Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-05-2013 | Brief Report

Brief Report: Retrospective Case Series of Oxcarbazepine for Irritability/Agitation Symptoms in Autism Spectrum Disorder

Auteurs: Jessica F. Douglas, Kevin B. Sanders, M. Hannah Benneyworth, Jessica L. Smith, Virginia M. DeJean, Susan G. McGrew, Jeremy Veenstra-VanderWeele

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2013

Abstract

We examined response to oxcarbazepine prescribed for irritability/agitation symptoms in a retrospective case series of 30 patients with Autism Spectrum Disorder (ASD). The average patient was 12.0 years old (range 5–21) and taking two other psychotropic medications (range 0–4). Fourteen patients (47 %) had a clinical global impression of improvement score of ‘much improved’ during treatment. Ten patients (33 %) showed an improvement on their clinical global impression of severity score. Seven patients (23 %) had a clinically significant adverse event or side effect leading to oxcarbazepine discontinuation. Without a placebo group, it is not possible to evaluate whether oxcarbazepine provides benefit for irritability/agitation symptoms in ASD. The high rate of adverse events suggests its use should be accompanied by caution.

vorige artikel Brief Report: Comparability of DSM-IV and DSM-5 ASD Research Samples

volgende artikel Yale University Offering an ONLINE COURSE: Autism and Related Disorders

Aman, M. G., Lam, K. S., & Collier-Crespin, A. (2003). Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of Ohio. Journal of Autism and Developmental Disorders, 33(5), 527–534.PubMedCrossRef

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders-text revision (DSM-IV-TR) (4th ed.). Washington, D.C.: American Psychiatric Association Press, Inc.

Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators; Centers for Disease Control and Prevention. (2007). Prevalence of autism spectrum disorders–autism and developmental disabilities monitoring network, 14 sites, United States, 2002. MMWR Surveillance Summaries, 56(1), 12–28.

Barry, J. J., Lembke, A., & Bullock, K. D. (2004). Current status of the utilization of antiepileptic treatments in mood, anxiety and aggression: Drugs and devices. Clinical EEG and Neuroscience, 35(1), 4–13.PubMed

Belsito, K., Law, P., Kirk, K., Landa, R., & Zimmerman, A. (2001). Lamotrigine therapy for autistic disorder: A randomized, double-blind, placebo-controlled trial. Journal of Autism and Developmental Disorders, 31(2), 175–181.PubMedCrossRef

Cueva, J. E., Overall, J. E., Small, A. M., Armenteros, J. L., Perry, R., & Campbell, M. (1996). Carbamazepine in aggressive children with conduct disorder: A double-blind and placebo-controlled study. Journal of the American Academy of Child and Adolescent Psychiatry, 35(4), 480–490. doi:10.1097/00004583-199604000-00014.PubMedCrossRef

Danielsson, S., Gillberg, I. C., Billstedt, E., Gillberg, C., & Olsson, I. (2005). Epilepsy in young adults with autism: A prospective population-based follow-up study of 120 individuals diagnosed in childhood. Epilepsia, 46(6), 918–923. doi:10.1111/j.1528-1167.2005.57504.x.PubMedCrossRef

Di Martino, A., & Tuchman, R. F. (2001). Antiepileptic drugs: Affective use in autism spectrum disorders. Pediatric Neurology, 25(3), 199–207.PubMedCrossRef

Gayatri, N. A., & Livingston, J. H. (2006). Aggravation of epilepsy by anti-epileptic drugs. Developmental Medicine and Child Neurology, 48(5), 394–398. doi:10.1017/S0012162206000843.PubMedCrossRef

Gjevik, E., Eldevik, S., Fjaeran-Granum, T., & Sponheim, E. (2011). Kiddie-SADS reveals high rates of DSM-IV disorders in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 41(6), 761–769. doi:10.1007/s10803-010-1095-7.PubMedCrossRef

Grunze, H. C. (2008). The effectiveness of anticonvulsants in psychiatric disorders. Dialogues in Clinical Neuroscience, 10(1), 77–89.PubMed

Guy, W. (1976). ECDEU assessment manual for psychopharmacology. Rockville, MD: United States Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs.

Hirschfeld, R. M., & Kasper, S. (2004). A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder. International Journal of Neuropsychopharmacology, 7(4), 507–522. doi:10.1017/S1461145704004651.PubMedCrossRef

Hollander, E., Chaplin, W., Soorya, L., Wasserman, S., Novotny, S., Rusoff, J., et al. (2010). Divalproex sodium vs placebo for the treatment of irritability in children and adolescents with autism spectrum disorders. Neuropsychopharmacology, 35(4), 990–998. doi:10.1038/npp.2009.202.PubMedCrossRef

Joshi, G., Petty, C., Wozniak, J., Henin, A., Fried, R., Galdo, M., et al. (2010). The heavy burden of psychiatric comorbidity in youth with autism spectrum disorders: A large comparative study of a psychiatrically referred population. Journal of Autism and Developmental Disorders, 40(11), 1361–1370. doi:10.1007/s10803-010-0996-9.PubMedCrossRef

Kakkar, A. K., Rehan, H. S., Unni, K. E., Gupta, N. K., Chopra, D., & Kataria, D. (2009). Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: A pilot study. European Psychiatry, 24(3), 178–182. doi:10.1016/j.eurpsy.2008.12.014.PubMedCrossRef

Kapetanovic, S. (2007). Oxcarbazepine in youths with autistic disorder and significant disruptive behaviors. American Journal of Psychiatry, 164(5), 832–833. doi:10.1176/appi.ajp.164.5.832.PubMedCrossRef

Langworthy-Lam, K. S., Aman, M. G., & Van Bourgondien, M. E. (2002). Prevalence and patterns of use of psychoactive medicines in individuals with autism in the Autism Society of North Carolina. Journal of Child and Adolescent Psychopharmacology, 12(4), 311–321. doi:10.1089/104454602762599853.PubMedCrossRef

Levy, S. E., Giarelli, E., Lee, L. C., Schieve, L. A., Kirby, R. S., Cunniff, C., et al. (2010). Autism spectrum disorder and co-occurring developmental, psychiatric, and medical conditions among children in multiple populations of the United States. Journal of Developmental and Behavioral Pediatrics, 31(4), 267–275. doi:10.1097/DBP.0b013e3181d5d03b.PubMedCrossRef

Lopez-Larson, M., & Frazier, J. A. (2006). Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disorders. Harvard Review of Psychiatry, 14(6), 285–304. doi:10.1080/10673220601082869.PubMedCrossRef

Mandell, D. S. (2008). Psychiatric hospitalization among children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 38(6), 1059–1065. doi:10.1007/s10803-007-0481-2.PubMedCrossRef

Marcus, R. N., Owen, R., Kamen, L., Manos, G., McQuade, R. D., Carson, W. H., et al. (2009). A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 48(11), 1110–1119. doi:10.1097/CHI.0b013e3181b76658.PubMedCrossRef

Matson, J. L., & Nebel-Schwalm, M. S. (2007). Comorbid psychopathology with autism spectrum disorder in children: An overview. Research in Developmental Disabilities, 28(4), 341–352. doi:10.1016/j.ridd.2005.12.004.PubMedCrossRef

McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., et al. (2002). Risperidone in children with autism and serious behavioral problems. New England Journal of Medicine, 347(5), 314–321.PubMedCrossRef

McPheeters, M. L., Warren, Z., Sathe, N., Bruzek, J. L., Krishnaswami, S., Jerome, R. N., et al. (2011). A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics, 127(5), e1312–e1321. doi:10.1542/peds.2011-0427.PubMedCrossRef

Monji, A., Maekawa, T., Yanagimoto, K., Yoshida, I., & Hashioka, S. (2004). Carbamazepine may trigger new-onset epileptic seizures in an individual with autism spectrum disorders: A case report. European Psychiatry, 19(5), 322–323. doi:10.1016/j.eurpsy.2004.06.001.PubMedCrossRef

Oswald, D. P., & Sonenklar, N. A. (2007). Medication use among children with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 17(3), 348–355. doi:10.1089/cap.2006.17303.PubMedCrossRef

Owen, R., Sikich, L., Marcus, R. N., Corey-Lisle, P., Manos, G., McQuade, R. D., et al. (2009). Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder. Pediatrics, 124(6), 1533–1540. doi:10.1542/peds.2008-3782.PubMedCrossRef

Parikh, M. S., Kolevzon, A., & Hollander, E. (2008). Psychopharmacology of aggression in children and adolescents with autism: A critical review of efficacy and tolerability. Journal of Child and Adolescent Psychopharmacology, 18(2), 157–178. doi:10.1089/cap.2007.0041.PubMedCrossRef

Pedrini, M., Noguera, A., Vinent, J., Torra, M., & Jimenez, R. (2009). Acute oxcarbazepine overdose in an autistic boy. British Journal of Clinical Pharmacology, 67(5), 579–581. doi:10.1111/j.1365-2125.2009.03398.x.PubMedCrossRef

Shea, S., Turgay, A., Carroll, A., Schulz, M., Orlik, H., Smith, I., et al. (2004). Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders. Pediatrics, 114(5), e634–e641. doi:10.1542/peds.2003-0264-F.PubMedCrossRef

Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929. doi:10.1097/CHI.0b013e318179964f.PubMedCrossRef

Stigler, K. A., & McDougle, C. J. (2008). Pharmacotherapy of irritability in pervasive developmental disorders. Child and Adolescent Psychiatric Clinics of North America, 17(4), 739–752, vii–viii. doi:10.1016/j.chc.2008.06.002.

Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. Lancet Neurology, 1(6), 352–358.PubMedCrossRef

Vasudev, A., Macritchie, K., Watson, S., Geddes, J. R., & Young, A. H. (2008). Oxcarbazepine in the maintenance treatment of bipolar disorder. Cochrane Database of Systematic Reviews (1), CD005171. doi:10.1002/14651858.CD005171.pub2.

Wagner, K. D., Kowatch, R. A., Emslie, G. J., Findling, R. L., Wilens, T. E., McCague, K., et al. (2006). A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents. American Journal of Psychiatry, 163(7), 1179–1186. doi:10.1176/appi.ajp.163.7.1179.PubMedCrossRef

Yildiz, A., Vieta, E., Leucht, S., & Baldessarini, R. J. (2011). Efficacy of antimanic treatments: Meta-analysis of randomized, controlled trials. Neuropsychopharmacology, 36(2), 375–389. doi:10.1038/npp.2010.192.PubMedCrossRef

Titel: Brief Report: Retrospective Case Series of Oxcarbazepine for Irritability/Agitation Symptoms in Autism Spectrum Disorder
Auteurs: Jessica F. Douglas
Kevin B. Sanders
M. Hannah Benneyworth
Jessica L. Smith
Virginia M. DeJean
Susan G. McGrew
Jeremy Veenstra-VanderWeele
Publicatiedatum: 01-05-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1661-2

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 5/2013

Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic Study

A Comparison of Social Cognitive Profiles in children with Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder: A Matter of Quantitative but not Qualitative Difference?

From Action to Interaction: Exploring the Contribution of Body Motion Cues to Social Understanding in Typical Development and in Autism Spectrum Disorders

Sex Differences in the Timing of Identification Among Children and Adults with Autism Spectrum Disorders

Theory of Mind, Socio-Emotional Problem-Solving, Socio-Emotional Regulation in Children with Intellectual Disability and in Typically Developing Children

Social Anxiety Predicts Aggression in Children with ASD: Clinical Comparisons with Socially Anxious and Oppositional Youth