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01-02-2014

Cannabis use and HIV antiretroviral therapy adherence and HIV-related symptoms

Auteurs: Marcel O. Bonn-Miller, Megan L. Oser, Meggan M. Bucossi, Jodie A. Trafton

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 1/2014

Abstract

Occasional cannabis use has been associated with increased antiretroviral therapy (ART) adherence and relief of HIV symptoms, while heavy use has been associated with low ART adherence and negative psychological symptoms. The purpose of the present study was to investigate differences between non-cannabis use (NC), non-dependent cannabis use (C), and dependent use (CD) in terms of ART adherence and HIV symptoms/ART side effects. A cross-sectional sample of 180 HIV+ individuals (78.3 % male) completed measures of substance use and psychopathology, medication adherence, and HIV symptoms/ART side effects. Adherence was also measured via pill count, viral load, and CD4 count. Results indicated that the CD group reported lower adherence and greater HIV symptoms/ART side effects than the other two groups, with no differences observed between NC and C groups. There is a clinical need to address dependent cannabis use among those prescribed ART. Further examination is needed to ascertain the functions of cannabis use among individuals with HIV.

volgende artikel The importance of affectively-laden beliefs about health risks: the case of tobacco use and sun protection

Diagnostic criteria for cannabis dependence were consistent with the definition set forth in the DSM-IV-TR (APA, 2000), with the addition of withdrawal, as proposed for DSM-5 (Budney et al., 2004).

Thirteen participants were excluded from analyses involving pill count adherence due to inability to calculate pill counts.

As absolute CD4 count and viral load have been associated with disease progression (Mellors et al., 1997; Viana et al., 2011), analyses were repeated with both absolute CD4 count and log viral load serving as additional covariates in the ANCOVA model. With these additional covariates, the significant effect for group in terms of HIV symptoms/medication side effects, remained [F(2,155) = 3.26, p = 0.041].

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Titel: Cannabis use and HIV antiretroviral therapy adherence and HIV-related symptoms
Auteurs: Marcel O. Bonn-Miller
Megan L. Oser
Meggan M. Bucossi
Jodie A. Trafton
Publicatiedatum: 01-02-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 1/2014
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-012-9458-5

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