Swipe om te navigeren naar een ander artikel
We studied the association between specific congenital syndromes and autism spectrum disorders (ASD) in the large Finnish Register material. Our data include all children diagnosed with ASD (n = 4441) according to Finnish Hospital Discharge Register in 1987–2000. Four controls per each case were matched to sex, birthplace, date of birth (±30 days) and residence in Finland (n = 17,695). The prevalence of specific congenital syndromes in the Finnish Register of Congenital Malformations was evaluated among the ASD group and the controls by sex. The results of this study suggest that there is an association between several etiologically different syndromes and ASD when compared to controls without ASD. Statistically significant associations were observed with 47,XYY, Sotos syndrome, neurofibromatosis I, and syndrome not otherwise specified. Syndromes were more common among males with ASD compared to controls. These results support the previous studies of etiological heterogeneity of ASD and have importance in clinical examination, management and rehabilitation.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Bhanumathi, B., Chetna, V. B., & Neelan, A. G. (2009). Genetic studies in children with intellectual disability and autistic spectrum of disorders. Indian Journal of Human Genetics,15(3), 103–107. CrossRef
EUROCAT—European surveillance of congenital anomalies. Collaboration Centre for the surveillance of Congenital anomalies. www.eurocat-network.eu.
Lampi, K., Sourander, A., & Gissler, M. (2010). Brief report: Validity of Finnish Registry based diagnoses of autism with the ADI-R. Acta Pediatrics,99(9), 1425–1428. CrossRef
MMWR surveillance. (2014). Prevalence of autism spectrum disorders among children aged 8 years-autism and developmental disabilities monitoring network 11 sites, USA 2010. Centre for Disease Control and Prevention (CDC),63(2), 1–21.
Nanson, J. (1992). Autism in fetal alcohol syndrome: A report of six cases. Alcohol Clinical Experimental Research,16, 558–565. CrossRef
Niklasson, L., Rasmussen, P., Oskardottir, S., & Gillberg, C. (2009). Autism, ADHD, mental retardation and behavioral problems in 100 individuals with 22q11 deletion syndrome. Research of Developmental Disabilities,30(4), 763–773. CrossRef
OMIM—Online Mendelian Inheritance in Man. www.omim.org.
Sheth, K., Moss, J., Hyland, S., Stinton, C., Cole, T., & Oliver, C. (2015). The behavioral characteristics of Sotos syndrome. American Journal of Medical Genetics Part A,167(12), 2945–2956. CrossRef
World Health Organization (WHO). (1977). International Classification of Diseases, Ninth Revision (ICD-9). Geneva, Switzerland.
- Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort
- Springer US