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The Human Adolescent Brain and Alcohol Use Disorders

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 17))

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References

  • Adams, K. M., Gilman, S., Johnson-Greene, D., Koeppe, R. A., Junck, L., Kluin, K. J., et al. (1998). The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. Alcoholism, Clinical and Experimental Research, 22(1), 105–110.

    PubMed  Google Scholar 

  • Almasy, L., Porjesz, B., Blangero, J., Chorlian, D. B., O'Connor, S. J., Kuperman, S., et al. (1999). Heritability of event-related brain potentials in families with a history of alcoholism. American Journal of Medical Genetics, 88(4), 383–390.

    Article  PubMed  Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Aytaclar, S., Tarter, R. E., Kirisci, L., & Lu, S. (1999). Association between hyperactivity and executive cognitive functioning in childhood and substance use in early adolescence. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 172–178.

    Article  Google Scholar 

  • Bauer, L., & Hesselbrock, V. (1999a). P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. Biological Psychiatry, 46, 263–272.

    Article  PubMed  Google Scholar 

  • Bauer, L., & Hesselbrock, V. (1999b). Subtypes of family history and conduct disorder: effects on P300 during the Stroop Test. Neuropsychopharmacology, 21, 51–62.

    Article  PubMed  Google Scholar 

  • Bauer, L. O. (1997). Frontal P300 decrements, childhood conduct disorder, family history and the prediction of relapse among abstinent cocaine abusers. Drug & Alcohol Dependence, 44, 1–10.

    Article  Google Scholar 

  • Bauer, L. O., & Hesselbrock, V. M. (2002). Lateral asymmetries in the frontal brain: effects of depression and a family history of alcoholism in female adolescents. Alcohol Clin Exp Res, 26(11), 1662–1668.

    Article  PubMed  Google Scholar 

  • Bauer, L. O., & Hesselbrock, V. M. (2003). Brain maturation and subtypes of conduct disorder: interactive effects on p300 amplitude and topography in male adolescents. J Am Acad Child Adolesc Psychiatry, 42(1), 106–115.

    Article  PubMed  Google Scholar 

  • Begleiter, H., & Porjesz, B. (1999). What is inherited in the predisposition toward alcoholism? A proposed model. Alcoholism: Clinical and Experimental Research, 23, 1125–1135.

    Google Scholar 

  • Begleiter, H., Porjesz, B., Bihari, B., & Kissin, B. (1984). Event-related brain potentials in boys at risk for alcoholism. Science, 225, 1493–1496.

    PubMed  Google Scholar 

  • Begleiter, H., Porjesz, B., & Bihiari, B. (1987). Auditory brainstem potentials in sons of alcoholic fathers. Alcohol Clin Exp Res, 11, 477–480.

    Article  PubMed  Google Scholar 

  • Berman, S. M., & Noble, E. P. (1995). Reduced visuospatial performance in children with the D2 dopamine receptor Al allele. Behavior Genetics, 25(1), 45–58.

    Article  PubMed  Google Scholar 

  • Brandt, J., Butters, N., Ryan, C., & Bayog, R. (1983). Cognitive loss and recovery in long-term alcohol abusers. Archives of General Psychiatry, 40, 435–442.

    PubMed  Google Scholar 

  • Brickman, A. S., McManus, M. M., Grapentine, W. L., & Alessi, N. (1984). Neuropsychological assessment of seriously delinquent adolescents. Journal of the American Academy of Child Psychiatry, 23, 453–457.

    PubMed  Google Scholar 

  • Brown, S. A., Tapert, S. F., Granholm, E., & Delis, D. C. (2000). Neurocognitive functioning of adolescents: effects of protracted alcohol use. Alcoholism: Clinical and Experimental Research, 24(2), 164–171.

    Article  Google Scholar 

  • Caldwell, L. C., Schweinsburg, A. D., Nagel, B. J. Barlett, V. C., Brown, S. A., & Tapert, S. F (in preparation). Gender and adolescent alcohol use disorders on BOLD response to spatial working memory.

    Google Scholar 

  • Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000). Structural and functional brain development and its relation to cognitive development. Biological Psychology, 54(1–3), 241–257.

    Article  PubMed  Google Scholar 

  • Chugani, H. T. (1998). A critical period of brain development: studies of cerebral glucose utilization with PET. Preventative Medicine, 27(2), 184–188.

    Article  Google Scholar 

  • Cohen, P., Cohen, J., Kasen, S., Velez, C. N., Hartmark, C., Johnson, J., et al. (1993). An epidemiological study of disorders in late childhood and adolescence—I. Age-and gender-specific prevalence. Journal of Child Psychology and Psychiatry and Allied Disciplines, 34(6), 851–867.

    Google Scholar 

  • Conrod, P. J., Pihl, R. O., & Ditto, B. (1995). Autonomic reactivity and alcohol-induced dampening in men at risk for alcoholism and men at risk for hypertension. Alcoholism, Clinical and Experimental Research, 19(2), 482–489.

    Article  PubMed  Google Scholar 

  • Corral, M. M., Holguin, S. R., & Cadaveira, E (1999). Neuropsychological characteristics in children of alcoholics: familial density. Journal of Studies on Alcohol, 60, 509–513.

    PubMed  Google Scholar 

  • Courchesne, E., Chisum, H. J., Townsend, J., Cowles, A., Covington, J., Egaas, B., et al. (2000). Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology, 216(3), 672–682.

    PubMed  Google Scholar 

  • De Bellis, M. D., Clark, D. B., Beers, S. R., Soloff, P. H., Boring, A. M., Hall, J., et al. (2000). Hippocampal volume in adolescent-onset alcohol use disorders. American Journal of Psychiatry, 157(5), 737–744.

    Article  PubMed  Google Scholar 

  • De Bellis, M. D., Keshavan, M. S., Beers, S. R., Hall, J., Frustaci, K., Masalehdan, A., et al. (2001). Sex differences in brain maturation during childhood and adolescence. Cereb Cortex, 11(6), 552–557.

    Article  PubMed  Google Scholar 

  • Deckel, A. W., Bauer, L., & Hesselbrock, V. (1995). Anterior brain dysfunctioning as a risk factor in alcoholic behaviors. Addiction, 90, 1323–1334.

    Article  PubMed  Google Scholar 

  • Delamater, A. M., & Lahey, B. B. (1983). Physiological correlates of conduct problems in hyperactive and learning disabled children. Journal of Abnormal Child Psychology, 11, 85–100.

    Article  PubMed  Google Scholar 

  • Demir, B., Ulug, B., Lay Ergun, E., & Erbas, B. (2002). Regional cerebral blood flow and neuropsy-chological functioning in early and late onset alcoholism. Psychiatry Research, 115(3), 115–125.

    PubMed  Google Scholar 

  • Déry, M., Toupin, J., Pauze, R., Mercier, H., & Fortin, L. (1999). Neuropsychological characteristics of adolescents with conduct disorder: Association with attention-deficit-hyperactivity and aggression. Journal of Abnormal Child Psychology, 27, 225–236.

    Article  PubMed  Google Scholar 

  • Epstein, H. T. (1999). Stages of increased cerebral blood flow accompany stages of rapid brain growth. Brain and Development, 21(8), 535–539.

    Article  PubMed  Google Scholar 

  • Fein, G., Meyerhoff, D. J., Discalfani, V., Ezekiel, F., Poole, N., MacKay, S., et al. (1994). 1H magnetic resonance spectroscopic imaging separates neuronal from glial changes in alcohol-related brain atrophy. In F. E. Lancaster (Ed.), Alcohol and Glial Cells (Vol. 27, pp. 227–241). Bethesda, MD: National Institutes of Health.

    Google Scholar 

  • Finn, P., & Justus, A. (1999). Reduced EEG alpha power in the male and female offspring of alcoholics. Alcohol Clin Exp Res, 23(2), 256–262.

    PubMed  Google Scholar 

  • Fuerst, D. R., & Rourke, B. P. (1993). Psychosocial functioning of children: Relations between personality subtypes and academic achievement. Journal of Abnormal Child Psychology, 21, 597–607.

    Article  PubMed  Google Scholar 

  • Garralda, M. E., Connell, J., & Taylor, D. C. (1991). Psychophysiological anomalies in children with emotional and conduct disorders. Psychological Medicine, 21, 947–957.

    Article  PubMed  Google Scholar 

  • George, M. S., Anton, R. F, Bloomer, C., Teneback, C., Drobes, D. J., Lorberbaum, J. P., et al. (2001). Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues. Archives of General Psychiatry, 58(4), 345–352.

    Article  PubMed  Google Scholar 

  • Giancola, P. R., Martin, C. S., Tarter, R. E., Pelham, W. E., & Moss, H. B. (1996). Executive cognitive functioning and aggressive behavior in preadolescent boys at high risk for substance abuse/dependence. Journal of Studies on Alcohol, 57(4), 352–359.

    PubMed  Google Scholar 

  • Giancola, P. R., Mezzich, A. C., & Tarter, R. E. (1998a). Disruptive, delinquent and aggressive behavior in female adolescents with a psychoactive substance use disorder: Relation to executive cognitive functioning. Journal of Studies on Alcohol, 59, 560–567.

    PubMed  Google Scholar 

  • Giancola, P. R., Mezzich, A. C., & Tarter, R. E. (1998b). Executive cognitive functioning, temperament, and antisocial behavior in conduct-disordered adolescent females. Journal of Abnormal Psychology, 107, 629–641.

    Article  PubMed  Google Scholar 

  • Giancola, P. R., Peterson, J. B., & Pihl, R. O. (1993). Risk for alcoholism, antisocial behavior, and response perseveration. Journal of Clinical Psychology, 49, 423–428.

    PubMed  Google Scholar 

  • Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., et al. (1999). Brain development during childhood and adolescence: A longitudinal MRI study. Nature Neuroscience, 2(10), 861–863.

    Article  PubMed  Google Scholar 

  • Giedd, J. N., Snell, J. W., Lange, N., Rajapakse, J. C., Casey, B. J., Kozuch, P. L., et al. (1996). Quantitative magnetic resonance imaging of human brain development: Ages 4–18. Cerebral Cortex, 6(4), 551–560.

    PubMed  Google Scholar 

  • Grant, I. (1987). Alcohol and the brain: neuropsychological correlates. Journal of Consulting and Clinical Psychology, 55(3), 310–324.

    Article  PubMed  Google Scholar 

  • Harden, P. W., & Pihl, R. O. (1995). Cognitive function, cardiovascular reactivity, and behavior in boys at high risk for alcoholism. Journal of Abnormal Psychology, 104, 94–103.

    Article  PubMed  Google Scholar 

  • Haynes, J. P., & Bensch, M. (1981). The P > V sign of the WISC-R and recidivism in delinquents. Journal of Consulting and Clinical Psychology, 49, 480–481.

    Article  PubMed  Google Scholar 

  • Hegedus, A. M., Alterman, A. I., & Tarter, R. E. (1984). Learning achievement in sons of alcoholics. Alcoholism: Clinical and Experimental Research, 8, 330–333.

    Google Scholar 

  • Hill, S. Y., De Bellis, M. D., Keshavan, M. S., Lowers, L., Shen, S., Hall, J., et al. (2001). Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biol Psychiatry, 49(11), 894–905.

    Article  PubMed  Google Scholar 

  • Hill, S. Y., & Shen, S. (2002). Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis. Biol Psychiatry, 51(8), 621–631.

    Article  PubMed  Google Scholar 

  • Hill, S. Y., Shen, S., Locke, J., Lowers, L., Steinhauer, S., & Konicky, C. (2000). Developmental changes in postural sway in children at high and low risk for developing alcohol-related disorders. Biological Psychiatry, 47(6), 501–511.

    Article  PubMed  Google Scholar 

  • Hill, S. Y., Shen, S., Lowers, L., & Locke, J. (2000). Factors predicting the onset of adolescent drinking in families at high risk for developing alcoholism. Biological Psychiatry, 48(4), 265–275.

    Article  PubMed  Google Scholar 

  • Hingson, R., Heeren, T., & Winter, M. (1994). Lower legal blood alcohol limit for young drivers. Public Health Rep, 109, 738–744.

    PubMed  Google Scholar 

  • Holguin, S., Corral, M., & Cadaveira, F. (1998). Visual and auditory event-related potentials in young children of alcoholics from high-and low-density families. Alcohol Clin Exp Res, 22, 87–96.

    Google Scholar 

  • Hommer, D., Momenan, R., Kaiser, E., & Rawlings, R. (2001). Evidence for a gender-related effect of alcoholism on brain volumes. American Journal of Psychiatry, 158(2), 198–204.

    Article  PubMed  Google Scholar 

  • Huttenlocher, P. R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28(6), 517–527.

    Article  PubMed  Google Scholar 

  • Huttenlocher, P. R., & Dabholkar, A. S. (1997). Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol, 387(2), 167–178.

    Article  PubMed  Google Scholar 

  • Jernigan, T. L., Trauner, D. A., Hesselink, J. R., & Tallal, P. A. (1991). Maturation of human cerebrum observed in vivo during adolescence. Brain, 114(Pt 5), 2037–2049.

    PubMed  Google Scholar 

  • Johnston, L. D., O'Malley, P. M., & Bachman, J. G. (2003). The Monitoring the Future national survey results on adolescent drug use: Overview of key findings, 2002 (No. NIH Publication No. 03-5374). Bethesda, MD: National Institute on Drug Abuse.

    Google Scholar 

  • Klingberg, T., Forssberg, H., & Westerberg, H. (2002). Increased brain activity in frontal and parietal cortex underlies the development of visuospatial working memory capacity during childhood. Journal of Cognitive Neuroscience, 14(1), 1–10.

    Article  PubMed  Google Scholar 

  • Kruesi, M. J. P., Hibbs, E. D., Zahn, T. P., Keysor, C. S., Hamburger, S. D., Bartko, J., et al. (1992). A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Archives of General Psychiatry, 49, 429–435.

    Google Scholar 

  • Kruesi, M. J. P., Rapoport, J. L., Hamburger, S., Hibbs, E., Potter, W. Z., Lenane, M., et al. (1990). Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry, 47, 419–426.

    PubMed  Google Scholar 

  • Kucuk, N. O., Kilic, E. O., Ibis, E., Aysev, A., Gencoglu, E. A., Aras, G., et al. (2000). Brain SPECT findings in long term inhalant abuse. Nucl Med Commun, 21(8), 769–773.

    Article  PubMed  Google Scholar 

  • Lahey, B. B., Loeber, R., Quay, H. C., Applegate, B., Shaffer, D., Waldman, I., et al. (1998). Validity of DSM-IV subtypes of conduct disorder based on age of onset. Journal of the American Academy of Child and Adolescent Psychiatry, 37(4), 435–442.

    Article  PubMed  Google Scholar 

  • LeMarquand, D. G., Benkelfat, C., Pihl, R. O., Palmour, R. M., & Young, S. N. (1999). Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism. American Journal of Psychiatry, 156(11), 1771–1779.

    PubMed  Google Scholar 

  • Luna, B., Thulborn, K. R., Munoz, D. P., Merriam, E. P., Garver, K. E., Minshew, N. J., et al. (2001). Maturation of widely distributed brain function subserves cognitive development. Neuroimage, 13(5), 786–793.

    Article  PubMed  Google Scholar 

  • Lynam, D., Moffitt, T. E., & Stouthamer-Loeber, M. (1993). Explaining the relation between IQ and delinquency. Journal of Abnormal Psychology, 102, 187–196.

    Article  PubMed  Google Scholar 

  • Mattson, S. N., Schoenfeld, A. M., & Riley, E. P. (2001). Teratogenic effects of alcohol on brain and behavior. Alcohol Res Health, 25(3), 185–191.

    PubMed  Google Scholar 

  • McBurnett, K., Lahey, B. B., Rathouz, P. J., & Loeber, R. (2000). Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Archives of General Psychiatry, 57(1), 38–43.

    Article  PubMed  Google Scholar 

  • Moffitt, T. E. (1993). The neuropsychology of conduct disorder. Development & Psychopathology, 5, 135–151.

    Google Scholar 

  • Moffitt, T. E., & Henry, B. (1989). Neuropsychological assessment of executive functions in self-reported delinquents. Development and Psychopathology, 1, 105–118.

    Google Scholar 

  • Moffitt, T. E., & Silva, P. A. (1988a). IQ and delinquency: A direct test of the differential detection hypothesis. Journal of Abnormal Psychology, 97, 330–333.

    Article  PubMed  Google Scholar 

  • Moffitt, T. E., & Silva, P. A. (1988b). Self-reported delinquency, neuropsychological deficit, and history of attention deficit disorder. Journal of Abnormal Child Psychology, 16, 553–569.

    Article  PubMed  Google Scholar 

  • Moss, H. B., Kirisci, L., Gordon, H. W., & Tarter, R. E. (1994). A neuropsychologic profile of adolescent alcoholics. Alcoholism: Clinical and Experimental Research, 18(1), 159–163.

    Article  Google Scholar 

  • Najam, N., Tarter, R. E., & Kirisci, L. (1997). Language deficits in children at high risk for drug abuse. Journal of Child & Adolescent Substance Abuse, 6, 69–80.

    Article  Google Scholar 

  • National Center for Health Statistics. (1999). 10 leading causes of death, United States. Atlanta, GA: Office of Statistics and Programming, National Center for Injury Prevention and Control, Center for Disease Control.

    Google Scholar 

  • Nixon, S. J., & Parsons, O. A. (1991). Alcohol related efficiency deficits using an ecologically valid test. Alcohol Clin Exp Res, 15(4), 601–606.

    Article  PubMed  Google Scholar 

  • Nixon, S. J., Paul, R., & Phillips, M. (1998). Cognitive efficiency in alcoholics and polysubstance abusers. Alcoholism: Clinical and Experimental Research, 22(7), 1414–1420.

    Google Scholar 

  • Ozkaragoz, T., Satz, P., & Noble, E. P. (1997). Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers. Alcohol, 14, 31–37.

    Article  PubMed  Google Scholar 

  • Ozkaragoz, T. Z., & Noble, E. P. (1995). Neuropsychological differences between sons of active alcoholic and non-alcoholic fathers. Alcohol and Alcoholism, 30(1), 115–123.

    PubMed  Google Scholar 

  • Peterson, J., Finn, P., & Pihl, R. (1992). Cognitive dysfunction and the inherited predisposition to alcoholism. J Stud Alcohol, 53, 154–160.

    PubMed  Google Scholar 

  • Peterson, J. B., Pihl, R. O., Gianoulakis, C., Conrod, P., Finn, P. R., Stewart, S. H., et al. (1996). Ethanol-induced change in cardiac and endogenous opiate function and risk for alcoholism. Alcoholism, Clinical and Experimental Research, 20(9), 1542–1552.

    Article  PubMed  Google Scholar 

  • Peterson, J. L., Coates, T. J., Catania, J. A., Middleton, B. A., Hilliard, B., & Hearst, N. (1992). Highrisk sexual behavior and condom use among gay and bisexual African-American men. American Journal of Public Health, 82, 1490–1494.

    Article  PubMed  Google Scholar 

  • Pfefferbaum, A., Desmond, J., Galloway, C., Menon, V., Glover, G., & Sullivan, E. (2001). Reorganization of frontal systems used by alcoholics for spatial working memory: an fMRI study. Neurolmage, 14, 7–20.

    Article  Google Scholar 

  • Pfefferbaum, A., Lim, K., Desmond, J., & Sullivan, E. (1996). Thinning of the corpus callosum in older alcoholic men: A magnetic resonance imaging study. Alcohol Clin Exp Res, 20, 752–757.

    Article  PubMed  Google Scholar 

  • Pfefferbaum, A., Mathalon, D. H., Sullivan, E. V., Rawles, J. M., Zipursky, R. B., & Lim, K. 0. (1994). A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Archives of Neurology, 51(9), 874–887.

    PubMed  Google Scholar 

  • Pfefferbaum, A., Sullivan, E., Mathalon, D., Shear, P., Rosenbloom, M., & Lim, K. (1995). Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcoholism: Clinical and Experimental Research, 19, 1177–1191.

    Article  Google Scholar 

  • Pfefferbaum, A., Sullivan, E., Rosenbloom, M., Mathalon, D., & Lim, K. (1998). A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Arch Gen Psychiatry, 55, 905–912.

    Article  PubMed  Google Scholar 

  • Pfefferbaum, A., & Sullivan, E. V. (2002). Microstructural but not macrostructural disruption of white matter in women with chronic alcoholism. Neuroimage, 15(3), 708–718.

    Article  PubMed  Google Scholar 

  • Pfefferbaum, A., Sullivan, E. V., Hedehus, M., Adalsteinsson, E., Lim, K. O., & Moseley, M. (2000). In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. Alcoholism: Clinical and Experimental Research, 24(8), 1214–1221.

    Article  Google Scholar 

  • Pfefferbaum, A., Sullivan, E. V., Hegehus, M., Adalsteinsson, E., Lim, K. L., & Moseley, M. (2000). In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. Alcoholism: Clinical and Experimental Research, 24, 1214–1221.

    Article  Google Scholar 

  • Pihl, R., & Bruce, K. (1995). Cognitive impairment in children of alcoholics. Alcohol Health & Research World, 19, 142–147.

    Google Scholar 

  • Pihl, R. O., & Peterson, J. (1996). Characteristics and putative mechanisms in boys at risk for drug abuse and aggression. In T. G. Craig F. Ferris (Ed.), Understanding aggressive behavior in children. Annals of the New York Academy of Sciences, Vol. 794. (pp. 238–252): New York Academy of Sciences, New York, NY, US.

    Google Scholar 

  • Pihl, R. O., Peterson, J., & Finn, P. R. (1990). Inherited predisposition to alcoholism: Characteristics of sons of male alcoholics. Journal of Abnormal Psychology, 99, 291–301.

    Article  PubMed  Google Scholar 

  • Pishkin, V., Lovallo, W. R., & Bourne, L. E., Jr. (1985). Chronic alcoholism in males: cognitive deficit as a function of age of onset, age, and duration. Alcoholism: Clinical and Experimental Research, 9(5), 400–406.

    Google Scholar 

  • Polich, J., Pollock, V. E., & Bloom, E E. (1994). Meta-analysis of P300 amplitude from males at risk for alcoholism. Psychological Bulletin, 115, 55–73.

    Article  PubMed  Google Scholar 

  • Poon, E., Ellis, D. A., Fitzgerald, H. E., & Zucker, R. A. (2000). Intellectual, cognitive, and academic performance among sons of alcoholics during the early school years: Differences related to subtypes of familial alcoholism. Alcoholism: Clinical & Experimental Research, 24, 1020–1027.

    Google Scholar 

  • Porjesz, B., Begleiter, H., Reich, T., Van Eerdewegh, P., Edenberg, H., Foroud, T., et al. (1998). Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project. Alcohol Clin Exp Res, 22(6), 1317–1323.

    PubMed  Google Scholar 

  • Prentice, N. M., & Kelly, F. J. (1963). Intelligence and delinquency: A reconsideration. Journal of Social Psychology, 60, 327–337.

    Article  PubMed  Google Scholar 

  • Raine, A., & Jones, E (1987). Attention, autonomic arousal, and personality in behaviorally disordered children. Journal of Abnormal Child Psychology, 15, 583–599.

    Article  PubMed  Google Scholar 

  • Raine, A., & Venables, P. H. (1987). Contingent negative variation, P3 evoked potentials, and antisocial behavior. Psychophysiology, 24, 191–199.

    PubMed  Google Scholar 

  • Raine, A., Venables, P. H., & Williams, M. (1990a). Autonomic orienting responses in 15 year-old male subjects and criminal behavior at age 24. American Journal of Psychiatry, 147, 933–937.

    PubMed  Google Scholar 

  • Raine, A., Venables, P. H., & Williams, M. (1990b). Relationships between central and autonomic measures of arousal at age 15 and criminality at age 24 years. Archives of General Psychiatry, 47, 1003–1007.

    PubMed  Google Scholar 

  • Rohde, P., Lewinsohn, P. M., & Seeley, J. R. (1996a). Psychiatric comorbidity with problematic alcohol use in high school students. Journal of the American Academy of Child and Adolescent Psychiatry, 35(1), 101–109.

    Article  PubMed  Google Scholar 

  • Rohde, P., Lewinsohn, P. M., & Seeley, J. R. (1996b). Psychiatric comorbidity with problematic alcohol use in high school students. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 101–109.

    Article  Google Scholar 

  • Ryan, C., & Butters, N. (1988). Neuropsychology of alcoholism. In D. Wedding & H. MacNeil, Jr. (Eds.), The Neuropsychology Handbook: Behavioral and Clinical Perspectives (pp. in press).

    Google Scholar 

  • Santerre, L., Dager, A., Cheung, E., Meloy, M., Paulus, M., Brown, G., et al. (2002). Chronic smoking and fMRI response in alcohol use disordered adolescents. Alcoholism: Clinical and Experimental Research, 26, 711.

    Google Scholar 

  • Schuckit, M. A. (1998). Biological, psychological and environmental predictors of the alcoholism risk: A longitudinal study. Journal of Studies on Alcohol, 59(5), 485–494.

    PubMed  Google Scholar 

  • Schuckit, M. A., Butters, N., Lyn, L., & Irwin, M. (1987). Neuropsychologic deficits and the risk for alcoholism. Neuropsychopharmacology, 1(1), 45–53.

    Article  PubMed  Google Scholar 

  • Schuckit, M. A., & Smith, T. L. (1997). Assessing the risk for alcoholism among sons of alcoholics. Journal of Studies on Alcohol, 58(2), 141–145.

    PubMed  Google Scholar 

  • Schweinsburg, B. C., Alhassoon, O. M., Taylor, M. J., Gonzalez, R., Videen, J. S., Brown, G. G., et al. (2003). Effects of alcoholism and gender on brain metabolism. American Journal of Psychiatry, 160(6), 1180–1183.

    Article  PubMed  Google Scholar 

  • Schweinsburg, B. C., Taylor, M. J., Alhassoon, O. M., Videen, J. S., Brown, G. G., Patterson, T. L., et al. (2001). Chemical pathology in brain white matter of recently detoxified alcoholics: a 1H magnetic resonance spectroscopy investigation of alcohol-associated frontal lobe injury. Alcoholism: Clinical and Experimental Research, 25(6), 924–934.

    Article  Google Scholar 

  • Schweinsburg, B. C., Taylor, M. J., Videen, J. S., Alhassoon, O. M., Patterson, T. L., & Grant, I. (2000). Elevated myo inositol in gray matter of recently detoxified but not long term abstinent alcoholics: a preliminary MR spectroscopy study. Alcohol Clin Exp Res, 24(5), 699–705.

    Article  PubMed  Google Scholar 

  • Sher, K. J., Bartholow, B. D., & Wood, M. D. (2000). Personality and substance use disorders: A prospective study. Journal of Consulting & Clinical Psychology, 68(5), 818–829.

    Article  Google Scholar 

  • Sher, K. J., Walitzer, K. S., Wood, P. K., & Brent, E. E. (1991). Characteristics of children of alcoholics: Putative risk factors, alcohol and other drug use and abuse, and psychopathology. Journal of Abnormal Psychology, 100, 427–448.

    Article  PubMed  Google Scholar 

  • Shrier, L. A., Harris, S. K., Kurland, M., & Knight, J. R. (2003). Substance use problems and associated psychiatric symptoms among adolescents in primary care. Pediatrics, 111(6 Pt 1), MID-12777342.

    Google Scholar 

  • Skoff, B. E, & Libon, J. (1987). Impaired executive functions in a sample of male juvenile delinquents. Journal of Clinical and Experimental Neuropsychology, 9, 60.

    Google Scholar 

  • Soloff, P. H., Lynch, K. G., & Moss, H. B. (2000). Serotonin, impulsivity, and alcohol use disorders in the older adolescent: A psychobiological study. Alcoholism: Clinical & Experimental Research, 24, 1609–1619.

    Article  Google Scholar 

  • Sowell, E. R., Delis, D., Stiles, J., & Jernigan, T. L. (2001). Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study. J Int Neuropsychol Soc, 7(3), 312–322.

    Article  PubMed  Google Scholar 

  • Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003). Mapping cortical change across the human life span. Nature Neuroscience, 6(3), 309–315.

    Article  PubMed  Google Scholar 

  • Sowell, E. R., Thompson, P. M., Holmes, C. J., Batth, R., Jernigan, T. L., & Toga, A. W. (1999). Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. Neuroimage, 9(6 Pt 1), 587–597.

    Article  PubMed  Google Scholar 

  • Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999). In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience, 2(10), 859–861.

    Article  PubMed  Google Scholar 

  • Sowell, E. R., Thompson, P. M., Mattson, S. N., Tessner, K. D., Jernigan, T. L., Riley, E. P., et al. (2002). Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure. Cereb Cortex, 12(8), 856–865.

    Article  PubMed  Google Scholar 

  • Sullivan, E. V., Desmond, J. E., Lim, K. O., & Pfefferbaum, A. (2002). Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women. Alcohol Clin Exp Res, 26(5), 705–713.

    Article  PubMed  Google Scholar 

  • Sullivan, E. V., Harding, A. J., Pentney, R., Dlugos, C., Martin, P. R., Parks, M. H., et al. (2003). Disruption of frontocerebellar circuitry and function in alcoholism. Alcohol Clin Exp Res, 27(2), 301–309.

    PubMed  Google Scholar 

  • Tapert, S. F., Baratta, M., Abrantes, A., & Brown, S. (2002). Attention dysfunction predicts substance involvement in community youth. Journal of the American Academy of Child and Adolescent Psychiatry, 41, 680–686.

    Article  PubMed  Google Scholar 

  • Tapert, S. F., Schweinsburg, A. D., Barlett, V. C., Brown, S. A., Frank, L. R., Brown, G. G., & Meloy, M. J. (in press). BOLD response and spatial working memory in adolescents with alcohol use disorders. Alcoholism: Clinical and Experimental Research.

    Google Scholar 

  • Tapert, S. F., Myers, M., Tomlinson, K., & Brown, S. (1999). Influence of smoking and substance withdrawal on cognitive efficiency among young adults. Annals of Behavioral Medicine, 21, S190.

    Google Scholar 

  • Tapert, S. F., Brown, G. G., Kindermann, S. S., Cheung, E. H., Frank, L. R., & Brown, S. A. (2001). fMRI measurement of brain dysfunction in alcohol-dependent young women. Alcoholism: Clinical and Experimental Research, 25(2), 236–245.

    Article  Google Scholar 

  • Tapert, S. F., & Brown, S. A. (1999a, 1999, August). Gender differences in neuropsychological functioning of young adult substance abusers. Paper presented at the Annual Meeting of the American Psychological Association, Boston, MA.

    Google Scholar 

  • Tapert, S. F, & Brown, S. A. (1999b). Neuropsychological correlates of adolescent substance abuse: Four-year outcomes. Journal of the International Neuropsychological Society, 5(6), 481–493.

    Article  PubMed  Google Scholar 

  • Tapert, S. E, & Brown, S. A. (1999). Neuropsychological correlates of adolescent substance abuse: Four-year outcomes. Journal of the International Neuropsychological Society, 5, 481–493.

    Article  PubMed  Google Scholar 

  • Tapert, S. E, & Brown, S. A. (2000). Substance dependence, family history of alcohol dependence, and neuropsychological functioning in adolescence. Addiction, 95, 1043–1053.

    Article  PubMed  Google Scholar 

  • Tapert, S. F., Brown, S. A., Myers, M. G., & Granholm, E. (1999). The role of neurocognitive abilities in coping with adolescent relapse to alcohol and drug use. Journal of Studies on Alcohol., 60, 500–508.

    PubMed  Google Scholar 

  • Tapert, S. F., Cheung, E. H., Brown, G. G., Frank, L. R., Paulus, M. P., Schweinsburg, A. D., et al. (2003). Neural response to alcohol stimuli in adolescents with alcohol use disorder. Archives of General Psychiatry, 60(7), 727–735.

    Article  PubMed  Google Scholar 

  • Tapert, S. F., Granholm, E., Leedy, N., & Brown, S. A. (2002). Substance use and withdrawal: Neuropsychological functioning over 8 years in youth. Journal of the International Neuropsychological Society, 8, 873–883.

    Article  PubMed  Google Scholar 

  • Tapert, S. F., Granholm, E., Leedy, N. G., & Brown, S. A. (2002). Substance use and withdrawal: neuropsychological functioning over 8 years in youth. Journal of the International Neuropsychological Society, 8(7), 873–883.

    Article  PubMed  Google Scholar 

  • Tapert, S. F., McCarthy, D. M., Aarons, G. A., Schweinsburg, A. D., & Brown, S. A. (2003). Influence of language abilities and alcohol expectancies on the persistence of heavy drinking in youth. J Stud Alcohol, 64, 313–321.

    PubMed  Google Scholar 

  • Tapert, S. F., Theilmann, R. J., Schweinsburg, A. D., Yafai, S., & Frank, L. R. (2003). Reduced fractional anisotropy in the splenium of adolescents with alcohol use disorder.

    Google Scholar 

  • Tarter, R., Jacob, T., & Bremer, D. (1989). Specific cognitive impairment in sons of early onset alcoholics. Alcohol Clin Exp Res, 13, 786–789.

    Article  PubMed  Google Scholar 

  • Tarter, R. E., Alterman, A. I., & Edwards, K. L. (1985). Vulnerability to alcoholism in men: A behavior-genetic perspective. Journal of Studies on Alcohol, 46, 329–356.

    PubMed  Google Scholar 

  • Tarter, R. E., Hegedus, A. M., Goldstein, G., Shelly, C., & Alterman, A. I. (1984). Adolescent sons of alcoholics: Neuropsychological and personality characteristics. Alcoholism: Clinical and Experimental Research, 8, 216–222.

    Google Scholar 

  • Tarter, R. E., Hegedus, A. M., Winsten, N. E., & Alterman, A. L. (1984). Neuropsychological, personality, and familial characteristics of physically abused delinquents. Journal of the American Academy of Child Psychiatry, 23, 668–674.

    Article  PubMed  Google Scholar 

  • Tarter, R. E., Kirisci, L., Mezzich, A., Cornelius, J. R., Pajer, K., Vanyukov, M., et al. (2003). Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. Am J Psychiatry, 160(6), 1078–1085.

    Article  PubMed  Google Scholar 

  • Tarter, R. E., Mezzich, A. C., Hsieh, Y. C., & Parks, S. M. (1995). Cognitive capacity in female adolescent substance abusers. Drug and Alcohol Dependence, 39(1), 15–21.

    Article  PubMed  Google Scholar 

  • Toupin, J., Déry, M., Pauze, R., Mercier, H., & Fortin, L. (2000). Cognitive and familial contributions to conduct disorder in children. Journal of Child Psychology and Psychiatry and Allied Disciplines, 41(3), 333–344.

    Google Scholar 

  • Twitchell, G. R., Hanna, G. L., Cook, E. H., Fitzgerald, H. E., & Zucker, R. A. (2000). Serotonergic function, behavioral disinhibition, and negative affect in children of alcoholics: The moderating effects of puberty. Alcoholism: Clinical & Experimental Research, 24, 972–979.

    Google Scholar 

  • Verger, K., Junque, C., Levin, H. S., Jurado, M. A., Perez Gomez, M., Bartres Faz, D., et al. (2001). Correlation of atrophy measures on MRI with neuropsychological sequelae in children and adolescents with traumatic brain injury. Brain Inj, 15(3), 211–221.

    Article  PubMed  Google Scholar 

  • Virkkunen, M., De Jong, J., Bartko, J., Goodwin, E K., & Linnoila, M. (1989). Relationship of psychobiological variables to recidivism in violent offenders and impulsive firesetters: A follow-up study. Archives of General Psychiatry, 46, 600–603.

    PubMed  Google Scholar 

  • Virkkunen, M., & Linnoila, M. (1997). Serotonin in early-onset alcoholism. In E. Marc Galanter & et al. (Eds.), Recent developments in alcoholism, Vol. 13: Alcohol and violence: Epidemiology, neurobiology, psychology, family issues. (pp. 173–189). New York: Plenum Press.

    Google Scholar 

  • Wall, T. L., Schuckit, M. A., Mungas, D., & Ehlers, C. L. (1990). EEG alpha activity and personality traits. Alcohol, 7, 461–464.

    Article  PubMed  Google Scholar 

  • West, D. J., & Farrington, D. P. (1973). Who becomes delinquent?: London: Heinemann Educational Books.

    Google Scholar 

  • White, J. L., Moffitt, T. E., Caspi, A., Bartusch, D. J., Needles, D. J., & Stouthamer-Loeber, M. (1994). Measuring impulsivity and examining its relationship to delinquency. Journal of Abnormal Psychology, 103, 192–205.

    Article  PubMed  Google Scholar 

  • Wiers, R. W., Wood, M. D., Darkes, J., Corbin, W. R., Jones And, B. T., & Sher, K. J. (2003). Changing expectancies: cognitive mechanisms and context effects. Alcohol Clin Exp Res, 27(2), 186–197.

    PubMed  Google Scholar 

  • Wolff, P. H., Waber, D., Bauermeister, M., Cohen, C., & Ferber, E (1982). The neuropsychological status of adolescent delinquent boys. Journal of Child Psychology and Psychiatry, 23, 267–279.

    PubMed  Google Scholar 

  • Yakovlev, P. I., & Lecours, A. R. (1967). The myelogenetic cycles of regional maturation of the brain. In A. Mikowski (Ed.), Regional Development of the Brain in Early Life (pp. 3–70). Oxford, England: Blackwell Scientific.

    Google Scholar 

  • Yi, H.-y., Williams, G. D., & Dufour, M. C. (2001). Surveillance report #56: Trends in alcohol-related fatal traffic crashes, United States, 1977–99. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism.

    Google Scholar 

  • Zoccolillo, M. (1993). Gender and the development of conduct disorder. Development & Psychopathology, 5, 65–78.

    Article  Google Scholar 

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Tapert, S.F., Schweinsburg, A.D. (2005). The Human Adolescent Brain and Alcohol Use Disorders. In: Galanter, M., Lowman, C., Boyd, G.M., Faden, V.B., Witt, E., Lagressa, D. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 17. Springer, Boston, MA. https://doi.org/10.1007/0-306-48626-1_9

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