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Gepubliceerd in: Quality of Life Research 10/2016

01-10-2016 | Brief Communication

Change in health-related quality of life over 1 month in cancer patients with high initial levels of symptoms and problems

Auteurs: Charlotte Lund Rasmussen, Anna Thit Johnsen, Morten Aagaard Petersen, Mogens Groenvold

Gepubliceerd in: Quality of Life Research | Uitgave 10/2016

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Abstract

Purpose

To investigate the mean changes over time in health-related quality of life among advanced cancer patients who did not receive any intervention, comparing changes among all patients versus changes in subgroups of patients with high initial symptom scores.

Methods

Patients with advanced cancer answered two questionnaires, containing the EORTC QLQ-C30 (15 multi- or single-item scales), with approximately 1 month in between and received no known intervention in between. For each QLQ-C30 scale, we estimated the mean change among all patients and in subgroups of patients scoring at least 33, 50, and 66 %, respectively, of maximum (maximal symptom score or maximally reduced function score) in the first questionnaire.

Results

In total, 1014 patients completed both questionnaires. As hypothesized, we found no change over time in mean scores when including all patients [average mean change = −0.9 (95 % CI −1.5;−0.6)]. In the subgroups of patients initially scoring at least 33, 50, or 66 % of maximum, the score improved with mean changes of −9.2 (95 % CI −10.1;−8.4), −13.1 (95 % CI −14.4;−11.8), and −15.6 (95 % CI −17.2;−13.9), respectively.

Conclusions

We quantified the magnitude of change over a 1-month period in health-related quality of life in advanced cancer patients, and in subgroups selected according to certain initial symptom levels. This information may help the interpretation of longitudinal studies of patients selected via screening.
Literatuur
1.
go back to reference Hutchison, S. D., Steginga, S. K., & Dunn, J. (2006). The tiered model of psychosocial intervention in cancer: A community based approach. Psycho-Oncology, 15(6), 541–546. doi:10.1002/pon.973.CrossRefPubMed Hutchison, S. D., Steginga, S. K., & Dunn, J. (2006). The tiered model of psychosocial intervention in cancer: A community based approach. Psycho-Oncology, 15(6), 541–546. doi:10.​1002/​pon.​973.CrossRefPubMed
2.
go back to reference Ross, L., Boesen, E. H., Dalton, S. O., & Johansen, C. (2002). Mind and cancer: does psychosocial intervention improve survival and psychological well-being? European Journal of Cancer, 38(11), 1447–1457.CrossRefPubMed Ross, L., Boesen, E. H., Dalton, S. O., & Johansen, C. (2002). Mind and cancer: does psychosocial intervention improve survival and psychological well-being? European Journal of Cancer, 38(11), 1447–1457.CrossRefPubMed
3.
go back to reference Galton, F. (1886). Regression towards mediocrity in hereditary stature. Journal of the Anthropological Institute of Great Britain and Ireland, 15, 246–263.CrossRef Galton, F. (1886). Regression towards mediocrity in hereditary stature. Journal of the Anthropological Institute of Great Britain and Ireland, 15, 246–263.CrossRef
4.
5.
go back to reference Johnsen, A. T., Tholstrup, D., Petersen, M. A., Pedersen, L., & Groenvold, M. (2009). Health related quality of life in a nationally representative sample of haematological patients. European Journal of Haematology, 83(2), 139–148.CrossRefPubMedPubMedCentral Johnsen, A. T., Tholstrup, D., Petersen, M. A., Pedersen, L., & Groenvold, M. (2009). Health related quality of life in a nationally representative sample of haematological patients. European Journal of Haematology, 83(2), 139–148.CrossRefPubMedPubMedCentral
6.
go back to reference Fleming, I. D., Cooper, J. S., Henson, D. E., Hutter, R. V. P., Kennedy, B. J., Murphy, G. P., et al. (1997). American Joint Committee on Cancer. AJCC cancer staging manual (5th ed.). Philadelphia: Lippincott-Raven. Fleming, I. D., Cooper, J. S., Henson, D. E., Hutter, R. V. P., Kennedy, B. J., Murphy, G. P., et al. (1997). American Joint Committee on Cancer. AJCC cancer staging manual (5th ed.). Philadelphia: Lippincott-Raven.
7.
go back to reference Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European organization for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376. doi:10.1093/jnci/85.5.365.CrossRefPubMed Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European organization for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376. doi:10.​1093/​jnci/​85.​5.​365.CrossRefPubMed
8.
go back to reference SAS, I. I. (n.d.). SAS/STAT 9.3 user’s guide. Cary, NC: SAS Institute Inc. SAS, I. I. (n.d.). SAS/STAT 9.3 user’s guide. Cary, NC: SAS Institute Inc.
9.
go back to reference Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). The EORTC QLQ-C30 scoring manual. Brussels: European Organization for Research and Treatment of Cancer. CIT0033. Fayers, P. M., Aaronson, N. K., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). The EORTC QLQ-C30 scoring manual. Brussels: European Organization for Research and Treatment of Cancer. CIT0033.
10.
go back to reference Fleiss, J. L., & Cohen, J. (1973). The equivalence of weighted kappa and the intraclass correlation coefficient as measures of reliability. Educational and Psychological Measurement, 33, 613–619.CrossRef Fleiss, J. L., & Cohen, J. (1973). The equivalence of weighted kappa and the intraclass correlation coefficient as measures of reliability. Educational and Psychological Measurement, 33, 613–619.CrossRef
11.
go back to reference Johnson, W. D., & George, V. T. (1991). Effect of regression to the mean in the presence of within-subject variability. Statistics in Medicine, 10(8), 1295–1302.CrossRefPubMed Johnson, W. D., & George, V. T. (1991). Effect of regression to the mean in the presence of within-subject variability. Statistics in Medicine, 10(8), 1295–1302.CrossRefPubMed
12.
go back to reference Schectman, G., & Hoffmann, R. G. (1988). A history of hypercholesterolemia influences cholesterol measurements. Archives of Internal Medicine, 148(5), 1169–1171.CrossRefPubMed Schectman, G., & Hoffmann, R. G. (1988). A history of hypercholesterolemia influences cholesterol measurements. Archives of Internal Medicine, 148(5), 1169–1171.CrossRefPubMed
13.
go back to reference Hageman, W. J., & Arrindell, W. A. (1999). Establishing clinically significant change: Increment of precision and the distinction between individual and group level of analysis. Behaviour Research and Therapy, 37(12), 1169–1193.CrossRefPubMed Hageman, W. J., & Arrindell, W. A. (1999). Establishing clinically significant change: Increment of precision and the distinction between individual and group level of analysis. Behaviour Research and Therapy, 37(12), 1169–1193.CrossRefPubMed
14.
go back to reference Lutz, W., Leach, C., Barkham, M., Lucock, M., Stiles, W. B., Evans, C., et al. (2005). Predicting change for individual psychotherapy clients on the basis of their nearest neighbors. Journal of Consulting and Clinical Psychology, 73(5), 904–913. doi:10.1037/0022-006X.73.5.904.CrossRefPubMed Lutz, W., Leach, C., Barkham, M., Lucock, M., Stiles, W. B., Evans, C., et al. (2005). Predicting change for individual psychotherapy clients on the basis of their nearest neighbors. Journal of Consulting and Clinical Psychology, 73(5), 904–913. doi:10.​1037/​0022-006X.​73.​5.​904.CrossRefPubMed
15.
go back to reference Lutz, W., Martinovich, Z., & Howard, K. I. (1999). Patient profiling: An application of random coefficient regression models to depicting the response of a patient to outpatient psychotherapy. Journal of Consulting and Clinical Psychology, 67(4), 571–577. doi:10.1037/0022-006X.67.4.571.CrossRefPubMed Lutz, W., Martinovich, Z., & Howard, K. I. (1999). Patient profiling: An application of random coefficient regression models to depicting the response of a patient to outpatient psychotherapy. Journal of Consulting and Clinical Psychology, 67(4), 571–577. doi:10.​1037/​0022-006X.​67.​4.​571.CrossRefPubMed
Metagegevens
Titel
Change in health-related quality of life over 1 month in cancer patients with high initial levels of symptoms and problems
Auteurs
Charlotte Lund Rasmussen
Anna Thit Johnsen
Morten Aagaard Petersen
Mogens Groenvold
Publicatiedatum
01-10-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 10/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1287-5

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