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Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways

  • Chapter
Behavioral Neurobiology of Psychedelic Drugs

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 36))

Abstract

The neuropsychological effects of naturally occurring psychoactive chemicals have been recognized for millennia. Hallucinogens, which include naturally occurring chemicals such as mescaline and psilocybin, as well as synthetic compounds, such as lysergic acid diethylamide (LSD), induce profound alterations of human consciousness, emotion, and cognition. The discovery of the hallucinogenic effects of LSD and the observations that LSD and the endogenous ligand serotonin share chemical and pharmacological profiles led to the suggestion that biogenic amines like serotonin were involved in the psychosis of mental disorders such as schizophrenia. Although they bind other G protein-coupled receptor (GPCR) subtypes, studies indicate that several effects of hallucinogens involve agonist activity at the serotonin 5-HT2A receptor. In this chapter, we review recent advances in understanding hallucinogen drug action through characterization of structure, neuroanatomical location, and function of the 5-HT2A receptor.

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Acknowledgements

The preparation of this review article has been supported at least in part by the National Institutes of Health R01MH084894 and R01MH111940 (J.G.M.) and the Spanish Government SAF2010-15663 (J.F.L.G.).

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Authors and Affiliations

  1. Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC-CSIC, 39011, Santander, Cantabria, Spain

    Juan F. López-Giménez

  2. Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA

    Javier González-Maeso

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  1. Juan F. López-Giménez
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Correspondence to Javier González-Maeso .

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  1. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    Adam L. Halberstadt

  2. Psychiatric University Hospital, Heffter Research Center Zurich, University of Zurich, Zurich, Switzerland

    Franz X. Vollenweider

  3. Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, NC, USA

    David E. Nichols

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López-Giménez, J.F., González-Maeso, J. (2017). Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways. In: Halberstadt, A.L., Vollenweider, F.X., Nichols, D.E. (eds) Behavioral Neurobiology of Psychedelic Drugs. Current Topics in Behavioral Neurosciences, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2017_478

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