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01-10-2009 | Brief Report | Uitgave 10/2009

Brief Report: Parental Age and the Sex Ratio in Autism

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 10/2009

Auteurs:: Alene Anello, Abraham Reichenberg, Xiaodong Luo, James Schmeidler, Eric Hollander, Christopher J. Smith, Connor M. Puleo, Lauren A. Kryzak, Jeremy M. Silverman

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Abstract

The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30–34, 35–39, 40–44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.

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Titel: Brief Report: Parental Age and the Sex Ratio in Autism
Auteurs:: Alene Anello
Abraham Reichenberg
Xiaodong Luo
James Schmeidler
Eric Hollander
Christopher J. Smith
Connor M. Puleo
Lauren A. Kryzak
Jeremy M. Silverman
Publicatiedatum: 01-10-2009
DOI: https://doi.org/10.1007/s10803-009-0755-y
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 10/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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