Skip to main content
Top
Gepubliceerd in:

19-06-2017 | Brief Report

Brief Report: The Negev Hospital-University-Based (HUB) Autism Database

Auteurs: Gal Meiri, Ilan Dinstein, Analya Michaelowski, Hagit Flusser, Michal Ilan, Michal Faroy, Asif Bar-Sinai, Liora Manelis, Dana Stolowicz, Lili Lea Yosef, Nadav Davidovitch, Hava Golan, Shosh Arbelle, Idan Menashe

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse population. The collected data includes social-demographic characteristics, standardized behavioral testing, detailed clinical history from electronic patient records, genetic samples, and various neurological measures. We describe the initial cohort characteristics following the first 18 months of data collection (188 children with autism). We believe that the Negev HUB autism database offers a unique and valuable resource for studying the heterogeneity of autism etiologies across different ethnic populations.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Arlington: American Psychiatric Publishing.CrossRef American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Arlington: American Psychiatric Publishing.CrossRef
go back to reference American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). Arlington: American Psychiatric Publishing.CrossRef American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). Arlington: American Psychiatric Publishing.CrossRef
go back to reference Amir, H., Weintraub, A., Aricha-Tamir, B., Apel-Sarid, L., Holcberg, G., & Sheiner, E. (2009). A piece in the puzzle of intrauterine fetal death: Pathological findings in placentas from term and preterm intrauterine fetal death pregnancies. The Journal of Maternal-Fetal and Neonatal Medicine: The official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet, 22, 759–764. doi:10.3109/14767050902929396.CrossRef Amir, H., Weintraub, A., Aricha-Tamir, B., Apel-Sarid, L., Holcberg, G., & Sheiner, E. (2009). A piece in the puzzle of intrauterine fetal death: Pathological findings in placentas from term and preterm intrauterine fetal death pregnancies. The Journal of Maternal-Fetal and Neonatal Medicine: The official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet, 22, 759–764. doi:10.​3109/​1476705090292939​6.CrossRef
go back to reference Bilenko, N., Fraser D., Vardy H., & Belmaker I. (2014). Impact of multiple micronutrient supplementation (“sprinkles”) on iron deficiency anemia in Bedouin Arab and Jewish infants. The Israel Medical Association Journal: IMAJ 16, 434–438.PubMed Bilenko, N., Fraser D., Vardy H., & Belmaker I. (2014). Impact of multiple micronutrient supplementation (“sprinkles”) on iron deficiency anemia in Bedouin Arab and Jewish infants. The Israel Medical Association Journal: IMAJ 16, 434–438.PubMed
go back to reference Buxbaum, J. D., et al. (2014). The autism simplex collection: An international, expertly phenotyped autism sample for genetic and phenotypic analyses. Molecular Autism: The International Journal of Research and Practice, 5, 34. doi:10.1186/2040-2392-5-34.CrossRef Buxbaum, J. D., et al. (2014). The autism simplex collection: An international, expertly phenotyped autism sample for genetic and phenotypic analyses. Molecular Autism: The International Journal of Research and Practice, 5, 34. doi:10.​1186/​2040-2392-5-34.CrossRef
go back to reference CDC. (2014). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries 63(Suppl 2), 1–21. CDC. (2014). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries 63(Suppl 2), 1–21.
go back to reference Dinstein, I., Haar, S., Atsmon, S., & Schtaerman, H. (2017). No evidence of early head circumference enlargements in children later diagnosed with autism in Israel. Molecular Autism: The International Journal of Research and Practice, 8, 15. doi:10.1186/s13229-017-0129-9.CrossRef Dinstein, I., Haar, S., Atsmon, S., & Schtaerman, H. (2017). No evidence of early head circumference enlargements in children later diagnosed with autism in Israel. Molecular Autism: The International Journal of Research and Practice, 8, 15. doi:10.​1186/​s13229-017-0129-9.CrossRef
go back to reference Dunn, W., & Westman, K. (1997). The Sensory Profile: The performance of a national sample of children without disabilities. American Journal of Occupational Therapy, 51, 25–34.CrossRefPubMed Dunn, W., & Westman, K. (1997). The Sensory Profile: The performance of a national sample of children without disabilities. American Journal of Occupational Therapy, 51, 25–34.CrossRefPubMed
go back to reference Gabis, L. V., & Pomeroy J. (2014). An etiologic classification of autism spectrum disorders. The Israel Medical Association Journal: IMAJ 16, 295–298.PubMed Gabis, L. V., & Pomeroy J. (2014). An etiologic classification of autism spectrum disorders. The Israel Medical Association Journal: IMAJ 16, 295–298.PubMed
go back to reference Georgiades, S., et al. (2012). Investigating phenotypic heterogeneity in children with autism spectrum disorder: A factor mixture modeling approach. Journal of Child Psychology and Psychiatry, and Allied Disciplines. doi:10.1111/j.1469-7610.2012.02588.x. Georgiades, S., et al. (2012). Investigating phenotypic heterogeneity in children with autism spectrum disorder: A factor mixture modeling approach. Journal of Child Psychology and Psychiatry, and Allied Disciplines. doi:10.​1111/​j.​1469-7610.​2012.​02588.​x.
go back to reference Harel, T., Goldberg, Y., Shalev, S. A., Chervinski, I., Ofir, R., & Birk, O. S. (2004). Limb-girdle muscular dystrophy 2I: Phenotypic variability within a large consanguineous Bedouin family associated with a novel FKRP mutation. European Journal of Human Genetics: EJHG, 12, 38–43. doi:10.1038/sj.ejhg.5201087.CrossRefPubMed Harel, T., Goldberg, Y., Shalev, S. A., Chervinski, I., Ofir, R., & Birk, O. S. (2004). Limb-girdle muscular dystrophy 2I: Phenotypic variability within a large consanguineous Bedouin family associated with a novel FKRP mutation. European Journal of Human Genetics: EJHG, 12, 38–43. doi:10.​1038/​sj.​ejhg.​5201087.CrossRefPubMed
go back to reference Israel, T.C.B.o.S.o. (2006–2016). Live birth statistics. Statistical abstract of Israel. Israel, T.C.B.o.S.o. (2006–2016). Live birth statistics. Statistical abstract of Israel.
go back to reference Israel, T.C.B.o.S.o. (2016). Total population. Statistical abstract of Israel. Israel, T.C.B.o.S.o. (2016). Total population. Statistical abstract of Israel.
go back to reference Kessous, R., Shoham-Vardi, I., Pariente, G., Holcberg, G., & Sheiner, E. (2013a). An association between preterm delivery and long-term maternal cardiovascular morbidity. American Journal of Obstetrics and Gynecology, 209(368), e1–e8. doi:10.1016/j.ajog.2013.05.041. Kessous, R., Shoham-Vardi, I., Pariente, G., Holcberg, G., & Sheiner, E. (2013a). An association between preterm delivery and long-term maternal cardiovascular morbidity. American Journal of Obstetrics and Gynecology, 209(368), e1–e8. doi:10.​1016/​j.​ajog.​2013.​05.​041.
go back to reference Kim, S. H., Macari, S., Koller, J., & Chawarska, K. (2015). Examining the phenotypic heterogeneity of early autism spectrum disorder: Subtypes and short-term outcomes. Journal of Child Psychology and Psychiatry, and Allied Disciplines. doi:10.1111/jcpp.12448. Kim, S. H., Macari, S., Koller, J., & Chawarska, K. (2015). Examining the phenotypic heterogeneity of early autism spectrum disorder: Subtypes and short-term outcomes. Journal of Child Psychology and Psychiatry, and Allied Disciplines. doi:10.​1111/​jcpp.​12448.
go back to reference Kridin, K., Zelber-Sagi, S., Khamaisi, M., Cohen, A. D., & Bergman, R. (2016). Remarkable differences in the epidemiology of pemphigus among two ethnic populations in the same geographic region. Journal of the American Academy of Dermatology. doi:10.1016/j.jaad.2016.06.055.PubMed Kridin, K., Zelber-Sagi, S., Khamaisi, M., Cohen, A. D., & Bergman, R. (2016). Remarkable differences in the epidemiology of pemphigus among two ethnic populations in the same geographic region. Journal of the American Academy of Dermatology. doi:10.​1016/​j.​jaad.​2016.​06.​055.PubMed
go back to reference Landau, D., Mishori-Dery, A., Hershkovitz, R., Narkis, G., Elbedour, K., & Carmi, R. (2003). A new autosomal recessive congenital contractural syndrome in an Israeli Bedouin kindred. American Journal of Medical Genetics Part A, 117 A, 37–40. doi:10.1002/ajmg.a.10894.CrossRef Landau, D., Mishori-Dery, A., Hershkovitz, R., Narkis, G., Elbedour, K., & Carmi, R. (2003). A new autosomal recessive congenital contractural syndrome in an Israeli Bedouin kindred. American Journal of Medical Genetics Part A, 117 A, 37–40. doi:10.​1002/​ajmg.​a.​10894.CrossRef
go back to reference Lane, A. E., Molloy, C. A., & Bishop, S. L. (2014). Classification of children with autism spectrum disorder by sensory subtype: A case for sensory-based phenotypes. Autism Research. doi:10.1002/aur.1368.PubMed Lane, A. E., Molloy, C. A., & Bishop, S. L. (2014). Classification of children with autism spectrum disorder by sensory subtype: A case for sensory-based phenotypes. Autism Research. doi:10.​1002/​aur.​1368.PubMed
go back to reference Lazarev, I., Flaschner, M., Geffen, D. B., & Ariad, S. (2014). Breast cancer in Bedouin-Arab patients in southern Israel: Epidemiologic and biologic features in comparison with Jewish patients. Asian Pacific Journal of Cancer Prevention: APJCP 15, 7533–7537.CrossRefPubMed Lazarev, I., Flaschner, M., Geffen, D. B., & Ariad, S. (2014). Breast cancer in Bedouin-Arab patients in southern Israel: Epidemiologic and biologic features in comparison with Jewish patients. Asian Pacific Journal of Cancer Prevention: APJCP 15, 7533–7537.CrossRefPubMed
go back to reference Lebel, D. E., Sergienko, R., Wiznitzer, A., Velan, G. J., & Sheiner, E. (2012). Mode of delivery and other pregnancy outcomes of patients with documented scoliosis. The journal of Maternal-Fetal and Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet, 25, 639–641. doi:10.3109/14767058.2011.598587.CrossRef Lebel, D. E., Sergienko, R., Wiznitzer, A., Velan, G. J., & Sheiner, E. (2012). Mode of delivery and other pregnancy outcomes of patients with documented scoliosis. The journal of Maternal-Fetal and Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet, 25, 639–641. doi:10.​3109/​14767058.​2011.​598587.CrossRef
go back to reference Leshem, E., Givon-Lavi, N., Vinje, J., Gregoricus, N., Parashar, U., & Dagan, R. (2015). Differences in norovirus-associated hospital visits between Jewish and Bedouin children in Southern Israel. The Pediatric Infectious Disease Journal, 34, 1036–1038. doi:10.1097/inf.0000000000000786.CrossRefPubMed Leshem, E., Givon-Lavi, N., Vinje, J., Gregoricus, N., Parashar, U., & Dagan, R. (2015). Differences in norovirus-associated hospital visits between Jewish and Bedouin children in Southern Israel. The Pediatric Infectious Disease Journal, 34, 1036–1038. doi:10.​1097/​inf.​0000000000000786​.CrossRefPubMed
go back to reference Lord, C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.CrossRefPubMed Lord, C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.CrossRefPubMed
go back to reference Ministry of Justice, I. (1981). Protection of Privacy Law, 5741. Ministry of Justice, I. (1981). Protection of Privacy Law, 5741.
go back to reference Owens, J. A., Spirito, A., & McGuinn, M. (2000). The Children’s Sleep Habits Questionnaire (CSHQ): Psychometric properties of a survey instrument for school-aged children. Sleep, 23, 1043–1051.CrossRefPubMed Owens, J. A., Spirito, A., & McGuinn, M. (2000). The Children’s Sleep Habits Questionnaire (CSHQ): Psychometric properties of a survey instrument for school-aged children. Sleep, 23, 1043–1051.CrossRefPubMed
go back to reference Pariente, G., Sheiner, E., Kessous, R., Michael, S., & Shoham-Vardi, I. (2013). Association between delivery of a small-for-gestational-age neonate and long-term maternal cardiovascular morbidity. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics, 123, 68–71. doi:10.1016/j.ijgo.2013.06.008.CrossRef Pariente, G., Sheiner, E., Kessous, R., Michael, S., & Shoham-Vardi, I. (2013). Association between delivery of a small-for-gestational-age neonate and long-term maternal cardiovascular morbidity. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics, 123, 68–71. doi:10.​1016/​j.​ijgo.​2013.​06.​008.CrossRef
go back to reference Ramsey, J. M., et al. (2013). Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders. Molecular Autism: The International Journal of Research and Practice, 4, 27. doi:10.1186/2040-2392-4-27.CrossRef Ramsey, J. M., et al. (2013). Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders. Molecular Autism: The International Journal of Research and Practice, 4, 27. doi:10.​1186/​2040-2392-4-27.CrossRef
go back to reference Raz, R., Weisskopf, M. G., Davidovitch, M., Pinto, O., & Levine, H. (2014). Differences in autism spectrum disorders incidence by sub-populations in Israel 1992–2009: A total population study. Journal of Autism and Developmental Disorders. doi:10.1007/s10803-014-2262-z. Raz, R., Weisskopf, M. G., Davidovitch, M., Pinto, O., & Levine, H. (2014). Differences in autism spectrum disorders incidence by sub-populations in Israel 1992–2009: A total population study. Journal of Autism and Developmental Disorders. doi:10.​1007/​s10803-014-2262-z.
go back to reference Shatzky, S., et al. (2000). Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: Genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. American Journal of Medical Genetics, 92, 353–360.CrossRefPubMed Shatzky, S., et al. (2000). Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: Genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. American Journal of Medical Genetics, 92, 353–360.CrossRefPubMed
go back to reference Shimony, A., Afawi, Z., Asher, T., Mahajnah, M., & Shorer, Z. (2009). Epidemiological characteristics of febrile seizures–comparing between Bedouin and Jews in the southern part of Israel. Seizure: The Journal of the British Epilepsy Association, 18, 26–29. doi:10.1016/j.seizure.2008.05.011.CrossRef Shimony, A., Afawi, Z., Asher, T., Mahajnah, M., & Shorer, Z. (2009). Epidemiological characteristics of febrile seizures–comparing between Bedouin and Jews in the southern part of Israel. Seizure: The Journal of the British Epilepsy Association, 18, 26–29. doi:10.​1016/​j.​seizure.​2008.​05.​011.CrossRef
go back to reference Volkmar, F. R., Reichow, B., & McPartland, J. (2012). Classification of autism and related conditions: Progress, challenges, and opportunities. Dialogues in Clinical Neuroscience, 14, 229–237.PubMedPubMedCentral Volkmar, F. R., Reichow, B., & McPartland, J. (2012). Classification of autism and related conditions: Progress, challenges, and opportunities. Dialogues in Clinical Neuroscience, 14, 229–237.PubMedPubMedCentral
go back to reference Wechsler, D. (1989). Wechsler preschool and primary scale of intelligence—revised. San Antonio, TX: The Psychological Corporation. Wechsler, D. (1989). Wechsler preschool and primary scale of intelligence—revised. San Antonio, TX: The Psychological Corporation.
Metagegevens
Titel
Brief Report: The Negev Hospital-University-Based (HUB) Autism Database
Auteurs
Gal Meiri
Ilan Dinstein
Analya Michaelowski
Hagit Flusser
Michal Ilan
Michal Faroy
Asif Bar-Sinai
Liora Manelis
Dana Stolowicz
Lili Lea Yosef
Nadav Davidovitch
Hava Golan
Shosh Arbelle
Idan Menashe
Publicatiedatum
19-06-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3207-0