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Gepubliceerd in: Journal of Behavioral Medicine 4/2014

01-08-2014

C-reactive protein is elevated in atypical but not nonatypical depression: data from the National Health and Nutrition Examination Survey (NHANES) 1999–2004

Auteurs: Ruth J. Hickman, Tasneem Khambaty, Jesse C. Stewart

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 4/2014

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Abstract

Little is known about the association of depression subtypes with inflammatory markers predictive of coronary artery disease. In a sample of younger adults representative of the U.S. population, we examined differences in serum C-reactive protein (CRP) among individuals with atypical major depressive disorder (MDD; n = 16), nonatypical MDD (n = 93), and no MDD (n = 1,682). Adults with atypical MDD exhibited higher CRP levels than those with no MDD (mean difference = 1.56 mg/L) or nonatypical MDD (mean difference = 1.40 mg/L), even after adjustment for potential cofounders, anxiety disorders, body mass, and smoking. Nearly twice as many adults with atypical MDD had CRP levels in the high cardiovascular risk range than did those with no MDD or nonatypical MDD. CRP levels of adults with nonatypical MDD or no MDD did not differ. Individuals with atypical depression may be partially driving the overall depression-inflammation relationship and may be a subgroup at elevated risk for coronary artery disease.
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Metagegevens
Titel
C-reactive protein is elevated in atypical but not nonatypical depression: data from the National Health and Nutrition Examination Survey (NHANES) 1999–2004
Auteurs
Ruth J. Hickman
Tasneem Khambaty
Jesse C. Stewart
Publicatiedatum
01-08-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 4/2014
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-013-9510-0

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