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Reward and Neurocomputational Processes

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Behavioral Neurobiology of Eating Disorders

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 6))

Abstract

The neurobiology of eating disorders (EDs) is largely unknown. However, brain imaging studies over the past decade have identified neurotransmitter alterations that could be part of dysfunctional behavior characteristics of EDs. In this chapter we focus on a specific behavioral construct, the brain reward system, and demonstrate a functional brain imaging approach toward identifying dopamine function in anorexia nervosa (AN). We demonstrate how human brain reward activation can be used in a translational approach to test whether computer models, based on basic science research, can predict expected in vivo reward system activation, and how such an approach can identify specific biologic alterations in a psychiatric population.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Developmental Brain Research Program, University of Colorado Denver, The Children’s Hospital, Gary Pavilion A036/B-130, 13123 East 16th Avenue, Aurora, CO, 80045, USA

    Guido K. W. Frank

  2. Department of Neuroscience, University of Colorado Denver, The Children’s Hospital, Gary Pavilion A036/B-130, 13123 East 16th Avenue, Aurora, CO, 80045, USA

    Guido K. W. Frank

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  1. Guido K. W. Frank
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Correspondence to Guido K. W. Frank .

Editor information

Editors and Affiliations

  1. Neuroscience, Dept. Pharmacology, Rudolf Magnus Institute of, Universiteitsweg 100, Utrecht, 3508 AB, Netherlands

    Roger A.H. Adan

  2. Dept. Psychiatry, University of California, San Diego, La Jolla Drive 8950, La Jolla, 92037, California, USA

    Walter H. Kaye

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Frank, G.K.W. (2010). Reward and Neurocomputational Processes. In: Adan, R., Kaye, W. (eds) Behavioral Neurobiology of Eating Disorders. Current Topics in Behavioral Neurosciences, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_81

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