Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-11-2008 | Brief Report

Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin

Auteurs: Frederike Schirmbeck, Alexander Georgi, Jana Strohmaier, Christine Schmael, Katja V. Boesshenz, Thomas W. Mühleisen, Stefan Herms, Per Hoffmann, Rami Abou Jamra, Johannes Schumacher, Wolfgang Maier, Peter Propping, Markus M. Nöthen, Sven Cichon, Marcella Rietschel, Thomas G. Schulze

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2008

Abstract

Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831–838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.

vorige artikel Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism

volgende artikel Brief Report: Narratives of Personal Events in Children with Autism and Developmental Language Disorders: Unshared Memories

Alaghband-Rad, J., McKenna, K., Gordon, C.T., Albus, K.E., Hamburger, S.D., Rumsey, J.M., et al. (1995). Childhood-onset schizophrenia: The severity of premorbid course. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 1273–1283. doi:10.1097/00004583-199510000-00012.PubMedCrossRef

Bakker, S. C., Hoogendoorn, M. L., Hendriks, J., Verzijlbergen, K., Caron, S., Verduijn, W., Selten, J. P., Person, P. L., Kahn, R. S., & Sinke, R. J. (2007). The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia. Genes, Brain, and Behavior, 6, 113–119. doi:10.1111/j.1601-183X.2006.00234.x.PubMedCrossRef

Burdick, K. E., Goldberg, T. E., Funke, B., Bates, J. A., Lencz, T., Kucherlapati, R., & Malhotra, A. K. (2007). DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophrenia Research, 89, 169–172. doi:10.1016/j.schres.2006.09.008.PubMedCrossRef

Burdick, K. E., Lencz, T., Funke, B., Finn, C. T., Szeszko, P. R., Kane, J. M., Kucherlapati, R., & Malhotra, A. K. (2006). Genetic variation in DTNBP1 influences general cognitive ability. Human Molecular Genetics, 15, 1563–1568. doi:10.1093/hmg/ddi481.PubMedCrossRef

Cannon-Spoor, E. H., Potkin, S. G., & Wyatt, R. J. (1982). Measurement of premorbid adjustment in chronic schizophrenia. Schizophrenia Bulletin, 8, 470–484.PubMed

Craddock, N., O'Donovan, M. C., & Owen, M. J. (2007). Phenotypic and genetic complexity of psychosis. Invited commentary on Schizophrenia: A common disease caused by multiple rare alleles. The British Journal of Psychiatry, 190, 200–203. doi:10.1192/bjp.bp.106.033761.PubMedCrossRef

Donohoe, G., Morris, D. W., Clarke, S., McGhee, K. A., Schwaiger, S., Nangle, J.-M., Garavan, H., Robertson, I. H., Gill, M., & Corvin, A. (2007). Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study. Neuropsychologia, 45, 454–458. doi:10.1016/j.neuropsychologia.2006.06.016.PubMedCrossRef

Dudbridge F. (2006). UNPHASED user guide. Technical Report 2006/5. Cambridge, UK: MRC Biostatistics Unit.

Fangerau, H., Ohlraun, S., Granath, R. O., Nothen, M. M., Rietschel, M., & Schulze, T. G. (2004). Computer-assisted phenotype characterisation for genetic research in psychiatry. Human Heredity, 58, 122–130. doi:10.1159/000083538.PubMedCrossRef

First, M. B., Spitzer, R. L., & Gibbon, M. (1994). Structured Clinical Interview for Axis I DSM-IV Disorders. New York: Biometrics Research.

Gornick, M. C., Addington, A. M., Sporn, A., Gogtay, N., Greenstein, D., Lenane, M., Gochman, P., Ordonez, A., Balkissoon, R., Vakkalanka, R., Weinberger, D. R., Rapoport, J. L., & Straub, R. E. (2005). Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS). Journal of Autism and Developmental Disorders, 35, 831–838. doi:10.1007/s10803-005-0028-3.PubMedCrossRef

Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. The American Journal of Psychiatry, 160, 636–645. doi:10.1176/appi.ajp.160.4.636.PubMedCrossRef

Hamshere, M. L., Williams, N. M., Norton, N., Williams, H., Cardno, A. G., Zammit, S., Jones, L. A., Murphy, K. C., Sanders, R. D., McCarthy, G., Gray, M. Y., Jones, G., Holmans, P., O'Donovan, M. C., Owen, M. J., & Craddock, N. (2006). Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics, 43, 563–567. doi:10.1136/jmg.2005.035345.PubMedCrossRef

Hecht, H., Genzwürker, S., Helle, M., & Van Calker, D. (2005). Social functioning and personality of subjects at familial risk for affective disorder. Journal of Affective Disorders, 84, 33–42. doi:10.1016/j.jad.2004.09.002.PubMedCrossRef

Hollis, C. (1995): Child and adolescent (juvenile onset) schizophrenia: A case–control study of premorbid developmental impairments. The British Journal of Psychiatry, 166, 489–495.PubMedCrossRef

Kumra, S., Shaw, M., Merka, P., Nakayama, E., & Augustin, R. (2001). Childhood-onset schizophrenia: Research update. Canadian Journal of Psychiatry, 46, 923–930.

Leboyer, M., & Henry, C. (2005). Pathogenesis of bipolar disorders: Genetic vulnerability and environmental factors. La Revue du Praticien, 55, 487–492.PubMed

McGuffin, P., Farmer, A. E., & Harvey, I. (1991). A polydiagnostic application of the operational criteria in studies of psychotic illness. Archives of General Psychiatry, 48, 764–770.PubMed

Mutsuddi, M., Morris, D. W., Waggoner, S. G., Daly, M. J., Scolnick, E. M., & Sklar, P. (2006). Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. American Journal of Human Genetics, 79, 903–909. doi:10.1086/508942.PubMedCrossRef

Nicolson, R., & Rapoport, J. L. (1999). Childhood-onset schizophrenia: Rare but worth studying. Biological Psychiatry, 46, 1418–1428. doi:10.1016/S0006-3223(99)00231-0.PubMedCrossRef

Posthuma, D., Luciano, M., de geus, E. J. C., Wright, M. J., Slagboom, P. E., Montgomery, G. W., Boomsma, D. I., & Martin, N. G. (2005). A genomwide scan for intelligence identifies quantitative trait loci on 2q and 6p. American Journal of Human Genetics, 77, 318–326. doi:10.1086/432647.PubMedCrossRef

Potash, J. B. (2006). Carving chaos: Genetics and the classification of mood and psychotic syndromes. Harvard Review of Psychiatry, 14, 47–63. doi:10.1080/10673220600655780.PubMedCrossRef

Purcell, S., Cherny, S. S., & Sham, P. C. (2003). Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics, 19, 149–150. doi:10.1093/bioinformatics/19.1.149.PubMedCrossRef

Reichenberg, A., Rabinowitz, J., Weiser, M., Mark, M., Kaplan, Z., & Davidson, M. (2000). Premorbid functioning in a national population of male twins discordant for psychoses. American Journal of Psychiatry, 157, 1514–1516. doi:10.1176/appi.ajp.157.9.1514.PubMedCrossRef

Remschmidt, H., & Theisen, F. M. (2005) Schizophrenia and related disorders in children and adolescents. Journal of Neural Transmission. Supplementum, 69, 121–141.PubMed

Schmael, C., Georgi, A., Krumm, B., Buerger, C., Deschner, M., Nöthen, M. M., Schulze, T. G., & Rietschel, M. (2007). Premorbid adjustment in schizophrenia – An important aspect of phenotype definition. Schizophrenia Research, 92, 50–62. doi:10.1016/j.schres.2007.01.016.PubMedCrossRef

Schulze, T. G., Hedeker, D., Zandi, P., Rietschel, M., & McMahon, F. J. (2006). What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics. Archives of General Psychiatry, 63, 1368–1376. doi:10.1001/archpsyc.63.12.1368.PubMedCrossRef

Schulze, T. G., & McMahon, F. J. (2004). Defining the phenotype in human genetic studies: Forward genetics and reverse phenotyping. Human Heredity, 58, 131–138. doi:10.1159/000083539.PubMedCrossRef

Schumacher, J., Jamra, R. A., Becker, T., Ohlraun, S., Klopp, N., Binder, E. B., Schulze, T. G., Deschner, M., Schmäl, C., Höfels, S., Zobel, A., Illig, T., Propping, P., Holsboer, F., Rietschel, M., Nöthen, M. M., & Cichon, S. (2005). Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biological Psychiatry, 58, 307–314. doi:10.1016/j.biopsych.2005.04.006.PubMedCrossRef

Schwab, S. G., Knapp, M., Mondabon, S., Hallmayer, J., Borrmann-Hassenbach, M., Albus, M., Lerer, B., Rietschel, M., Trixler, M., Maier, W., & Wildenauer, D. B. (2003). Support for association of schizophrenia with genetic variation in the 6p22.3 gene, Dysbindin, in sib-pair families with linkage and in an additional sample of triad families. American Journal of Human Genetics, 72, 185–190. doi:10.1086/345463.PubMedCrossRef

Straub, R. E., Jiang, X., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris-Kerr, C., Wormley, B., Sadek, H., Kadambi, B., Cesare, A. J., Gibberman, A., Wang, X., O’Neill, F. A., Walsh, D., & Kendler, K. S. (2002). Genetic variation in the 6p22.3 Gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. American Journal of Human Genetics, 71, 337–348. doi:10.1086/341750.PubMedCrossRef

Williams, N. M., Preece, A., Morris, D. W., Spurlock, G., Bray, N. J., Stephens, M., Norton, N., Williams, H., Clement, M., Dwyer, S., Curran, C., Wilkinson, J., Moskvina, V., Waddington, J. L., Gill, M., Corvin, A. P., Zammit, S., Kirov, G., Owen, M. J., & O'Donovan, M. C. (2004). Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry, 61, 336–344. doi:10.1001/archpsyc.61.4.336.PubMedCrossRef

Wozniak, J., Biederman, J., Monuteaux, M. C., Richards, J., & Faraone, S. V. (2002). Parsing the comorbidity between bipolar disorder and anxiety disorders: A familial risk analysis. Journal of Child and Adolescent Psychopharmacology, 12, 101–111. doi:10.1089/104454602760219144.PubMedCrossRef

Zinkstok, J. R., de Wilde, O., van Amelsvoort, T. A., Tanck, M. W., Baas, F., & Linszen, D. H. (2007). Association between the DTNBP1 gene and intelligence: A case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behavioral and Brain Functions, 3, 19–28.doi:10.1186/1744-9081-3-19.PubMedCrossRef

Titel: Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin
Auteurs: Frederike Schirmbeck
Alexander Georgi
Jana Strohmaier
Christine Schmael
Katja V. Boesshenz
Thomas W. Mühleisen
Stefan Herms
Per Hoffmann
Rami Abou Jamra
Johannes Schumacher
Wolfgang Maier
Peter Propping
Markus M. Nöthen
Sven Cichon
Marcella Rietschel
Thomas G. Schulze
Publicatiedatum: 01-11-2008
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0582-6

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 10/2008

LEGO ® Therapy and the Social Use of Language Programme: An Evaluation of Two Social Skills Interventions for Children with High Functioning Autism and Asperger Syndrome

Feeding and Eating Behaviors in Children with Autism and Typically Developing Children

JADD Announcements for November 2008

Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study

Effect of Social Familiarity on Salivary Cortisol and Self-Reports of Social Anxiety and Stress in Children with High Functioning Autism Spectrum Disorders

An Investigation of Sleep Characteristics, EEG Abnormalities and Epilepsy in Developmentally Regressed and Non-regressed Children with Autism