Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

20-07-2021 | Letter to the Editor

Case Reports: Clozapine for the Treatment of Catatonia in Autism Spectrum Disorder

Auteurs: Robyn P. Thom, Christopher J. McDougle

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2022

Abstract

Catatonia is a severe clinical syndrome which has been increasingly reported in autism spectrum disorder (ASD). The prevalence of catatonia in ASD is unknown. Diagnosing catatonia in ASD is complicated by overlapping clinical features such as mutism, stereotypies, and echophenomena. Here, we present the clinical histories of two individuals with ASD and catatonia who were successfully treated with clozapine. We have reported on a novel potential treatment option for catatonia in ASD. Additional studies are needed to evaluate the safety, efficacy, and tolerability of clozapine for the treatment of catatonia in ASD.

vorige artikel Correction to: Concerns About ABA-Based Intervention: An Evaluation and Recommendations

Billstedt, E., Gillberg, C., & Gillberg, C. (2005). Autism after adolescence: Population-based 13- to 22-year follow-up study of 120 individuals with autism diagnosed in childhood. Journal of Autism and Developmental Disorders, 35(3), 351–360.CrossRef

Chattopadhyay, S., Saha, I., Dan, A., & Bhattacharyya, K. (2012). Clozapine responsive catatonia: A series of five cases. Industrial Psychiatry Journal, 21(1), 66.CrossRef

Collins, J., Halder, N., & Chaudhry, N. (2012). Use of ECT in patients with an intellectual disability: Review. The Psychiatrist, 36(2), 55–60.CrossRef

DeJong, H., Bunton, P., & Hare, D. J. (2014). A systematic review of interventions used to treat catatonic symptoms in people with autistic spectrum disorders. Journal of Autism and Developmental Disorders, 44(9), 2127–2136.CrossRef

Dhossche, D. M., Shah, A., & Wing, L. (2006). Blueprints for the assessment, treatment, and future study of catatonia in autism spectrum disorders. International Review of Neurobiology, 72, 267–284.CrossRef

Dhossche, D. M., & Stanfill, S. (2004). Could ECT be effective in autism? Med Hypotheses [internet], 63(3), 371–376.CrossRef

Ellul, P., Rotgé, J. Y., & Choucha, W. (2015). Resistant catatonia in a high-functioning autism spectrum disorder patient successfully treated with amantadine [Internet]. Journal of Child and Adolescent Psychopharmacology, 25(9), 726.CrossRef

England, M. L., Öngür, D., Konopaske, G. T., & Karmacharya, R. (2011). Catatonia in psychotic patients: Clinical features and treatment response. Journal of Neuropsychiatry and Clinical Neurosciences, 23(2), 223–226.CrossRef

Fink, M., Taylor, M. A., & Ghaziuddin, N. (2006). Catatonia in autistic spectrum disorders: A medical treatment algorithm. International Review of Neurobiology, 72, 233–244.CrossRef

Ghaziuddin, N., Dhossche, D., & Marcotte, K. (2012). Retrospective chart review of catatonia in child and adolescent psychiatric patients. Acta Psychiatrica Scand., 125(1), 33–38.CrossRef

Honigfeld, G., Arellano, F., Sethi, J., Bianchini, A., & Schein, J. (1998). Reducing clozapine-related morbidity and mortality: 5 years of experience with the Clozaril National Registry. Journal of Clinical Psychiatry, 59(SUPPL. 3), 3–7.PubMed

Horder, J., Petrinovic, M. M., Mendez, M. A., et al. (2018). Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models. Translational Psychiatry, 8(1), 106.CrossRef

Jann, M. W. (1991). Clozapine. Pharmacother J Hum Pharmacol Drug Ther, 11(3), 179–195.

Lamberti, J. (2006). Prevalence of the metabolic syndrome among patients receiving clozapine. American Journal of Psychiatry, 163(7), 1273.CrossRef

Marrosu, F., Marrosu, G., Rachel, M. G., & Biggio, G. (1987). Paradoxical reactions elicited by diazepam in children with classic autism. Functional Neurology, 2(3), 355–361.PubMed

Meltzer, H. Y. (2012). Clozapine: Balancing safety with superior antipsychotic efficacy. Clinical Schizophrenia & Related Psychoses, 6(3), 134–144.CrossRef

Pelzer, A. C. M., van der Heijden, F. M. M. A., & den Boer, E. (2018). Systematic review of catatonia treatment. Neuropsychiatric Disease and Treatment, 14, 317–326.CrossRef

Rosebush, P. I., & Mazurek, M. F. (2010). Catatonia and its treatment. Schizophrenia Bulletin, 36(2), 239–242.CrossRef

Sienaert, P., Dhossche, D. M., Vancampfort, D., De Hert, M., & Gazdag, G. (2014). A clinical review of the treatment of catatonia. Front Psychiatry. https://doi.org/10.3389/fpsyt.2014.00181/fullCrossRefPubMedPubMedCentral

Siskind, D., McCartney, L., Goldschlager, R., & Kisely, S. (2016). Clozapine v first- and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis. British Journal of Psychiatry, 209(5), 385–392.CrossRef

Wing, L., & Shah, A. (2000). Catatonia in autistic spectrum disorders. British Journal of Psychiatry, 176, 357–362.CrossRef

Wu, Y., Blichowski, M., Daskalakis, Z. J., et al. (2011). Evidence that clozapine directly interacts on the GABAB receptor. NeuroReport, 22(13), 637–641.CrossRef

Titel: Case Reports: Clozapine for the Treatment of Catatonia in Autism Spectrum Disorder
Auteurs: Robyn P. Thom
Christopher J. McDougle
Publicatiedatum: 20-07-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05149-8

Andere artikelen Uitgave 6/2022

Healthcare Services During the Transitions to Adulthood Among Individuals with ASD Aged 15–25 Years Old: Stakeholders’ Perspectives

Original Paper

Promoting Career Design in Youth and Young Adults with ASD: A Feasibility Study

Original Paper

Development, Feasibility, and Acceptability of a Nationally Relevant Parent Training to Improve Service Access During the Transition to Adulthood for Youth with ASD

Original Paper

Correction to: Concerns About ABA-Based Intervention: An Evaluation and Recommendations

Correction

Brief Report: The Influence of Autism Severity and Depression on Self-Determination Among Young Adults with Autism Spectrum Disorder

Brief Report

The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI)

Brief Report