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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2012

01-07-2012 | Brief Report

Brief Report: Platelet-Poor Plasma Serotonin in Autism

Auteurs: George M. Anderson, Margaret E. Hertzig, P. A. McBride

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2012

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Abstract

Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT.
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Metagegevens
Titel
Brief Report: Platelet-Poor Plasma Serotonin in Autism
Auteurs
George M. Anderson
Margaret E. Hertzig
P. A. McBride
Publicatiedatum
01-07-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1371-1

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