Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-03-2010 | Original Paper

Cerebellum, Language, and Cognition in Autism and Specific Language Impairment

Auteurs: Steven M. Hodge, Nikos Makris, David N. Kennedy, Verne S. Caviness Jr., James Howard, Lauren McGrath, Shelly Steele, Jean A. Frazier, Helen Tager-Flusberg, Gordon J. Harris

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2010

Abstract

We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6–13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I–V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.

vorige artikel Investigation of Mentalizing and Visuospatial Perspective Taking for Self and Other in Asperger Syndrome

volgende artikel The Medical Home for Children with Autism Spectrum Disorders: Parent and Pediatrician Perspectives

Alleen toegankelijk voor geautoriseerde gebruikers

Ackermann, H., Wildgruber, D., Daum, I., & Grodd, W. (1998). Does the cerebellum contribute to cognitive aspects of speech production? A functional magnetic resonance imaging (fMRI) study in humans. Neuroscience Letters, 247, 187–190.PubMed

Alarcon, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., et al. (2008). Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. American Journal of Human Genetics, 82, 150–159.PubMed

Alarcon, M., Cantor, R. M., Liu, J., Gilliam, T. C., & Geschwind, D. H. (2002). Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. American Journal of Human Genetics, 70, 60–71.PubMed

Almasy, L., & Blangero, J. (2001). Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design. American Journal of Medical Genetics, 105, 42–44.PubMed

APA. (1994). DSM-IV: Diagnostic and statistic manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Press.

Arnold, J. B., Liow, J. S., Schaper, K. A., Stern, J. J., Sled, J. G., Shattuck, D. W., et al. (2001). Qualitative and quantitative evaluation of six algorithms for correcting intensity nonuniformity effects. Neuroimage, 13, 931–943.PubMed

Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.PubMed

Barrett, S., Beck, J. C., Bernier, R., Bisson, E., Braun, T. A., Casavant, T. L., et al. (1999). An autosomal genomic screen for autism. Collaborative linkage study of autism. American Journal of Medical Genetics, 88, 609–615.PubMed

Bartlett, C. W., Flax, J. F., Logue, M. W., Vieland, V. J., Bassett, A. S., Tallal, P., et al. (2002). A major susceptibility locus for specific language impairment is located on 13q21. American Journal of Human Genetics, 71, 45–55.PubMed

Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism. Neurology, 35, 866–874.PubMed

Benson, R. R., FitzGerald, D. B., LeSueur, L. L., Kennedy, D. N., Kwong, K. K., Buchbinder, B. R., et al. (1999). Language dominance determined by whole brain functional MRI in patients with brain lesions. Neurology, 52, 798–809.PubMed

Binder, J. R., Frost, J. A., Hammeke, T. A., Cox, R. W., Rao, S. M., & Prieto, T. (1997). Human brain language areas identified by functional magnetic resonance imaging. Journal of Neuroscience, 17, 353–362.PubMed

Bishop, D. V. (2003). Autism and specific language impairment: Categorical distinction or continuum? Novartis Foundation Symposium, 251, 213–226 (discussion 226–234, 281–297).

Bobylova, M. Y., Petrukhin, A. S., Dunaevskaya, G. N., Piliya, S. V., & Il’ina, E. S. (2007). Clinical-psychological characteristics of children with dysgenesis of the cerebellar vermis. Neuroscience and Behavioral Physiology, 37, 755–759.PubMed

Boddaert, N., Chabane, N., Belin, P., Bourgeois, M., Royer, V., Barthelemy, C., et al. (2004). Perception of complex sounds in autism: Abnormal auditory cortical processing in children. American Journal of Psychiatry, 161, 2117–2120.PubMed

Botez-Marquard, T., & Botez, M. I. (1997). Olivopontocerebellar atrophy and Friedreich’s ataxia: Neuropsychological consequences of bilateral versus unilateral cerebellar lesions. In R. J. Bradly, R. A. Harris & P. Jenner (Series Eds.), J. D. Schmahmann (Vol. Ed.), International review of neurobiology, Vol. 41. The cerebellum and cognition (pp. 387–410). San Diego: Academic Press.

Bradford, Y., Haines, J., Hutcheson, H., Gardiner, M., Braun, T., Sheffield, V., et al. (2001). Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics, 105, 539–547.PubMed

Brambilla, P., Hardan, A., di Nemi, S. U., Perez, J., Soares, J. C., & Barale, F. (2003). Brain anatomy and development in autism: Review of structural MRI studies. Brain Research Bulletin, 61, 557–569.PubMed

Breiter, H. C., & Gasic, G. P. (2004). A general circuitry processing reward/aversion information and its implications for neuropsychiatric illness. In M. S. Gazzaniga (Ed.), The cognitive neurosciences (pp. 1043–1065). Cambridge: MIT.

Burroni, L., Orsi, A., Monti, L., Hayek, Y., Rocchi, R., & Vattimo, A. G. (2008). Regional cerebral blood flow in childhood autism: A SPET study with SPM evaluation. Nuclear Medicine Communications, 29, 150–156.PubMed

Catts, H., Bridges, M., Little, T., & Tomblin, J. B. (2008). Reading achievement growth in children with language impairments. Journal of Speech Language and Hearing Research, 51, 1569–1579.

Caviness, V. S., Jr., Meyer, J. W., Makris, N., & Kennedy, D. N. (1996). MRI-based topographic parcellation of the human neocortex: An anatomically specified method with estimate of reliability. Journal of Cognitive Neuroscience, 8, 566–587.

Chheda, M., Sherman, J., & Schmahmann, J. D. (2002). Neurologic, psychiatric and cognitive manifestations in cerebellar agenesis. Neurology, 58, 356.

Chiron, C., Leboyer, M., Leon, F., Jambaque, I., Nuttin, C., & Syrota, A. (1995). SPECT of the brain in childhood autism: Evidence for a lack of normal hemispheric asymmetry. Developmental Medicine and Child Neurology, 37, 849–860.PubMed

Conti-Ramsden, G. (2003). Processing and linguistic markers in young children with specific language impairment (sli). Journal of Speech, Language and Hearing Research, 46(5), 1029–1037.

Conti-Ramsden, G., & Botting, N. (1999). Classification of children with specific language impairment: Longitudinal considerations. Journal of Speech, Language, and Hearing Research, 42, 1195–1204.PubMed

Courchesne, E. (1999). An MRI study of autism: The cerebellum revisited. Neurology, 52, 1106–1107.PubMed

Courchesne, E., Saitoh, O., Yeung-Courchesne, R., Press, G. A., Lincoln, A. J., Haas, R. H., et al. (1994). Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: Identification of hypoplastic and hyperplastic subgroups with MR imaging. AJR. American Journal of Roentgenology, 162, 123–130.PubMed

Courchesne, E., Yeung-Courchesne, R., Press, G. A., Hesselink, J. R., & Jernigan, T. L. (1988). Hypoplasia of cerebellar vermal lobules VI and VII in autism. New England Journal of Medicine, 318, 1349–1354.PubMed

Dale, A. M., Fischl, B., & Sereno, M. I. (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage, 9, 179–194.PubMed

Dawson, G., Finley, C., Phillips, S., & Galpert, L. (1986). Hemispheric specialization and the language abilities of autistic children. Child Development, 57, 1440–1453.PubMed

De Fosse, L., Hodge, S. M., Makris, N., Kennedy, D. N., Caviness, V. S., Jr., McGrath, L., et al. (2004). Language-association cortex asymmetry in autism and specific language impairment. Annals of Neurology, 56, 757–766.PubMed

Dean, R. S. (1978). Cerebral laterality and reading comprehension. Neuropsychologia, 16, 633–636.PubMed

Dean, R. S. (1982). Assessing patterns of lateral preference. Journal of Clinical Neuropsychology, 4, 124–128.

Desmond, J. E., & Fiez, J. A. (1998). Neuroimaging studies of the cerebellum: Language, learning and memory. Trends in Cognitive Science, 2, 355–362.

Desmond, J. E., Gabrieli, J. D., Wagner, A. D., Ginier, B. L., & Glover, G. H. (1997). Lobular patterns of cerebellar activation in verbal working-memory and finger-tapping tasks as revealed by functional MRI. Journal of Neuroscience, 17, 9675–9685.PubMed

Dunn, L. M., & Dunn, L. M. (1997). Peabody picture vocabulary test (3rd ed.). Circle Pines, MN: American Guidance Service.

Eckert, M. A., Leonard, C. M., Richards, T. L., Aylward, E. H., Thomson, J., & Berninger, V. W. (2003). Anatomical correlates of dyslexia: Frontal and cerebellar findings. Brain, 126, 482–494.PubMed

Elliot, C. D. (1990). Differential ability scales. San Antonio, TX: The Psychological Corporation, Harcourt Brace and Co.

Fiez, J. A., Petersen, S. E., Cheney, M. K., & Raichle, M. E. (1992). Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. Brain, 115(Pt 1), 155–178.PubMed

Fiez, J. A., & Raichle, M. E. (1997). Linguistic processing. In R. J. Bradly, R. A. Harris & P. Jenner (Series Eds.), J. D. Schmahmann (Vol. Ed.), International review of neurobiology: Vol. 41. The cerebellum and cognition (pp. 233–254). San Diego: Academic Press.

Fisher, S. E., Lai, C. S., & Monaco, A. P. (2003). Deciphering the genetic basis of speech and language disorders. Annual Review of Neuroscience, 26, 57–80.PubMed

Folstein, S. E., Santangelo, S. L., Gilman, S. E., Piven, J., Landa, R., Lainhart, J., et al. (1999). Predictors of cognitive test patterns in autism families. Journal of Child Psychology and Psychiatry and Allied Disciplines, 40, 1117–1128.

Fombonne, E., Bolton, P., Prior, J., Jordan, H., & Rutter, M. (1997). A family study of autism: cognitive patterns and levels in parents and siblings. Journal of Child Psychology and Psychiatry and Allied Disciplines, 38, 667–683.

Foundas, A. L., Eure, K. F., Luevano, L. F., & Weinberger, D. R. (1998). MRI asymmetries of Broca’s area: The pars triangularis and pars opercularis. Brain and Language, 64, 282–296.PubMed

Galaburda, A. M., Rosen, G. D., & Sherman, G. F. (1990). Individual variability in cortical organization: Its relationship to brain laterality and implications to function. Neuropsychologia, 28, 529–546.PubMed

Galloway, J. (1990). Developmental biology. A handle on handedness. Nature, 346, 223–224.PubMed

Gebhart, A. L., Petersen, S. E., & Thach, W. T. (2002). Role of the posterolateral cerebellum in language. Annals of the New York Academy of Sciences, 978, 318–333.PubMed

Giedd, J. N. (2004). Structural magnetic resonance imaging of the adolescent brain. Annals of the New York Academy of Sciences, 1021, 77–85.PubMed

Giedd, J. N., Vaituzis, A. C., Hamburger, S. D., Lange, N., Rajapakse, J. C., Kaysen, D., et al. (1996). Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4–18 years. Journal of Comparative Neurology, 366, 223–230.PubMed

Hardan, A. Y., Minshew, N. J., Harenski, K., & Keshavan, M. S. (2001). Posterior fossa magnetic resonance imaging in autism. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 666–672.PubMed

Harris, G. J., Chabris, C. F., Clark, J., Urban, T., Aharon, I., Steele, S., et al. (2006). Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging. Brain and Cognition, 61, 54–68.PubMed

Hashimoto, T., Tayama, M., Miyazaki, M., Murakawa, K., & Kuroda, Y. (1993). Brainstem and cerebellar vermis involvement in autistic children. Journal of Child Neurology, 8, 149–153.PubMed

Heath, R. G. (1977). Modulation of emotion with a brain pacemamer. Treatment for intractable psychiatric illness. Journal of Nervous and Mental Disease, 165, 300–317.PubMed

Herbert, M. R., Harris, G. J., Adrien, K. T., Ziegler, D. A., Makris, N., Kennedy, D. N., et al. (2002). Abnormal asymmetry in language association cortex in autism. Annals of Neurology, 52, 588–596.PubMed

Herbert, M. R., Ziegler, D. A., Deutsch, C. K., O’Brien, L. M., Lange, N., Bakardjiev, A., et al. (2003). Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain, 126, 1182–1192.PubMed

Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., et al. (2004). Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology, 55, 530–540.PubMed

Hubrich-Ungureanu, P., Kaemmerer, N., Henn, F. A., & Braus, D. F. (2002). Lateralized organization of the cerebellum in a silent verbal fluency task: A functional magnetic resonance imaging study in healthy volunteers. Neuroscience Letters, 319, 91–94.PubMed

Hyatt, B. A., & Yost, H. J. (1998). The left–right coordinator: the role of Vg1 in organizing left–right axis formation. Cell, 93, 37–46.PubMed

IMGSAC. (1998). A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International molecular genetic study of autism consortium. Human Molecular Genetics, 7, 571–578.

Jansen, A., Floel, A., Van Randenborgh, J., Konrad, C., Rotte, M., Forster, A. F., et al. (2005). Crossed cerebro-cerebellar language dominance. Human Brain Mapping, 24, 165–172.PubMed

Joseph, R. M., Steele, S. D., Meyer, E., & Tager-Flusberg, H. (2005). Self-ordered pointing in children with autism: Failure to use verbal mediation in the service of working memory? Neuropsychologia, 43, 1400–1411.PubMed

Just, M. A., Cherkassky, V. L., Keller, T. A., & Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain, 127, 1811–1821.PubMed

Kaufmann, W. E., Cooper, K. L., Mostofsky, S. H., Capone, G. T., Kates, W. R., Newschaffer, C. J., et al. (2003). Specificity of cerebellar vermian abnormalities in autism: A quantitative magnetic resonance imaging study. Journal of Child Neurology, 18, 463–470.PubMed

Keller, S. S., Highley, J. R., Garcia-Finana, M., Sluming, V., Rezaie, R., & Roberts, N. (2007). Sulcal variability, stereological measurement and asymmetry of Broca’s area on MR images. Journal of Anatomy, 211, 534–555.PubMed

Kelly, R. M., & Strick, P. L. (2003). Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J Neurosci, 23, 8432–8444.PubMed

Kemper, T. L., & Bauman, M. (1998). Neuropathology of infantile autism. Journal of Neuropathology and Experimental Neurology, 57, 645–652.PubMed

Kemper, T. L., & Bauman, M. L. (2002). Neuropathology of infantile autism. Molecular Psychiatry, 7(Suppl 2), S12–S13.PubMed

Kennedy, D. N., Filipek, P. A., & Caviness, V. S. (1989). Autonomic segmentation and volumetric calculations in nuclear magnetic resonance imaging. IEEE Transactions on Medical Imaging, 8, 1–7.PubMed

Kibby, M. Y., Fancher, J. B., Markanen, R., & Hynd, G. W. (2008). A quantitative magnetic resonance imaging analysis of the cerebellar deficit hypothesis of dyslexia. J Child Neurol, 23, 368–380.PubMed

Kjelgaard, M. M., & Tager-Flusberg, H. (2001). An investigation of language impairment in autism: Implications for genetic subgroups. Language and Cognitive Processes, 16, 287–308.PubMed

Kleiman, M. D., Neff, S., & Rosman, N. P. (1992). The brain in infantile autism: Are posterior fossa structures abnormal? Neurology, 42, 753–760.PubMed

Korkman, M., Kirk, U., & Kemp, S. (1998). NEPSY: A developmental neuropsychological assessment. San Antonio, TX: The Pyschological Corporation, Harcourt Brace and Co.

Kulesza, R. J., & Mangunay, K. (2008). Morphological features of the medial superior olive in autism. Brain Research, 1200, 132–137.PubMed

Leggio, M. G., Silveri, M. C., Petrosini, L., & Molinari, M. (2000). Phonological grouping is specifically affected in cerebellar patients: A verbal fluency study. Journal of Neurology, Neurosurgery and Psychiatry, 69, 102–106.

Leiner, H. C., Leiner, A. L., & Dow, R. S. (1986). Does the cerebellum contribute to mental skills? Behavioral Neuroscience, 100, 443–454.PubMed

Leiner, H. C., Leiner, A. L., & Dow, R. S. (1991). The human cerebro-cerebellar system: Its computing, cognitive, and language skills. Behavioral Brain Research, 44, 113–128.

Leonard, C. M., Eckert, M. A., Lombardino, L. J., Oakland, T., Kranzler, J., Mohr, C. M., et al. (2001). Anatomical risk factors for phonological dyslexia. Cereb Cortex, 11, 148–157.PubMed

Levisohn, L., Cronin-Golomb, A., & Schmahmann, J. D. (2000). Neuropsychological consequences of cerebellar tumour resection in children: Cerebellar cognitive affective syndrome in a paediatric population. Brain, 123(Pt 5), 1041–1050.PubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMed

Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMed

Lowe, L. A., Supp, D. M., Sampath, K., Yokoyama, T., Wright, C. V., Potter, S. S., et al. (1996). Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus. Nature, 381, 158–161.PubMed

Makris, N., Gasic, G. P., Seidman, L. J., Goldstein, J. M., Gastfriend, D. R., Elman, I., et al. (2004). Decreased absolute amygdala volume in cocaine addicts. Neuron, 44, 729–740.PubMed

Makris, N., Hodge, S. M., Haselgrove, C., Kennedy, D. N., Dale, A., Fischl, B., et al. (2003). Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging. Journal of Cognitive Neuroscience, 15, 584–599.PubMed

Makris, N., Schlerf, J. E., Hodge, S. M., Haselgrove, C., Albaugh, M. D., Seidman, L. J., et al. (2005). MRI-based surface-assisted parcellation of human cerebellar cortex: An anatomically specified method with estimate of reliability. Neuroimage, 25, 1146–1160.PubMed

Mathiak, K., Hertrich, I., Grodd, W., & Ackermann, H. (2002). Cerebellum and speech perception: A functional magnetic resonance imaging study. Journal of Cognitive Neuroscience, 14, 902–912.PubMed

Metter, E. J., Kempler, D., Jackson, C. A., Hanson, W. R., Riege, W. H., Camras, L. R., et al. (1987). Cerebellar glucose metabolism in chronic aphasia. Neurology, 37, 1599–1606.PubMed

Molinari, M., Leggio, M. G., & Silveri, M. C. (1997). Verbal fluency and agrammatism. In R. J. Bradly, R. A. Harris & P. Jenner (Series Eds.), J. D. Schmahmann (Vol. Ed.), International Review of Neurobiology: Vol. 41. The Cerebellum and Cognition (pp. 325–339). San Diego: Academic Press.

Muller, R. A., Behen, M. E., Rothermel, R. D., Chugani, D. C., Muzik, O., Mangner, T. J., et al. (1999). Brain mapping of language and auditory perception in high-functioning autistic adults: A PET study. Journal of Autism and Developmental Disorders, 29, 19–31.PubMed

Neau, J. P., Arroyo-Anllo, E., Bonnaud, V., Ingrand, P., & Gil, R. (2000). Neuropsychological disturbances in cerebellar infarcts. Acta Neurologica Scandinavica, 102, 363–370.PubMed

O’Brien, E. K., Zhang, X., Nishimura, C., Tomblin, J. B., & Murray, J. C. (2003). Association of specific language impairment (SLI) to the region of 7q31. American Journal of Human Genetics, 72, 1536–1543.PubMed

Ohnishi, T., Matsuda, H., Hashimoto, T., Kunihiro, T., Nishikawa, M., Uema, T., et al. (2000). Abnormal regional cerebral blood flow in childhood autism. Brain, 123(Pt 9), 1838–1844.PubMed

Oldfield, R. C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97–113.PubMed

Orvaschel, H., & Puig-Antich, J. (1987). Schedule for affective disorders and schizophrenia for school-age children-epidemiologic version (K-SADS-E) (4th ed.). Fort Lauderdale, FL: Nova University, Center for Psychological Studies.

Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., & Raichle, M. E. (1988). Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature, 331, 585–589.PubMed

Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., & Raichle, M. E. (1989). Positron emission tomographic studies of the processing of single-words. Journal of Cognitive Neuroscience, 1, 153–170.

Piedra, M. E., Icardo, J. M., Albajar, M., Rodriguez-Rey, J. C., & Ros, M. A. (1998). Pitx2 participates in the late phase of the pathway controlling left–right asymmetry. Cell, 94, 319–324.PubMed

Piven, J., & Arndt, S. (1995). The cerebellum and autism. Neurology, 45, 398–402.PubMed

Piven, J., Arndt, S., Bailey, J., Havercamp, S., Andreasen, N. C., & Palmer, P. (1995). An MRI study of brain size in autism. American Journal of Psychiatry, 152, 1145–1149.PubMed

Piven, J., Nehme, E., Simon, J., Barta, P., Pearlson, G., & Folstein, S. E. (1992). Magnetic resonance imaging in autism: Measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry, 31, 491–504.PubMed

Piven, J., Saliba, K., Bailey, J., & Arndt, S. (1997). An MRI study of autism: The cerebellum revisited. Neurology, 49, 546–551.PubMed

Pollack, I. F., Polinko, P., Albright, A. L., Towbin, R., & Fitz, C. (1995). Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: Incidence and pathophysiology. Neurosurgery, 37, 885–893.PubMedCrossRef

Rae, C., Harasty, J. A., Dzendrowskyj, T. E., Talcott, J. B., Simpson, J. M., Blamire, A. M., et al. (2002). Cerebellar morphology in developmental dyslexia. Neuropsychologia, 40, 1285–1292.PubMed

Rapin, I. (1999). Autism in search of a home in the brain. Neurology, 52, 902–904.PubMed

Rapin, I. (Vol. Ed.). (1996). Clinics in developmental medicine:Vol. 139. Preschool children with inadequate communication. London: Mac Keith Press.

Ritvo, E. R., Freeman, B. J., Scheibel, A. B., Duong, T., Robinson, H., Guthrie, D., et al. (1986). Lower Purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC autopsy research report. American Journal of Psychiatry, 143, 862–866.PubMed

Riva, D., & Giorgi, C. (2000). The cerebellum contributes to higher functions during development: Evidence from a series of children surgically treated for posterior fossa tumours. Brain, 123(Pt 5), 1051–1061.PubMed

Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., & Tregellas, J. R. (2006). Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry, 6, 56.PubMed

Roskies, A. L., Fiez, J. A., Balota, D. A., Raichle, M. E., & Petersen, S. E. (2001). Task-dependent modulation of regions in the left inferior frontal cortex during semantic processing. Journal of Cognitive Neuroscience, 13, 829–843.PubMed

Ruser, T. F., Arin, D., Dowd, M., Putnam, S., Winklosky, B., Rosen-Sheidley, B., et al. (2007). Communicative competence in parents of children with autism and parents of children with specific language impairment. Journal of Autism and Developmental Disorders, 37, 1323–1336.PubMed

Santangelo, S. L., & Folstein, S. E. (1999). Autism: A genetic perspective. In H. Tager-Flusberg (Ed.), Neurodevelopmental disorders (pp. 431–447). Cambridge, MA: MIT.

Schmahmann, J. D. (1991). An emerging concept. The cerebellar contribution to higher function. Archives of Neurology, 48, 1178–1187.PubMed

Schmahmann, J. D. (1996). From movement to thought: Anatomic substrates of the cerebellar contribution to cognitive processing. Human Brain Mapping, 4, 174–198.PubMed

Schmahmann, J. D. (2000). The role of the cerebellum in affect and psychosis. Journal of Neurolinguistics, 13, 189–214.

Schmahmann, J. D. (2001). The cerebrocerebellar system: Anatomic substrates of the cerebellar contribution to cognition and emotion. International Review of Psychiatry, 13, 247–260.

Schmahmann, J. D. (2004). Disorders of the cerebellum: Ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. Journal of Neuropsychiatry and Clinical Neurosciences, 16, 367–378.PubMed

Schmahmann, J. D., Doyon, J., Toga, A., Petrides, M., & Evans, A. (2000). MRI atlas of the human cerebellum. San Diego: Academic Press.

Schmahmann, J. D., & Sherman, J. C. (1998). The cerebellar cognitive affective syndrome. Brain, 121(Pt 4), 561–579.PubMed

Semel, E., Wiig, E. H., & Secord, W. A. (1995). Clinical evaluation of language fundamentals (3rd ed.). San Antonio, TX: The Psychological Corporation, Harcourt Brace and Co.

Silveri, M. C., Leggio, M. G., & Molinari, M. (1994). The cerebellum contributes to linguistic production: A case of agrammatic speech following a right cerebellar lesion. Neurology, 44, 2047–2050.PubMed

Slifer, K. J., Cataldo, M. F., Cataldo, M. D., Llorente, A. M., & Gerson, A. C. (1993). Behavior analysis of motion control for pediatric neuroimaging. Journal of Applied Behavior Analysis, 26, 469–470.PubMed

Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008). Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies. European Psychiatry, 23, 289–299.PubMed

Stoodley, C. J., & Schmahmann, J. D. (2009). Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies. Neuroimage, 44, 489–501.PubMed

Sun, T., Patoine, C., Abu-Khalil, A., Visvader, J., Sum, E., Cherry, T. J., et al. (2005). Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science, 308, 1794–1798.PubMed

Tager-Flusberg, H. (2003). Language impairments in children with complex neurodevelopmental disorders: The case of autism. In Y. Levy & J. C. Schaeffer (Eds.), Language competence across populations: Toward a definition of specific language impairment (pp. 297–321). Mahwah, NJ: Lawrence Erlbaum Associates.

Tager-Flusberg, H. (2006). Defining language phenotypes in autism. Clinical Neuroscience Research, 6, 219–224.

Tager-Flusberg, H., & Caronna, E. (2007). Language disorders: Autism and other pervasive developmental disorders. Pediatric Clinics of North America, 54, 469–481. vi.PubMed

Tager-Flusberg, H., & Cooper, J. (1999). Present and future possibilities for defining a phenotype for specific language impairment. Journal of Speech, Language, and Hearing Research, 42(5), 1275–1278.PubMed

Tager-Flusberg, H., & Joseph, R. M. (2003). Identifying neurocognitive phenotypes in autism. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 358, 303–314.PubMed

Tager-Flusberg, H., Paul, R., & Lord, C. E. (2005). Language and communication in autism. In F. Volkmar, R. Paul, A. Klin, & D. J. Cohen (Eds.), Handbook of autism and pervasive developmental disorders: Vol. 1. Diagnosis, development, neurobiology, and behavior (3rd ed., pp. 335–364). New York: Wiley.

Takeuchi, M., Harada, M., Matsuzaki, K., Nishitani, H., & Mori, K. (2004). Difference of signal change by a language task on autistic patients using functional MRI. The Journal of Medical Investigation: JMI, 51, 59–62.PubMed

Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical Publishers, Inc.

Tomblin, J. B., Hafeman, L. L., & O’Brien, M. (2003). Autism and autism risk in siblings of children with specific language impairment. International Journal of Language and Communication Disorders, 38, 235–250.PubMed

Wechsler, D. (1991). The wechsler intelligence scale for children (3rd ed.). San Antonio, TX: The Psychological Corporation, Harcourt Brace and Co.

Williams, K. T. (1997). Expressive vocabulary test. Circle Pines, MN: American Guidance Service.

Worth, A. J., Makris, N., Meyer, J. W., Caviness, V. S., Jr., & Kennedy, D. N. (1998a). Semiautomatic segmentation of brain exterior in magnetic resonance images driven by empirical procedures and anatomical knowledge. Medical Image Analysis, 2, 315–324.PubMed

Worth, A. J., Makris, N., Patti, M. R., Goodman, J. M., Hoge, E. A., Caviness, V. S., Jr., et al. (1998b). Precise segmentation of the lateral ventricles and caudate nucleus in MR brain images using anatomically driven histograms [letter]. IEEE Transactions on Medical Imaging, 17, 303–310.PubMed

Xiang, H., Lin, C., Ma, X., Zhang, Z., Bower, J. M., Weng, X., et al. (2003). Involvement of the cerebellum in semantic discrimination: An fMRI study. Human Brain Mapping, 18, 208–214.PubMed

Titel: Cerebellum, Language, and Cognition in Autism and Specific Language Impairment
Auteurs: Steven M. Hodge
Nikos Makris
David N. Kennedy
Verne S. Caviness Jr.
James Howard
Lauren McGrath
Shelly Steele
Jean A. Frazier
Helen Tager-Flusberg
Gordon J. Harris
Publicatiedatum: 01-03-2010
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-009-0872-7

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 3/2010

Brief Report: Signals Enhance the Suppressive Effects of Noncontingent Reinforcement

Sarah Attwood: Making Sense of Sex: A Forthright Guide to Puberty, Sex, and Relationships for People with Asperger’s Syndrome

Brief Report: Representational Momentum for Dynamic Facial Expressions in Pervasive Developmental Disorder

Enhancing Emotion Recognition in Children with Autism Spectrum Conditions: An Intervention Using Animated Vehicles with Real Emotional Faces

The Medical Home for Children with Autism Spectrum Disorders: Parent and Pediatrician Perspectives

Emotion Recognition in Children with Autism Spectrum Disorders: Relations to Eye Gaze and Autonomic State