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Stress, Substance Abuse, and Addiction

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Behavioral Neurobiology of Stress-related Disorders

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 18))

Abstract

Experiencing stressful life events is reciprocally associated with substance use and abuse. The nature of these relationships varies based on the age of stress exposure and stage of substance use involvement. This chapter reviews the developmental and biological processes involved in the relationship of stress exposure and substance use initiation, substance use maintenance and relapse, and response to substance abuse treatment. Special emphasis is given to describing the various stress-related mechanisms involved in substance use and abuse, highlighting the differences between each of these phases of drug use and drawing upon current research to make suggestions for treatments of substance use disorder (SUD) patients. Stress is inherent to the experience of life and, in many situations, unavoidable. Through ongoing research and treatment development, there is the potential to modify the relationship of stress with ongoing substance use and abuse.

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Acknowledgments

Research reported in this chapter was supported by the National Institute on Drug Abuse (R01-DA026868), National Institute on Alcohol Abuse and Alcoholism (R01-AA014988), and the National Institute of Mental Health (R01-MH077684; R01-MH081181) of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr. Dougherty also acknowledges the support of the William & Marguerite Wurzbach Distinguished Professorship, and the University of Texas Star Program.

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  1. Fielding Graduate University, Santa Barbara, CA, USA

    Tiffany M. Duffing & Stefanie G. Greiner

  2. Division of Neurobehavioral Research, NRLC MC 7793, Department of Psychiatry, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA

    Charles W. Mathias & Donald M. Dougherty

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  1. Tiffany M. Duffing
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Correspondence to Donald M. Dougherty .

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  1. Department of Psychological Medicine, Institute of Psychiatry Kings College London, London, United Kingdom

    Carmine M. Pariante

  2. Family and Community Health Systems, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    M. Danet Lapiz-Bluhm

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Duffing, T.M., Greiner, S.G., Mathias, C.W., Dougherty, D.M. (2014). Stress, Substance Abuse, and Addiction. In: Pariante, C., Lapiz-Bluhm, M. (eds) Behavioral Neurobiology of Stress-related Disorders. Current Topics in Behavioral Neurosciences, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_276

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