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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2010

01-03-2010 | Original Paper

Cerebellum, Language, and Cognition in Autism and Specific Language Impairment

Auteurs: Steven M. Hodge, Nikos Makris, David N. Kennedy, Verne S. Caviness Jr., James Howard, Lauren McGrath, Shelly Steele, Jean A. Frazier, Helen Tager-Flusberg, Gordon J. Harris

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2010

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Abstract

We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6–13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I–V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.
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Metagegevens
Titel
Cerebellum, Language, and Cognition in Autism and Specific Language Impairment
Auteurs
Steven M. Hodge
Nikos Makris
David N. Kennedy
Verne S. Caviness Jr.
James Howard
Lauren McGrath
Shelly Steele
Jean A. Frazier
Helen Tager-Flusberg
Gordon J. Harris
Publicatiedatum
01-03-2010
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-009-0872-7

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