01-02-2008 | Brief Report | Uitgave 2/2008 Open Access

Brief Report: Normal Intestinal Permeability at Elevated Platelet Serotonin Levels in a Subgroup of Children with Pervasive Developmental Disorders in Curaçao (The Netherlands Antilles)
- Tijdschrift:
- Journal of Autism and Developmental Disorders > Uitgave 2/2008
Introduction
Methods
Patients
Sugar Absorption Test
Serotonin Assays
Exclusion of Celiac Disease
Statistics
Results
Patients
Parameter
|
|
Gender (male/female)
|
18 (75%) / 6 (25%)
|
Age (years)
|
9.9 (±3.9)
|
DSM-IV TR diagnoses
|
|
299.00 (autistic disorder)
|
8 (33%)
|
299.80 (PDD-NOS)
|
16 (67%)
|
Ethnicity
|
|
Caucasian
|
8 (33%)
|
African–American
|
13 (54%)
|
Other
|
3 (13%)
|
Comorbidity
|
|
Epilepsy
|
5 (22%)
|
Allergy
|
2 (9%)
|
Asthma
|
1 (4%)
|
Intestinal yeast infection
|
1 (4%)
|
Medication for comorbidity
|
9 (38%)
|
Nutritional supplements (vitamins/
ω3-oils)
|
9 (38%) / 2 (4%)
|
Diet (gluten and casein free)
a
|
2 (9%)
|
Physical complaints related to GI tract
a
|
13 (57%)
|
Nausea
|
0 (0%)
|
Vomiting
|
1 (4%)
|
Diarrhea
|
4 (17%)
|
Constipation
|
4 (17%)
|
Bloating and gaseousness
|
8 (35%)
|
Parameter
|
Reference values
|
<RV
|
≥RV
|
||
---|---|---|---|---|---|
PLT 5-HT (nmol/10
9 PLT)
a
|
3.4 (2.0–7.1)
|
<4.55
b
|
6 (26%)
|
||
<5.4
c
|
4 (17%)
|
||||
Tryp (
μmol/l)
a
|
50.0 (±10.9)
|
2–18y: 0–79
d
|
0 (0%)
|
0 (0%)
|
|
2y: 35–73
d
|
}
|
||||
6y: 37–76
d
|
3 (13%)
|
0 (0%)
|
|||
16y: 54–93
d
|
|||||
5-HIAA (
μmol/24 h)
e
|
8.4 (3.9–36.4)
|
3–8y: 2.1–29.3
d
|
}
|
||
9–12y: 5.2–32.9
d
|
1 (5%)
|
1 (5%)
|
|||
13–17: 4.7–34.0
d
|
|||||
>18y: 5.2–36.6
d
|
|||||
5-HT (nmol/24 h)
e
|
305 (±92)
|
||||
Lactulose (mmol/5 h)
f
|
0.024 (±0.11)
|
||||
Mannitol (mmol/5 h)
f
|
1.32 (±0.59)
|
||||
L/M ratio (mol/mol)
f
|
0.019 (±0.007)
|
<0.090
g
|
23 (100%)
|
0 (0%)
|