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Journal of Autism and Developmental Disorders

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02-11-2015 | Brief Report

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder

Auteurs: Sarah Marler, Bradley J. Ferguson, Evon Batey Lee, Brittany Peters, Kent C. Williams, Erin McDonnell, Eric A. Macklin, Pat Levitt, Catherine Hagan Gillespie, George M. Anderson, Kara Gross Margolis, David Q. Beversdorf, Jeremy Veenstra-VanderWeele

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2016

Abstract

Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD.

vorige artikel Brief Report: Fast Mapping Predicts Differences in Concurrent and Later Language Abilities Among Children with ASD

volgende artikel Erratum to: Autism Developmental Profiles and Cooperation with Oral Health Screening

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Titel: Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder
Auteurs: Sarah Marler
Bradley J. Ferguson
Evon Batey Lee
Brittany Peters
Kent C. Williams
Erin McDonnell
Eric A. Macklin
Pat Levitt
Catherine Hagan Gillespie
George M. Anderson
Kara Gross Margolis
David Q. Beversdorf
Jeremy Veenstra-VanderWeele
Publicatiedatum: 02-11-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2646-8

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