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Imaging Modalities for Pain

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Biobehavioral Approaches to Pain

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References

  • al Absi, M., Rokke, P. D. (1991) Can anxiety help us tolerate pain? Pain 46: 43–51

    Article  PubMed  CAS  Google Scholar 

  • Alkire, M. T., White, N. S., Hsieh, R., Haier, R. J. (2004) Dissociable brain activation responses to 5-Hz electrical pain stimulation: a high-field functional magnetic resonance imaging study. Anesthesiology 100: 939–946

    Article  PubMed  Google Scholar 

  • Amanzio, M., Benedetti, F. (1999) Neuropharmacological dissection of placebo analgesia: expectation – activated opioid systems versus conditioning-activated specific subsystems. Journal of Neuroscience 19: 484–494

    PubMed  CAS  Google Scholar 

  • Andersson, J. L., Lilja, A., Hartvig, P., Langstrom, B., Gordh, T., Handwerker, H., Torebjork, E. (1997) Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography. Experimental Brain Research 117: 192–199

    Article  CAS  Google Scholar 

  • Apkarian, A. V., Bushnell, M. C., Treede, R. D., Zubieta, J. K. (2005) Human brain mechanisms of pain perception and regulation in health and disease. European Journal of Pain 9: 463–484

    Article  PubMed  Google Scholar 

  • Arendt-Nielsen, L., Graven-Nielsen, T., Svarrer, H., Svensson, P. (1996) The influence of low back pain on muscle activity and coordination during gait – A clinical and experimental study. Pain 64: 231–240

    Article  PubMed  CAS  Google Scholar 

  • Arendt-Nielsen, L., Yamasaki, H., Nielsen, J., Naka, D., Kakigi, R. (1999) Magnetoencephalographic responses to painful impact stimulation. Brain Research 839: 203–208

    Article  PubMed  CAS  Google Scholar 

  • Bailey, D. L. (1992) 3D acquisition and reconstruction in positron emission tomography. Annals of Nuclear Medicine 6: 123–130

    Article  PubMed  CAS  Google Scholar 

  • Bandettini PA (2001) Selection of the optimal pulse sequence for functional MRI. In: Jezzard P, Matthews PB, Smith SM (eds) Functional MRI. An introduction to methods. Oxford University Press, New York, pp. 123–143

    Google Scholar 

  • Bantick, S. J., Wise, R. G., Ploghaus, A., Clare, S., Smith, S. M., Tracey, I. (2002) Imaging how attention modulates pain in humans using functional MRI. Brain 125: 310–319

    Article  PubMed  Google Scholar 

  • Baumgartner, U., Buchholz, H. G., Bellosevich, A., Magerl, W., Siessmeier, T., Rolke, R., Hohnemann, S., Piel, M., Rosch, F., Wester, H. J., Henriksen, G., Stoeter, P., Bartenstein, P., Treede, R. D., Schreckenberger, M. (2006) High opiate receptor binding potential in the human lateral pain system. Neuroimage 30: 692–699

    Article  PubMed  Google Scholar 

  • Beckmann, C. F., DeLuca, M., Devlin, J. T., Smith, S. M. (2005) Investigations into resting-state connectivity using independent component analysis. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 360: 1001–1013

    Article  PubMed  Google Scholar 

  • Benedetti, F., Arduino, C., Amanzio, M. (1999) Somatotopic activation of opioid systems by target-directed expectations of analgesia. Journal of Neuroscience 19: 3639–3648

    PubMed  CAS  Google Scholar 

  • Benedetti, F., Lanotte, M., Lopiano, L., Colloca, L. (2007) When words are painful: Unraveling the mechanisms of the nocebo effect. Neuroscience 147: 260–271

    Article  PubMed  CAS  Google Scholar 

  • Benedetti, F., Pollo, A., Lopiano, L., Lanotte, M., Vighetti, S., Rainero, I. (2003) Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. Journal of Neuroscience 23: 4315–4323

    PubMed  CAS  Google Scholar 

  • Bingel, U., Lorenz, J., Glauche, V., Knab, R., Glascher, J., Weiller, C., Büchel, C. (2004) Somatotopic organization of human somatosensory cortices for pain: a single trial fMRI study. Neuroimage 23: 224–232

    Article  PubMed  CAS  Google Scholar 

  • Bingel, U., Lorenz, J., Schoell, E., Weiller, C., Buchel, C. (2006) Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 120: 8–15

    Article  PubMed  CAS  Google Scholar 

  • Blomqvist A, Craig AD (1991) Organization of spinal and trigeminal input to the PAG. In: Depaulis A, Bandler R (eds) The midbrain periaqueductal gray matter: functional, anatomical and neurochemical organization. Plenum Press, New York, pp. 345–363

    Google Scholar 

  • Bornhövd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C., Büchel, C. (2002) Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain 125: 1326–1336

    Article  PubMed  Google Scholar 

  • Brooks, J. C., Nurmikko, T. J., Bimson, W. E., Singh, K. D., Roberts, N. (2002) fMRI of thermal pain: effects of stimulus laterality and attention. Neuroimage 15: 293–301

    Article  PubMed  Google Scholar 

  • Bruckbauer, T., Christian, B., Mantil, J., Valk, P. (2000) 9:–9:15. 3D Data Acquisition for Whole Body Images on the ECAT HR+. Clin.Positron.Imaging 3: 145

    Article  PubMed  Google Scholar 

  • Büchel, C., Bornhövd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C. (2002) Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study. Journal Of Neuroscience 22: 970–976

    PubMed  Google Scholar 

  • Buchel, C., Dolan, R. J., Armony, J. L., Friston, K. J. (1999) Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. Journal of Neuroscience 19: 10869–10876

    PubMed  CAS  Google Scholar 

  • Bullmore, E., Fadili, J., Breakspear, M., Salvador, R., Suckling, J., Brammer, M. (2003) Wavelets and statistical analysis of functional magnetic resonance images of the human brain. Statistical Methods in Medical Research. 12: 375–399

    Article  PubMed  Google Scholar 

  • Burton, H., Videen, T. O., Raichle, M. E. (1993) Tactile-vibration-activated foci in insular and parietal-opercular cortex studied with positron emission tomography: mapping the second somatosensory area in humans. Somatosensory Motor Research 10: 297–308

    Article  PubMed  CAS  Google Scholar 

  • Bush, G., Luu, P., Posner, M. I. (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences 4: 215–222

    Article  PubMed  Google Scholar 

  • Bushnell, M. C., Duncan, G. H., Hofbauer, R. K., Ha, B., Chen, J. I., Carrier, B. (1999) Pain perception: is there a role for primary somatosensory cortex? Proceedings of The National Academy of Science of the USA 96: 7705–7709

    Google Scholar 

  • Buxton, R. B., Uludag, K., Dubowitz, D. J., Liu, T. T. (2004) Modeling the hemodynamic response to brain activation. Neuroimage 23(Suppl 1): S220–S233

    Article  PubMed  Google Scholar 

  • Casey, K. L. (1999) Forebrain mechanisms of nociception and pain: analysis through imaging. Proceedings of The National Academy of Science of the USA 96: 7668–7674

    Google Scholar 

  • Casey, K. L., Lorenz, J., Minoshima, S. (2003) Insights into the pathophysiology of neuropathic pain through functional brain imaging. Experimental Neurology 184 Suppl 1: S80–S88

    Article  PubMed  Google Scholar 

  • Casey, K. L., Minoshima, S., Morrow, T. J., Koeppe, R. A. (1996) Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. Journal of Neurophysiology 76: 571–581

    PubMed  CAS  Google Scholar 

  • Casey, K. L., Morrow, T. J., Lorenz, J., Minoshima, S. (2001) Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. Journal of Neurophysiology 85: 951–959

    PubMed  CAS  Google Scholar 

  • Casey, K. L., Svensson, P., Morrow, T. J., Raz, J., Jone, C., Minoshima, S. (2000) Selective opiate modulation of nociceptive processing in the human brain. Journal of Neurophysiology 84: 525–533

    PubMed  CAS  Google Scholar 

  • Casey KL, Tran DT (2006) Cortical mechanisms and chronic pain in humans. In: Cervero F, Jensen TS (eds) Handbook of Clinical Neurology. Elsevier, pp. 159–177

    Google Scholar 

  • Chen, J. I., Ha, B., Bushnell, M. C., Pike, B., Duncan, G. H. (2002) Differentiating noxious- and innocuous-related activation of human somatosensory cortices using temporal analysis of fMRI. Journal of Neurophysiology 88: 464–474

    Article  PubMed  Google Scholar 

  • Christmann, C., Koeppe, C., Braus, D. F., Ruf, M., Flor, H. (2007) A simultaneous EEG-fMRI study of painful electric stimulation. Neuroimage 34: 1428–1437

    Article  PubMed  Google Scholar 

  • Coghill, R. C., Sang, C. N., Maisog, J. M., Iadarola, M. J. (1999) Pain intensity processing within the human brain: a bilateral, distributed mechanism. Journal of Neurophysiology 82: 1934–1943

    PubMed  CAS  Google Scholar 

  • Coghill, R. C., Talbot, J. D., Evans, A. C., Meyer, E., Gjedde, A., Bushnell, M. C., Duncan, G. H. (1994) Distributed processing of pain and vibration by the human brain. Journal of Neuroscience 14: 4095–4108

    PubMed  CAS  Google Scholar 

  • Cohen, D. (1972) Magnetoencephalography: detection of the brain's electrical activity with a superconducting magnetometer. Science 175: 664–666

    Article  PubMed  CAS  Google Scholar 

  • Cole, L. J., Farrell, M. J., Duff, E. P., Barber, J. B., Egan, G. F., Gibson, S. J. (2006) Pain sensitivity and fMRI pain-related brain activity in Alzheimer's disease. Brain 129: 2957–2965

    Article  PubMed  Google Scholar 

  • Colloca, L., Benedetti, F. (2006) How prior experience shapes placebo analgesia. Pain 124: 126–133

    Article  PubMed  Google Scholar 

  • Craig, A. D., Chen, K., Bandy, D., Reiman, E. M. (2000) Thermosensory activation of insular cortex. Nature Neuroscience 3: 184–190

    Article  PubMed  CAS  Google Scholar 

  • Dannecker, E. A., Price, D. D., Robinson, M. E. (2003) An examination of the relationships among recalled, expected, and actual intensity and unpleasantness of delayed onset muscle pain. Journal of Pain 4: 74–81

    Article  PubMed  Google Scholar 

  • Davis, K. D. (2003) Neurophysiological and anatomical considerations in functional imaging of pain. Pain 105: 1–3

    Article  PubMed  Google Scholar 

  • Davis KD (2000) Studies of pain using functional magnetic resonance imaging. In: Casey KL, Bushnell MC (eds) Pain Imaging. Progress in pain research and management. IASP Press, Seattle, pp. 195–210

    Google Scholar 

  • Davis, K. D., Kwan, C. L., Crawley, A. P., Mikulis, D. J. (1998) Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli. Journal of Neurophysiology 80: 1533–1546

    PubMed  CAS  Google Scholar 

  • Davis, K. D., Taylor, S. J., Crawley, A. P., Wood, M. L., Mikulis, D. J. (1997) Functional MRI of pain- and attention-related activations in the human cingulate cortex. Journal of Neurophysiology 77: 3370–3380

    PubMed  CAS  Google Scholar 

  • Derbyshire, S. W. (2000) Exploring the pain “neuromatrix”. Current Review of Pain 4: 467–477

    PubMed  CAS  Google Scholar 

  • Derbyshire, S. W. (2003) A systematic review of neuroimaging data during visceral stimulation. American Journal of Gastroenterology 98: 12–20

    Article  PubMed  Google Scholar 

  • Devor M (2005) Response of nerves to injury in relation to neuropathic pain. In: McMahon S, Koltzenburg M (eds) Wall and Melzack's Textbook of Pain. Elsevier, pp. 905–928

    Google Scholar 

  • Djouhri, L., Koutsikou, S., Fang, X., McMullan, S., Lawson, S. N. (2006) Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors. Journal of Neuroscience 26: 1281–1292

    Article  PubMed  CAS  Google Scholar 

  • Dowman, R. (2001) Attentional set effects on spinal and supraspinal responses to pain. Psychophysiology 38: 451–464

    Article  PubMed  CAS  Google Scholar 

  • Downar, J., Crawley, A. P., Mikulis, D. J., Davis, K. D. (2002) A cortical network sensitive to stimulus salience in a neutral behavioral context across multiple sensory modalities. Journal of Neurophysiology 87: 615–620

    PubMed  Google Scholar 

  • Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., Burger, A. L. (1988) Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 95: 701–708

    PubMed  CAS  Google Scholar 

  • Druschky, K., Lang, E., Hummel, C., Kaltenhauser, M., Kohlloffel, L. U., Neundorfer, B., Stefan, H. (2000) Pain-related somatosensory evoked magnetic fields induced by controlled ballistic mechanical impacts. Journal of Clinical Neurophysiology 17: 613–622

    Article  PubMed  CAS  Google Scholar 

  • Duncan, G. H., Albanese, M. C. (2003) Is there a role for the parietal lobes in the perception of pain? Advances in Neurology 93: 69–86

    PubMed  Google Scholar 

  • Eccleston, C. (1995) The attentional control of pain: methodological and theoretical concerns. Pain 63: 3–10

    Article  PubMed  CAS  Google Scholar 

  • Eccleston, C., Crombez, G. (1999) Pain demands attention: A cognitive-affective model of the interuptive function of pain. Psychological Bulletin 125: 356–366

    Article  PubMed  CAS  Google Scholar 

  • Ernst, T., Hennig, J. (1994) Observation of a fast response in functional MR. Magnetic Resonance Medicine 32: 146–149

    Article  CAS  Google Scholar 

  • Expectation. “expectation n.” The Concise Oxford English Dictionary, Eleventh edition revised .Ed. Catherine Soanes and Angus Stevenson. Oxford University Press 2006. Oxford Reference Online.Oxford University Press.STAMI.25 June 2007 www.oxfordreference.com/views/ENTRY.html?subview=Main&entry=t23.e19371. 2006.

  • Fair, D. A., Brown, T. T., Petersen, S. E., Schlaggar, B. L. (2006) A comparison of analysis of variance and correlation methods for investigating cognitive development with functional magnetic resonance imaging. Developmental Neuropsychology 30: 531–546

    Article  PubMed  Google Scholar 

  • Farrar, J. T., Berlin, J. A., Strom, B. L. (2003) Clinically important changes in acute pain outcome measures: a validation study. Journal of Pain and Symptom Management 25: 406–411

    Article  PubMed  Google Scholar 

  • Farrar, J. T., Young, J. P., Jr., LaMoreaux, L., Werth, J. L., Poole, R. M. (2001) Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 94: 149–158

    Article  PubMed  CAS  Google Scholar 

  • Faymonville, M. E., Laureys, S., Degueldre, C., DelFiore, G., Luxen, A., Franck, G., Lamy, M., Maquet, P. (2000) Neural mechanisms of antinociceptive effects of hypnosis. Anesthesiology 92: 1257–1267

    Article  PubMed  CAS  Google Scholar 

  • Faymonville, M. E., Roediger, L., Del, F. G., Delgueldre, C., Phillips, C., Lamy, M., Luxen, A., Maquet, P., Laureys, S. (2003) Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Brain Research. Cognitive Brain Research 17: 255–262; Copyright Elsevier.

    Article  PubMed  Google Scholar 

  • Ferretti, A., Del, G. C., Babiloni, C., Caulo, M., Arienzo, D., Tartaro, A., Rossini, P. M., Romani, G. L. (2004) Functional topography of the secondary somatosensory cortex for nonpainful and painful stimulation of median and tibial nerve: an fMRI study. Neuroimage 23: 1217–1225

    Article  PubMed  Google Scholar 

  • Fields, H. L. (1999) Pain: an unpleasant topic. Pain 83(Suppl 6): S61–S69

    Article  Google Scholar 

  • Fields HL, Basbaum AI, Heinricher MM (2005) Central nervous system mechanisms of pain modulation. In: McMahon S, Koltzenburg M (eds) Wall and Melzack's Textbook of Pain. Elsevier.

    Google Scholar 

  • Flandin, G., Penny, W. D. (2007) Bayesian fMRI data analysis with sparse spatial basis function priors. Neuroimage 34: 1108–1125

    Article  PubMed  Google Scholar 

  • Flor, H., Elbert, T., Knecht, S., Wienbruch, C., Pantev, C., Birbaumer, N., Larbig, W., Taub, E. (1995) Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375: 482–484

    Article  PubMed  CAS  Google Scholar 

  • Flor, H., Nikolajsen, L., Staehelin, J. T. (2006) Phantom limb pain: a case of maladaptive CNS plasticity? Nature Reviews Neuroscience 7: 873–881

    Article  PubMed  CAS  Google Scholar 

  • Frankenstein, U. N., Richter, W., McIntyre, M. C., Remy, F. (2001) Distraction modulates anterior cingulate gyrus activations during the cold pressor test. Neuroimage 14: 827–836

    Article  PubMed  CAS  Google Scholar 

  • Friston, K. (1994) Functional and effective connectivity in neuroimaging: A synthesis. Human Brain Mapping 2: 56–78

    Article  Google Scholar 

  • Friston, K. J. (2005) Models of brain function in neuroimaging. Annual Review of Psychology 56: 57–87

    Article  PubMed  Google Scholar 

  • Gatchel, R. J., Polatin, P. B., Mayer, T. G. (1995) The dominant role of psychosocial risk factors in the development of chronic low back pain disability. Spine 20: 2702–2709

    Article  PubMed  CAS  Google Scholar 

  • Gedney, J. J., Logan, H. (2007) Perceived control and negative affect predict expected and experienced acute clinical pain: a structural modeling analysis. Clinical Journal of Pain 23: 35–44

    Article  PubMed  Google Scholar 

  • Gedney, J. J., Logan, H., Baron, R. S. (2003) Predictors of short-term and long-term memory of sensory and affective dimensions of pain. J Pain 4: 47–55

    Article  PubMed  Google Scholar 

  • Gracely RH (2005) Studies of pain in human subjects. In: McMahon S, Koltzenburg M (eds) Wall and Melzack's Textbook of Pain. Elsevier.

    Google Scholar 

  • Gracely, R. H., Geisser, M. E., Giesecke, T., Grant, M. A., Petzke, F., Williams, D. A., Clauw, D. J. (2004) Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 127: 835–843

    Article  PubMed  CAS  Google Scholar 

  • Hadjipavlou, G., Dunckley, P., Behrens, T. E., Tracey, I. (2006) Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: a diffusion tensor imaging study in healthy controls. Pain 123: 169–178

    Article  PubMed  Google Scholar 

  • Hamalainen, M., Hari, R., Ilmoniemi, R. J., Knuutila, J., Lounasmaa, O. V. (1993) Magnetoencephalography—theory, instrumentation, and applications to noninvasive studies of the working human brain. Reviews of Modern Physics 65: 413–97

    Article  CAS  Google Scholar 

  • Hari, R., Hamalainen, M., Kaukoranta, E., Reinikainen, K., Teszner, D. (1983) Neuromagnetic responses from the second somatosensory cortex in man. Acta Neurologica Scandinavica 68: 207–212

    Article  PubMed  CAS  Google Scholar 

  • Hari, R., Joutsiniemi, S. L., Sarvas, J. (1988) Spatial resolution of neuromagnetic records: theoretical calculations in a spherical model. Electroencephalography and Clinical Neurophysiology 71: 64–72

    Article  PubMed  CAS  Google Scholar 

  • Head, H., Holmes, G. (1911) Sensory disturbances from cerebral lesions. Brain 34:

    Google Scholar 

  • Heymans, M. W., de Vet, H. C., Knol, D. L., Bongers, P. M., Koes, B. W., van, M. W. (2006) Workers' beliefs and expectations affect return to work over 12 months. Journal of Occupational Rehabilitation 16: 685–695

    Article  PubMed  Google Scholar 

  • Hirsch, M. S., Liebert, R. M. (1998) The physical and psychological experience of pain: the effect of labelling and cold pressor temperature on three pain measures in college women. Pain 77: 41–48

    Article  PubMed  CAS  Google Scholar 

  • Hofbauer, R. K., Rainville, P., Duncan, G. H., Bushnell, M. C. (2001) Cortical representation of the sensory dimension of pain. Journal of Neurophysiology 86: 402–411

    PubMed  CAS  Google Scholar 

  • Hoffman, H. G., Richards, T. L., Bills, A. R., Van, O. T., Magula, J., Seibel, E. J., Sharar, S. R. (2006) Using FMRI to study the neural correlates of virtual reality analgesia. CNS Spectrums 11: 45–51

    PubMed  Google Scholar 

  • Hrobjartsson, A., Gotzsche, P. C. (2001) Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. The New England Journal of Medicine 344: 1594–1602

    Article  PubMed  CAS  Google Scholar 

  • Hsieh, J. C., Belfrage, M., Stone-Elander, S., Hansson, P., Ingvar, M. (1995) Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain 63: 225–236

    Article  PubMed  CAS  Google Scholar 

  • Hsieh, J. C., Hagermark, O., Stahle-Backdahl, M., Ericson, K., Eriksson, L., Stone-Elander, S., Ingvar, M. (1994) Urge to scratch represented in the human cerebral cortex during itch. Journal of Neurophysiology. 72: 3004–3008

    PubMed  CAS  Google Scholar 

  • Hu, D., Yan, L., Liu, Y., Zhou, Z., Friston, K. J., Tan, C., Wu, D. (2005) Unified SPM-ICA for fMRI analysis. Neuroimage 25: 746–755

    Article  PubMed  Google Scholar 

  • Huttunen, J., Kobal, G., Kaukoranta, E., Hari, R. (1986) Cortical responses to painful CO2 stimulation of nasal mucosa; a magnetoencephalographic study in man. Electroencephalography And Clinical Neurophysiology 64: 347–349

    Article  PubMed  CAS  Google Scholar 

  • Iannetti, G. D., Niazy, R. K., Wise, R. G., Jezzard, P., Brooks, J. C., Zambreanu, L., Vennart, W., Matthews, P. M., Tracey, I. (2005) Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans. Neuroimage 28: 708–719

    Article  PubMed  CAS  Google Scholar 

  • Inui, K., Tran, T. D., Qiu, Y., Wang, X., Hoshiyama, M., Kakigi, R. (2002) Pain-related magnetic fields evoked by intra-epidermal electrical stimulation in humans. Clinical Neurophysiology 113: 298–304

    Article  PubMed  Google Scholar 

  • Jones, A. K., Cunningham, V. J., Ha-Kawa, S., Fujiwara, T., Luthra, S. K., Silva, S., Derbyshire, S., Jones, T. (1994) Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. British Journal of Rheumatology 33: 909–916

    Article  PubMed  CAS  Google Scholar 

  • Kain, Z. N., Sevarino, F., Alexander, G. M., Pincus, S., Mayes, L. C. (2000) Preoperative anxiety and postoperative pain in women undergoing hysterectomy. A repeated-measures design. Journal of Psychosomatic Research 49: 417–422

    Article  PubMed  CAS  Google Scholar 

  • Kakigi, R., Inui, K., Tran, D. T., Qiu, Y., Wang, X., Watanabe, S., Hoshiyama, M. (2004) Human brain processing and central mechanisms of pain as observed by electro- and magneto-encephalography. Journal of Chinese Medical Association 67: 377–386

    Google Scholar 

  • Kakigi, R., Koyama, S., Hoshiyama, M., Kitamura, Y., Shimojo, M., Watanabe, S. (1995) Pain-related magnetic fields following painful CO2 laser stimulation in man. Neuroscience Letters 192: 45–48

    Article  PubMed  CAS  Google Scholar 

  • Kanda, M., Nagamine, T., Ikeda, A., Ohara, S., Kunieda, T., Fujiwara, N., Yazawa, S., Sawamoto, N., Matsumoto, R., Taki, W., Shibasaki, H. (2000) Primary somatosensory cortex is actively involved in pain processing in human. Brain Research 853: 282–289

    Article  PubMed  CAS  Google Scholar 

  • Kiebel, S. J., Friston, K. J. (2004) Statistical parametric mapping for event-related potentials: I. Generic considerations. Neuroimage 22: 492–502

    Article  PubMed  Google Scholar 

  • Kitamura, Y., Kakigi, R., Hoshiyama, M., Koyama, S., Shimojo, M., Watanabe, S. (1995) Pain-related somatosensory evoked magnetic fields. Electroencephalography and Clinical Neurophysiology 95: 463–474

    Article  PubMed  CAS  Google Scholar 

  • Kitamura, Y., Kakigi, R., Hoshiyama, M., Koyama, S., Watanabe, S., Shimojo, M. (1997) Pain-related somatosensory evoked magnetic fields following lower limb stimulation. Journal of Neurology and Science 145: 187–194

    Article  CAS  Google Scholar 

  • Knecht, S., Henningsen, H., Elbert, T., Flor, H., Hohling, C., Pantev, C., Birbaumer, N., Taub, E. (1995) Cortical reorganization in human amputees and mislocalization of painful stimuli to the phantom limb. Neuroscience Letters 201: 262–264

    Article  PubMed  CAS  Google Scholar 

  • Knecht, S., Soros, P., Gurtler, S., Imai, T., Ringelstein, E. B., Henningsen, H. (1998) Phantom sensations following acute pain. Pain 77: 209–213

    Article  PubMed  CAS  Google Scholar 

  • Kong, J., White, N. S., Kwong, K. K., Vangel, M. G., Rosman, I. S., Gracely, R. H., Gollub, R. L. (2006) Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Human Brain Mapping 27: 715–721

    Article  PubMed  Google Scholar 

  • Koyama, T., McHaffie, J. G., Laurienti, P. J., Coghill, R. C. (2005) The subjective experience of pain: where expectations become reality. Proceedings of the National Academy of Science of the USA 102: 12950–12955

    Google Scholar 

  • Kupers, R., Kehlet, H. (2006) Brain imaging of clinical pain states: a critical review and strategies for future studies. Lancet Neurology 5: 1033–1044

    Article  PubMed  Google Scholar 

  • Leijon, G., Boivie, J., Johansson, I. (1989) Central post-stroke pain – neurological symptoms and pain characteristics. Pain 36: 13–25

    Article  PubMed  CAS  Google Scholar 

  • Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., Oeltermann, A. (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412: 150–157

    Article  PubMed  CAS  Google Scholar 

  • Lorenz, J., Cross, D., Minoshima, S., Morrow, T., Paulson, P., Casey, K. (2002) A unique representation of heat allodynia in the human brain. Neuron 35: 383

    Article  PubMed  CAS  Google Scholar 

  • Lorenz, J., Minoshima, S., Casey, K. L. (2003) Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 126: 1079–1091

    Article  PubMed  CAS  Google Scholar 

  • Maihofner, C., Kaltenhauser, M., Neundorfer, B., Lang, E. (2002) Temporo-spatial analysis of cortical activation by phasic innocuous and noxious cold stimuli – a magnetoencephalographic study. Pain 100: 281–290

    Article  PubMed  Google Scholar 

  • Matre, D., Casey, K. L., Knardahl, S. (2006) Placebo-induced changes in spinal cord pain processing. Journal of Neuroscience 26: 559–563

    Article  PubMed  CAS  Google Scholar 

  • Melzack R, Casey KL (1968) Sensory, motivational, and central control determinants of pain: a new conceptual model. In: Kenshalo D, Thomas CC (eds) The skin senses. Springfield, IL, pp. 423–439

    Google Scholar 

  • Minoshima S, Cross DJ, Koeppe RA, Casey KL (2000) Brain activation studies using PET and SPECT: Execution and analysis. In: Casey KL, Bushnell MC (eds) Pain Imaging. IASP Press, Seattle, pp. 95–121

    Google Scholar 

  • Mitiche, A., Sekkati, H. (2006) Optical flow 3D segmentation and interpretation: a variational method with active curve evolution and level sets. IEEE Transactions On Pattern Analysis and Machine Intelligence 28: 1818–1829

    Article  PubMed  Google Scholar 

  • Montgomery, G. H., Kirsch, I. (1997) Classical conditioning and the placebo effect. Pain 72: 107–113

    Article  PubMed  CAS  Google Scholar 

  • Morris, J. S., Ohman, A., Dolan, R. J. (1998) Conscious and unconscious emotional learning in the human amygdala. Nature 393: 467–470

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, Y., Paur, R., Zimmermann, R., Bromm, B. (2002) Attentional modulation of human pain processing in the secondary somatosensory cortex: a magnetoencephalographic study. Neuroscience Letters 328: 29–32

    Article  PubMed  CAS  Google Scholar 

  • Ninomiya, Y., Kitamura, Y., Yamamoto, S., Okamoto, M., Oka, H., Yamada, N., Kuroda, S. (2001) Analysis of pain-related somatosensory evoked magnetic fields using the MUSIC (multiple signal classification) algorithm for magnetoencephalography. Neuroreport. 12: 1657–1661

    Article  PubMed  CAS  Google Scholar 

  • Ogawa, S., Menon, R. S., Tank, D. W., Kim, S. G., Merkle, H., Ellermann, J. M., Ugurbil, K. (1993) Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophysical Journal 64: 803–812

    Article  PubMed  CAS  Google Scholar 

  • Osborne, T. L., Jensen, M. P., Ehde, D. M., Hanley, M. A., Kraft, G. (2007) Psychosocial factors associated with pain intensity, pain-related interference, and psychological functioning in persons with multiple sclerosis and pain. Pain 127: 52–62

    Article  PubMed  Google Scholar 

  • Parker, G. J., Roberts, C., Macdonald, A., Buonaccorsi, G. A., Cheung, S., Buckley, D. L., Jackson, A., Watson, Y., Davies, K., Jayson, G. C. (2006) Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Magnetic Resonance on Medicine 56: 993–1000

    Article  Google Scholar 

  • Penfield, W., Boldrey, E. (1937) Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 60: 389–443

    Article  Google Scholar 

  • Petersen, E. T., Zimine, I., Ho, Y. C., Golay, X. (2006) Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques. British Journal of Radiology 79: 688–701

    Article  PubMed  CAS  Google Scholar 

  • Petrovic, P., Dietrich, T., Fransson, P., Andersson, J., Carlsson, K., Ingvar, M. (2005) Placebo in emotional processing – induced expectations of anxiety relief activate a generalized modulatory network. Neuron 46: 957–969

    Article  PubMed  CAS  Google Scholar 

  • Petrovic, P., Ingvar, M., Stone-Elander, S., Petersson, K. M., Hansson, P. (1999) A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy. Pain 83: 459–470

    Article  PubMed  CAS  Google Scholar 

  • Petrovic, P., Kalso, E., Petersson, K. M., Ingvar, M. (2002) Placebo and opioid analgesia – imaging a shared neuronal network. Science 295: 1737–1740

    Article  PubMed  CAS  Google Scholar 

  • Petrovic, P., Petersson, K. M., Ghatan, P. H., Stone-Elander, S., Ingvar, M. (2000) Pain-related cerebral activation is altered by a distracting cognitive task. Pain 85: 19–30

    Article  PubMed  CAS  Google Scholar 

  • Peyron, R., Frot, M., Schneider, F., Garcia-Larrea, L., Mertens, P., Barral, F. G., Sindou, M., Laurent, B., Mauguiere, F. (2002) Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials. Neuroimage 17: 1336–1346

    Article  PubMed  CAS  Google Scholar 

  • Peyron, R., Garcia-Larrea, L., Gregoire, M. C., Convers, P., Lavenne, F., Veyre, L., Froment, J. C., Mauguiere, F., Michel, D., Laurent, B. (1998) Allodynia after lateral-medullary (Wallenberg) infarct. A PET study. Brain 121 (Pt 2): 345–356

    Article  PubMed  Google Scholar 

  • Peyron, R., Garcia-Larrea, L., Gregoire, M. C., Costes, N., Convers, P., Lavenne, F., Mauguiere, F., Michel, D., Laurent, B. (1999) Haemodynamic brain responses to acute pain in humans: sensory and attentional networks. Brain 122 (Pt 9): 1765–1780

    Article  PubMed  Google Scholar 

  • Peyron, R., Laurent, B., Garcia-Larrea, L. (2000) Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiologie Clinique. 30: 263–288

    Article  PubMed  CAS  Google Scholar 

  • Peyron, R., Schneider, F., Faillenot, I., Convers, P., Barral, F. G., Garcia-Larrea, L., Laurent, B. (2004) An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology 63: 1838–1846

    PubMed  CAS  Google Scholar 

  • Phelps, M. E., Kuhl, D. E., Mazziota, J. C. (1981) Metabolic mapping of the brain's response to visual stimulation: studies in humans. Science 211: 1445–1448

    Article  PubMed  CAS  Google Scholar 

  • Phillips, M. L., Young, A. W., Senior, C., Brammer, M., Andrew, C., Calder, A. J., Bullmore, E. T., Perrett, D. I., Rowland, D., Williams, S. C., Gray, J. A., David, A. S. (1997) A specific neural substrate for perceiving facial expressions of disgust. Nature 389: 495–498

    Article  PubMed  CAS  Google Scholar 

  • Ploghaus, A., Becerra, L., Borras, C., Borsook, D. (2003) Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends in Cognitive Sciences 7: 197–200

    Article  PubMed  Google Scholar 

  • Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N., Tracey, I. (2001) Exacerbation of pain by anxiety is associated with activity in a hippocampal network. Journal of Neurosciences 21: 9896–9903

    CAS  Google Scholar 

  • Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., Rawlins, J. N. (1999) Dissociating pain from its anticipation in the human brain. Science 284: 1979–1981

    Article  PubMed  CAS  Google Scholar 

  • Ploner, M., Gross, J., Timmermann, L., Schnitzler, A. (2002) Cortical representation of first and second pain sensation in humans. Proceedings of the National Academy of Science of the USA 99: 12444–12448

    Google Scholar 

  • Ploner, M., Schmitz, F., Freund, H. J., Schnitzler, A. (1999) Parallel activation of primary and secondary somatosensory cortices in human pain processing. Journal of Neurophysiology 81: 3100–3104

    PubMed  CAS  Google Scholar 

  • Porreca, F., Ossipov, M. H., Gebhart, G. F. (2002) Chronic pain and medullary descending facilitation. TINS 25: 319–325

    PubMed  CAS  Google Scholar 

  • Porro, C. A., Baraldi, P., Pagnoni, G., Serafini, M., Facchin, P., Maieron, M., Nichelli, P. (2002) Does anticipation of pain affect cortical nociceptive systems? Journal of Neuroscience 22: 3206–3214

    PubMed  CAS  Google Scholar 

  • Porro, C. A., Cettolo, V., Francescato, M. P., Baraldi, P. (1998) Temporal and intensity coding of pain in human cortex. Journal of Neurophysiology 80: 3312–3320

    PubMed  CAS  Google Scholar 

  • Price, D. D. (2000) Psychological and neural mechanisms of the affective dimension of pain. Science 288: 1769–1772

    Article  PubMed  CAS  Google Scholar 

  • Price DD, Bushnell MC (2004) Overview of pain dimensions and their psychological modulation. In: Price DD, Bushnell MC (eds) IASP Press, Seattle, pp. 3–17

    Google Scholar 

  • Qiu, Y., Inui, K., Wang, X., Nguyen, B. T., Tran, T. D., Kakigi, R. (2004) Effects of distraction on magnetoencephalographic responses ascending through C-fibers in humans. Clinical Neurophysiology 115: 636–646

    Article  PubMed  Google Scholar 

  • Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., Shulman, G. L. (2001) A default mode of brain function. Proceedings of the National Academy of Science of the USA 98: 676–682

    Google Scholar 

  • Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., Bushnell, M. C. (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277: 968–971

    Article  PubMed  CAS  Google Scholar 

  • Rauch, S. L., Savage, C. R., Alpert, N. M., Miguel, E. C., Baer, L., Breiter, H. C., Fischman, A. J., Manzo, P. A., Moretti, C., Jenike, M. A. (1995) A positron emission tomographic study of simple phobic symptom provocation. Archives of General Psychiatry 52: 20–28

    PubMed  CAS  Google Scholar 

  • Rhudy, J. L., Meagher, M. W. (2000) Fear and anxiety: divergent effects on human pain thresholds. Pain 84: 65–75

    Article  PubMed  CAS  Google Scholar 

  • Roelofs, J., Peters, M. L., McCracken, L., Vlaeyen, J. W. (2003) The pain vigilance and awareness questionnaire (PVAQ): further psychometric evaluation in fibromyalgia and other chronic pain syndromes. Pain 101: 299–306

    Article  PubMed  Google Scholar 

  • Ruben, J., Schwiemann, J., Deuchert, M., Meyer, R., Krause, T., Curio, G., Villringer, K., Kurth, R., Villringer, A. (2001) Somatotopic organization of human secondary somatosensory cortex. Cerebral Cortex 11: 463–473

    Article  PubMed  CAS  Google Scholar 

  • Salaffi, F., Stancati, A., Silvestri, C. A., Ciapetti, A., Grassi, W. (2004) Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. European Journal of Pain 8: 283–291

    Article  PubMed  Google Scholar 

  • Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., Shibasaki, H. (2000) Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: an event-related functional magnetic resonance imaging study. Journal of Neuroscience 20: 7438–7445

    PubMed  CAS  Google Scholar 

  • Schmahl, C., Bohus, M., Esposito, F., Treede, R. D., Di, S. F., Greffrath, W., Ludaescher, P., Jochims, A., Lieb, K., Scheffler, K., Hennig, J., Seifritz, E. (2006) Neural correlates of antinociception in borderline personality disorder. Archives of General Psychiatry 63: 659–667

    Article  PubMed  Google Scholar 

  • Schnitzler, A., Ploner, M. (2000) Neurophysiology and functional neuroanatomy of pain perception. Journal of Clinical Neurophysiology 17: 592–603

    Article  PubMed  CAS  Google Scholar 

  • Schweinhardt, P., Glynn, C., Brooks, J., McQuay, H., Jack, T., Chessell, I., Bountra, C., Tracey, I. (2006) An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage 32: 256–265

    Article  PubMed  Google Scholar 

  • Scott, D. J., Heitzeg, M. M., Koeppe, R. A., Stohler, C. S., Zubieta, J. K. (2006) Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity. Journal of Neuroscience 26: 10789–10795

    Article  PubMed  CAS  Google Scholar 

  • Seghier, M. L., Lazeyras, F., Vuilleumier, P., Schnider, A., Carota, A. (2005b) Functional magnetic resonance imaging and diffusion tensor imaging in a case of central poststroke pain. Journal of Pain 6: 208–212

    Google Scholar 

  • Seghier, M. L., Lazeyras, F., Vuilleumier, P., Schnider, A., Carota, A. (2005a) Functional magnetic resonance imaging and diffusion tensor imaging in a case of central poststroke pain. Journal of Pain 6: 208–212

    Google Scholar 

  • Seminowicz, D. A., Davis, K. D. (2007) Interactions of pain intensity and cognitive load: the brain stays on task. Cerebral Cortex 17: 1412–1422

    Article  PubMed  Google Scholar 

  • Seminowicz, D. A., Davis, K. D. (2006) Cortical responses to pain in healthy individuals depends on pain catastrophizing. Pain 120: 297–306

    Article  PubMed  Google Scholar 

  • Shepp, L. A., Logan, B. F. (1974) The Fourier reconstruction of a head section. IEEE Transactions on Nuclear Science NS-21: 21–43

    Google Scholar 

  • Sheth, S. A., Nemoto, M., Guiou, M., Walker, M., Pouratian, N., Toga, A. W. (2004) Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses. Neuron 42: 347–355

    Article  PubMed  CAS  Google Scholar 

  • Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., Frith, C. D. (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303: 1157–1162

    Article  PubMed  CAS  Google Scholar 

  • Smith SM (2001) Overview of fMRI analysis. In: Jezzard P, Matthews PB, Smith SM (eds) Functional MRI. An introduction to methods. Oxford University Press, New York, pp. 215–227

    Google Scholar 

  • Spiegel, D. (1991) Neurophysiological correlates of hypnosis and dissociation. Journal of Neuropsychiatry Clinical Neuroscience 3: 440–445

    CAS  Google Scholar 

  • Sprenger, T., Valet, M., Boecker, H., Henriksen, G., Spilker, M. E., Willoch, F., Wagner, K. J., Wester, H. J., Tolle, T. R. (2006) Opioidergic activation in the medial pain system after heat pain. Pain 122: 63–67

    Article  PubMed  CAS  Google Scholar 

  • Stoeter, P., Bauermann, T., Nickel, R., Corluka, L., Gawehn, J., Vucurevic, G., Vossel, G., Egle, U. T. (2007) Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: An fMRI study. Neuroimage 36: 418–430

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, M. J., Thorn, B., Haythornthwaite, J. A., Keefe, F., Martin, M., Bradley, L. A., Lefebvre, J. C. (2001) Theoretical perspectives on the relation between catastrophizing and pain. Clinical Journal of Pain 17: 52–64

    Article  PubMed  CAS  Google Scholar 

  • Suzuki, R., Rygh, L. J., Dickenson, A. H. (2004) Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends in Pharmacological Science 25: 613–617

    Article  CAS  Google Scholar 

  • Svensson, P. (2007) What can human experimental pain models teach us about clinical TMD? Archives of Oral Biology 52: 391–394

    Article  PubMed  Google Scholar 

  • Svensson, P., Minoshima, S., Beydoun, A., Morrow, T. J., Casey, K. L. (1997) Cerebral processing of acute skin and muscle pain in humans. Journal of Neurophysiology 78: 450–460

    PubMed  CAS  Google Scholar 

  • Sweet WH (1982) Cerebral localization of pain. In: Thompson RA, Green JR (eds) New Perspectives in Cerebral Localization. Raven Press, New York, pp. 205–242

    Google Scholar 

  • Timmermann, L., Ploner, M., Haucke, K., Schmitz, F., Baltissen, R., Schnitzler, A. (2001) Differential coding of pain intensity in the human primary and secondary somatosensory cortex. Journal of Neurophysiology. 86: 1499–1503

    PubMed  CAS  Google Scholar 

  • Todd, K. H. (1996) Clinical versus statistical significance in the assessment of pain relief. Annals of Emerging Medicine. 27: 439–441

    Article  CAS  Google Scholar 

  • Tracey, I. (2005) Functional connectivity and pain: how effectively connected is your brain? Pain 116: 173–174

    Article  PubMed  Google Scholar 

  • Tracey, I., Ploghaus, A., Gati, J. S., Clare, S., Smith, S., Menon, R. S., Matthews, P. M. (2002) Imaging attentional modulation of pain in the periaqueductal gray in humans. Journals of Neuroscience 22: 2748–2752

    CAS  Google Scholar 

  • Tran, T. D., Inui, K., Hoshiyama, M., Lam, K., Qiu, Y., Kakigi, R. (2002) Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study. Neuroscience 113: 375–386

    Article  PubMed  CAS  Google Scholar 

  • Turk, D. C. (2000) Statistical significance and clinical significance are not synonyms!. Clinical Journal of Pain 16: 185–187

    Article  PubMed  CAS  Google Scholar 

  • Turner, J. A., Franklin, G., Fulton-Kehoe, D., Sheppard, L., Wickizer, T. M., Wu, R., Gluck, J. V., Egan, K. (2006) Worker recovery expectations and fear-avoidance predict work disability in a population-based workers' compensation back pain sample. Spine 31: 682–689

    Article  PubMed  Google Scholar 

  • Urban, M. O., Gebhart, G. F. (1999) Supraspinal contributions to hyperalgesia. Proceeding of the National Academy of Science of the USA 96: 7687–7692

    Google Scholar 

  • Valet, M., Sprenger, T., Boecker, H., Willoch, F., Rummeny, E., Conrad, B., Erhard, P., Tolle, T. R. (2004) Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain – an fMRI analysis. Pain 109: 399–408

    Article  PubMed  Google Scholar 

  • Van Damme, S., Crombez, G., Eccleston, C. (2004) Disengagement from pain: the role of catastrophic thinking about pain. Pain 107: 70–76

    Article  PubMed  Google Scholar 

  • van den Hout, J. H., Vlaeyen, J. W., Houben, R. M., Soeters, A. P., Peters, M. L. (2001) The effects of failure feedback and pain-related fear on pain report, pain tolerance, and pain avoidance in chronic low back pain patients. Pain 92: 247–257

    Google Scholar 

  • Wager, T. D. (2005) The neural bases of placebo effects in anticipation and pain. Seminars in Pain Medicine 3: 22–30

    Article  Google Scholar 

  • Wager, T. D., Matre, D., Casey, K. L. (2006) Placebo effects in laser-evoked pain potentials. Brain, Behavior, and Immunity 20: 219–230

    Article  PubMed  Google Scholar 

  • Wager, T. D., Phan, K. L., Liberzon, I., Taylor, S. F. (2003) Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging. Neuroimage 19: 513–531

    Article  PubMed  Google Scholar 

  • Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., Cohen, J. D. (2004) Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 303: 1162–1167

    Article  PubMed  CAS  Google Scholar 

  • Wager, T. D., Scott, D. J., Zubieta, J. K. (2007) Placebo effects on human {micro}-opioid activity during pain. Proceedings of the National Academy of Science of the USA

    Google Scholar 

  • Wagner, K. J., Sprenger, T., Kochs, E. F., Tolle, T. R., Valet, M., Willoch, F. (2007) Imaging human cerebral pain modulation by dose-dependent opioid analgesia: a positron emission tomography activation study using remifentanil. Anesthesiology 106: 548–556

    Article  PubMed  CAS  Google Scholar 

  • White JC, Sweet WH (1969) Pain and the Neurosurgeon. A Forty-Year Experience. C.C. Thomas, Springfield Illinois

    Google Scholar 

  • Willoch, F. PET studies on pain and analgesia: brain activity changes & opioidergic mechanisms. 2001. Dept of Pharmacology, University of Oslo, Norway. Ref Type: Thesis/Dissertation

    Google Scholar 

  • Willoch, F., Schindler, F., Wester, H. J., Empl, M., Straube, A., Schwaiger, M., Conrad, B., Tolle, T. R. (2004) Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study. Pain 108: 213–220

    Article  PubMed  CAS  Google Scholar 

  • Wise, R. G., Tracey, I. (2006) The role of fMRI in drug discovery. Journal of Magnetic Resonance Imaging 23: 862–876

    Article  PubMed  Google Scholar 

  • Woolrich, M. W., Behrens, T. E. (2006) Variational Bayes inference of spatial mixture models for segmentation. IEEE Transactions on Medical Imaging 25: 1380–1391

    Article  PubMed  Google Scholar 

  • Worsley K (2001) Statistical activation of activation images. In: Jezzard P, Matthews PB, Smith SM (eds) Functional MRI. An introduction to methods. Oxford University Press, New York, pp. 251–270

    Google Scholar 

  • Xu, X., Fukuyama, H., Yazawa, S., Mima, T., Hanakawa, T., Magata, Y., Kanda, M., Fujiwara, N., Shindo, K., Nagamine, T., Shibasaki, H. (1997) Functional localization of pain perception in the human brain studied by PET. Neuroreport 8: 555–559

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman, J. E., Thiene, P., Harding, J. T. (1970) Design and operation of stable rf-biased superconductiong point-contact quantum devices and a note on the properties of perfectly clean metal contacts. Journal of Applied Physiology 41: 1572–1580

    Article  Google Scholar 

  • Zubieta, J. K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., Stohler, C. S. (2005) Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. Journal of Neuroscience 25: 7754–7762

    Article  PubMed  CAS  Google Scholar 

  • Zubieta, J. K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., Stohler, C. S. (2001) Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293: 311–315

    Article  PubMed  CAS  Google Scholar 

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We thank Kenneth L. Casey for critically reading a previous version of this manuscript.

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Matre, D., Tran, T.D. (2009). Imaging Modalities for Pain. In: Biobehavioral Approaches to Pain. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78323-9_17

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