. (1996). The empirical behavioral pathology in Alzheimer’s disease (E-BEHAVE-AD) rating scale. International Psychogeriatrics, 8, 247–266.

    PubMed  Google Scholar 

  • Reisberg, B., Auer, S. R., & Monteiro, I. M. (1996). Behavioral pathology in Alzheimer’s disease (BEHAVE-AD) rating scale. International Psychogeriatrics, 8(Suppl 3), 301–308.

    PubMed  Google Scholar 

  • Reisberg, B., Borenstein, J., Salob, S. P., Ferris, S. H., Franssen, E., & Georgotas, A. (1987). Behavioral symptoms in Alzheimer’s disease: Phenomenology and treatment. The Journal of Clinical Psychiatry, 48(Suppl), 9–15.

    PubMed  Google Scholar 

  • Rimersma-van der Lek, R. F., Swaab, D. F., Tiwsk, J., Hol, E. M., Hoogendijk, W. J., & Van Someren, E. J. (2008). Effect of bright light and melatonin on cognitive and noncognitive ­function in elderly residents of group care facilities: A randomized controlled trial. Journal of the American Medical Association, 299, 2642–2655.

    Google Scholar 

  • Roehrs, T. R., & Roth, T. (2009). The effect of drugs on sleep quality and architecture. UpTo Date. Available from www.uptodate.com/patients/content/topic.do?topicKey=∼91BE3rs_xppRr958. Accessed September 28, 2009.

  • Ropacki, S. A., & Jeste, D. V. (2005). Epidemiology of and risk factors for psychosis of Alzheimer’s disease: A review of 55 studies published from 1990 to 2003. The American Journal of Psychiatry, 162, 2022–2030.

    PubMed  Google Scholar 

  • Schneider, L. S., & Dagerman, K. S. (2004). Psychosis of Alzheimer’s disease: Clinical characteristics and history. Journal of Psychiatric Research, 38, 105–111.

    PubMed  Google Scholar 

  • Schneider, L. S., Dagerman, K. S., & Insel, P. (2005). Risk of deaths with atypical antipsychotic treatment for dementia: Meta analysis of randomized placebo controlled trials. Journal of the American Medical Association, 294, 1934–1943.

    PubMed  CAS  Google Scholar 

  • Schneider, L. S., Pollack, V. E., & Lyness, S. A. (1990). A meta analysis of controlled trials of neuroleptic treatment in dementia. Journal of the American Geriatrics Society, 38, 553–563.

    PubMed  CAS  Google Scholar 

  • Sclan, S. G., Saillon, A., Franssen, L., Hugonot-Diener, L., Saillon, A., Reisberg, B., et al. (1996). The behavioral pathology in Alzheimer’s Disease Rating Scale (BEHAVE-AD): Reliability and analysis of symptom category scores. International Journal of Geriatric Psychiatry, 11, 819–830.

    Google Scholar 

  • Seignourel, P., Kunik, M. E., Snow, L., Wilson, N., & Stanley, M. (2008). Anxiety in dementia: A critical review. Clinical Psychology Review, 28, 1071–1082.

    PubMed  Google Scholar 

  • Serfaty, M., Kennell-Webb, S., Warner, J., Blizard, R., & Raven, P. (2002). Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. International Journal of Geriatric Psychiatry, 17, 1120–1127.

    PubMed  Google Scholar 

  • Shankar, K. K., Walker, M., & Frost, D. (1999). The development of a valid and reliable scale for rating anxiety in dementia (RAID). Aging & Mental Health, 3, 39–49.

    Google Scholar 

  • Shankar, Q. K., & Orre, M. (2003). Managing anxiety in people with dementia. A case series. Journal of Affective Disorders, 76, 261–265.

    PubMed  Google Scholar 

  • Shub, D., Darvishi, R., & Kunik, M. E. (2009). Non-pharmacologic treatment of insomnia in persons with dementia. Geriatrics, 64, 22–26.

    PubMed  Google Scholar 

  • Shub, D., & Kunik, M. E. (2009). Psychiatric comorbidity in persons with dementia. Psychiatric Times, 26, 32–35.

    Google Scholar 

  • Siddique, H., Hynan, L. S., & Weiner, M. F. (2009). Effect of a serotonin reuptake inhibitor on irritability, apathy, and psychotic symptoms in patients with Alzheimer’s disease. The Journal of Clinical Psychiatry, 70, 915–918.

    PubMed  CAS  Google Scholar 

  • Singer, C., Tractenberg, R. E., Kaye, J., Schafer, K., Gamst, A., Grundman, M., et al. (2003). A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer’s disease. Sleep, 26, 893–901.

    PubMed  Google Scholar 

  • Sink, K. M., Holden, K. L., & Yaffe, K. (2005). Pharmacological treatment of neuropsychiatric symptoms in dementia: A review of the evidence. Journal of the American Medical Association, 293, 596–608.

    PubMed  CAS  Google Scholar 

  • Skinner, B. (1953). Science and human behavior. New York: The Free Press.

    Google Scholar 

  • Sloane, P. D., Williams, C. S., Mitchell, C. M., Preisser, J. S., Wood, W., Barrick, A. L., et al. (2007). High-intensity environmental light in dementia: Effect on sleep and activity. Journal of the American Geriatrics Society, 55, 1524–1533.

    PubMed  Google Scholar 

  • Smith, S. S., Dingwall, K., Jorgenson, G., & Douglas, J. (2006). Associations between the use of common medications and sleep architecture in patients with untreated obstructive sleep apnea. Journal of Clinical Sleep Medicine, 2, 156–162.

    PubMed  Google Scholar 

  • Snow, A. L., Weber, J. B., O’Malley, K. J., Cody, M., Beck, C., Bruera, E., et al. (2004). NOPPAIN: A nursing assistant administered pain assessment instrument for use in dementia. Dementia and Geriatric Cognitive Disorders, 17, 240–246.

    PubMed  Google Scholar 

  • Staal, J., Pinkney, L., & Roane, D. (2003). Assessment of stimulus preferences in multisensory environment therapy for older people with dementia. British Journal of Occupational Therapy, 66, 542–549.

    Google Scholar 

  • Staal, J. A., Sacks, A., Matheis, R., Collier, L., Calia, T., Hanif, H., et al. (2007). The effects of snoezelen (multi-sensory behavior therapy) and psychiatric care on agitation, apathy, and activities of daily living in dementia patients on a short term geriatric psychiatric inpatient unit. International Journal of Psychiatry in Medicine, 37, 357–370.

    PubMed  Google Scholar 

  • Starkstein, S., Ingram, L., Garau, M., & Mizrahi, R. (1983). On the overlap between apathy and depression in dementia. Journal of Neurology Neurosurgery Psychiatry Research, 17, 37–49.

    Google Scholar 

  • Starkstein, S. E., Jorge, R., Petracca, G., & Robinson, R. G. (2007). The construct of generalized anxiety disorder in Alzheimer disease. The American Journal of Geriatric Psychiatry, 15, 42–49.

    PubMed  Google Scholar 

  • Stern, Y., Albert, M., Brandt, J., Jacobs, D. M., Tang, M. X., Marder, K., et al. (1994). Utility of extrapyramidal signs and psychosis as predictors of cognitive and functional decline, nursing home admission, and death in Alzheimer’s disease: Prospective analyses from the predictors study. Neurology, 44, 2300–2307.

    PubMed  CAS  Google Scholar 

  • Stone, M. (2005). Deaths in controlled trials of atypical antipsychotics in patients with behavioral disturbances from dementia. In Presented at the 45th annual New Clinical Drug Evaluation Unit (NCDEU) meeting, June 6–9, Boca Raton, FL.

    Google Scholar 

  • Strauss, M. E., & Sperry, S. D. (2002). An informant-based assessment of apathy in Alzheimer disease. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 15(3), 176–183.

    PubMed  Google Scholar 

  • Stuss, D. T., van Reekum, R., & Murphy, K. J. (2000). Differentiation of states and causes of apathy. In J. Borod (Ed.), The neuropsychology of emotion (pp. 340–363). New York: Oxford University Press.

    Google Scholar 

  • Sultzer, D. L., Brown, C. V., Mandelkern, M. D., Mahler, M. E., Mendez, M. F., Chen, S. T., et al. (2003). Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer’s disease. The American Journal of Psychiatry, 160, 341–349.

    PubMed  Google Scholar 

  • Sultzer, D. L., Davis, S. M., Tariot, P. N., Dagerman, K. S., Lebowitz, B. D., Lyketsos, C. G., et al. (2008). Clinical symptom responses to atypical antipsychotic medications in Alzheimer’s disease: Phase 1 outcomes from the CATIE-AD effectiveness trial. The American Journal of Psychiatry, 165, 844.

    PubMed  Google Scholar 

  • Sultzer, D. L., Gray, K. F., Gunay, I., Berisford, M. A., & Mahler, M. E. (1997). A double-blind comparison of trazodone and haloperidol for treatment of agitation in patients with dementia. The American Journal of Geriatric Psychiatry, 5, 60–69.

    PubMed  CAS  Google Scholar 

  • Sultzer, D. L., Mahler, M. E., Mandelkern, M. A., Cummings, J. L., Van Gorp, W. G., Hinkin, C. H., et al. (1995). The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 7, 476–484.

    PubMed  CAS  Google Scholar 

  • Tariot, P. N. (1999). Treatment of agitation in dementia. The Journal of Clinical Psychiatry, 60(Suppl 8), 11–20.

    PubMed  Google Scholar 

  • Teri, L. (1994). Behavioral treatment of depression in patients with dementia. Alzheimer’s Disease and Associated Disorders, 8, suppl 3, 66–74.

    Google Scholar 

  • Teri, L., Ferretti, L. E., Gibbons, L. E., Logsdon, R. G., McCurry, S. M., Kukull, W. A., et al. (1999). Anxiety in Alzheimer’s disease: Prevalence and comorbidity. The Journals of Gerontology Series A, Biological Sciences and Medical Sciences, 54, M348–M352.

    PubMed  CAS  Google Scholar 

  • Teri, L., & Gallagher-Thompson, D. (1991). Cognitive-behavioral interventions for treatment of depression in Alzheimer’s patients. The Gerontologist, 31, 413–416.

    PubMed  CAS  Google Scholar 

  • Teri, L., Gibbons, L. E., McCurry, S. M., Logsdon, R. G., Buchner, D. M., Barlow, W. E., et al. (2003). Exercise plus behavioral management in patients with Alzheimer disease. Journal of the American Medical Association, 290, 2015–2022.

    PubMed  CAS  Google Scholar 

  • Teri, L., McKenzie, G., & La Fazia, D. (2005). Psycho-social treatment of depression in older adults, with dementia. Clinical Psychology: Science and Practice, 12, 303–16.

    Google Scholar 

  • van Reekum, R., Stuss, D. T., & Ostrander, L. (2005). Apathy: Why care? The Journal of Neuropsychiatry and Clinical Neurosciences, 17, 7–19.

    PubMed  Google Scholar 

  • Vaughan, M., & Michael, J. (1982). Automatic reinforcement: An important but ignored concept. Behaviorism, 10(212), 217–227.

    Google Scholar 

  • Vitiello, M. V., & Borson, S. (2001). Sleep disturbances in patients with Alzheimer’s disease. CNS Drugs, 15, 777–796.

    PubMed  CAS  Google Scholar 

  • Wands, K., Merskey, H., Hachinski, V. C., Fisman, M., Fox, H., & Boniferro, M. (1990). A questionnaire investigation of anxiety and depression in early dementia. Journal of the American Geriatrics Society, 38, 535–538.

    PubMed  CAS  Google Scholar 

  • Wang, J. J. (2007). Group reminiscence therapy for cognitive and affective function of dementia elderly in Taiwan. International Journal of Geriatric Psychiatry, 22, 1235–1240.

    PubMed  Google Scholar 

  • Weintraub, D., & Hurtig, H. (2007). Presentation and management of psychosis in Parkinson’s disease and dementia with Lewy bodies. The American Journal of Psychiatry, 164, 1491.

    PubMed  Google Scholar 

  • Wetherell, J. L., Gatz, M., & Craske, M. G. (2003). Treatment of generalized anxiety disorder in older adults. Journal of Consulting and Clinical Psychology, 71, 31–40.

    PubMed  Google Scholar 

  • Wick, J. Y., & Zanni, O. R. (2005). Sundowning: Disruptive behavior with many causes. The Consultant Pharmacist, 20(947–50), 957–961.

    Google Scholar 

  • Wilson, R. S., Arnold, S. E., Schneider, J. A., & Bennett, D. A. (2007). Chronic distress, age related neuropathology, and late-life dementia. Psychosomatic Medicine, 69, 47–53.

    PubMed  Google Scholar 

  • Wimo, A., Winblad, B., & Jonsson, L. (2007). An estimate of the total worldwide societal costs of dementia in 2005. Alzheimers Dementia, 3, 81–91.

    Google Scholar 

  • Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Aday, M., et al. (1983). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17, 37–49.

    CAS  Google Scholar 

  • Yesavage, J. A., & Taylor, B. (1991). Anxiety and dementia. In C. Salzman & B. D. Lebowitz (Eds.), Anxiety in the elderly: Treatment and research (pp. 79–85). New York: Springer.

    Google Scholar 

  • Zanetti, O., Vallotti, B., Frisoni, G. B., Geroldi, C., Bianchetti, A., Pasqualetti, P., et al. (1999). Insight in dementia: When does it occur? Evidence for a nonlinear relationship between insight and cognitive status. The Journals of Gerontology Series B, Psychological Sciences and Social Sciences, 54, P100–P106.

    PubMed  CAS  Google Scholar 

  • Zill, P., Padberg, F., de Jonge, S., Hampel, H., Burger, K., Stubner, S., et al. (2000). Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients. Neuroscience Letters, 284(1–2), 113–115.

    PubMed  CAS  Google Scholar 

  • Zubenko, G. S., Moossy, J., Martinez, A. J., Rao, G., Claassen, D., Rosen, J., et al. (1991). Neuropathologic and neurochemical correlates of psychosis in primary dementia. Archives of Neurology, 48, 619–624.

    PubMed  CAS  Google Scholar 

  • Zubenko, G. S., Zubenko, W. N., McPherson, S., Spoor, E., Marin, D. B., Farlow, M. R., et al. (2003). A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer’s disease. The American Journal of Psychiatry, 160, 857–866.

    PubMed  Google Scholar 

  • Zuidema, S., Koopmans, R., & Verhey, F. (2007). Prevalence and predictors of neuropsychiatric symptoms in cognitively impaired nursing home patients. Geriatric Psychiatry Neurology, 20, 41–49.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carla Bejjani MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Bejjani, C., Kunik, M.E. (2011). Psychological Co-morbidities of Dementia. In: Pagoto, S. (eds) Psychological Co-morbidities of Physical Illness. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0029-6_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-0029-6_9

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0030-2

  • Online ISBN: 978-1-4419-0029-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics