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01-07-2012 | Brief Report

Brief Report: Platelet-Poor Plasma Serotonin in Autism

Auteurs: George M. Anderson, Margaret E. Hertzig, P. A. McBride

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2012

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Abstract

Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT.
Literatuur
go back to reference Anderson, G. M., Cook, E. H., Jr, & Blakely, R. D. (2009). Serotonin rising. New England Journal of Medicine, 360, 2580.PubMedCrossRef Anderson, G. M., Cook, E. H., Jr, & Blakely, R. D. (2009). Serotonin rising. New England Journal of Medicine, 360, 2580.PubMedCrossRef
go back to reference Anderson, G. M., Feibel, F. C., & Cohen, D. J. (1987a). Determination of serotonin in whole blood, PRP, PPP and plasma ultrafiltrate. Life Sciences, 40, 1063–1070.PubMedCrossRef Anderson, G. M., Feibel, F. C., & Cohen, D. J. (1987a). Determination of serotonin in whole blood, PRP, PPP and plasma ultrafiltrate. Life Sciences, 40, 1063–1070.PubMedCrossRef
go back to reference Anderson, G. M., Gutknecht, L., Cohen, D. J., Brailly-Tabard, S., Cohen, J. H., Ferrari, P., et al. (2002). Serotonin transporter promoter variants in autism: Functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry, 7, 831–836.PubMedCrossRef Anderson, G. M., Gutknecht, L., Cohen, D. J., Brailly-Tabard, S., Cohen, J. H., Ferrari, P., et al. (2002). Serotonin transporter promoter variants in autism: Functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry, 7, 831–836.PubMedCrossRef
go back to reference Anderson, G. M., Minderaa, R. B., Cho, S. C., Volkmar, F. R., & Cohen, D. J. (1989). The issue of hyperserotonemia and platelet serotonin exposure: A preliminary study. Journal of Autism and Developmental Disorders, 19, 349–351.PubMedCrossRef Anderson, G. M., Minderaa, R. B., Cho, S. C., Volkmar, F. R., & Cohen, D. J. (1989). The issue of hyperserotonemia and platelet serotonin exposure: A preliminary study. Journal of Autism and Developmental Disorders, 19, 349–351.PubMedCrossRef
go back to reference Anderson, G. M., Stevenson, J. M., & Cohen, D. J. (1987b). Steady-state model for plasma free and platelet serotonin in man. Life Sciences, 41, 1777–1785.PubMedCrossRef Anderson, G. M., Stevenson, J. M., & Cohen, D. J. (1987b). Steady-state model for plasma free and platelet serotonin in man. Life Sciences, 41, 1777–1785.PubMedCrossRef
go back to reference Beck, O., Wallen, N. H., Broijersen, A., Larsson, P. T., & Hjemdahl, P. (1993). On the accurate determination of serotonin in human plasma. Biochemical Biophysical Research Communications, 196, 260–266.CrossRef Beck, O., Wallen, N. H., Broijersen, A., Larsson, P. T., & Hjemdahl, P. (1993). On the accurate determination of serotonin in human plasma. Biochemical Biophysical Research Communications, 196, 260–266.CrossRef
go back to reference Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., et al. (2011). A transient placental source of serotonin for the fetal forebrain. Nature, 472, 347–350.PubMedCrossRef Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., et al. (2011). A transient placental source of serotonin for the fetal forebrain. Nature, 472, 347–350.PubMedCrossRef
go back to reference Brand, T., & Anderson, G. M. (2011). The measurement of platelet-poor plasma serotonin: A systematic review of prior reports and recommendations for improved analysis. Clinical Chemistry, 57, 1376–1386.PubMedCrossRef Brand, T., & Anderson, G. M. (2011). The measurement of platelet-poor plasma serotonin: A systematic review of prior reports and recommendations for improved analysis. Clinical Chemistry, 57, 1376–1386.PubMedCrossRef
go back to reference Bursztejn, C., Ferrari, P., Dreux, C., Braconnier, A., & Lancrenon, S. (1988). Metabolism of serotonin in autism in children. Encephale, 14, 413–419.PubMed Bursztejn, C., Ferrari, P., Dreux, C., Braconnier, A., & Lancrenon, S. (1988). Metabolism of serotonin in autism in children. Encephale, 14, 413–419.PubMed
go back to reference Buznikov, G. A., Lambert, H. W., & Lauder, J. M. (2001). Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Research, 305, 177–186.PubMedCrossRef Buznikov, G. A., Lambert, H. W., & Lauder, J. M. (2001). Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Research, 305, 177–186.PubMedCrossRef
go back to reference Carneiro, A. M., Cook, E. H., Murphy, D. L., & Blakely, R. D. (2008). Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Journal of Clinical Investigation, 118, 1544–1552.PubMedCrossRef Carneiro, A. M., Cook, E. H., Murphy, D. L., & Blakely, R. D. (2008). Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Journal of Clinical Investigation, 118, 1544–1552.PubMedCrossRef
go back to reference Chugani, D. C., Muzik, O., Behen, M., Rothermel, R., Janisse, J. J., Lee, J., et al. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology, 45, 287–295.PubMedCrossRef Chugani, D. C., Muzik, O., Behen, M., Rothermel, R., Janisse, J. J., Lee, J., et al. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology, 45, 287–295.PubMedCrossRef
go back to reference Connors, S. L., Matteson, K. J., Sega, G. A., Lozzio, C. B., Carroll, R. C., & Zimmerman, A. W. (2006). Plasma serotonin in autism. Pediatric Neurology, 35, 182–186.PubMedCrossRef Connors, S. L., Matteson, K. J., Sega, G. A., Lozzio, C. B., Carroll, R. C., & Zimmerman, A. W. (2006). Plasma serotonin in autism. Pediatric Neurology, 35, 182–186.PubMedCrossRef
go back to reference Cook, E., & Leventhal, B. (1996). The serotonin system in autism. Current Opinion in Pediatrics, 8, 348–354.PubMedCrossRef Cook, E., & Leventhal, B. (1996). The serotonin system in autism. Current Opinion in Pediatrics, 8, 348–354.PubMedCrossRef
go back to reference Cook, E. H., Jr, Leventhal, B. L., & Freedman, D. X. (1988). Free serotonin in plasma: Autistic children and their first-degree relatives. Biological Psychiatry, 24, 488–491.PubMedCrossRef Cook, E. H., Jr, Leventhal, B. L., & Freedman, D. X. (1988). Free serotonin in plasma: Autistic children and their first-degree relatives. Biological Psychiatry, 24, 488–491.PubMedCrossRef
go back to reference Coutinho, A. M., Sousa, I., Martins, M., Correia, C., Morgadinho, T., Bento, C., et al. (2008). Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human Genetics, 121, 243–256.CrossRef Coutinho, A. M., Sousa, I., Martins, M., Correia, C., Morgadinho, T., Bento, C., et al. (2008). Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human Genetics, 121, 243–256.CrossRef
go back to reference Croonenberghs, J., Delmeire, L., Verkerk, R., Lin, A. H., Meskal, A., Neels, H., et al. (2000). Peripheral markers of serotonergic and noradrenergic function in post-pubertal caucasian males with autistic disorder. Neuropsychopharmacology, 22, 275–283.PubMedCrossRef Croonenberghs, J., Delmeire, L., Verkerk, R., Lin, A. H., Meskal, A., Neels, H., et al. (2000). Peripheral markers of serotonergic and noradrenergic function in post-pubertal caucasian males with autistic disorder. Neuropsychopharmacology, 22, 275–283.PubMedCrossRef
go back to reference Cross, S., Kim, S. J., Weiss, L. A., Delahanty, R. J., Sutcliffe, J. S., Leventhal, B. L., et al. (2008). Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology, 33, 353–360.PubMedCrossRef Cross, S., Kim, S. J., Weiss, L. A., Delahanty, R. J., Sutcliffe, J. S., Leventhal, B. L., et al. (2008). Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology, 33, 353–360.PubMedCrossRef
go back to reference Goldberg, J., Anderson, G. M., Zwaigenbaum, L., Hall, G. B., Nahmias, C., Thompson, A., et al. (2009). Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 97–104.PubMedCrossRef Goldberg, J., Anderson, G. M., Zwaigenbaum, L., Hall, G. B., Nahmias, C., Thompson, A., et al. (2009). Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 97–104.PubMedCrossRef
go back to reference Hanley, H. G., Stahl, S. M., & Freedman, D. X. (1977). Hyperserotonemia and amine metabolites in autistic and retarded children. Archives of General Psychiatry, 34, 521–531.PubMedCrossRef Hanley, H. G., Stahl, S. M., & Freedman, D. X. (1977). Hyperserotonemia and amine metabolites in autistic and retarded children. Archives of General Psychiatry, 34, 521–531.PubMedCrossRef
go back to reference Hérault, J., Petit, E., Martineau, J., Cherpi, C., Perrot, A., Barthélémy, C., et al. (1996). Serotonin and autism: Biochemical and molecular biology features. Psychiatry Research, 65, 33–43.PubMedCrossRef Hérault, J., Petit, E., Martineau, J., Cherpi, C., Perrot, A., Barthélémy, C., et al. (1996). Serotonin and autism: Biochemical and molecular biology features. Psychiatry Research, 65, 33–43.PubMedCrossRef
go back to reference Launay, J. M., Ferrari, P., Haimart, M., Bursztejn, C., Tabuteau, F., Braconnier, A., et al. (1988). Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children. Neuropsychobiology, 20, 1–11.PubMedCrossRef Launay, J. M., Ferrari, P., Haimart, M., Bursztejn, C., Tabuteau, F., Braconnier, A., et al. (1988). Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children. Neuropsychobiology, 20, 1–11.PubMedCrossRef
go back to reference Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., et al. (2006). Platelet-derived serotonin mediates liver regeneration. Science, 312(5770), 104–107.PubMedCrossRef Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., et al. (2006). Platelet-derived serotonin mediates liver regeneration. Science, 312(5770), 104–107.PubMedCrossRef
go back to reference Makkonen, I., Riikonen, R., Kokki, H., Airaksinen, M. M., & Kuikka, J. T. (2008). Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental Medicine and Child Neurology, 50, 593–597.PubMedCrossRef Makkonen, I., Riikonen, R., Kokki, H., Airaksinen, M. M., & Kuikka, J. T. (2008). Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental Medicine and Child Neurology, 50, 593–597.PubMedCrossRef
go back to reference Martineau, J., Barthélémy, C., Jouve, J., Muh, J. P., & Lelord, G. (1992). Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: Age-related changes and drug effects. Developmental Medicine and Child Neurology, 34, 593–603.PubMedCrossRef Martineau, J., Barthélémy, C., Jouve, J., Muh, J. P., & Lelord, G. (1992). Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: Age-related changes and drug effects. Developmental Medicine and Child Neurology, 34, 593–603.PubMedCrossRef
go back to reference McBride, P. A., Anderson, G. M., Hertzig, M. E., Snow, M. E., Thompson, S. M., Khait, V. D., et al. (1998). Effects of diagnosis, race and pubertal status on platelet serotonin levels in autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 767–779.PubMedCrossRef McBride, P. A., Anderson, G. M., Hertzig, M. E., Snow, M. E., Thompson, S. M., Khait, V. D., et al. (1998). Effects of diagnosis, race and pubertal status on platelet serotonin levels in autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 767–779.PubMedCrossRef
go back to reference McBride, P. A., Anderson, G. M., Hertzig, M. E., Sweeney, J. A., Kream, J., Cohen, D. J., et al. (1989). Serotonergic responsivity in male young adults with autistic disorder. Archives of General Psychiatry, 46, 205–212.CrossRef McBride, P. A., Anderson, G. M., Hertzig, M. E., Sweeney, J. A., Kream, J., Cohen, D. J., et al. (1989). Serotonergic responsivity in male young adults with autistic disorder. Archives of General Psychiatry, 46, 205–212.CrossRef
go back to reference Minderaa, R. B., Anderson, G. M., Volkmar, F. R., Akkerhuis, G. W., & Cohen, D. J. (1987). Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biological Psychiatry, 22, 933–940.PubMedCrossRef Minderaa, R. B., Anderson, G. M., Volkmar, F. R., Akkerhuis, G. W., & Cohen, D. J. (1987). Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biological Psychiatry, 22, 933–940.PubMedCrossRef
go back to reference Mulder, E. J., Anderson, G. M., Kema, I. P., de Bildt, A., van Lang, N. D., den Boer, J. A., et al. (2004). Platelet serotonin levels in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 491–499.PubMedCrossRef Mulder, E. J., Anderson, G. M., Kema, I. P., de Bildt, A., van Lang, N. D., den Boer, J. A., et al. (2004). Platelet serotonin levels in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 491–499.PubMedCrossRef
go back to reference Mulder, E. J., Anderson, G. M., Kemperman, R. F., Oosterloo-Duinkerken, A., Minderaa, R. B., & Kema, I. P. (2010). Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals. Neuropsychobiology, 61, 27–32.PubMedCrossRef Mulder, E. J., Anderson, G. M., Kemperman, R. F., Oosterloo-Duinkerken, A., Minderaa, R. B., & Kema, I. P. (2010). Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals. Neuropsychobiology, 61, 27–32.PubMedCrossRef
go back to reference Murphy, D. G., Daly, E., Schmitz, N., Toal, F., Murphy, K., Curran, S., et al. (2006). Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger’s syndrome: An in vivo SPECT study. American Journal of Psychiatry, 163, 934–936.PubMedCrossRef Murphy, D. G., Daly, E., Schmitz, N., Toal, F., Murphy, K., Curran, S., et al. (2006). Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger’s syndrome: An in vivo SPECT study. American Journal of Psychiatry, 163, 934–936.PubMedCrossRef
go back to reference Posey, D. J., Erickson, C. A., & McDougle, C. J. (2008). Developing drugs for core social and communication impairment in autism. Child and Adolescent Psychiatric Clinics of North America, 17, 787–801.PubMedCrossRef Posey, D. J., Erickson, C. A., & McDougle, C. J. (2008). Developing drugs for core social and communication impairment in autism. Child and Adolescent Psychiatric Clinics of North America, 17, 787–801.PubMedCrossRef
go back to reference Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. Journal of Pediatrics, 58, 315–320.PubMedCrossRef Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. Journal of Pediatrics, 58, 315–320.PubMedCrossRef
go back to reference Spivak, B., Golubchik, P., Mozes, T., Vered, Y., Nechmad, A., Weizman, A., et al. (2004). Low platelet-poor plasma levels of serotonin in adult autistic patients. Neuropsychobiology, 50, 157–160.PubMedCrossRef Spivak, B., Golubchik, P., Mozes, T., Vered, Y., Nechmad, A., Weizman, A., et al. (2004). Low platelet-poor plasma levels of serotonin in adult autistic patients. Neuropsychobiology, 50, 157–160.PubMedCrossRef
go back to reference Vered, Y., Golubchik, P., Mozes, T., Strous, R., Nechmad, A., Mester, R., et al. (2003). The platelet-poor plasma 5-HT response to carbohydrate rich meal administration in adult autistic patients compared with normal controls. Human Psychopharmacology, 18, 395–399.PubMedCrossRef Vered, Y., Golubchik, P., Mozes, T., Strous, R., Nechmad, A., Mester, R., et al. (2003). The platelet-poor plasma 5-HT response to carbohydrate rich meal administration in adult autistic patients compared with normal controls. Human Psychopharmacology, 18, 395–399.PubMedCrossRef
Metagegevens
Titel
Brief Report: Platelet-Poor Plasma Serotonin in Autism
Auteurs
George M. Anderson
Margaret E. Hertzig
P. A. McBride
Publicatiedatum
01-07-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1371-1