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01-03-2013 | Brief Report | Uitgave 3/2013

Journal of Autism and Developmental Disorders 3/2013

Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials

Tijdschrift:
Journal of Autism and Developmental Disorders > Uitgave 3/2013
Auteurs:
Lawrence Scahill, Victoria Hallett, Michael G. Aman, Christopher J. McDougle, L. Eugene Arnold, James T. McCracken, Elaine Tierney, Yanhong Deng, James Dziura, Benedetto Vitiello, the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network)
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Electronic supplementary material

The online version of this article (doi:10.​1007/​s10803-012-1689-3) contains supplementary material, which is available to authorized users.
Disclaimer: The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government.

Abstract

There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials.

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Supplementary material 1 (DOCX 29 kb)
10803_2012_1689_MOESM1_ESM.docx
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