Abstract
Over the past 30 years, there have been a number of important developments in our understanding of the etiology and consequences of excessive drinking among humans. Probably one of the most important findings to date is that there are large individual differences among humans in appetite for alcohol and age of onset of problem drinking. We recognize this finding in at least two different alcoholic types, each with its own estimate of genetic influence. We have also come to realize that there are important differences between men and women, both in etiology of problem drinking and in the consequences of chronic alcohol use. In this chapter, the advantages and limitations of applying genetically defined animal models, primarily, selected lines and inbred strains of mice, are evaluated with examples from the literature.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wilsnack SC, Wilsnack RW: Epidemiology of women’s drinking. J Subst Abuse 3:133–157, 1991.
Robbins C: Sex differences in psychosocial consequences of alcohol and drug abuse. J Health SocBehav 30:117–130, 1989.
Weibel-Orlando J: Women and alcohol: Special populations and cross-cultural variations, in Women and Alcohol: Health-Related Issues. Rockville, MD, National Institute on Alcohol Abuse and Alcoholism, 1986, p 161.
Armstrong RW: Tobacco and alcohol use among urban Malaysians in 1980. Int J Addict 20:1803–1808, 1985.
Cloninger CR: Neurogenetic adaptive mechanisms in alcoholism. Science 236:410–416, 1987.
Hill SY, Smith TR: Evidence for genetic mediation of alcoholism in women. J Subst Abuse 3:159–174,1991.
Cadoret RJ, O’Gorman TW, Troughton E, Heywood E: Alcoholism and antisocial personality: Interrelationships, genetic and environmental factors. Arch Gen Psychiatry 42:161–167, 1985.
Saunders JB, Davis M, Williams R: Do women develop alcoholic liver disease more readily than men? Br Med J 282:1140–1142, 1981.
Norton R, Batey R, Dwyer T, MacMahon S: Alcohol consumption and the risk of alcohol-related cirrhosis in women. Br Med J 295:80–82, 1987.
Mann K, Batra A, Güunthner A, Schroth G: Do women develop alcoholic brain damage more readily than men? Alcohol Clin Exp Res 16:1052–1056, 1992.
McClearn GE: The tools of pharmacogenetics, in Crabbe JC Jr, Harris RA (eds): The Genetic Basis of Alcohol and Drug Actions. New York, Plenum Press, 1991, p 1.
McClearn GE, Kakihana R: Selective breeding for ethanol sensitivity: Short-Sleep and Long-Sleep mice, in McClearn GE, Deitrich RA, Erwin VG (eds): Development of Animal Models as Pharmacogeneic Tools. DHHS Publication No. (ADM) 81-1133. Washington, DC, US Government Printing Office, 1981, p 147.
Bailey DW: Strategic uses of recombinant inbred and congenic strains in behavioral genetics research, inGershon ES, Breakfield XO, Ciaranello RD (eds): Genetic Research Strategies for Psychobiology and Psychiatry. NewYork, Boxwood Press, 1981, p 189.
McClearn GE: Sex distinctiveness in effective genotype, in Galanter M (ed): Recent Developments in Alcoholism. New York, Plenum Press, 1995, p xx.
Collins AC, Yeager TN, Lebsack ME, Panter SS: Variations in alcohol metabolism: Influence of sex and age. Pharmacol Biochem Behav 3:973–978, 1975.
Dudek BC, Phillips TJ: Distinctions among sedative, disinhibitory and ataxic properties of ethanol in inbred and selectively bred mice. Psychopharmacology 101:93–99, 1990.
DeFries JC, Wilson JR, Erwin VG, Petersen DR: LS × SS recombinant inbred strains of mice: Initial characterization. Alcohol Clin Exp Res 13:196–200, 1989.
Crabbe JC, Feller DJ, Dorow JS: Sensitivity and tolerance to ethanol-induced hypothermia in genetically selected mice. J Pharmacol Exp Ther 249:456–461, 1989.
Dudek BC, Phillips TJ, Hahn ME: Genetic analysis of the biphasic nature of the alcohol dose-response curve. Alcohol Clin Exp Res 15:262–269, 1991.
Erwin VG, Radcliffe RA, Jones BC: Chronic ethanol consumption produces genotype-dependent tolerance to ethanol in LS/Ibg and SS/Ibg mice. Pharmacol Biochem Behav 41:275–281, 1992.
Erwin VG, Jones BC, Radcliffe RA: Further characterization of LS × SS recombinant inbred strains of mice: Activating and hypothermic effects of ethanol. Alcohol Clin Exp Res 14:200–204, 1990.
Middaugh LD, Frackelton WF, Boggan WO, et al: Gender differences in the effects of ethanol on C57BL/6 mice. Alcohol 9:257–260, 1992.
Jones BC, Connell JM, Erwin VG: Appetite for and sensitivity to ethanol in C57BL by Short-Sleep and Long-Sleep mouse hybrids.Alcohol Clin Exp Res 14:301, 1990.
Erwin VG, Jones BC: Genetic correlations among ethanol-related behaviors and neurotensin-receptors in Long-Sleep (LS) × Short-Sleep (SS) recombinant inbred strains of mice. Behav Genet 23:191–196, 1993.
Plomin R, McClearn GE: Quantitative trait loci (QTL) analyses and alcohol-related behaviors. Behav Genet 23:197–211, 1993.
Neale MC, Martin NG: The effects of age, sex and genotype of self-reported drunkenness following a challenge dose of alcohol. Behav Genet 19:63–78, 1989.
Heath AC, Neale MC, Hewett JK, et al: Testing structural equation models for twin data using LISREL. Behav Genet 19:9–35, 1989.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Jones, B.C., Whitfield, K.E. (2002). Sex Differences in Ethanol-Related Behaviors in Genetically Defined Murine Stocks. In: Galanter, M., et al. Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 12. Springer, Boston, MA. https://doi.org/10.1007/0-306-47138-8_14
Download citation
DOI: https://doi.org/10.1007/0-306-47138-8_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-44921-5
Online ISBN: 978-0-306-47138-4
eBook Packages: Springer Book Archive