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01-05-2012

Changes in drug use are associated with health-related quality of life improvements among methadone maintenance patients with HIV/AIDS

Auteurs: Bach Xuan Tran, Arto Ohinmaa, Anh Thuy Duong, Nhan Thi Do, Long Thanh Nguyen, Quoc Cuong Nguyen, Steve Mills, Philip Jacobs, Stan Houston

Gepubliceerd in: Quality of Life Research | Uitgave 4/2012

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Abstract

Purpose

This longitudinal study assessed the changes in drug use patterns and health-related quality of life (HRQL) among HIV-positive drug users in the first methadone maintenance treatment (MMT) cohort in Vietnam.

Methods

A secondary analysis was conducted on 370 HIV-positive drug users (age: mean ± SD: 29.5 ± 5.9 years; 95.7% men). Modified WHOQOL-BREF, self-report, and opioid confirmatory urine tests were used to assess HRQL and drug use behaviours at baseline, 3, 6, and 9 months. Generalized estimating equations (GEE) models were constructed to adjust for intra-individual correlations.

Results

MMT response rate after 9 months was 89.9%. Rates of positive heroin urine tests rapidly decreased at the first trimester (18.1%) and then stabilized during the next 2 trimesters (11.8 and 14.4%). Among patients with continued drug use, frequency of use decreased from 3.4 to 0.7 time/day. Improvements in HRQL were large over the course of the study and highest in the psychological domain. Adjusting for propensity score in GEE models, ongoing heroin use during MMT resulted in large decrements in all HRQL domains.

Conclusions

MMT improved the outcomes of treatment for drug users in ways that might facilitate success of antiretroviral therapy. Integrating MMT to HIV care and treatment services could be beneficial in injection-driven HIV epidemics in resource-scare settings.
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Metagegevens
Titel
Changes in drug use are associated with health-related quality of life improvements among methadone maintenance patients with HIV/AIDS
Auteurs
Bach Xuan Tran
Arto Ohinmaa
Anh Thuy Duong
Nhan Thi Do
Long Thanh Nguyen
Quoc Cuong Nguyen
Steve Mills
Philip Jacobs
Stan Houston
Publicatiedatum
01-05-2012
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2012
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-9963-y

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