Abstract
Hostility has long been thought to play a role in health, and recent research has now documented substantial effects on disease etiology, with much of the attention given to its role in cardiovascular disease. Several measures of this construct have been found to predict adverse cardiovascular events as well as cardiac and total mortality. It is apparent, however, that the hostility construct has multiple aspects, including cynical and suspicious attitudes, various negative emotions, and antagonistic behavior patterns. Interpersonal experiences, such as child rearing patterns and adult adversity in combination with physiological and genetic factors, influence the development of these tendencies. The links to physical health appear to involve several processes such as enhanced autonomic reactivity and altered glucose metabolism that are the product of the stress associated with antagonistic experiences. In addition, high hostility is associated with a lifestyle that produces an adverse risk factor pattern. There is promising evidence in clinical samples suggesting that interventions based on coping skills training may be able to improve health through the reduction of these hostile tendencies.
Disclosure: Redford Williams is a founder and major stockholder in Williams LifeSkills, Inc., a company that develops, tests, and markets behavioral interventions that target psychosocial risk factors. Redford Williams holds a U.S. patent on the use of the 5HTTLPR L allele as a marker of increased CVD risk in persons exposed to chronic stress.
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References
Adams, S. H. (1994). The role of hostility in women’s health during midlife: a longitudinal study. Health Psychol, 13, 488–495.
Allred, K. D., and Smith, T. W. (1991). Social cognition in cynical hostility. Cog Ther Res, 15, 399–412.
al’ Absi, M., Carr, S. B., and Bongard, S. (2007). Anger and psychobiological changes during smoking abstinence and in response to acute stress: prediction of smoking relapse. Int J Psychophys, 66, 109–115.
Angerer, P., Siebert, U., Kothny, W., Muhlbauer, D., Mudra, H. et al (2000). Impact of social support, cynical hostility and anger expression on progression of coronary atherosclerosis. J Am Coll Card 36, 1781–1788.
Arinami, T., Ohtsuki, T., Yamakawa-Kobayashi, J. R., Amemiya, H., Fujiwara, H. et al (1999). A synergistic effect of serotonin transporter gene polymorphism and smoking in association with CHD. Thromb Haemost, 81, 853–856.
Barefoot, J. C., Beckham, J. C., Peterson, B. L., Haney, T. L., and Williams, R. B. (1992). Measures of neuroticism and disease status in coronary angiography patients. J Consult Clin Psycho, 60, 127–132.
Barefoot, J. C., Beckham, J. C., Haney, T. L., Siegler, I. C., and Lipkus, I. M. (1993). Age differences in hostility among middle-aged and older adults. Psych Aging, 8, 3–9.
Barefoot, J. C., Brummett, B. H., Clapp-Channing, N., Williams, R. B., Siegler, I. C. et al (2008). Recovery expectations of cardiac patients as predictors of survival. APS Meeting Abstract 2008, 70, Number 3, A-117.
Barefoot, J. C., Larsen, S., von der Lieth, L., and Schroll, M. (1995). Hostility, incidence of acute myocardial infarction, and mortality in a sample of older Danish men and women. Am J Epid, 142, 477–484.
Barefoot, J. C., and Lipkus, I. M. (1994). Assessment of anger-hostility. In A. W. Siegman & T. W. Smith (Eds.), Anger, Hostility and the Heart. Hillside, NJ: Lawrence Erlbaum.
Barefoot, J. C., Peterson, B. L., Dahlstrom, W. G., Siegler, I. C., Anderson, N. B. et al (1991). Hostility patterns and health implications: correlates of Cook-Medley scores in a national survey. Health Psych, 10, 18–24.
Beckham, J. C., Roodman, A. A., Barefoot, J. C., Haney, T. L., Helms, M. J. et al (1996). Interpersonal and self-reported hostility among combat veterans with and without Posttraumatic Stress Disorder. J Traumatic Stress, 9, 335–340.
Benotsch, E. G., Christensen, A. J., and McKelvey, L. (1997). Hostility, social support, and ambulatory cardiovascular activity. J Behav Med, 20, 163–176.
Bishop, G. D., Kaur, D. J., Tan, V. L. M., Chua, Y. L., Liew, S. M. et al (2005). Effect of a psychosocial skills training workshop on psychophysiological and psychosocial risk in patients undergoing coronary artery bypass grafting. Am Heart J, 150, 602–609.
Bishop, G. D., and Robinson, G. (2000). Anger, harassment, and cardiovascular reactivity among Chinese and Indian men in Singapore. Psychosom Med, 62, 684–692.
Boyle, S. H., Mortensen, L., Grønbæk, M., and Barefoot, J. C. (2007). Hostility, drinking pattern, and mortality. Addiction, 163, 54–59.
Boyle, S. H., Williams, R. B., Mark, D. B., Brummett, B. H., Siegler, I. C., and Barefoot, J. C. (2004). Hostility as a predictor of survival in patients with coronary artery disease. Psychosom Med, 66, 629–632.
Boyle, S. H., Williams, R. B., Mark, D. B., Brummett, B. H., Siegler, I. C. et al (2005). Hostility, age, and mortality in a sample of cardiac patients. Am J Card, 96, 64–66.
Boyle, S. H., Wang, L., Surwit, R. S., Zeng, Z., Holden, W. et al (2009). Central nervous system serotonin, hostility and glucose metabolism in African American women. APS Meeting Abstract 2009, 71, Number 3, A-26.
Brissette, I., and Cohen, S. (2002). The contribution of individual differences in hostility to the associations between daily interpersonal conflict, affect, and sleep. Pers Soc Psychol Bull 28, 1265–1274.
Brondolo, E., Rieppi, R., Erickson, S. A., Bagiella, E., Shapiro, P. A. et al (2003). Hostility, interpersonal interactions, and ambulatory blood pressure. Psychosom Med, 65, 1003–1011.
Brummett, B. H., Boyle, S. H., Siegler, I. C., Kuhn, C. M., Ashley-Koch, A. et al (2008a). Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav Genet 38, 34–43.
Brummett, B. H., Muller, C. L., Collins, A. L., Boyle, S. H., Kuhn, C. M. et al (2008b). 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet, 38, 476–483.
Bunde, J., and Suls, J. (2006). A quantitative analysis of the relationship between the Cook-Medley Hostility Scale and traditional coronary artery disease risk factors. Health Psychol, 25, 493–500.
Burg, M. M., Graeber, B., Vashist, A., Collins, A., Earley, C. et al (2009). Noninvasive detection of risk for emotion provoked myocardial ischemia. Psychosom Med, 71, 14–21.
Buss, A. H., and Durkee, A. (1957). An inventory for assessing different kinds of hostility. J Consult Psychol, 21, 343–349.
Butler, E. A., Lee, T. L., and Gross, J. J. (2007). Emotion regulation and culture: are the social consequences of emotion suppression culture specific? Emotion, 7, 30–48.
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J. et al (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.
Chaput, L. A., Adams, S. H., Simon, J. A., Blumenthal, R. S., and Vittinghoff, E. et al (2002). Hostility predicts recurrent events among postmenopausal women with coronary heart disease. Am J Epid, 156, 1092–1099.
Chida, Y., and Steptoe, A. (2009). The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Card, 53, 936–946.
Christakis, N. A., and Fowler, J. H. (2008). The collective dynamics of smoking in a large social network. NEJM, 358, 2249–2258.
Cook, W. W., and Medley, D. M. (1954). Proposed hostility and pharisaic virtue scales for the MMPI. J Applied Psychol, 38: 414–418.
Coto, E., Reguero, J. R., Alvarez, V., Morales, B., Batalia, A. et al (2003). 5-Hytroxytrptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction. Clin Sci, 104, 241–245.
Denollet, J., and Brutsaert, D. L. (1998). Personality, disease severity, and the risk of long-term cardiac events in patients with a decreased ejection fraction after myocardial infarction. Circulation, 97, 167–173.
Dodge, K. A. (2006). Translational science in action: hostile attributional style and the development of aggressive behavior problems. Devel Psychopathol, 18, 791–814.
Davidson, K. W., Gidron, Y., Mostofsky, E. et al (2007). Hospitalization cost offset of a hostility intervention for coronary heart disease patients. J Consult Clin Psychol, 75, 657–672.
Enkleman, H. C., Bishop, G. D., Tong, E. M. W., Diong, S. M., Why, Y. P. et al (2005). The relationship of hostility, negative affect, and ethnicity to cardiovascular responses: an ambulatory study in Singapore. Int J Psychophys, 56, 185–197.
Berkman, L. F., Blumenthal, J., Burg, M., Carney, R. M., Catellier, D. et al (2003). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA, 289, 3106–3116.
Everson-Rose, S. A., and Lewis, T. T. (2005). Psychosocial factors and cardiovascular disease. Ann Rev Pub Health, 26, 469–500.
Everson-Rose, S. A., Lewis, T. T., Karavolos, K., Matthews, K. A., and Sutton-Tyrrell, K. (2006). Cynical hostility and carotid atherosclerosis in African American and white women: The Study of Women’s Health Across the Nation (SWAN) Heart Study. Am Heart J, 152, 982.e7–13.
Fallon, J. H., Keator, D. B., Mbogori, J., Turner, J., and Potkin, S. G. (2004). Hostility differentiates the brain metabolic effects of nicotine. Cog Brain Res, 18, 142–148.
Fowler, J. H., and Christakis, N. A. (2008). Dynamic spread of happiness in a large social network: longitudinal analysis over 20 years in the Framingham Heart Study. BMJ, 337, a2338.
Frasure-Smith, N., and Lesperance, F. (2003). Depression and other psychological risks following myocardial infarction. Arch Gen Psychiatry, 60, 627–636.
Fukudo, S., Lane, J. D., Anderson, N. B., Kuhn, C. M., Schanberg, S. M. et al (1992). Accentuated vagal antagonism of beta-adrenergic effects on ventricular repolarization: differential responses between Type A and Type B men. Circulation, 85, 2045–2053.
Fumeron, F., Betoulle, D., Nicaud, V., Evans, A., Kee, F. et al (2002). Serotonin transporter gene polymorphism and myocardial infarction. Circulation, 105, 2943–2945.
Gallo, L. C., and Matthews, K. A. (2003). Understanding the association between socioeconomic status and health: do negative emotions play a role? Psych Bull, 129, 10–51.
Georgiades, A., Lane, J. D., Boyle, S. H., Brummett, B. H., Barefoot, J. C. et al (2009). Hostility and fasting glucose in African American women. Psychosom Med, 71, 642–645.
Gidron, Y., Davidson, K., and Bata, I. (1999). The short-term effects of a hostility-reduction intervention in CHD patients. Health Psychol, 18, 416–420.
Graham, J. E., Robles, T. F., Kiecolt-Glaser, J. K., Malarkey, W. B., Bissell, M. G. et al (2006). Hostility and pain are related to inflammation in older adults. Brain Behav Immun, 20, 389–400.
Grano, N., Vahtera, J., Virtanen, M., Keltikangas-Jarvinen, L., and Kivimaki, M. (2008). Association of hostility with sleep duration and sleep disturbances in an employee population. Int J Behav Med, 15, 73–80.
Guyll, M., and Contrada, R. (1998). Trait hostility and ambulatory cardiovascular activity: responses to social interaction. Health Psychol, 17, 30–39.
Haukkala, A. (2002). Socio-economic differences in hostility measures – a population based study. Psychol Health, 17, 191–202.
Iribarren, C., Sidney, S., Bild, D. E., Liu, K., Markowitz, J. H. et al (2000). Association of hostility with coronary artery calcification in young adults: The CARDIA Coronary Artery Risk Development in Young Adults study. JAMA, 283, 2546–2551.
Jakupcak, M., Conybeare, D., Phelps, L., Hunt, S., Holmes, H. A. et al (2007). Anger, hostility, and aggression among Iraq and Afghanistan War veterans reporting PTSD and subthreshold PTSD. J Traum Stress, 20, 945–954.
Jamner, L. D., Shapiro, D., Goldstein, I. B., and Hug, R. (1991). Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. Psychosom Med, 53, 393–406.
Jamner, L. D., Shapiro, D., and Jarvik, M. E. (1999). Nicotine reduces the frequency of anger reports in smokers and nonsmokers with high but not low hostility: an ambulatory study. Exp Clin Psychopharm, 7, 454–463.
John, O. P., and Gross, J. J. (2004). Healthy and unhealthy emotional regulation: personality processes, individual differences, and life span development. J Personality, 72, 1301–1333.
Julkunen, J., Salonen, R., Kaplan, G. A., Chesney, M. A., and Salonen, J. T. (1994). Hostility and the progression of carotid atherosclerosis. Psychosom Med, 56, 519–525.
Kahler, C. W., Strong, D. R., Niaura, R., and Brown, R. A. (2004). Hostility in smokers with past major depressive disorder: relation to smoking patterns, reasons for quitting, and cessation outcomes. Nicot Tobac Res, 6, 809–818.
Kaplan, J. R., Manuck, S. B., Fontenot, M. B. et al (2002). Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis). Neuropsychopharmacology, 26, 431–443.
Kawachi, I., and Berkman, L. (2000). Social cohesion, social capital, and health. In L. F. Berkman & I. Kawachi (Eds.), Social Epidemiology. New York: Oxford University Press.
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S. et al (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry, 62, 1377–1384.
Kivimaki, M., Vahtera, J., Koskenvuo, M., Uutela, A., and Pentti, J. (1998). Response of hostile individuals to stressful changes in their working lives: test of a psychosocial vulnerability model. Psychol Med, 28, 903–913.
Knox, S. S., Weidner, G., Adelman, A., Stoney, C. M., and Ellison, R. C. (2004). Hostility and physiological risk in the National Heart, Lung, and Blood Institute Family Heart Study. Arch Int Med, 164, 2442–2448.
Kopp, M., Skrabski, A., Szántó, Z., and Siegrist, J. (2006). Psychosocial determinants of premature cardiovascular mortality differences within Hungary. J Epid Commun Health, 60, 782–788.
Kubzansky, L. D., Sparrow, D., Jackson, B., Cohen, S., Weiss, S. T. et al (2006). Angry breathing: a prospective study of hostility and lung function in the Normative Aging Study. Thorax, 61, 833–834.
Larkin, K. T., Martin, R. R., and McClain, S. E. (2002). Cynical hostility and the accuracy of decoding facial expressions of emotions. J Behav Med, 25, 286–292.
Lesch, K. P., Bengel, D., Heils, A., Sbol, S. Z., Greenberg, B. P. et al (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.
Luecken, L. J. (2000). Attachment and loss experiences during childhood are associated with adult hostility, depression, and social support. J Psychosom Res, 49, 85–91.
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J., and Muldoon, M. F. (2000). A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiat Res, 95, 9–23.
Manuck, S. B., Flory, J. D., McCaffery, J. M., Matthews, K. A., Mann, J. J. et al (1998). Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology, 19, 287–299.
Manuck, S. B., Flory, J. D., Muldoon, M. F., and Ferrell, R. E. (2002). Central nervous system serotonergic responsivity and aggressive disposition in men. Physiol Behav, 77, 705–709.
Markowitz, J. H. (1998). Hostility is associated with increased platelet activation in coronary heart disease. Psychosom Med, 60, 586–591.
Martin, R., Watson, D., and Wan, C. (2000). A three-factor model of trait anger: dimensions of affect, behavior, and cognition. J Personality, 68, 869–897.
Matthews, K. A., Gump, B. B., Harris, K. F., Haney, T. L., and Barefoot, J. C. (2004). Hostile behaviors predict cardiovascular mortality among men enrolled in the Multiple Risk Factor Intervention Trial. Circulation, 109, 66–70.
Matthews, K. A., Woodall, K. L., Kenyon, K., and Jacob, T. (1996). Negative family environment as a predictor of boys’ future status on measures of hostile attitudes, interview behavior, and anger expression. Health Psych, 15, 30–37.
McCann, B. S., Russo, J., Benjamin, G., and Andrew, H. (1997). Hostility, social support, and perceptions of work. J Occup Health Psychol, 2, 175–185.
Mechanic, D. (1972). Social psychologic factors affecting the presentation of bodily complaints New Eng J Med, 286, 1132–1139.
Mittleman, M. A., Maclure, M., Sherwood, J. B., Mulry, R. P., Tofler, G. H. et al (1995). Triggering of acute myocardial infarction onset by episodes of anger. Determinants of Myocardial Infarction Onset Study Investigators. Circulation, 9, 1720–1725.
Moffitt, T. E., Caspi, A., and Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry, 62, 473–481.
Muldoon, M. F., Mackey, R. H., Korytkowski, M. T., Flory, J. D., Pollock, B. G. et al (2006). The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers. J Clin Endocrinol Metab, 91, 718–721.
Muldoon, M. F., Mackey, R. H., Sutton-Tyrrell, K., Flory, J. D., Pollock, B. G. et al (2007). Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis. Stroke, 38, 2228–2233.
Möller, J., Hallqvist, J., Diderichsen, F., Theorell, T., Reuterwall, C. et al (1999). Do episodes of anger trigger myocardial infarction? A case-crossover analysis in the Stockholm Heart Epidemiology Program (SHEEP). Psychosom Med, 61, 842–849.
Niaura, R., Todaro, J. F., Stroud, L., Spiro, A., III, Ward, K. D. et al (2002). Hostility, the metabolic syndrome, and incident coronary heart disease. Health Psychol, 21, 588–593.
Orth, U., and Wieland, E. (2006). Anger, hostility, and posttraumatic stress disorder in trauma-exposed adults: a meta-analysis. J Consult Clin Psych, 74: 698–706.
Pulkki, L,. Kivimaki, M., Elovainio, M., Viikari, J., and Keltikangas-Jarvinen, L. (2003). Contribution of socioeconomic status to the association between hostility and cardiovascular risk behaviors: a prospective cohort study. Am J Epid, 158, 736–742.
Raynor, D. A., Pogue-Geile, M. F., Kamarck, T. W., McCaffery, J. M., and Manuck, S. B. (2002). Covariation of psychosocial characteristics associated with cardiovascular disease. Psychosom Med, 64, 191–203.
Saab, P. G., Bang, H., Williams, R. B., Powell, L. H., Schneiderman, N. et al (2009). The impact of cognitive behavioral group training on event-free survival in patients with myocardial infarction: the ENRICHD experience. J Psychosom Res, 67, 45–56.
Scheier, M. F., Matthews, K. A., Owens, J. F., Schultz, R., Bridges, M. W. et al (1999). Optimism and rehospitalization after coronary artery bypass surgery. Arch Intern Med, 159, 829–835.
Scherwitz, L. W., Perkins, L. L., Chesney, M. A., Hughes, G. H., Sidney, S. et al (1992). Hostility and health behaviors in young adults: The CARDIA study. Am J Epidemiol, 136, 136–145.
Shimbo, D., Chaplin, W., Kuruvilla, S., Wasson, L. T., Abraham, D. et al (2009). Hostility and platelet reactivity in individuals without a history of cardiovascular disease events. Psychosom Med, 71, 741–747.
Siegler, I. C., Peterson, B. L., Barefoot, J. C., and Williams, R. B. (1992). Hostility during late adolescence predicts coronary risk factors at mid-life. Am J Epidemiol, 136, 146–154.
Siegler, I. C., Helms, M. J., Kuhn, C. M., Surwit, R. S., James, S. A. et al (2008). Personality associations of high brain serotonin in men. APS Meeting Abstract 2008, 70, Number 3, A79.
Simons, R. L., Simons, L. G., Burt, C. H., Drummund, H., Stewart, E. et al (2006). Supportive parenting moderates the effect of discrimination upon anger, hostile view of relationships, and violence among African American boys. J Health Soc Behav, 47, 373–389.
Sloan, R. P., Shapiro, P. A., Bigger, J. T., Bagiella, E., Steinman, R. C. et al (1994). Cardiac autonomic control and hostility in healthy subjects. Am J Cardiol, 74, 298–300.
Smith, T. W., Glazer, K., Ruiz, J. M., and Gallo, L. C. (2004). Hostility, anger, aggressiveness, and coronary heart disease: an interpersonal perspective on personality, emotion, and health. J Personality, 72, 1217–1270.
Spielberger, C. D., Jacobs, G., Russell, S. F., and Crane, R. J. (1983). Assessment of anger: The State-Trait Anger Scale. In J. N. Butcher & C. D. Spielberger (Eds.), Advances in personality assessment, vol 2. Hillsdale, NJ: Lawrence Erlbaum.
Stewart, J. C., Janicki, D. L., Muldoon, M. F., Sutton-Tyrrell, K., and Kamarck, T. W. (2007). Negative emotions and 3-year progression of subclinical atherosclerosis. Arch Gen Psychiat, 64, 225–233.
Stoia-Caraballo, R., Rye, M. S., Pan, W., Brown-Kirschman, K. J., Lutz-Zois, C. et al (2008). Negative affect and anger rumination as mediators between forgiveness and sleep quality. J Behav Med, 31, 478–488.
Stoney, C. M., and Engebretson, T. O. (1994). Anger and hostility: Potential mediators of the gender difference in cardiovascular disease. In A. W. Siegman & T. W. Smith (Eds.), Anger, hostility and the heart (pp. 215–238). Hillsdale, NJ: Erlbaum.
Strike, P. C., Perkins-Porras, L., Whitehead, D. L., McEwan, J., and Steptoe, A. (2006). Triggering of acute coronary syndromes by physical exertion and anger: clinical and sociodemographic characteristics. Heart, 92, 1035–1040.
Strike, P. C., and Steptoe, A. (2005). Behavioral and emotional triggers of acute coronary syndromes: a systematic review and critique. Psychosom Med, 67, 179–186.
Suarez, E. C., Kuhn, C. M., Schanberg, S. M., Williams, R. B., and Zimmerman, E. A. (1998). Neuroendocrine, cardiovascular, and emotional responses of hostile men: the role of interpersonal challenge. Psychosom Med, 60, 78–88.
Suls, J., and Bunde, J. (2005). Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions. Psych Bull, 131, 260–300.
Surwit, R. S., Williams, R. B., Siegler, I. C., Lane, J. D., Helms, M. J. et al (2002). Hostility, race, and glucose metabolism in non-diabetic individuals. Diabetes Care, 25, 835–839.
Tindle, H. A., Chang, Y. F., Kuller, L. H., Manson, J. E., Robinson, J. G. et al (2009). Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women’s Health Initiative. Circulation, 20, 656–662.
Whiteman, M. C., Fowkes, F. G., Deary, I. J., and Lee, A. J. (1997). Hostility, cigarette smoking and alcohol consumption in the general population. Soc Sci Med, 44, 1089–1096.
Williams, J. E., Nieto, F. J., Sanford, C. P., and Tyroler, H. A. (2001). Effects of an angry temperament of coronary heart disease risk. Am J Epidemiol, 154, 230–235.
Williams, J. E., Nieto, F. J., Sanford, C. P., Couper, D. J., and Tyroler, H. A. (2002). The association between trait anger and incident stroke risk: the Atherosclerosis Risk in Communities (ARIC) Study. Stroke, 33: 13–19.
Williams, R. B. (2000). Psychological factors, health, and disease: the impact of aging and the life cycle. In: S. B. Manuck, R. Jennings, B. S. Rabin, & A. Baum (Eds.), Behavior, Health, and Aging. Hillsdale, NJ: Lawrence Erlbaum Associates.
Williams, R. B. (1994). Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosom Med, 56, 308–315.
Williams, R. B., and Barefoot, J. C. (1988). Coronary-prone behavior: the emerging role of the hostility complex. In B. K. Houston, & C. R. Snyder (Eds.), Type A Behavior Pattern: Research, Theory, and Intervention. New York: Wiley.
Williams, R. B., Barefoot, J. C., and Schneiderman, N. (2003a). Psychosocial risk factors for cardiovascular disease: more than one culprit at work. JAMA, 290, 2190–2192.
Williams, R. B., Marchuk, D. A., Gadde, K. M., Barefoot, J. C., Grichnik, K. et al (2003b). Serotonin-Related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology, 28, 533–541.
Williams, R. B., Marchuk, D. A., Siegler, I. C., Barefoot, J. C., Helms, M. J. et al (2008). Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress. Psychosom Med, 70, 32–39.
Williams, R. B., and Williams, V. P. (1993). Anger Kills: Seventeen Strategies for Controlling the Hostility That Can Harm Your Health. New York: Times Books. Trade paperback edition published by Harper-Collins, Spring, 1994.
Williams, V. P., and Williams, R. B. (1998). LifeSkills: 8 Simple Ways to Build Stronger Relationships, Communicate More Clearly, Improve Your Health, and Even the Health of Those Around You. New York: Times Books/Random House.
Williams, V. P., Brenner, S. L., Helms, M. J., and Williams, R. B. (2009). Coping skills training to reduce psychosocial risk factors for medical disorders: a field trial evaluating effectiveness in multiple worksites. J Occup Health, 51, 437–442.
Yan, L. L., Liu, K., Matthews, K. A., Daviglus, M. L., Ferguson, T. F. et al (2003). Psychosocial factors and risk of hypertension: The Coronary Artery Disease Risk Development in Young Adults (CARDIA) study. JAMA, 290, 2138–2148.
Zeichner, A., Giancola, P. R., and Allen, J. D. (1995). Effects of hostility on alcohol stress-response-dampening. Alcoholism: Clin Exper Res, 19, 977–983.
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This work was supported by National Heart, Lung, and Blood Institute grant P01HL36587 (RBW), Clinical Research Unit grant M01RR30, RO1 HL54780 and the Duke University Behavioral Medicine Research Center.
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Barefoot, J.C., Williams, R.B. (2010). Hostility and Health. In: Steptoe, A. (eds) Handbook of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09488-5_13
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